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Christiano
Angela M. Christiano, Upper Saddle River, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090208484 | R-SPONDIN COMPOSITIONS AND METHODS OF USE THEREOF - The invention provides for a method for screening compounds that bind to and modulate a regulator of Wnt signaling, R-spondin 4. The invention further provides for methods for diagnosing a keratin-related abnormality, such as anonychia congenital, in a subject. The invention also provides for isolated RSPO4 mutant molecules. | 08-20-2009 |
| 20100303767 | METHODS FOR COMPACT AGGREGATION OF DERMAL CELLS - The invention provides for a method for aggregating dermal papilla cells or dermal sheath cells or a combination thereof, the method comprising: growing dermal papilla cells or dermal sheath cells or a combination thereof in suspension culture; and contacting the culture with an effective amount of an enzyme, wherein a substrate of the enzyme is an extracellular matrix molecule in the suspension culture, so as to aggregate dermal papilla cells or dermal sheath cells. The culture may be a hanging drop culture and the enzyme may be a hyaluronidase. | 12-02-2010 |
Angela M. Christiano, West Orange, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090004169 | Nucleic Acids For Inhibiting Hairless Protein Expression and Methods of Use Thereof - The present invention provides DNAzymes and ribozymes that specifically cleave Hairless protein mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of Hairless Protein mRNA. The present invention also provides various methods of inhibiting the expression of Hairless Protein. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes and antisense oligonucleotides as active ingredients. | 01-01-2009 |
| 20100221318 | NUCLEIC ACIDS FOR INHIBITING HAIRLESS PROTEIN EXPRESSION AND METHODS OF USE THEREOF - The present invention provides DNAzymes and ribozymes that specifically cleave Hairless protein mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of Hairless Protein mRNA. The present invention also provides various methods of inhibiting the expression of Hairless Protein. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes and antisense oligonucleotides as active ingredients. | 09-02-2010 |
Angela M. Christiano, Saddle River, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20080287359 | CADHERIN-11-MEDIATED MODULATION OF HAIR GROWTH - The present invention provides for methods of inhibiting hair growth, comprising decreasing the level of CAD1 1 mRNA and/or protein in hair follicle cells of a subject. The present invention further provides for methods of promoting hair growth, comprising increasing the level of CADI 1 mKNA and/or protein in hair follicle cells of a subject. The invention also provides for transgenic animals with aberrancies in CADI 1 expression, and for assay systems (including transgenic animals and cell-based systems) that may be used to identify agents that decrease or increase CADI 1 expression. | 11-20-2008 |
| 20100137416 | CADHERIN-11-MEDIATED MODULATION OF HAIR GROWTH - The present invention provides for methods of inhibiting hair growth, comprising decreasing the level of CAD1 1 mRNA and/or protein in hair follicle cells of a subject. The present invention further provides for methods of promoting hair growth, comprising increasing the level of CADI 1 mKNA and/or protein in hair follicle cells of a subject. The invention also provides for transgenic animals with aberrancies in CADI 1 expression, and for assay systems (including transgenic animals and cell-based systems) that may be used to identify agents that decrease or increase CADI 1 expression. | 06-03-2010 |
| 20110189199 | METHODS FOR P2RY5 MEDIATED REGULATION OF HAIR GROWTH AND MUTANTS THEREOF - The invention provides for a method for screening compounds that bind to and modulate the hair-specific G-protein coupled receptor, P2RY5. The invention further provides for methods for controlling hair growth by administering a P2RY5 modulating compound to a subject. | 08-04-2011 |
| 20120003244 | METHODS FOR APCDD1 MEDIATED REGULATION OF HAIR GROWTH AND PIGMENTATION AND MUTANTS THEREOF - The invention provides for methods for controlling hair growth by administering an APCDD1 modulating compound to a subject. The invention further provides for a method for screening compounds that bind to and modulate APCDD1. | 01-05-2012 |
John P. Christiano, Old Lyme, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20120090819 | HEATER-COOLER SYSTEM FOR A BARREL OF AN EXTRUDER AND A METHOD OF USING THE SAME - A heater-cooler system for a barrel of an extruder is disclosed. The system includes a heater adapted to be in thermal communication with at least a portion of a barrel of an extruder. The system further includes a shroud assembly that defines a cavity. The shroud assembly encloses the heater. The shroud assembly has an intake port and an exhaust port. A valve is in fluid communication with the exhaust port. The valve is moveable between an open position and a closed position. When the valve is in the closed position the exhaust port is substantially sealed. When the valve is moved between the closed position and the open position or is in the open position the cavity is in fluid communication an area outside of the cavity through the exhaust port. | 04-19-2012 |