Chen, Stanford
Bob Chen, Stanford, CA US
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20130053314 | Mutant Epidermal Growth Factor Polypeptides with Improved Biological Activity and Methods of Their Making and Use - Compositions that are EGF polypeptides that possess improved biological activity as compared to the biological activity exhibited by wild-type EGF are provided. Also provided are methods for the preparation of these mutants, methods for the use of these mutants, methods for rationally designing new polypeptide mutants, and methods for screening mutants polypeptides to identify novel EGF mutants with desirable biological activities. | 02-28-2013 |
Chang-Zheng Chen, Stanford, CA US
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20080200416 | Modulation of T cell signaling threshold and T cell sensitivity to antigens - MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens. | 08-21-2008 |
20090004668 | Pre-miRNA loop-modulated target regulation - By employing essential nucleotides from both the stem and loop of precursor-miRNA, greater specificity is achieved as to the mRNAs that are repressed. It is found that besides the seed sequence of the stem of the pre-miRNA, nucleotides in the loop affect the activity and specificity of the cursor- and the processing and binding to target mRNA. By using both sequences in the natural pre-miRNA or modified mimetics, one can screen for cellular miRNA expression, modulate cell properties with greater specificity and investigate cellular activity as to phenotype and response to external stimuli in the presence and absence of target protein expression. | 01-01-2009 |
20100048674 | Role of miRNA in T cell leukemia - The ability of miR-181a to support active signaling between Notch and pre-TCR pathways by coordinately dampening negative regulators of these pathways allows the use of miR-181a as a therapeutic target for T-ALL. | 02-25-2010 |
20110020816 | Precursor miRNA loop-modulated target regulation - By modifying nucleotides from either or both the stem and loop of precursor-miRNA, greater specificity is achieved as to the mRNAs targeted. The improved efficiency in target regulation can be either mediated by direct base-pairings between targets and precursor miRNAs or indirectly by energy constraints on the availability of such base-pairings. It is found that pri- and pre-miRNA are active in the absence of functional mature miRNA, so pri- or pre-miRNA or truncated portion thereof, but not as mature miRNA, can be used as RNAi agents by themselves. Furthermore, besides the seed sequence of the stem of the pre-miRNA and 3′-extensions thereof to provide greater complementarity to the target mRNA, nucleotides in the loop can affect the activity and specificity of the precursor-miRNA and the processing and binding to target mRNA. By using mutated sequences in the natural pri- or pre-miRNA or modified mimetics, one can screen for target mRNA, target a unique mRNA or a group of mRNAs for regulation, and modulate cell properties with greater specificity and investigate cellular activity as to phenotype and response to external stimuli in the presence or absence of at least partial target protein expression. | 01-27-2011 |
20110034532 | Modulation of T Cell Signaling Threshold and T Cell Sensitivity to Antigens - MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens. | 02-10-2011 |
Chiang-Yu Chen, Stanford, CA US
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20100135482 | INTERFERENCE CANCELLATION SYSTEM - An adaptive interference cancellation system is described. In one example the system operates by receiving a data signal using a DSL (Digital Subscriber Line) and receiving a reference signal, the reference signal corresponding, in part, to noise on the data signal. The reference signal is classified and a noise cancellation signal is applied to the data signal based on the classification. | 06-03-2010 |
Gongxing Chen, Stanford, CA US
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20150099655 | Methods and Compositions for Providing a Preeclampsia Assessment - Preeclampsia markers, preeclampsia marker panels, and methods for obtaining a preeclampsia marker level representation for a sample are provided. These compositions and methods find use in a number of applications, including, for example, diagnosing preeclampsia, prognosing a preeclampsia, monitoring a subject with preeclampsia, and determining a treatment for preeclampsia. In addition, systems, devices and kits thereof that find use in practicing the subject methods are provided. | 04-09-2015 |
Huizhong Chen, Stanford, CA US
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20150243276 | SYSTEMS AND METHODS FOR USING LATENT VARIABLE MODELING FOR MULTI-MODAL VIDEO INDEXING - A computer-implemented method performed in connection with a computerized system incorporating a processing unit and a memory, the computer-implemented method involving: using the processing unit to generate a multi-modal language model for co-occurrence of spoken words and displayed text in the plurality of videos; selecting at least a portion of a first video; extracting a plurality of spoken words from the selected portion of the first video; extracting a first displayed text from the selected portion of the first video; and using the processing unit and the generated multi-modal language model to rank the extracted plurality of spoken words based on probability of occurrence conditioned on the extracted first displayed text. | 08-27-2015 |
Lisa Chen, Stanford, CA US
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20140350348 | PASSIVE AND WIRELESS PRESSURE SENSOR - Aspects of the present disclosure are directed to pressure sensing. As may be implemented in accordance with one or more embodiments, an external energy field is applied to a resonant circuit having inductive conductors separated by a compressible dielectric, for wirelessly detecting pressure. Specifically, the resonant circuit is responsive to the energy field and applied pressures by operating in respective states exhibiting different resonant frequencies that are based upon pressure-related compression of the compressible dielectric. These resonant frequencies, or a change in the resonant frequencies, can be used as an indication of the pressure. | 11-27-2014 |
Ming-Yang Chen, Stanford, CA US
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20100111232 | METHOD AND APPARATUS FOR ITERATIVE RECEIVER STRUCTURES FOR OFDM/MIMO SYSTEMS WITH BIT INTERLEAVED CODED MODULATION - The techniques and components described herein may improve the performance for a class of reduced-complexity receiver designs for coded OFDM MIMO systems with bit interleaved coded modulation. The receiver structures described are soft-input soft-output inner/outer decoder receiver structures that include one or more of the following: 1) an inner decoder that includes a linear front-end followed by a limited tree-search based on a soft-output M-algorithm; 2) a conventional near-optimal or optimal decoder for the outer binary code; and 3) iterative decoding (ID), whereby decoding (output) information is passed from one decoder module as input to the other and used to refine and improve the inner/outer decoding module outputs. | 05-06-2010 |
Sheng Chen, Stanford, CA US
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20100235368 | Multiple Related Event Handling Based on XML Encoded Event Handling Definitions - In a method and system for collecting event information, XML documents specifying event parsing logic for respective groups of related events are loaded. Representations for the parsing logic contained in the plurality of XML documents are stored in one or more parsing trees. Events are received, including events in a plurality of groups of events. The received events are processed in accordance with the event parsing logic in the one or more parsing trees. The received events are also processed in accordance with stored program instructions that are independent of the parsing logic for the plurality of groups of events. Event information for the received events is stored. The stored event information includes information determined in accordance with the event parsing logic in at least one or more parsing trees. | 09-16-2010 |
20100332652 | Distributed Methodology for Approximate Event Counting - In a method and system for aggregating event information, events are received at a first plurality of nodes in a distributed system. For the events received at each node aggregated attribute information is determined in accordance with two or more rules and stored in distinct first tables, each table storing aggregated attribute information for a respective rule of the two or more rules. At each node of the first plurality of nodes, the two or more distinct first tables are transmitted to a respective node of a second set of nodes in the distributed system. At each node of the second set of nodes, two or more distinct second tables are generated by merging the aggregated attribute information in the tables transmitted to the node. Each rule of the two or more rules is evaluating using the aggregated attribute information obtained from a corresponding table of the second tables. | 12-30-2010 |
Shu-Lu Chen, Stanford, CA US
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20090176353 | CRYSTALLINE-TYPE DEVICE AND APPROACH THEREFOR - Single-crystalline growth is realized using a liquid-phase crystallization approach involving the inhibition of defects typically associated with liquid-phase crystalline growth of lattice mismatched materials. According to one example embodiment, a semiconductor device structure includes a substantially single-crystal region. A liquid-phase material, such as Ge or a semiconductor compound, is crystallized to form the single-crystal region using an approach involving defect inhibition for the promotion of single-crystalline growth. In some instances, this defect inhibition involves the reduction and/or elimination of defects using a relatively small physical opening via which a crystalline growth front propagates. In other instances, this defect inhibition involves causing a change in crystallization front direction relative to a crystallization seed location. The relatively small physical opening and/or the change in crystalline front direction may be implemented, for example, using a material that is substantially unreactive with the liquid-phase material to contain the crystalline growth. | 07-09-2009 |
Tze Wee Chen, Stanford, CA US
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20090296292 | Electrostatic Discharge Protection Circuit Employing a Micro Electro-Mechanical Systems (MEMS) Structure - An ESD protection circuit for protecting a host circuit coupled to a signal pad from an ESD event occurring at the signal pad includes at least one MEMS switch which is electrically connected to the signal pad. The MEMS switch includes a first contact structure adapted for connection to the signal pad, and a second contact structure adapted for connection to a voltage supply source. The first and second contact structures are coupled together during the ESD event for shunting an ESD current from the signal pad to the voltage supply source. The first and second contact structures are electrically isolated from one another in the absence of the ESD event. At least one of the first and second contact structures includes a passivation layer for reducing contact adhesion between the first and second contact structures. | 12-03-2009 |
20100100859 | DESIGN METHODOLOGY FOR PREVENTING FUNCTIONAL FAILURE CAUSED BY CDM ESD - A design methodology which prevents functional failure caused by CDM ESD events. A transistor model is used to model the final states of cells, and a simulator is then used to identify invulnerable cells. Cells that are potential failure sites are then identified. The cells which have been identified as being potential victims are replaced by the previously-identified invulnerable cells that have the identical logic function. On the other hand, if a cell with identical function cannot be found, an invulnerable buffer cell (that will not effect logic function) can be inserted in front of the potential victim transistor as protection. By replacing all the potential victim cells with cells which have been determined to be invulnerable, the resulting design will be guaranteed to be CDM ESD tolerant. | 04-22-2010 |
Vincent Chen, Stanford, CA US
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20120115236 | Device and Method For Indirect Electronic Condition Control in Biomolecule Detection Platforms - A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a hydrogel composition loaded with a chemical factor at the test site, providing an actuator configured to activate the hydrogel composition to release a chemical factor at the test site, controlling the actuator to activate the hydrogel composition to release a chemical factor at the test site, and modifying the local chemical environment at the test site with the chemical factor. | 05-10-2012 |
Yihong Chen, Stanford, CA US
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20140291163 | CATALYSTS FOR LOW TEMPERATURE ELECTROLYTIC CO2 REDUCTION - A method for electrochemically reducing CO | 10-02-2014 |
Yi Wei Chen, Stanford, CA US
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20110278258 | Device and Method for Indirect Modulation of Detection Environment - A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a first activatable stimulant at the test site, providing an actuator configured to activate the first activatable stimulant at the test site, controlling the actuator to activate the first activatable stimulant, and modifying the local chemical environment at the test site with the first activated stimulant. | 11-17-2011 |