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Chen, Palo Alto
Caifu Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090087858 | Two-color Real-time/End-point Quantitation of MicroRNAs (miRNAs) - The present invention is directed to methods, reagents, kits, and compositions for detecting target polynucleotide sequences, especially small target polynucleotides such as miRNAs, between two samples. A pair of linker probes can be employed in two different reactions to query a particular species of target polynucleotide. A pair of detector probes, a single forward primer specific for the target polynucleotide, and a reverse primer can be employed in an amplification reaction to query the difference in expression level of the target polynucleotide between the two samples. In some embodiments a plurality of small miRNAs are queried with a plurality of linker probes. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions. | 04-02-2009 |
| 20100015631 | CONCATAMERIC LIGATION PRODUCTS: COMPOSITIONS METHODS AND KITS FOR SAME - The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures. | 01-21-2010 |
| 20100112573 | Methods, Compositions, and Kits Comprising Linker Probes for Quantifying Polynucleotides - The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. A detector probe, a specific forward primer, and a reverse primer can be employed in an amplification reaction wherein the detector probe can detect the amplified target polynucleotide based on the stem nucleotides introduced by the linker probe. In some embodiments a plurality of short miRNAs are queried with a plurality of linker probes, wherein the linker probes all comprise a universal reverse primer portion a different 3′ target specific portion and different stems. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions. | 05-06-2010 |
| 20100203545 | Two-color Real-time/End-point Quantitation of MicroRNAs (miRNAs) - The present invention is directed to methods, reagents, kits, and compositions for detecting target polynucleotide sequences, especially small target polynucleotides such as miRNAs, between two samples. A pair of linker probes can be employed in two different reactions to query a particular species of target polynucleotide. A pair of detector probes, a single forward primer specific for the target polynucleotide, and a reverse primer can be employed in an amplification reaction to query the difference in expression level of the target polynucleotide between the two samples. In some embodiments a plurality of small miRNAs are queried with a plurality of linker probes. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions. | 08-12-2010 |
| 20100221717 | Methods, Compositions, and Kits for Detecting Allelic Variants - In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant (e.g., wild type) allelic variants with high specificity and selectivity. In particular, in some embodiments, the invention relates to a highly selective method for mutation detection referred to as competitive allele-specific TaqMan PCR (“cast-PCR”). | 09-02-2010 |
| 20100285478 | Methods, Compositions, and Kits for Detecting Allelic Variants - In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant (e.g., wild type) allelic variants with high specificity and selectivity. In particular, in some embodiments, the invention relates to a highly selective method for mutation detection referred to as competitive allele-specific TaqMan PCR (“cast-PCR”). | 11-11-2010 |
| 20110212494 | Method to Quantify siRNAs, miRNAs and Polymorphic miRNAs - The present teachings provide methods, compositions, and kits for quantifying target, polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3′ end of a target polynucleotide, using a ligase that can ligate the 3′ end of RNA to the 5′ end of DNA using a DNA template, such as T4 DNA ligase. Following digestion to form an elongated target polynucleotide with a liberated end, a reverse transcription reaction can be performed, followed by a PCR. In some embodiments, the methods of the present teachings can discriminate between polymorphic polynucleotides that vary by as little as one nucleotide. | 09-01-2011 |
| 20110257385 | METHODS FOR FLIP-STRAND IMMOBILIZING AND SEQUENCING NUCLEIC ACIDS - Provided herein are compositions, materials, methods and kits for immobilizing a template polynucleotide in a first orientation, and immobilizing a complementary sequence of the template polynucleotide in an orientation that is flipped compared to the orientation of the template polynucleotide. Provided herein are adaptive oligonucleotides that can be used in various nucleic acid manipulations to generate immobilized complement polynucleotides that are flipped in orientation compared to the orientation of the immobilized template polynucleotides. | 10-20-2011 |
| 20110281755 | Karyotyping Assay - This disclosure relates to methods and kits for karyotyping in which chromosomes are interrogated by amplifying loci that are not within copy number variable regions thereof. | 11-17-2011 |
| 20110287424 | METHYLATION-SPECIFIC COMPETITIVE ALLELE-SPECIFIC TAQMAN POLYMERASE CHAIN REACTION (CAST-PCR) - In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating between different methylated and/or unmethylated nucleic acid loci. In certain embodiments, the inventions provides for detecting or quantitating undifferentiated embryonic stem cells in a population of differentiated cells. The invention is also useful for discriminating between fetal versus maternal cells, or healthy versus infected cells, or normal versus cancerous cells, or detecting reduction in viral load or measuring therapeutic efficiency in a patient, and more. | 11-24-2011 |
Chi-Chung K. Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090245246 | SYSTEMS AND METHODS FOR IMPROVING PACKET SCHEDULING ACCURACY - A packet scheduler is configured to perform quality of service (QoS) scheduling on a per-data unit basis. A downstream processing engine is operatively connected to the packet scheduler for receiving forwarded packets. A feedback path is operatively connected between the downstream processing engine and the packet scheduler for transmitting a net data unit change value reflecting a change in packet size between an output of the packet scheduler and an output of the downstream processing engine. | 10-01-2009 |
Chi-Chung Kenny Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100158031 | METHODS AND APPARATUS FOR TRANSMISSION OF GROUPS OF CELLS VIA A SWITCH FABRIC - In one embodiment, a method can include receiving at an egress schedule module a request to schedule transmission of a group of cells from an ingress queue through a switch fabric of a multi-stage switch. The ingress queue can be associated with an ingress stage of the multi-stage switch. The egress schedule module can be associated with an egress stage of the multi-stage switch. The method can also include determining, in response to the request, that an egress port at the egress stage of the multi-stage switch is available to transmit the group of cells from the multi-stage switch. | 06-24-2010 |
Chieh Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080213579 | Organic light emitting device having a protective barrier - In an organic light emitting device package including a plurality of layers of materials formed on a substrate the plurality of layers of materials including an organic light emitting layer a protective barrier for protecting the organic light emitting device from environmental degradation the protective barrier comprising a first semi-crystalline parylene-based layer an inorganic barrier layer and a second semi-crystalline parylene-based layer. | 09-04-2008 |
| 20100119839 | System and Method for Forming a Thin-Film Phosphor Layer for Phosphor-Converted Light Emitting Devices - A thin-film phosphor layer can be formed by an improved deposition method involving: (1) forming a phosphor powder layer that is substantially uniformly deposited on a substrate surface; and (2) forming a polymer binder layer to fill gaps among loosely packed phosphor particles, thereby forming a substantially continuous layer of thin film. | 05-13-2010 |
| 20100123386 | Phosphor-Coated Light Extraction Structures for Phosphor-Converted Light Emitting Devices - A conformal thin-film phosphor layer is disposed over a surface of a hemispherical lens, a Fresnel lens, or a microlens array, thereby forming a phosphor-coated light extraction structure. Also disclosed is a phosphor-converted photonic crystal light emitting device that incorporates a thin-film phosphor layer. A wafer-level packaging process incorporating a thin-film phosphor layer is also disclosed herein. | 05-20-2010 |
Chong Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090080746 | System and method for automated magnetic resonance scan prescription for optic nerves - A method and system for automated magnetic resonance (MR) scan prescription is disclosed. A 3D MR scout image is obtained by an initial MR scan. The location of an optic nerve in the scout image is determined by registering a template image to the scout image using a hierarchical series of rigid registrations. The hierarchical series of rigid registrations utilizes a coarse to fine scheme to register regions in the template image to the scout image, starting with the whole template image and finishing with the optic nerve. A diagnostic MR scan is then aligned based on the location of the optic nerve in the scout image, and the diagnostic scan is performed resulting in a high quality diagnostic 3D MR image. | 03-26-2009 |
| 20090093706 | Automatic Alignment of Magnetic Resonance Imaging (MRI) Brain Scan By Anatomic Landmarks - A method to automatically align magnetic resonance (MR) brain scans for diagnostic scan planning, including: acquiring a three-dimensional (3D) localizer image of a patient; selecting a two-dimensional (2D) coronal view and a 2D transverse view from the localizer image; identifying a mid-sagittal plane (MSP) line in each of the coronal and transverse views and calculating a 3D MSP based on the MSP lines; reconstructing the localizer image based on an equation for the 3D MSP to obtain an image of the MSP of the patient's brain; identifying crista galli (CG) and tip of the occipital bone (TOB) in the image of the MSP of the patient's brain; calculating a transformation matrix based on the MSP, CG and TOB in the image and using the transformation matrix to obtain a scan plan for the patient; and outputting the scan plan for the patient. | 04-09-2009 |
Cuiping Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120077878 | GASTRIC RETENTIVE DOSAGE FORMS FOR EXTENDED RELEASE OF ACAMPROSATE INTO THE UPPER GASTROINTESTINAL TRACT - Gastric retentive dosage forms for sustained release of acamprosate are described which may allow once- or twice-daily dosing for both acute and long-term treatment of a disorder including alcohol dependence, tinnitus, sleep apnea, Parkinson's disease, levodopa-induced dyskinesias in Parkinson's disease, Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, Cortical spreading depression, migraine, schizophrenia, anxiety, tardive dyskinesia, spasticity, multiple sclerosis, various types pain, or binge eating. Methods of treatment using the dosage forms and methods of making the dosage forms are also described. | 03-29-2012 |
David H. C. Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110238234 | SYSTEMS, DEVICES AND METHODS OF ENERGY MANAGEMENT, PROPERTY SECURITY AND FIRE HAZARD PREVENTION - Systems and devices for and methods of energy management, property security and fire hazard prevention are provided. The systems, devices and methods are able to be centralized, computerized, and expandable. The devices and systems are capable of automatically reducing energy consumptions and minimizing losses of property caused by fire, theft, and vandalism using monitoring sensors (e.g., occupancy sensors) and computer software and equipments. | 09-29-2011 |
Eugene I. Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090309111 | SEMICONDUCTOR LIGHT EMITTING DEVICE INCLUDING GRADED REGION - One or more regions of graded composition are included in a III-P light emitting device, to reduce the V | 12-17-2009 |
Francine Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090306988 | SYSTEMS AND METHODS FOR REDUCING SPEECH INTELLIGIBILITY WHILE PRESERVING ENVIRONMENTAL SOUNDS - An audio privacy system reduces the intelligibility of speech in an audio signal while preserving prosodic information, such as pitch, relative energy and intonation so that a listener has the ability to recognize environmental sounds but not the speech itself. An audio signal is processed to separate non-vocalic information, such as pitch and relative energy of speech, from vocalic regions, after which syllables are identified within the vocalic regions. Representations of the vocalic regions are computed to produce a vocal tract transfer function and an excitation. The vocal tract transfer function for each syllable is then replaced with the vocal tract transfer function from another prerecorded vocalic sound. In one aspect, the identity of the replacement vocalic sound is independent of the identity of the syllable being replaced. A modified audio signal is then synthesized with the original prosodic information and the modified vocal tract transfer function to produce unintelligible speech that preserves the pitch and energy of the speech as well as environmental sounds. | 12-10-2009 |
Guoqing Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110086834 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS - Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like. | 04-14-2011 |
James K. Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100069386 | Modulators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto - The present invention makes available methods and reagents for inhibiting aberrant growth states resulting form hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity. Such methods and reagents may also inhibit the hedgehog pathway in normal cells, e.g., where normal levels of hedgehog signalling are unwanted. | 03-18-2010 |
Jer-Kang Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080268440 | BIOMOLECULE IMMOBILIZATION ON SURFACE VIA HYDROPHOBIC INTERACTIONS - A method, apparatus, or system for generating a pattern of polynucleotides on a substrate. The method includes providing a substrate having a hydrophobic surface. The method further includes conjugating a polystyrene moiety to a polynucleotide and applying a polystyrene-polynucleotide conjugate to create a plurality of reaction spots on the hydrophobic surface of the substrate. An apparatus includes a substrate with at least one polystyrene-polynucleotide conjugate on a surface of the substrate. A system can analyze a polystyrene-polynucleotide conjugate and the system may perform PCR. | 10-30-2008 |
| 20090142761 | METHODS AND KITS FOR METHYLATION DETECTION - Ligation-based methods and kits are disclosed for determining the degree of methylation of one or more target nucleotides. In certain embodiments, the methylation status of one or more target nucleotides is determined by generating misligation products. In certain embodiments, at least one target nucleotide is amplified prior to the ligation reaction. In certain embodiments, at least one ligation product, at least one ligation product surrogate, at least one misligation product, at least one misligation product surrogate, or combinations thereof are amplified. In certain embodiments, one or more ligation probes comprise at least one nucleotide analog, at least one Modification, at least one mismatched nucleotide, or combinations thereof. | 06-04-2009 |
| 20090269759 | UNNATURAL POLYMERASE SUBSTRATES THAT CAN SUSTAIN ENZYMATIC SYNTHESIS OF DOUBLE STRANDED NUCLEIC ACIDS FROM A NUCLEIC ACID TEMPLATE AND METHODS OF USE - Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and their analogs; (ii) a label attached to the base or analog of the base via a cleavable linker; (iii) a deoxyribose; and (iv) one or more phosphate groups. The linker and/or the label inhibits template directed polymerase incorporation of a further nucleotide substrate onto an extended primer strand. In addition, cleavage of the linker leaves a residue attached to the base which is not present in the natural nucleotide and which does not inhibit extension of the primer strand. The nucleotide analogs can therefore be used as reversible terminators in sequencing by synthesis methods without blocking the 3′ hydroxyl group. Methods of sequencing DNA using the substrates are also described. | 10-29-2009 |
| 20090308736 | APPARATUS AND METHOD FOR SPECIFIC RELEASE OF CAPTURED EXTENSION PRODUCTS - Apparatus and methods for separating different polynucleotide populations in a mixture are provided, wherein different polynucleotides or polynucleotide populations are captured on different solid support. After hybridization, polynucleotides are selectively released from a selected support by altering a physical property of that support. The released polynucleotides can be eluted from a common flow path and isolated. | 12-17-2009 |
| 20110143343 | Methods and Kits for Methylation Detection - Ligation-based methods and kits are disclosed for determining the degree of methylation of one or more target nucleotides. In certain embodiments, the methylation status of one or more target nucleotides is determined by generating misligation products. In certain embodiments, at least one target nucleotide is amplified prior to the ligation reaction. In certain embodiments, at least one ligation product, at least one ligation product surrogate, at least one misligation product, at least one misligation product surrogate, or combinations thereof are amplified. In certain embodiments, one or more ligation probes comprise at least one nucleotide analog, at least one Modification, at least one mismatched nucleotide, or combinations thereof. | 06-16-2011 |
Jiavu Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120130241 | HANDHELD VOLUMETRIC ULTRASOUND SCANNING DEVICE - An apparatus and related methods for ultrasonically scanning a tissue volume are described, the apparatus being particularly advantageous in the context of freehand ultrasound assisted biopsy of the breast although readily applied to non-biopsy contexts and other body parts. The apparatus comprises a casing configured and dimensioned for single-handed manipulation relative to a surface of the tissue, and a texturably couplant-porous material sheet extending across an opening of the casing. The texturably couplant-porous material sheet has an outer side and an inner side relative to the casing, the outer side for compressively contacting the tissue surface. The apparatus further comprises an ultrasound transducer positioned against the inner side of the texturably couplant-porous material sheet and being mechanically translatable thereacross for volumetrically scanning the tissue volume therethrough. | 05-24-2012 |
Kay-Yut Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100106600 | Publication Planning Based On Estimated Content Usage Parameters - Planning a publication includes receiving information about an event, accessing a database of profiles that relate in general to content usage, and using a search engine to match the profiles with the event information to estimate parameters for using content for the event. The publication is planned according to the estimated usage parameters. | 04-29-2010 |
Marilyn Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110296468 | AUGMENTING TELEVISION MEDIA - This document describes techniques for, and apparatuses capable of, augmenting television media through a mobile computing device and/or a television-capable computing device. In one embodiment, a user's mobile computing device receives an event associated with a particular program of television media from the television-capable computing device, and, using this event, augments that television media through the mobile computing device with information associated with this event. | 12-01-2011 |
Mark H. Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090086456 | TOOL-LESS BLADE EJECTOR LATCH WITH INTEGRATED SPRING - An ejector latch for removing a blade module from a server chassis includes a latch lever, an ejector catch, and an ejector pull part. The latch lever includes a pivot hole near a first end thereof operable to be coupled to the blade module and a bend near a second end thereof. The ejector catch includes a through-hole passing therethrough and a hook operable to hook onto the server chassis. The ejector pull part includes an integrated spring operable to return the ejector pull part to an original position after being pulled. The second end of the latch lever passes through the through-hole of the ejector catch. The ejector pull part is disposed on the bend near the second end of the latch lever and inside the through-hole of the ejector catch such that, when the ejector pull part is pulled, the ejector pull part slides along the bend near the second end of the latch lever and pushes on a wall of the through-hole to disengage the hook of the ejector catch from the server chassis. | 04-02-2009 |
| 20090320267 | EXPANSION CARD CARRIER AND METHOD FOR ASSEMBLING THE SAME - An expansion card carrier is disclosed, the expansion card carrier including a top portion for covering an expansion card, at least one side portion for supporting the top portion, and at least one pair of card guides for allowing an expansion card to slide along into the expansion card carrier. A method for assembling an expansion card carrier is also disclosed, the method including casting a panel including a top portion for covering an expansion card and at least one side portion for supporting the top portion, forming at least one side portion by deforming the panel, and attaching at least one pair of card guides inside the expansion card carrier for allowing an expansion card to slide along into the expansion card carrier. | 12-31-2009 |
Mingdeng Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110037506 | DC OFFSET CALIBRATION FOR COMPLEX FILTERS - Exemplary techniques for DC offset calibration for complex filters are disclosed. A complex filter is provided having a first calibration path circuit and a second calibration path circuit, each including a first and a second set of switches, respectively. The first set of switches is enabled during calibration mode and the second set of switches is enabled during normal operation mode such that the network characteristics of each calibration path circuit are substantially the same during both modes of operation. In one embodiment, the complex filter is a low pass filter. | 02-17-2011 |
Pang-Chieh Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100162039 | High Availability and Disaster Recovery Using Virtualization - There is disclosed apparatus and processes which address problems in the area of providing high availability and disaster recovery for computing systems and the data in them. These apparatus and processes can be used to provide high availability and disaster recovery for a computing system to be protected. The protected computing systems may be virtual computing systems. | 06-24-2010 |
Shiah-Yun Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090239896 | AZAINDOLE COMPOUNDS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS - Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. The compounds include azaindoles of the formula below [insert FIG. | 09-24-2009 |
| 20090306171 | INDOLE COMPOUNDS HAVING C4-AMIDE SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS - Indole and indole-related compounds according to the formula (I) or (II) optionally having additional heteroatoms, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. Formula (I), formula (II). R | 12-10-2009 |
| 20090318492 | INDOLE COMPOUNDS HAVING C4-ACIDIC SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS - Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. | 12-24-2009 |
Shiao-Hua Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110211280 | METHOD AND APPARATUS FOR AT LEAST ONE ACTUATOR ARM DAMPER COVERING AT LEAST ONE LIGHTENING HOLE IN A HARD DISK DRIVE TO REDUCE TRACK MIS-REGISTRATION (TMR) - This application discloses a hard disk drive, a head stack assembly, an actuator arm, and an arm damper configured for coupling to an actuator arm to create the head stack assembly used in the hard disk drive. The actuator arm has two arm dampers covering a lightening hole on either side of the actuator arm and configured to reduce the effects of airflow turbulence and mechanical vibration in the hard disk drive. Also disclosed, methods of operating the hard disk drive and of manufacturing for the head stack assembly and the hard disk drive. | 09-01-2011 |
Shu-Lu Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090294869 | Negative Differential Resistance Device and Memory Using the Same - A negative differential resistance (NDR) device is designed and a possible compact device implementation is presented. The NDR device includes a voltage blocker and a current blocker and exhibits high peak-to-valley current ratio (PVCR) as well as high switching speed. The corresponding process and design are completely compatible with contemporary Si CMOS technology and area efficient. A single-NDR element SRAM cell prototype with a compact size and high speed is also proposed as its application suitable for embedded memory. | 12-03-2009 |
Shuyuan Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080263086 | Systems and methods for information exchange using object warehousing - Embodiments of the present invention improve information exchange, and in particular, the exchange of data objects between different software systems. In one embodiment, the present invention includes a method of exchanging information comprising analyzing the attributes of the objects. Objects may be stored in a repository and retrieved using attributes. In some applications, objects are received and sent to participants without accessing any information in the objects themselves. Different applications include object warehousing operable across different communication mediums that support different names or name spaces, classes, aliases, groups, geospatial information, or tokens, or combinations thereof. | 10-23-2008 |
Tong Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110285984 | Velocity measuring system - A laser Doppler velocimeter uses self-mixing amplification of backreflections from scatterers below the surface of a flow. | 11-24-2011 |
Weidong Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110314105 | SYSTEM AND METHOD FOR ATTRIBUTE DETECTION IN USER PROFILE CREATION AND UPDATE - In one embodiment, a scheduled collaboration session in a social network is detected, the scheduled collaboration session to occur at a time in the future and at that time provide real-time communication among participants. A plurality of participants expected to attend the scheduled collaboration session are detected. A subject matter of the scheduled collaboration session is detected. One or more key words are derived from the detected subject matter of the scheduled collaboration session. Profiles maintained in the social network for the plurality of participants expected to attend the scheduled collaboration session are updated based on the one or more key words, the updating to include refining an area of expertise indicated in the profiles. | 12-22-2011 |
Xiao-Hua Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090163594 | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors - The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a substrate specific manner. The invention provides an isolated cell wherein the cell stably expresses APP and at least one gamma secretase substrate other than APP. The invention provides assays and methods comprising contacting a cell with gamma secretase and detecting production of Abeta, detecting production of intracellular domain (ICD), and detecting a signal from a reporter gene under transcriptional control of the ICD. The invention also provides compounds that inhibit gamma secretase, pharmaceutical compositions comprising such compounds, and methods of treating Alzheimer's disease using such compounds. | 06-25-2009 |
Xiaoqi Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110034487 | CXCR3 ANTAGONISTS - Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, transplant rejection and type I diabetes. | 02-10-2011 |
| 20110319378 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER - The present invention provides MDM2 inhibitor compounds of Formula I, | 12-29-2011 |
Xingjie Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100234578 | ANTI-CD40 MONOCLONAL ANTIBODY - An antibody or a functional fragment thereof, acting agonistically or antagonistically on CD40. | 09-16-2010 |
Xun Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110083113 | System and Method for Lithography Simulation - There are many inventions described and illustrated herein. In one aspect, the present invention is directed to a technique of, and system for simulating, verifying, inspecting, characterizing, determining and/or evaluating the lithographic designs, techniques and/or systems, and/or individual functions performed thereby or components used therein. In one embodiment, the present invention is a system and method that accelerates lithography simulation, inspection, characterization and/or evaluation of the optical characteristics and/or properties, as well as the effects and/or interactions of lithographic systems and processing techniques. In this regard, in one embodiment, the present invention employs a lithography simulation system architecture, including application-specific hardware accelerators, and a processing technique to accelerate and facilitate verification, characterization and/or inspection of a mask design, for example, RET design, including detailed simulation and characterization of the entire lithography process to verify that the design achieves and/or provides the desired results on final wafer pattern. The system includes: (1) general purpose-type computing device(s) to perform the case-based logic having branches and inter-dependency in the data handling and (2) accelerator subsystems to perform a majority of the computation intensive tasks. | 04-07-2011 |
| 20120021343 | Process Window Signature Patterns for Lithography Process Control - A method for identifying process window signature patterns in a device area of a mask is disclosed. The signature patterns collectively provide a unique response to changes in a set of process condition parameters to the lithography process. The signature patterns enable monitoring of associated process condition parameters for signs of process drift, analyzing of the process condition parameters to determine which are limiting and affecting the chip yields, analyzing the changes in the process condition parameters to determine the corrections that should be fed back into the lithography process or forwarded to an etch process, identifying specific masks that do not transfer the intended pattern to wafers as intended, and identifying groups of masks that share common characteristics and behave in a similar manner with respect to changes in process condition parameters when transferring the pattern to the wafer. | 01-26-2012 |
Yenyu Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110251492 | ULTRASOUND ASSESSMENT OF LUMENS TO FACILITATE REPAIR OR REPLACEMENT - Devices and methods for assessing the orientation and shape of vessel lumens and hollow portions of organs are described. The devices and methods are particularly adapted for determining the orientation and shape of the native heart valves to facilitate the later implantation of a prosthetic heart valve. The devices are typically catheter-based having an expandable member fixed to a distal end of the catheter. Located within the expandable member is an ultrasonic imaging probe and an acoustic reflective material. The methods typically comprise deploying the balloon percutaneously to a target location, expanding the balloon, and determining the orientation and shape of a lumen, particularly a cardiac valve. | 10-13-2011 |
| 20110276127 | MULTIPLE INFLATION OF AN EXPANDABLE MEMBER AS A PRECURSOR TO AN IMPLANT PROCEDURE - Devices and methods for assessing the orientation and shape of vessel lumens and hollow portions of organs are described. The devices and methods are particularly adapted for determining the orientation and shape of the native heart valves to facilitate the later implantation of a prosthetic heart valve. The devices are typically catheter-based having an expandable member fixed to a distal end of the catheter. The devices and methods typically comprise deploying the expandable member percutaneously to a target location, expanding the expandable member, performing a valvuloplasty procedure to enlarge the diseased lumen and then performing an assessment of the diseased lumen with the expandable member to determine at least one property of the lumen. An implant device is inserted after assessment of the diseased lumen. | 11-10-2011 |
| 20120095334 | CONTROLLED INFLATION OF AN EXPANDABLE MEMBER DURING A MEDICAL PROCEDURE - Devices and methods for controlled inflation of a vessel lumen or a hollow portion of another organ located within a patient. The devices are typically catheter-based having an expandable member fixed to a distal end of the catheter. The devices and methods typically comprise deploying the expandable member percutaneously to a target location, expanding the expandable member, and performing an expansion procedure. The expandable member expands at a controlled rate of inflation during a medical procedure. | 04-19-2012 |
| 20120116213 | ORIENTATION DETERMINATION OF A MEDICAL DEVICE WITHIN A PATIENT - Devices and methods for assessing the orientation and shape of vessel lumens and hollow portions of organs are described. The devices and methods are particularly adapted for determining the orientation and shape of a lumen to, for example, perform a valvuloplasty or facilitate the later implantation of a prosthetic heart valve. The devices are typically catheter-based having an expandable member fixed to a distal end of the catheter. Located within the expandable member are materials of different densities wherein the materials of different densities cooperate to indicate the orientation of the device within a lumen. The methods typically comprise deploying the balloon percutaneously to a target location, expanding the balloon, and determining the orientation and shape of a lumen. | 05-10-2012 |
Yixiang Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110201351 | SYSTEM AND METHOD FOR PROVIDING MOBILE USER CLASSFICATION INFORMATION FOR A TARGET GEOGRAPHICAL AREA - A system and method for providing mobile user classification information for a target geographical area uses location information of mobile communication devices to detect the mobile communication devices within the target geographical area at a specified time and then further uses at least one of the location information of the detected mobile communication devices and Internet session information of the detected mobile communication devices to produce the mobile user classification information of the mobile communication devices within the target geographical area that are classified in one or more classifications. | 08-18-2011 |
Yuan Chen, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120011517 | GENERATION OF OPERATIONAL POLICIES FOR MONITORING APPLICATIONS - Example embodiments relate to generation of operational policies for monitoring applications. In example embodiments, data generated based on decomposition of a Service Level Agreement (SLA) is received. Furthermore, in example embodiments, an operational policy is generated using the decomposition data. The operational policy may be used to control operation of a monitoring application. | 01-12-2012 |