Chen, Plainsboro
Bang-Chi Chen, Plainsboro, NJ US
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20090149650 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS - The invention relates to processes for preparing compounds having the formula, | 06-11-2009 |
20100016320 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS - The present invention relates to compounds having the formula, | 01-21-2010 |
20100267669 | HETEROCYCLIC CETP INHIBITORS - Compounds of formula Ia and Ib | 10-21-2010 |
20110077400 | PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES - Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form. | 03-31-2011 |
20120322761 | HETEROCYCLIC CETP INHIBITORS - Compounds of formula Ia and Ib | 12-20-2012 |
Bank-Chi Chen, Plainsboro, NJ US
Patent application number | Description | Published |
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20080275092 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS - The present invention relates to compounds having the formula, | 11-06-2008 |
Frank X. Chen, Plainsboro, NJ US
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20090240063 | Process For The Preparation Of 6,6-Dimethyl-3-Azabicyclo-[3.1.0]-Hexane Compounds ... - The present invention provides for a process for preparing racemic methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate, its corresponding salt: (2S, 3R, 4S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-D-tartaric acid (“D-DTTA”) salt or a (2R, 3S, 4R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-L-tartaric acid salt (“L-DTTA”) in a high enantiomeric excess. This invention also provides for a process for preparing a (2S, 3R, 4S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate dibenzoyl-D-tartaric acid (“D-DBTA”) salt or a (2R, 3S, 4R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate L-tartaric acid (“L-DBTA”) salt in a high enantiomeric excess. Further, this invention provides a process for preparing intermediates II, IIB, III, IV, IV salt, V, VI, and VII. | 09-24-2009 |
Frank Xing Chen, Plainsboro, NJ US
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20090281321 | EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS - This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following: | 11-12-2009 |
20110124867 | Process and intermediates for the Synthesis of heterocyclic Substituted Piperazines with CXCR3 Antagonist Activity - The present invention relates to novel processes for the preparation of the compound of the Formula A45: | 05-26-2011 |
20110251392 | EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS - This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following: | 10-13-2011 |
20120296093 | EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS - This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following: | 11-22-2012 |
20140031549 | Process and Intermediates for the Synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one Compounds - This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes. | 01-30-2014 |
Yungiang Chen, Plainsboro, NJ US
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20090103682 | Method and system for intelligent digital subtraction - A method and system for intelligent digital subtraction is disclosed. The method and system for intelligent digital subtraction can be used in a roadmap application for a coronary intervention. A mask image is obtained with vessels highlighted by contrast media. A guide wire is inserted into the vessels, and a guide wire image is obtained. A direct subtraction image is generated from the guide wire image and the mask image. A reduced noise subtraction image is generated based on mutual image information between the subtraction image and the guide wire image and mutual image information between the subtraction image and the mask image. | 04-23-2009 |
Yunqiang Chen, Plainsboro, NJ US
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20080267474 | Layer Reconstruction From Dual-Energy Image Pairs - A system and method for layer reconstruction from dual-energy image pairs are provided, the method including: receiving a pair of dual-energy images, one having a relatively high energy dose and the other having a relatively low energy dose; ascertaining that a first relatively motionless layer is substantially aligned between the high and low dose images; computing a preliminary image of a second layer that has non-rigid motion relative to the first layer; detecting the relative motion of the second layer relative to the first layer; generating a mask in accordance with the detected motion; filling the motion area corresponding to the mask with gradients of the high-dose image; removing the first layer; and inpainting the motion area. | 10-30-2008 |
20090080756 | Method and system for correcting butting artifacts in X-ray images - A method and system for correcting butting artifacts in x-ray images is disclosed. In order to correct a butting artifact in an x-ray image, a butting artifact region in the x-ray image is normalized. Multiple intensity shift estimators are calculated for each pixel of each line of the butting artifact. Confidence intervals are calculated for each intensity shift estimator. A multiple hypothesis hidden Markov model (MH-HMM) is formulated based on the intensity shift operators and confidence measures subject to a smoothness constraint, and the MH-HMM is solved to determine intensity shift values for each pixel. A corrected image is generated by adjusting the intensity of each pixel of the butting artifact based on the intensity shift value for that pixel. | 03-26-2009 |
20090087070 | Method and system for bone suppression based on a single x-ray image - A method and system for suppressing bone structures based on a single x-ray image is disclosed. The bone structure suppressing method predicts a soft-tissue image without bone structures from an input x-ray image. A set of features is extracted for each pixel of the input x-ray image. A soft-tissue image is then generated from the input x-ray image using a trained regression function to determine an intensity value for the soft-tissue image corresponding to each pixel of the input x-ray image based on the set of features extracted for each pixel of the input x-ray image. The extracted features can be wavelet features and the regression function can be trained using Bayesian Committee Machine (BCM) to approximate Gaussian process regression (GPR). | 04-02-2009 |
20090087071 | Method and system for scale-based vessel enhancement in X-ray angiography - A method and system for scale-based vessel enhancement in x-ray angiography images is disclosed. An input x-ray image is denoised. A lighting field is estimated in the denoised image. Vessels are extracted from the denoised image by dividing the denoised image by the estimated lighting field. Vessels are enhanced in the input x-ray image by linearly combining the extracted vessels with the input x-ray image, resulting in an enhanced image. | 04-02-2009 |
20090116722 | Method and system for soft tissue image reconstruction in gradient domain - A method and system for soft tissue image reconstruction for dual x-ray imaging is disclosed. A multigrid PDE solver is used for solving a Poisson equation for soft tissue image reconstruction based on a soft tissue gradient field extracted from dual energy x-ray images. The divergence of the soft tissue gradient field is downsampled to a coarsest resolution level, and a soft tissue image is generated based on the divergence of the soft tissue gradient field at the coarsest level. The soft tissue image is interpolated to a next finest resolution level, and refined by at least one coarse grid correction cycle at the current resolution level. The coarse grid correction cycle calculates a defect based on the current soft tissue image, downsamples the defect to the coarsest level, calculates a correction based on the defect at the coarsest level, and upsamples the correction to the current resolution level to refine the current soft tissue image. The interpolation and refinement of the soft tissue image is repeated until the soft tissue image is refined at the finest resolution level. | 05-07-2009 |
20100092061 | SYSTEM AND METHOD FOR DECOMPOSED TEMPORAL FILTERING FOR X-RAY GUIDED INTERVENTION APPLICATION - A method for temporally filtering medical images during a fluoroscopy guided intervention procedure includes providing a mask image, a fluoroscopy intervention image acquired at a current time during a medical intervention procedure, forming a subtraction image by subtracting the mask image from the intervention image, calculating a motion image of a moving structure in the subtraction image, forming a residual image by subtracting the motion image from the subtraction image, temporally filtering the residual image with a filtered image from a previous time, and adding the motion image to the temporally filtered residual image. | 04-15-2010 |
20110064285 | SYSTEM AND METHOD FOR MULTI-IMAGE BASED STENT VISIBILITY ENHANCEMENT - A method for enhancing stent visibility in digital medical images includes providing a time series of 2-dimensional (2D) images of a stent in a vessel, estimating motion of the stent in a subset of images of the time series of images, estimating motion of clutter in the subset of images, where clutter comprises anatomical structures other than the stent, estimating a clutter layer in the subset of images from the estimated clutter motion, estimating a stent layer in the subset of images from the clutter layer and the estimated clutter motion, and minimizing a functional of the estimated stent motion, the estimated stent layer, the estimated clutter motion, and the estimated clutter layer to in calculate a refined stent layer image, where the refined stent layer image has enhanced visibility of the stent. | 03-17-2011 |
20110064292 | SYSTEM AND METHOD FOR MULTI-IMAGE BASED VIRTUAL NON-CONTRAST IMAGE ENHANCEMENT FOR DUAL SOURCE CT - A method for enhancing a virtual non-contrast image, includes receiving a pair of dual scan CT images and calculating a virtual non-contrast image from the pair of CT images using known tissue attenuation coefficients. A conditional probability distribution is estimated for tissue at first and second points in each of the pair of CT images and the virtual non-contrast image as being the same type. A conditional probability distribution for tissue is estimated at the first and second points in each of the pair of CT images and the virtual non-contrast image as being of different types. An a posteriori probability of the tissue at the first and second points as being the same type is calculated from the conditional probability distributions, and an enhanced virtual non-contrast image is calculated using the a posteriori probability of the tissue at the first and second points as being the same type. | 03-17-2011 |
20110103674 | MARKER DETECTION IN X-RAY IMAGES - A method for detecting markers within X-ray images includes applying directional filters to a sequence of X-ray image frames. Marker candidate pixels are determined based on the output of the directional filters. Candidate pixels are grouped into clusters and distances between each possible pair of clusters is determined and the most frequently occurring distance is considered an estimated distance between markers. A first marker is detected at the cluster that most closely resembles a marker based on certain criteria and a second marker is then detected at a cluster that is the estimated distance from the first marker. The pair of first and second marker detections is scored to determine detection quality. If the detected marker pair has an acceptable score then the detected marker pair is used. | 05-05-2011 |