Chiocca
Antonio Chiocca, Powell, OH US
Patent application number | Description | Published |
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20100272686 | ONCOLYTIC VIRUS - Malignant tumors that are intrinsically resistant to conventional therapies are significant therapeutic challenges. An embodiment of the present invention provides an oncolytic virus capable of killing target cells, such as a tumor cells. In various embodiments presented herein, the oncolytic virus is armed or encodes a therapeutic polypeptide. In at least one embodiment, a recombinant oncolytic virus has been generated that can specifically replicate in cancer cells leading to their destruction and at the same time secrete robust amounts of a therapeutic polypeptide. Compositions and methods disclosed herein have broad therapeutic applicability. | 10-28-2010 |
20130316447 | ONCOLYTIC VIRUS - Malignant tumors that are intrinsically resistant to conventional therapies are significant therapeutic challenges. An embodiment of the present invention provides an oncolytic virus capable of killing target cells, such as a tumor cells. In various embodiments presented herein, the oncolytic virus is armed or encodes a therapeutic polypeptide. In at least one embodiment, a recombinant oncolytic virus has been generated that can specifically replicate in cancer cells leading to their destruction and at the same time secrete robust amounts of a therapeutic polypeptide. Compositions and methods disclosed herein have broad therapeutic applicability. | 11-28-2013 |
E. Antonio Chiocca, Powell, OH US
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20100143500 | Methods and Compositions for Inhibiting GSK-3 In Glial Cell Related Disorders - A method of treating a glial cell related disorder in a mammalian subject includes administering a drug which enhances or prolongs GSK-3 α or β inactivation. | 06-10-2010 |
20100273258 | Interactive Microenvironment System - A culture cell for growing animal cells in vitro has sides and a bottom forming a volume. The volume contains a layer of nanofiber upon which animal cells can be cultured. The layer of nanofiber can be oriented or non-oriented. Multiple layers can be placed in the volume, where the layers have different composition and/or different porosity. The nanofiber can be, for example, surface treated or of a core-shell construction. | 10-28-2010 |
Rene Chiocca, Paris FR
Patent application number | Description | Published |
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20100179367 | Device For Cleaning And/Or Securing A Safe Containment Defined In A Device For Transporting And/Or Storing Radioactive Materials - A method for underwater packaging of radioactive materials includes creating a vacuum in a cavity of a cleaning device to automatically cause a portion of the cleaning device to move upward to actuate the cleaning device from an open position to a closed position; mounting the cleaning device inside a safe containment area of a transportation and/or storage device; placing the transportation and/or storage device in a pool after filling the safe containment area with water; loading a radioactive material into the safe containment area; closing the transportation and/or storage device using at least one cover; extracting the transportation and/or storage device from the pool; draining the water inside the safe containment area; and creating a pressure differential in the safe containment area to dry the safe containment area, wherein the pressure differential causes the cleaning device to automatically actuate from the closed position to the open position. | 07-15-2010 |
20100183110 | PACKAGING FOR THE TRANSPORTATION AND/OR STORAGE OF NUCLEAR MATERIALS WHICH INCLUDES RADIOLOGICAL PROTECTION MADE OF LEAD CAST OVER A METALLIC FRAMEWORK - A packaging for the transportation and/or storage of nuclear materials, which includes a lateral body which extends along a longitudinal direction (X), where this body is equipped with a radiological protection device. The radiological protection device includes at least one radiological protection structure which includes at least one metallic reinforcement framework which extends along the direction (X) and which is hugged by a block made out of lead or of one of its alloys, cast over the framework, the latter being equipped with at least one element for retaining the cast block along the direction (X). Furthermore, the framework is embedded in the cast block over at least part of its length along this direction (X). | 07-22-2010 |
René Chiocca, Paris FR
Patent application number | Description | Published |
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20100179367 | Device For Cleaning And/Or Securing A Safe Containment Defined In A Device For Transporting And/Or Storing Radioactive Materials - A method for underwater packaging of radioactive materials includes creating a vacuum in a cavity of a cleaning device to automatically cause a portion of the cleaning device to move upward to actuate the cleaning device from an open position to a closed position; mounting the cleaning device inside a safe containment area of a transportation and/or storage device; placing the transportation and/or storage device in a pool after filling the safe containment area with water; loading a radioactive material into the safe containment area; closing the transportation and/or storage device using at least one cover; extracting the transportation and/or storage device from the pool; draining the water inside the safe containment area; and creating a pressure differential in the safe containment area to dry the safe containment area, wherein the pressure differential causes the cleaning device to automatically actuate from the closed position to the open position. | 07-15-2010 |