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| 20080248126 | PARTICULATE DRUG DELIVERY - Methods for efficient preparation of drug-polymer (or oligomer) conjugates which are useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications. The invention additionally provides certain drug-polymer and drug-oligomer conjugates which are useful in the preparation of particles for delivery of the drug in vivo. The invention also provides nanoparticles of this invention prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention. | 10-09-2008 |
| 20080268063 | Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals - A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhesive coating may be selected to facilitate transfer of the particle through the intestinal mucosa. A molecular weight and cross-link density of the polymer may be selected such that the polymer core will decompose in a predetermined time interval. The fraction of the dose of the drug entering the system at circulation during the predetermined time interval may be between about 0.25% and about 25%. The composition may be formulated as a plurality of nanoparticles or microparticles that are combined with a pharmaceutically acceptable carrier to produce an edible or inhalable drug product. | 10-30-2008 |
| 20100266491 | SYSTEM FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS - The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof. | 10-21-2010 |
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| 20080217652 | Growth of AsSb-Based Semiconductor Structures on InP Substrates Using Sb-Containing Buffer Layers - This invention provides high quality and low defect density Sb-containing alloys on lattice-mismatched substrates using Sb-containing buffer layers. More specifically, provided is a method of forming an epitaxial semiconductor alloy on a substrate, comprising: providing a substrate (such as InP); growing an Sb-containing buffer layer on the substrate; and growing a layer of As/Sb-containing semiconductor alloy on the buffer layer. | 09-11-2008 |
| 20080296619 | ADHESIVE BONDING WITH LOW TEMPERATURE GROWN AMORPHOUS OR POLYCRYSTALLINE COMPOUND SEMICONDUCTORS - Amorphous and polycrystalline III-V semiconductor including (Ga,As), (Al,As), (In,As), (Ga,N), and (Ga,P) materials were grown at low temperatures on semiconductor substrates. After growth, different substrates containing the low temperature grown material were pressed together in a pressure jig before being annealed. The annealing temperatures ranged from about 300° C. to 800° C. for annealing times between 30 minutes and 10 hours, depending on the bonding materials. The structures remained pressed together throughout the course of the annealing. Strong bonds were obtained for bonding layers between different substrates that were as thin as 3 nm and as thick as 600 nm. The bonds were ohmic with a relatively small resistance, optically transparent, and independent of the orientation of the underlying structures. | 12-04-2008 |
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| 20090083262 | SYSTEM FOR ENTITY SEARCH AND A METHOD FOR ENTITY SCORING IN A LINKED DOCUMENT DATABASE - A system has a processor coupled to access a document database that indexes keywords and instances of entities having entity types in a plurality of documents. The processor is programmed to receive an input query including one or more keywords and one or more entity types, and search the database for documents having the keywords and entities with the entity types of the input query. The processor is programmed for aggregating a respective score for each of a plurality of entity tuples across the plurality of documents. The aggregated scores are normalized. Each respective normalized score provides a ranking of a respective entity tuple, relative to other entity tuples, as an answer to the input query. The processor has an interface to a storage or display device or network for outputting a list including a subset of the entity tuples having the highest normalized scores among the plurality of entity tuples. | 03-26-2009 |
| 20100082657 | GENERATING SYNONYMS BASED ON QUERY LOG DATA - An approach is described for generating synonyms to supplement at least one information item, such as, in one case, a set of related items. The approach can involve an expansion phase, a clean-up phase, and a reduction phase. In the expansion phase, the approach identifies, for each related item, a set of initial synonym candidates. In the clean-up phase, the approach removes noise from the set of initial synonym candidates (if such noise exists), to provide a set of filtered synonym candidate items. In the reduction phase, the approach ranks and applies a threshold (or thresholds) to the set of filtered synonym candidate items, to generate, for each information item, a set of selected synonyms. The approach uses query log data as at various points in its operation. The selected synonyms can be used to improve the effectiveness of user searches. | 04-01-2010 |
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| 20090065162 | CONTROLLABLE FILLER PREFLOCULATION USING A DUAL POLYMER SYSTEM - A method of preparing a stable dispersion of flocculated filler particles for use in papermaking processes comprises sequential addition of high and low molecular weight flocculating agents to an aqueous dispersion of filler particles followed by shearing of the resultant filler flocs to the desired particle size resulting in shear resistant filler flocs with a defined and controllable size distribution. | 03-12-2009 |
| 20090267258 | CONTROLLABLE FILLER PREFLOCULATION USING A DUAL POLYMER SYSTEM - A method of preparing a stable dispersion of flocculated filler particles for use in papermaking processes comprises sequential addition of a first flocculating agent to an aqueous dispersion of filler particles followed by shearing of the dispersion, followed by addition of a second flocculating agent to the dispersion and further shearing of the resultant filler flocs to the desired particle size resulting in shear resistant filler flocs with a defined and controllable size distribution. In addition, a neutralizing coagulant can be added to the dispersion to partially or completely neutralize the charge of the filler before the first flocculating agent is added. | 10-29-2009 |
| 20100126684 | METHOD OF INCREASING FILLER CONTENT IN PAPERMAKING - The invention provides a method of producing paper with a higher proportion of mineral filler particles than is otherwise be possible without the expected loss in paper strength. The method allows for the use of the greater amount of filler particles by coating at least some of the filler particles with a material that prevents the filler materials form adhering to a strength additive. The strength additive holds the cellulose fibers together tightly and is not wasted on the filler particles. The method is particularly effective when the filler particles are a PCC-GCC blend and when the GCC particles are coated with the adherence preventing coating. | 05-27-2010 |
| 20110088861 | RECYCLING OF WASTE COATING COLOR - The invention provides a method of recovering and recycling waste coating color from papermaking coating process for use as wet end filler. The inventive method overcomes many technical challenges inherent in using waste coating colors as wet end filler such as the coatings having fine pigments that hurts sheet strength more than regular filler, having strong anionic charge and tendency to disturb wet end chemistry, causing excessive foaming, and containing a large amount of hydrophobic binder particles that tend to agglomerate in the white water and deposit on papermaking equipment. The method involves mixing the coatings with fresh filler particles, adding de-foaming agent, adding cationic coagulant, then preflocculating the mixture. This process causes fresh filler particles, pigments and binders in waste coating color to agglomerate together and form stable flocs with defined particle size distribution. Moreover, using such agglomerate as wet end filler was found to improve sheet strength properties by taking advantage of the binding ability of the latex or binders contained in the waste coating color. | 04-21-2011 |
| 20110226433 | METHOD OF INCREASING FILLER CONTENT IN PAPERMAKING - The invention provides a method of producing paper with a higher proportion of mineral filler particles than is otherwise be possible without the expected loss in paper strength by preflocculating the filler particles. The method allows for the use of the greater amount of filler particles by coating at least some of the filler particles with a material that prevents the filler materials form adhering to a strength additive. The strength additive holds the paper fibers together tightly and is not wasted on the filler particles. | 09-22-2011 |
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| 20080259920 | Method and apparatus for establishing virtual resilient packet ring (RPR) subrings over a common communications path - A method and corresponding apparatus allows multiple virtual switches in a physical switch to share one physical Resilient Packet Ring (RPR) in an RPR network. Modules in the multiple virtual switches add multicast information to traffic to direct the traffic along a common path to other physical switches on the ring, and modules in the virtual switches inspect traffic to determine whether the traffic is directed to the respective virtual switch. Multiple virtual RPR subrings are made available in a single physical ring, increasing usefulness of virtual switches formerly only able to support multiple tributary connections to other networks but not able to share a single ring network communications path. Sharing a single communications path increases overall network bandwidth, and at least one implementation allows for spatial reuse. | 10-23-2008 |
| 20080310437 | Method and apparatus for carrying unknown traffic over a resilient packet ring (RPR) without flooding - A method and corresponding apparatus allows unknown packet traffic, such as Ethernet traffic, to be carried on a Resilient Packet Ring (RPR) network without flooding the traffic on the RPR network. Modules in a station of the ring network compare a destination address in a packet traffic signal with known addresses and associate an identifier of a tunnel in the ring network with the packet traffic signal based on the comparison. The modules then associate with the packet traffic signal an identifier of a destination station in the ring network that corresponds to the identifier of the tunnel and forward the packet traffic signal to the destination station via the tunnel. By transmitting the packet traffic via tunnels instead of flooding the RPR network, spatial reuse may be implemented allowing the network to support a higher volume of traffic. | 12-18-2008 |
| 20090016384 | Method and apparatus for distributing synchronization status messages over a Resilient Packet Ring (RPR) - Packets used for distributing timing information over a Resilient Packet Ring (RPR) are generated by encoding Synchronization Status Messaging (SSM) messages into IEEE 802.3ah OAM packets (or any other OAM packets, such as those defined in ITU Y.1731). Information indicating the direction that each message is to be transmitted around the RPR ring is also encoded in the packets in either the spare bits of the SSM messages or in the Type-Length-Value (TLV) bytes of the IEEE 802.3ah OAM packets or Y.1731 OAM packets. RPR protection is disabled for the packets carrying the SSM messages and the packets are transmitted to adjacent network nodes in the directions specified by the information encoded in the messages. Information encoded in received packets specifying timing quality and direction of the received messages is observed and compared to determine which timing information included in the messages to use for clock timing. | 01-15-2009 |
| 20110096670 | METHODS AND APPARATUSES FOR PERFORMING SWITCHING AND FOR EXCHANGING MANAGEMENT-REQUESTED SWITCHING MESSAGES BETWEEN NODES FOR 1:1 BIDIRECTIONAL VIRTUAL LOCAL AREA NETWORK (VLAN) PROTECTION WITHOUT USING Y.1731-BASED AUTOMATIC PROTECTION SWITCHING (APS) MESSAGES - To perform protection switching between tunnels in a network, Y.1731-based APS messages are often sent from a management system to nodes at the tunnels' end-points. If the management system is located near one node (local node) and far away from the other node (remote node), the APS message, which operates at the Ethernet service layer, travels to the remote node slower than traffic over the tunnels. This slower transmission time may prevent the remote node from performing a switch within a desired timeframe. The disclosed embodiments include a 1:1 bidirectional VLAN-based protection arrangement that accomplishes a 50 millisecond switching time without using Y.1731-based APS messages. The embodiments accomplish this by sending a switching command from the management system to the local node and modifying a message already traveling from the local node to the remote node to include a switching message that causes the remote node to perform the switch. | 04-28-2011 |
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| 20080215490 | INTELLIGENT ASSISTANT FOR CONTENT PURCHASING - A method, apparatus, and electronic device for optimizing content acquisition are disclosed. A memory may store usage of a previous set of media content by the mobile device. An input/output device may receive a request for a current set of media content. A processor may create a user profile based on the usage and provides a first recommendation of a first digital rights agreement based on the user profile. | 09-04-2008 |
| 20080256033 | METHOD AND APPARATUS FOR DISTRIBUTED VOICE SEARCHING - A method for distributed voice searching may include receiving a search query from a user of the mobile communication device, generating a lattice of coarse linguistic representations from speech parts in the search query, extracting query features from the generated lattice of coarse linguistic representations, generating coarse search feature vectors based on the extracted query features, performing a coarse search using the generated coarse search feature vectors and transmitting the generated coarse search feature vectors to a remote voice search processing unit, receiving remote resultant web indices from the remote voice search processing unit, generating a lattice of fine linguistic representations from speech parts in the search query, generating fine search feature vectors from the lattice of fine linguistic representations, performing a fine search using the coarse search results, the remote resultant web indices and the generated fine search feature vectors, and displaying the fine search results to the user. | 10-16-2008 |
| 20090131021 | DISTRIBUTION OF AN EMERGENCY WARNING USING PEER-TO-PEER COMMUNICATIONS | 05-21-2009 |
| 20100145971 | METHOD AND APPARATUS FOR GENERATING A MULTIMEDIA-BASED QUERY - A method and apparatus for generating a query from multimedia content is provided herein. During operation a query generator ( | 06-10-2010 |
| 20110144996 | ANALYZING AND PROCESSING A VERBAL EXPRESSION CONTAINING MULTIPLE GOALS - Disclosed is a method for parsing a verbal expression received from a user to determine whether or not the expression contains a multiple-goal command. Specifically, known techniques are applied to extract terms from the verbal expression. The extracted terms are assigned to categories. If two or more terms are found in the parsed verbal expression that are in associated categories and that do not overlap one another temporally, then the confidence levels of these terms are compared. If the confidence levels are similar, then the terms may be parallel entries in the verbal expression and may represent multiple goals. If a multiple-goal command is found, then the command is either presented to the user for review and possible editing or is executed. If the parsed multiple-goal command is presented to the user for review, then the presentation can be made via any appropriate interface including voice and text interfaces. | 06-16-2011 |
| 20110145214 | VOICE WEB SEARCH - A search system will receive a voice query and use speech recognition with a predefined vocabulary to generate a textual transcription of the voice query. Queries are sent to a text search engine, retrieving multiple web page results for each of these initial text queries. The collection of the keywords is extracted from the resulting web pages and is phonetically indexed to form a voice query dependent and phonetically searchable index database. Finally, a phonetically-based voice search engine is used to search the original voice query against the voice query dependent and phonetically searchable index database to find the keywords and/or key phrases that best match what was originally spoken. The keywords and/or key phrases that best match what was originally spoken are then used as a final text query for a search engine. Search results from the final text query are then presented to the user. | 06-16-2011 |
