Choyke
Peter Choyke, Bethesda, MD US
Patent application number | Description | Published |
---|---|---|
20100092384 | MULTIFUNCTIONAL NANOPARTICLES AND COMPOSITIONS AND METHODS OF USE THEREOF - Provided is a multifunctional particle comprising: (a) an inner metallic core, (b) a biocompatible shell comprising an optical contrast agent embedded therein, and (c) a targeting biomolecule conjugated to the biocompatible shell through a multidentate ligand, wherein the multidentate ligand is chelated to an imaging agent. Also provided are compositions comprising the multifunctional particle and methods of using the multifunctional particle, including a method of diagnostic imaging and a method of treatment. | 04-15-2010 |
20120010558 | PHOTOSENSITIZING ANTIBODY-FLUOROPHORE CONJUGATES - The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm | 01-12-2012 |
Peter Choyke, Rockville, MD US
Patent application number | Description | Published |
---|---|---|
20130336995 | PHOTOSENSITIZING ANTIBODY-FLUOROPHORE CONJUGATES - The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm | 12-19-2013 |
20140120119 | PHOTOSENSITIZING ANTIBODY-FLUOROPHORE CONJUGATES - The present disclosure relates to compositions and methods of killing cells. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein, such as a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm | 05-01-2014 |
Peter L. Choyke, Briarcliff Manor, NY US
Patent application number | Description | Published |
---|---|---|
20100208963 | SYSTEM AND METHOD FOR FUSING REAL-TIME ULTRASOUND IMAGES WITH PRE-ACQUIRED MEDICAL IMAGES - A method, apparatus and system for fusing real-time ultrasound images with pre-acquired medical images are described. | 08-19-2010 |
Peter Lyle Choyke, Bethesda, MD US
Patent application number | Description | Published |
---|---|---|
20110082363 | METHOD AND SYSTEM FOR PERFORMING BIOPSIES - A method and system for performing biopsies can include an imaging system (190) for obtaining diagnostic images of a target region (200); a tracking system (100); a probe (75) having a deployable biopsy needle for performing a biopsy procedure where the tracking system generates tracking information for at least one of the probe and the biopsy needle; an ultrasound imaging system (50) for obtaining ultrasound imaging of the target region; and a computer (150) in communication with the tracking system, the imaging system and the ultrasound imaging system. The computer can register the tracking system with the imaging system. The computer transfers a marking (500) of a biopsy site associated with the biopsy procedure from the ultrasound imaging to the diagnostic images based on the tracking information and the registration of the tracking system with the diagnostic images. | 04-07-2011 |
Sarah Choyke, Rockville, MD US
Patent application number | Description | Published |
---|---|---|
20110190295 | COMPOSITIONS AND METHODS FOR INHIBITION OF HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET SIGNALING - Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided. | 08-04-2011 |
Wolfgang J. Choyke, Pittsburgh, PA US
Patent application number | Description | Published |
---|---|---|
20110265616 | ULTRA-PURE, SINGLE-CRYSTAL SIC CUTTING TOOL FOR ULTRA-PRECISION MACHINING - Systems and methods that use a single-crystal boule SiC sharpened into a cutting tool for ultra-precision machining of ferrous alloys are disclosed. Conventional ultra-precision machining uses single-crystal natural diamond. Despite the exceptional mechanical properties of diamond, its chemical properties have inhibited the extension of ultra-precision machining to iron-containing (ferrous) alloys. A single-crystal SiC cutting tool can be used to cut many materials for which diamond cutting tools are conventionally used. Additionally, a single-crystal SiC cutting tool can be used to cut materials for which diamond cutting tools are inappropriate, such as ferrous metals or nickel. | 11-03-2011 |