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Christiane
Christiane Aichholzer, Graz AT
| Patent application number | Description | Published |
|---|---|---|
| 20120035267 | PARACETAMOL FOR PARENTERAL ADMINSTRATION - The invention relates to an aqueous pharmaceutical composition, preferably an infusion solution, for parenteral administration which contains paracetamol and has an electrical conductivity of not more than 200 μS cm | 02-09-2012 |
Christiane Amendt, Darmstadt DE
| Patent application number | Description | Published |
|---|---|---|
| 20090118267 | INDANES - Compounds of the formula (I), in which R | 05-07-2009 |
| 20090163556 | GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHBITORS - The present invention relates to glycinamide derivatives of formula I, | 06-25-2009 |
| 20090253688 | Semicarbazide derivatives as kinase inhibitors - The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. | 10-08-2009 |
| 20090298885 | METHYLENE UREA DERIVATIVES - The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. | 12-03-2009 |
Christiane Bauer, Burscheid DE
| Patent application number | Description | Published |
|---|---|---|
| 20090001669 | Sliding Element, in Particular Piston Ring, Method for Manufacturing a Sliding Element, Sliding System and Coating for a Sliding Element - A sliding element comprises at least one surface for sliding contact with a running face, wherein a wear layer and a run-in layer made from carbon are applied to the surface, and is characterized in that the run-in layer comprises hydrogen and nanocrystalline carbide phases. In a method for manufacturing a sliding element, the run-in layer is applied by means of a PVD process. A sliding system has an above-described sliding element and a body having a running face. A coating for a sliding element comprises a wear layer which can be applied to the upper side of the sliding element, and a run-in layer which is configured as a carbon layer, and is characterized in that the run-in layer comprises hydrogen and nanocrystalline carbide phases. | 01-01-2009 |
| 20100044968 | PISTON RING FOR INTERNAL COMBUSTION ENGINES - The invention relates to a piston ring which is produced from a carrier material, especially steel or a cast material. The piston ring has a wear-resistant coating from a periodic multilayer system, every periodicity consisting of at least two individual metal nitride layers. Adjacent individual layers within the periodicity have different metallic elements. The thickness of an individual layer is ≧15 nm. | 02-25-2010 |
| 20100044969 | PISTON RING FOR INTERNAL COMBUSTION ENGINES - The invention relates to a piston ring which is produced from a carrier material, especially steel or a cast material. The piston ring has a wear-resistant coating from a periodic multilayer system, every periodicity consisting of at least two individual metal nitride layers. The multilayer system has superlattice structures, the thickness of an individual layer being ≧2 nm to <15 nm and the thickness of the multilayer system being >4.5 μm and adjacent individual layers within the periodicity having different metallic elements. | 02-25-2010 |
| 20100171272 | PISTON RING - Disclosed is a piston ring comprising a supporting material and a wear-resistant coating. The wear-resistant coating is composed of a ternary system A-B—N which is applied using a PVD process and in which A and B each represent an element form the group encompassing Ti, Zr, Hf, V, Nb, Ta, Cr, Mo W, Al, Si and C, wherein A ≠B and N represents nitrogen. The thickness of the wear-resistant coating amounts to ≧3 μm. | 07-08-2010 |
| 20100187765 | PISTON RING - In order to avoid burn traces on piston rings, it is proposed to provide the piston ring with a wear-protection coating which consists of a material with a thermal conductivity of at least 180 W/(m.K). At least 5% vol. of the wear-protection coating consists of aluminum nitride. | 07-29-2010 |
Christiane Damge, Strasbourg FR
| Patent application number | Description | Published |
|---|---|---|
| 20100143484 | ORAL SUBMICRON PARTICLE DELIVERY SYSTEM FOR PROTEINS AND PROCESS FOR ITS PRODUCTION - The invention provides a novel submicron system for the oral administration of proteins. An effective oral carrier for proteins should shield its content against the gastrointestinal tract proteases and be capable of facilitating the uptake of the protein drug across the gastrointestinal epithelium. The present invention relates to production of gelled particles which comprises a protein drug susceptible to enzymatic degradation by enzymes and acid conditions in the stomach, a polymeric matrix which undergoes precipitation-swelling process, and two-layer-coating materials which are themselves capable of enhancing absorption of said drug across the intestinal mucosal tissues and of inbihiting degradation of said drug by gastric enzymes. Insulin-loaded particles with appropriate submicron size for gastrointestinal absorption were made of natural occurring polymers by emulsification-based method and proved to be gastric pH and protease protective. Effects on glycemia were observed during 14 h after their oral single administration to rats, achieving 42% of pharmacological activity compared to subcutaneous administration. Postprandial rise in blood glucose was suppressed and insulinemia levels increased by a factor of seven. The relative oral bioavailability of insulin calculated over 8 h by comparison with a subcutaneous injection of free insulin was 34%. | 06-10-2010 |
Christiane Fantauzzo, Aix-En-Provence FR
| Patent application number | Description | Published |
|---|---|---|
| 20110255064 | PHOTOLITHOGRAPHY METHOD AND DEVICE - A photolithography method includes projecting a light beam through a mask onto a photosensitive layer to form on the photosensitive layer an image of a mask pattern formed by the mask, and controlling a layer of active elements of the mask so that the light beam after having traversed the layer of active elements, reproduces the mask pattern onto the photosensitive layer. The active elements are distributed throughout the layer of active elements in conformance with a matrical organization of lines and columns, each active element being individually controllable to take a state transparent to the light of the light beam, or else a state opaque to or reflecting of the light of the light beam, as a function of a command signal supplied to the active element. | 10-20-2011 |
Christiane Gödl, Graz AT
| Patent application number | Description | Published |
|---|---|---|
| 20090318372 | Method For Producing 2-O-Glyceryl-Alpha-D-Glucopyranoside - The present invention relates to a method for producing 2-O-glyceryl-α-D-glucopyranoside (αGG; FIG. | 12-24-2009 |
Christiane Gödl, Graz AT
| Patent application number | Description | Published |
|---|---|---|
| 20090318372 | Method For Producing 2-O-Glyceryl-Alpha-D-Glucopyranoside - The present invention relates to a method for producing 2-O-glyceryl-α-D-glucopyranoside (αGG; FIG. | 12-24-2009 |
Christiane Gumera, Atlanta, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20090297607 | BIOMIMETIC POLYMERS AND USES THEREOF - Biodegradable polymers incorporating biomolecules and methods of their use are provided. Certain aspects provide biomolecules crosslinked with diglycidyl esters. The disclosed compositions have numerous applications including cellular regeneration, wound healing, and cellular differentiation. | 12-03-2009 |
Christiane Hoffmann, Frankfurt Am Main DE
| Patent application number | Description | Published |
|---|---|---|
| 20090254194 | Phase-and sedimentation-stable, plastically deformable preparation with intrinsic pore forming, intended for example for filling bone defects or for use as bone substitute material, and method of producing it - The invention relates to a phase and sedimentation-stable, plastically deformable preparation with intrinsic pore formation that can be used for instance for filling bone defects and for augmentation, and also relates to a method for producing and using same. | 10-08-2009 |
Christiane Honisch, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090006002 | COMPARATIVE SEQUENCE ANALYSIS PROCESSES AND SYSTEMS - Provided herein are processes for rapidly identifying or determining sequence information in a sample nucleic acid by comparing sample nucleic acid sequence information to reference nucleic acid sequence information or information obtained from reference samples. Also provided are automated systems for conducting comparative sequence analyses. | 01-01-2009 |
Christiane Huygen, Bruxelles BE
| Patent application number | Description | Published |
|---|---|---|
| 20110200603 | NEW ANTIGENS FOR PARATUBERCULOSIS DIAGNOSIS AND VACCINATION - Antigens of | 08-18-2011 |
Christiane Jacksch, Laatzen DE
| Patent application number | Description | Published |
|---|---|---|
| 20090087698 | MEMBRANE ELECTRODE ASSEMBLY WITH HYDROGENATABLE MATERIAL FOR A FUEL CELL - The invention relates to a membrane-electrode assembly ( | 04-02-2009 |
Christiane Kettlitz, Wernigerode DE
| Patent application number | Description | Published |
|---|---|---|
| 20080280775 | Determination of Antibiotic Resistance in Staphylococcus Aureus - The present invention relates to the detection of antibiotic resistance determinants in | 11-13-2008 |
Christiane Kleuss, Berlin DE
| Patent application number | Description | Published |
|---|---|---|
| 20100303803 | CATENATE FOR IMMUNOSTIMULATION - The invention relates to a multimeric, non-coding nucleic acid molecule for modulating the activity of the human or animal immune system, and to a production method therefor, and to a vaccine containing said multimeric, non-coding nucleic acid molecule. Said multimeric, non-coding nucleic acid molecules can be non-coding nucleic acid molecules that consist of at least two of said molecules (dimer) or assemblies of several non-coding nucleic acid molecules. | 12-02-2010 |
Christiane L'Heritier, Paris FR
| Patent application number | Description | Published |
|---|---|---|
| 20100173879 | USE OF A COMPOUND ANTAGONIST TO THE NK2 RECEPTORS OF NEUROKININ A FOR THE PREPARATION OF DRUGS USEFUL FOR PREVENTING AND TREATING OF SEXUAL DYSFUNCTION - The invention relates to the use of a compound antagonist to the NK | 07-08-2010 |
Christiane Lowke, Berlin DE
| Patent application number | Description | Published |
|---|---|---|
| 20110015578 | TAMPER-PROOF CLOSURE HAVING A RETAINING PIN - The invention relates to a tamperproof seal for a container or a syringe, with a lockable conical adapter which is sealed in a sterile manner by means of a rubber stopper and is protected by a safety sleeve, wherein the safety sleeve, which is pushed non-releasably onto the conical adapter lock, comprises a retaining part, a break-off part and a break-off zone located between said parts. The break-off part encloses the rubber stopper without radical contact. It has a retaining pin, the free end of which rests axially on the rubber stopper—when the tamperproof seal is fitted, and it has at least two open apertures. The length of the break-off part corresponds to at least twice the length of the internal thread of the conical adapter lock. | 01-20-2011 |
Christiane Meier, Seyring AT
| Patent application number | Description | Published |
|---|---|---|
| 20090298792 | Anti-Inflammatory Polymer - The present invention provides the use of cellulose sulfate or chitosan for the manufacture of an anti-inflammatory pharmaceutical or cosmetic composition for the treatment of inflammation. | 12-03-2009 |
| 20100040658 | ANTIVIRAL COMPOSITION AND METHOD OF USE - A method for manufacturing an antiviral pharmaceutical composition for the prophylaxis or treatment of a rhinovirus infection that includes the utilization of iota-, kappa- or lambda-carrageenan or mixtures thereof. | 02-18-2010 |
Christiane Metz-Weidmann, Frankfurt Am Main DE
| Patent application number | Description | Published |
|---|---|---|
| 20110177096 | USE OF GPR151 MODULATORS FOR THE TREATMENT OF PAIN - The present invention relates to nucleic acid arrays used to detect genes which are up or down regulated following a pain stimulus in a mammal. It further relates to the use of GPR151 in methods to detect pain or evaluate the effect of a compound on the level of pain in a mammal. Other aspects of the invention concern a method for screening pharmaceuticals, methods for the treatment of pain and a pharmaceutical composition comprising a GPR151 modulator for the treatment of pain. | 07-21-2011 |
Christiane Metz-Weidmann, Wollstadt 1 DE
| Patent application number | Description | Published |
|---|---|---|
| 20110091888 | USE OF CATHEPSIN C - Present invention concerns the use of Cathepsin C. Other aspects of the invention concern methods for screening pharmaceuticals, for diagnosing pain susceptibility and for the treatment of pain. | 04-21-2011 |
Christiane Meyer, Meunster DE
Christiane Moepert, Berlin DE
| Patent application number | Description | Published |
|---|---|---|
| 20090200263 | METHOD FOR METALLIZING INSULATING SUBSTRATES WHEREIN THE ROUGHENING AND ETCHING PROCESSES ARE CONTROLLED BY MEANS OF GLOSS MEASUREMENT - The invention relates to a control of etching processes of insulating substrates by means of gloss measurement. By this method a surface roughness can be achieved which leads to good adhesion of metals layers deposited in subsequent metallization steps. This method is particularly suited for the production of printed circuit boards. | 08-13-2009 |
Christiane Montastier, Paris FR
| Patent application number | Description | Published |
|---|---|---|
| 20080311100 | Treatment of Keratinous Dryness With Glycerides - The present invention provides the use of medium chain glyceride(s) as an active ingredient for the preparation of a composition for oral and/or parenteral absorption and intended to prevent and/or treat dry and/or delicate keratinous substances. | 12-18-2008 |
| 20100323984 | COSMETIC ORAL AND/OR PARENTERAL USE OF GLUCOSAMINE OPTIONALLY IN COMBINATION WITH AT LEAST ONE POLYPHENOL COMPOUND, AND CORRESPONDING COMPOSITION - The present invention relates to the cosmetic oral and/or parenteral use of glucosamine as an active agent for preventing and/or treating the cutaneous signs of ageing, optionally in combination with at least one polyphenol compound. | 12-23-2010 |
| 20110281941 | COMBINATION OF LYCOPENE, POLYPHENOL, AND VITAMINS FOR THE CARE OF KERATIN MATERIALS - The present invention relates to the cosmetic use, by the oral route, of a combination of lycopene, of vitamin C, of vitamin E and of at least one polyphenol compound derived from pine bark as active ingredient intended for maintaining and/or restoring the biomechanical properties of keratinous materials, and notably of the skin. | 11-17-2011 |
Christiane Muller, Baiersdorf DE
| Patent application number | Description | Published |
|---|---|---|
| 20090273437 | KEY-OPERATED SWITCH - A key-operated switch includes a first excitation device which generates a first alternating magnetic field and has a first inductance. The key-operated switch is constructed in such a manner that the first alternating magnetic field can be used to scan a first coding of a key, with the first coding changing the first inductance of the first excitation device. The first coding is read by the key-operated switch in this manner. The key associated with the key-operated switch has a carrier element which is not electrically conductive and is not magnetizable. Arranged on the carrier element is the first coding which is made of an electrically conductive and/or magnetizable material. As a result, the key can be scanned without wear. | 11-05-2009 |
Christiane Obled, Saint Amant-Tallende FR
| Patent application number | Description | Published |
|---|---|---|
| 20090209647 | NUTRITIONAL METHOD - A method of improving nutrition and/or treating low grade inflammation in an elderly human subject comprises administering to said subject a cysteine source so as to provide metabolically available cysteine in the diet of said subject in a proportion relative to all available amino acids which is greater that the proportion of cysteine relative to all amino acids which corresponds to the requirements of a healthy young human subject. | 08-20-2009 |
| 20110269678 | NUTRITIONAL METHOD - A method of improving nutrition and/or treating low grade inflammation in an elderly human subject comprises administering to said subject a cysteine source so as to provide metabolically available cysteine in the diet of said subject in a proportion relative to all available amino acids which is greater that the proportion of cysteine relative to all amino acids which corresponds to the requirements of a healthy young human subject. | 11-03-2011 |
Christiane Oppenheimer-Stix, Neuss DE
| Patent application number | Description | Published |
|---|---|---|
| 20120010435 | METHOD FOR ISOLATING DI-TRIMETHYLOL PROPANE - The present invention relates to a method for isolating ditrimethylol propane from secondary trimethylol propane production streams. | 01-12-2012 |
Christiane Ostermeyer, Hamburg DE
| Patent application number | Description | Published |
|---|---|---|
| 20090076084 | WOUND AND MUCOUS MEMBRANE DISINFECTANT - Aqueous wound and mucous membrane disinfectant containing a) octenidine dihydrochloride, and b) one or more active ingredients selected from the group ethanol, 1-propanol, 2-propanol, undecylene amidopropyl trimonium methosulfate, 3-(4-chlorophenoxy)-1,2-propanediol and/or sodium hydroxymethylglycinate and c) glycerin and/or 1,2-diols having 3 to 10 carbon atoms, and d) optionally surfactants, emulsifiers, solubilisers, pH regulators, dyestuffs, perfumes and/or thickeners, the agent being free of phenoxyethanol, phenoxypropanol, phenoxyisopropanol and organic acids. | 03-19-2009 |
| 20100119566 | USE OF A SYNERGISTIC COMPOSITIONS AS A THERAPEUTIC AGENT OR DISINFECTANT - The invention relates to the use of a composition comprising a vitamin, a metal ion, and a surfactant, as a therapeutic agent or disinfectant. The composition has been known as a decontaminant because the same efficiently decomposes DNA. It has now been possible to demonstrate that the agent has surprisingly good compatibility while having a wide-ranging disinfecting effect and is therefore also suitable for other purposes, e.g., for disinfecting or dressing wounds. | 05-13-2010 |
Christiane Parzyk, Stuttgart DE
| Patent application number | Description | Published |
|---|---|---|
| 20110301294 | PROCESS FOR PURIFYING POLYOL DISPERSIONS - The present invention relates to a process for purifying a polyol dispersion by stripping by means of at least one rotating body, to the polyol dispersion obtainable by the process according to the invention, and to the use thereof for preparing polyurethanes. | 12-08-2011 |
Christiane Peiker, Halstenbek DE
| Patent application number | Description | Published |
|---|---|---|
| 20100021939 | PROCESS FOR DETECTING ENZYME ACTIVITY IN AN IMMUNOASSAY - The invention relates to a process for detecting enzyme activity in an immunoassay comprising the following steps: | 01-28-2010 |
Christiane Petzold, Osto NO
| Patent application number | Description | Published |
|---|---|---|
| 20110166670 | PUFA COVERED IMPLANTS - A medical or dental implant which contains a metal material selected from the group consisting of titanium or an alloy thereof, wherein at least part of the surface of the metal material is coated with a layer of a polyunsaturated fatty acids (PUFA). In a preferred embodiment, the implant has been exposed to UV radiation for at least 30 seconds before, simultaneously with and/or after the coating with PUFA. Depending on the concentration of polyunsaturated fatty acids on the surface, at least parts of the implant exhibits improved effect on adhesion of mineralized and/or hard tissue, such as on bone remodeling and/or improved biocompatibility, or alternatively inhibits adhesion of mineralized and/or hard tissue to the implant. The metal material is preferably titanium, the polyunsaturated fatty acid is preferably EPA. | 07-07-2011 |
Christiane Poblenz, Goleta, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100075175 | LARGE-AREA SEED FOR AMMONOTHERMAL GROWTH OF BULK GALLIUM NITRIDE AND METHOD OF MANUFACTURE - A high-quality, large-area seed crystal for ammonothermal GaN growth and method for fabricating. The seed crystal comprises double-side GaN growth on a large-area substrate. The seed crystal is of relatively low defect density and has flat surfaces free of bowing. The seed crystal is useful for producing large-volume, high-quality bulk GaN crystals by ammonothermal growth methods for eventual wafering into large-area GaN substrates for device fabrication. | 03-25-2010 |
| 20100189981 | LARGE-AREA BULK GALLIUM NITRIDE WAFER AND METHOD OF MANUFACTURE - The present invention includes a high-quality, large-area bulk GaN seed crystal for ammonothermal GaN growth and method for fabricating. The seed crystal is of ultra-low defect density, has flat surfaces free of bowing, and is free of foreign substrate material. The seed crystal is useful for producing large-volume, high-quality bulk GaN crystals by ammonothermal growth methods for eventual wafering into large-area GaN substrates for device fabrication. | 07-29-2010 |
| 20110056429 | Rapid Growth Method and Structures for Gallium and Nitrogen Containing Ultra-Thin Epitaxial Structures for Devices - A method for rapid growth of gallium and nitrogen containing material is described. The method includes providing a bulk gallium and nitrogen containing substrate. A first epitaxial material of first thickness is formed over the substrate, preferably with a pseudomorphical process. The method also forms a second epitaxial layer over the first to create a stacked structure. The stacked structure consists of a total thickness of less than about 2 microns. | 03-10-2011 |
| 20110064100 | Growth Structures and Method for Forming Laser Diodes on or Off Cut Gallium and Nitrogen Containing Substrates - An optical device having a structured active region configured for one or more selected wavelengths of light emissions and formed on an off-cut m-plane gallium and nitrogen containing substrate. | 03-17-2011 |
| 20110064101 | Low Voltage Laser Diodes on Gallium and Nitrogen Containing Substrates - A low voltage laser device having an active region configured for one or more selected wavelengths of light emissions. | 03-17-2011 |
| 20110064102 | Growth Structures and Method for Forming Laser Diodes on or Off Cut Gallium and Nitrogen Containing Substrates - An optical device having a structured active region configured for one or more selected wavelengths of light emissions and formed on an off-cut m-plane gallium and nitrogen containing substrate. | 03-17-2011 |
| 20110262773 | Ammonothermal Method for Growth of Bulk Gallium Nitride - A high-quality, large-area seed crystal for ammonothermal GaN growth and method for fabricating. The seed crystal comprises double-side GaN growth on a large-area substrate. The seed crystal is of relatively low defect density and has flat surfaces free of bowing. The seed crystal is useful for producing large-volume, high-quality bulk GaN crystals by ammonothermal growth methods for eventual wafering into large-area GaN substrates for device fabrication. | 10-27-2011 |
Christiane Poel-Asendorf, Weyhe DE
| Patent application number | Description | Published |
|---|---|---|
| 20100295211 | Method for Producing a Vessel Closure - The invention relates to a method for producing a vessel closure for vessels comprising an opening that is to be closed by the vessel closure, an inner diameter of more than two cm and surrounds a polymer-based sealing element that is arranged in the vessel closure in such a manner that is sealingly rests on the opening of the vessel in the closed state. A polymer material becomes sufficiently free-flowing by warming and is applied to the vessel closure in the region of the sealing element that is to be produced, and optionally, is mechanically formed into the desired shape which it maintains after cooling. The invention also relates to a metal or plastic vessel closures for vessels for receiving drinks or food, and comprises a sealing insert, the material thereof being selected so that the migration of material components into the drink or food, that are a health risk, is prevented. The invention also relates to corresponding materials for said type of sealing inserts and to the use of specific polymers for producing the above-mentioned sealing inserts. | 11-25-2010 |
Christiane Prebet, Taluyers FR
| Patent application number | Description | Published |
|---|---|---|
| 20080312372 | Single-component polyorganosiloxane compositions crosslinkable into silicone elastomers - Single-component polyorganosiloxane (POS) compositions which are stable on storage in the absence of moisture and which crosslink, in the presence of water, into an elastomer, contain at least one crosslinkable linear polyorganopolysiloxane POS, an inorganic filler and a crosslinking catalyst, wherein the POS exhibits non-hydroxylated functionalized endgroups, in particular alkoxy, oxime, acyl and/or enoxy endgroups, preferably alkoxy endgroups, said compositions being essentially devoid of POS possessing hydroxylated endgroups and said catalyst being a vanadium compound. | 12-18-2008 |
Christiane Quiniou, Montreal CA
| Patent application number | Description | Published |
|---|---|---|
| 20090048161 | Cytokine receptor modulators and uses thereof - The present invention relates to cytokine receptor-binding compounds, such as non-competitive VEGF receptor, IL-1 receptor, IL-4 receptor, or IGF-1 receptor-binding peptides and petidomimetic antagonists, and therapeutic uses of such compounds. The compounds of the present invention may be used in the treatment of cytokine-associated diseases such as proliferative disorders (for example, colon, breast, prostate, and lung cancer), abnormal neovascularization and angiogenesis, age-related macular degeneration, and proliferative and/or inflammatory skin disorders such as psoriasis. | 02-19-2009 |
| 20090104706 | CYTOKINE RECEPTOR MODULATORS, METHOD OF IDENTIFYING SAME, AND METHOD OF MODULATING CYTOKINE RECEPTORS ACTIVITY WITH SAME - The present invention relates to a method for identifying a non-competitive peptide, which inhibits the activity of a cytokine receptor. This method includes the steps of selecting a candidate peptide containing from about 7 to about 20 amino acids derived from a flexible region of a cytokine receptor, and determining the ability of the peptide to inhibit or promote the oligomerization and/or activation of the receptor by measuring an activity of the receptor in the absence or the presence of the candidate peptide, wherein the non-competitive peptide is selected when the activity of the receptor is measurably lower in the presence of the peptide as compared to in the absence of the peptide so identified. This invention also provides agonists of cytokine receptor activity. Pharmaceutical compositions that comprise the identified peptides are disclosed. Also disclosed are methods for treating patients with a disease or condition associated with abnormal cytokine receptor mediated function or activity such as inflammatory, autoimmune and vascular diseases. | 04-23-2009 |
| 20100041609 | INTERLEUKIN-1 RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS OF TREATMENT - Peptides that are designed to inhibit the biological activity of the IL-1R type 1 receptor and inhibit IL-1R/IL-1RacP related cell signaling and biological activity are disclosed. Compositions comprising IL-1R antagonists of the present invention are useful in the treatment of IL-1 related diseases or conditions such as arthritis, rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease as well as other chronic or acute inflammatory diseases. This invention also discloses an isolated compound having an IL-1R antagonist activity, said compound being selected from the group consisting of: a peptide comprising the amino acid sequence RYTPELX, wherein R, Y, T, P, E, L, refer to their corresponding amino acids, and X is selected from no amino acid and alanine (A); and a derivative of (a) wherein the derivative incorporates one, two or three amino acid modification selected from an amino acid addition, deletion or substitution in the RYTPEL portion of the peptide, and wherein said derivative maintains its antagonist IL-1R activity. | 02-18-2010 |
| 20100190710 | IL-23 RECEPTOR ANTAGONISTS AND USES THEREOF - The present invention relates to IL-23 receptor antagonists and agonists. The use of IL-23 receptor antagonists in treating autoimmune and inflammatory disorders, as well as methods of identifying IL-23 receptor antagonists and agonists. | 07-29-2010 |
| 20110014128 | CYTOKINE RECEPTOR MODULATORS, METHOD OF IDENTIFYING SAME, AND METHOD OF MODULATING CYTOKINE RECEPTORS ACTIVITY WITH SAME - The present invention relates to a method for identifying a non-competitive peptide, which inhibits the activity of a cytokine receptor. This method includes the steps of selecting a candidate peptide containing from about 7 to about 20 amino acids derived from a flexible region of a cytokine receptor, and determining the ability of the peptide to inhibit or promote the oligomerization and/or activation of the receptor by measuring an activity of the receptor in the absence or the presence of the candidate peptide, wherein the non-competitive peptide is selected when the activity of the receptor is measurably lower in the presence of the peptide as compared to in the absence of the peptide so identified. This invention also provides agonists of cytokine receptor activity. Pharmaceutical compositions that comprise the identified peptides are disclosed. Also disclosed are methods for treating patients with a disease or condition associated with abnormal cytokine receptor mediated function or activity such as inflammatory, autoimmune and vascular diseases. | 01-20-2011 |
| 20110144014 | CYTOKINE RECEPTOR MODULATORS AND USES THEREOF - The present invention relates to cytokine receptor-binding compounds, such as non-competitive VEGF receptor, IL-1 receptor, IL-4 receptor, or IGF-1 receptor-binding peptides and petidomimetic antagonists, and therapeutic uses of such compounds. The compounds of the present invention may be used in the treatment of cytokine-associated diseases such as proliferative disorders (for example, colon, breast, prostate, and lung cancer), abnormal neovascularization and angiogenesis, age-related macular degeneration, and proliferative and/or inflammatory skin disorders such as psoriasis. | 06-16-2011 |
Christiane Reute, Leverkusen DE
| Patent application number | Description | Published |
|---|---|---|
| 20110152266 | CO-CRYSTAL COMPOUND OF RIVAROXABAN AND MALONIC ACID - The present invention relates to a novel cocrystal compound of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide (rivaroxaban) and malonic acid, to processes for its preparation, to medicaments comprising this compound and to their use for controlling diseases. | 06-23-2011 |
Christiane Schmidt, Braunschweig DE
| Patent application number | Description | Published |
|---|---|---|
| 20110208399 | METHOD AND APPARATUS FOR DETERMINING A DRIVING STRATEGY - A method for determining a driving strategy for a driver of a motor vehicle includes receiving local information about a plurality of other motor vehicles using a receiving device, wherein the plurality of other motor vehicles are ahead of the motor vehicle and are relevant to the traffic situation. The method further includes recording the local information using the receiving device and deriving driving information from the local information so as to provide a driving strategy in the form of at least one action recommendation for the driver, the at least one action recommendation including a recommended speed based on an average speed of the plurality of other motor vehicles and on a desired speed of the motor vehicle. | 08-25-2011 |
Christiane Stahl-Hennig, Goettingen DE
| Patent application number | Description | Published |
|---|---|---|
| 20100255032 | Parapoxviruses in combination with other antiviral agents for the treatment of viral diseases - The present invention relates to the use of | 10-07-2010 |
Christiane Strohm-Zimmermann, Wiesbaden DE
| Patent application number | Description | Published |
|---|---|---|
| 20090084286 | Diketopyrrolopyrrole Pigments Having Heightened Fastnesses and Processes for Preparing Them - The invention relates to a diketopyrrolopyrrole pigment of formula (I) | 04-02-2009 |
Christiane Susini, Lanta FR
| Patent application number | Description | Published |
|---|---|---|
| 20100222418 | Combination Products For Treating Cancer - The present invention concerns products containing (i) at least one nucleic acid sequence coding for the human somatostatin 2 receptor protein (sst2) having the sequence SEQ ID NO: 1, ortholog or derivative thereof, (ii) at least one nucleic acid sequence coding for the human deoxycytidine kinase protein (dck) having the sequence SEQ ID NO:2, ortholog or derivative thereof, (iii) at least one nucleic acid sequence coding for the human uridine monophosphate kinase protein (umk) having the sequence SEQ ID NO: 3 ortholog or derivative thereof, and (iv) gemcitabine, as a combined preparation for simultaneous, separate, or sequential use for treating cancer in a subject. | 09-02-2010 |
Christiane Wobus, Dexter, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20080254443 | Norovirus detection, methods and compositions therefor - A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed. A replicative form of norovirus as well as its use in the development of an anti-viral agent and a polypeptide expression system are also described. Further disclosed are methods of detecting norovirus in a sample. | 10-16-2008 |
Christiane Yoakim, Laval CA
| Patent application number | Description | Published |
|---|---|---|
| 20090143370 | Non-nucleoside Reverse Transcriptase Inhibitors - Compounds of formula (I): | 06-04-2009 |
| 20100041649 | INHIBITORS OF PAPILLOMA VIRUS - A compound of formula (I) or its enantiomers or diastereoisomers thereof: | 02-18-2010 |
| 20100069353 | INHIBITORS OF HIV REPLICATION - The present invention relates to compounds of formula (I) wherein R | 03-18-2010 |
| 20100261714 | INHIBITORS OF HIV REPLICATION - Compounds of formula (I): | 10-14-2010 |
| 20100292227 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION - Compounds of formula I: | 11-18-2010 |
Christiane Zamponi, Kiel DE
| Patent application number | Description | Published |
|---|---|---|
| 20090127226 | PROCESS FOR PRODUCING SELF-SUPPORTING TITANIUM AND NICKEL LAYERS - A process for producing a self-supporting layer made of a titanium and nickel alloy with superelastic and/or shape memory properties has the following steps: a substrate entirely or at least mainly made of silicon is provided, a layer of said alloy is applied to a surface of the substrate, the substrate with the desired form is cut out of a wafer or formed by a wafer with the desired form; at least some zones of the lateral surfaces of the substrate adjoining the zones of the surface of the substrate which receive the layer are subjected to an etching process; a layer of said alloy is applied to the surface of the substrate; and the substrate is removed from the applied layer. Also disclosed is a substrate suitable for carrying out the process and an object, in particular an implant, comprising at least one layer produced by this process. | 05-21-2009 |
| 20100009142 | METHOD FOR THE PRODUCTION OF STRUCTURED LAYERS OF TITANIUM AND NICKEL - A method for the production of a structured metal layer ( | 01-14-2010 |
| 20100049310 | METHOD FOR COATING A STENT - Method for applying a coating layer to a tubular intraluminal implant, in particular to a vascular support (stent), where the surface of the implant is perforated by a plurality of apertures, and where the coating layer is produced by deposition of material onto the surface of the implant. The implant is first pushed onto a cylindrical holder | 02-25-2010 |
| 20100145380 | THROMBOSIS FILTER WITH COVER LAYER - A method is provided for applying a cover layer ( | 06-10-2010 |