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Chen, IN
Danny Z. Chen, Granger, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20110091015 | Single-arc dose painting for precision radiation therapy - Provided herein are methods and systems for designing a radiation treatment for a subject using single arc dose painting. The methods and systems comprise an algorithm or a computer-readable product having the same, to plan the radiation treatment. The algorithm converts pairs of multiple leaf collimation (MLC) leaves to sets of leaf aperture sequences that form a shortest path single arc thereof where the pairs of MLC leaves each aligned to an intensity profile of densely-spaced radiation beams, and connects each single arc of leaf apertures to form a final treatment single arc. Also provided is a method for irradiating a tumor in a subject using single arc dose painting. | 04-21-2011 |
Daohong Chen, Westfield, IN US
| Patent application number | Description | Published |
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| 20100286209 | VINYL INDAZOLYL COMPOUNDS - The present invention provides vinyl indazolyl compounds useful in the treatment of cancer. | 11-11-2010 |
Hanying Chen, Zionsville, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20120093776 | METHODS FOR TREATING DISEASES USING A BONE MORPHOGENETIC PROTEIN - Described herein are methods, uses, and pharmaceutical compositions for treating heart disease that include a bone morphogenetic protein (BMP). In addition, described herein are methods, uses, and compositions for preventing or slowing fibrosis in diseased or injured tissue, and/or for preventing or slowing cell death in diseased or injured tissue. | 04-19-2012 |
Jake Yue Chen, Indianapolis, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20120011156 | INTER-CLASS MOLECULAR ASSOCIATION CONNECTIVITY MAPPING - Methods, systems, devices and/or apparatuses are provided for computationally deriving molecular association connectivity maps for the study of inter-class molecular associations in toxicogenomics and drug discovery applications. The inter-class molecular associations can be between at least one bio-molecular entity and at least one therapeutic agent. The methods, systems, devices and/or apparatuses apply integrated molecular interaction network mining and text mining techniques. | 01-12-2012 |
Jiehao Chen, Fishers, IN US
| Patent application number | Description | Published |
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| 20100081786 | Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation - The present invention provides isolated homogeneous polyfunctionalized proteins (e.g., erythropoietin), isolated glycopeptides, and a method for preparing polyfunctionalized peptides and/or proteins via cysteine-free native chemical ligation. In certain embodiments, the invention provides an isolated homogeneous polyfunctionalized protein having the structure (I). In certain other embodiments, the invention provides an isolated glycopeptide having Formula (II). In certain other embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently substituted with a moiety having the structure (III)-LH. wherein A and L1 are as defined herein. | 04-01-2010 |
Jing-Hwa Chen, West Lafayette, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20110227648 | Silicon-on-Insulator High Power Amplifiers - Illustrative embodiments of a power amplifier are disclosed which include a plurality of amplifier cells, each having an input and an output. The plurality of amplifier cells are formed on a semiconductor substrate such that the outputs of the plurality of amplifier cells are electrically coupled in series. Each of the plurality of amplifier cells may comprise a first transistor that is electrically insulated from the semiconductor substrate and a first feedback resistor configured to dynamically bias the first transistor. | 09-22-2011 |
Miao Chen, Bloomington, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20110213610 | Processor Implemented Systems and Methods for Measuring Syntactic Complexity on Spontaneous Non-Native Speech Data by Using Structural Event Detection - Systems and methods are provided for providing a score for a spontaneous non-native speech response to a prompt. A transcription of the spontaneous speech response is accessed. A plurality of clauses are identified within the spontaneous speech response, where identifying a clause includes identifying a beginning boundary and an end boundary of the clause in the spontaneous speech response. A plurality of disfluencies in the spontaneous speech response is identified. One or more proficiency metrics are calculated based on the plurality of identified clauses and the plurality of the identified disfluencies, and a score for the spontaneous speech response is generated based on the one or more proficiency metrics. | 09-01-2011 |
Peng-Sheng Chen, Indianapolis, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20100268289 | METHOD AND SYSTEM FOR THE PREDICTION OF CARDIAC ARRHYTHMIAS, MYOCARDIAL ISCHEMIA, AND OTHER DISEASED CONDITION OF THE HEART ASSOCIATED WITH ELEVATED SYMPATHETIC NEURAL DISCHARGES - Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges. | 10-21-2010 |
| 20110218415 | SYSTEM AND METHOD FOR DETECTING CARDIAC ARRHYTHMIAS FROM HEART NERVE ACTIVITY - A method has been developed that detects cardiac arrhythmia from intrinsic cardiac nerve signals obtained from a heart in a patient. The method includes sampling intrinsic cardiac nerve activity at a high sample rate, filtering the sampled signal with a high pass filter, comparing the filtered signal to a predetermined threshold, and initiating a therapeutic action in response to the filtered signal exceeding the predetermined threshold. The intrinsic cardiac nerve activity may be received through an electrode implanted on the heart or from an electrode inserted into the venous structure of the heart. | 09-08-2011 |
Shu-Hui Chen, Carmel, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20100137583 | Peptidomimetic protease inhibitors - The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient. | 06-03-2010 |
| 20120064034 | Peptidomimetic protease inhibitors - The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient. | 03-15-2012 |
Shuyou Chen, Noblesville, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20110208887 | Method and apparatus for performing arbitration - An apparatus for performing arbitration increases the fairness of arbitrations, decreases system latency, increases system throughput, and is suitable for use in more complex systems. According to an exemplary embodiment, the apparatus includes a generator for generating a plurality of arbitration numbers corresponding to a plurality of agents, and circuitry for selecting one of the agents to access a resource shared by the agents based on the arbitration numbers. At least one of the arbitration numbers includes a plurality of fields corresponding to a plurality of parameters. | 08-25-2011 |
Simon Chen-Meng Chen, Palatine, IN US
| Patent application number | Description | Published |
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| 20090050364 | FIELD CONVERTIBLE TELECOMMUNICATIONS DISTRIBUTION PEDESTAL - A cable mounting structure for a telecommunications cable distribution pedestal is provided. The structure has back to back compartments and a universal mounting plate. The structure also includes protection and organization features. The structure is field convertible, reconfigurable and upgradeable. A method for field converting a telecommunications cable distribution pedestal is also given. | 02-26-2009 |
Steve Chen, Westfield, IN US
| Patent application number | Description | Published |
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| 20090012558 | FISTULA GRAFTS HAVING A DEFLECTABLE GRAFT BODY PORTION - This invention provides, in certain aspects, unique devices and methods for treating fistulae. In one embodiment, an inventive device includes an elongate graft body having a proximal end and a distal end. The graft body is configurable to a first condition and a second condition, the second condition including the distal end deflected laterally relative to its position in the first condition of the body. The device also includes a tether, which is connected to the graft body, and is configured to traverse proximally along the body. The tether is manipulable to convert the graft body from the first condition to the second condition. Such a device may also include one or more additional tethers connected to the graft body. For instance, a second tether can be configured to extend distally from the distal end of the graft body, and may be effective in pulling the graft body along a fistula tract. | 01-08-2009 |
| 20090125119 | FISTULA GRAFTS AND RELATED METHODS AND SYSTEMS USEFUL FOR TREATING GASTROINTESTINAL AND OTHER FISTULAE - Described are medical graft products, systems, and methods useful for treating fistulae, particularly enterocutaneous fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member connected to an elongate plug member. The capping member is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and the elongate plug member is configured to extend into at least a portion of the fistula. A graft product of this sort may be particularly adapted to allow a portion of the capping member to be positioned alongside an exterior, lateral surface of the plug member, e.g., when placed in a delivery device lumen. Such a capping member may be hingedly or non-hingedly coupled to the elongate plug member. | 05-14-2009 |
| 20110093088 | SELF DEPLOYING IMPLANT IN NEEDLE - Described, in certain inventive embodiments, are unique devices and methods for introducing implants into soft tissue of a patient. One of these devices includes a tissue-penetrating member that is configured to pass in its entirety through a volume of patient tissue. The tissue-penetrating member has a leading end and a trailing end, and provides a receiving space for receipt of an implant body portion for carrying the implant body portion into the volume of patient tissue. The device also includes an implant that has an implant body portion removably received in the receiving space of the tissue-penetrating member. The implant body portion is configured for deployment from the receiving space in the volume of patient tissue so as to remain deployed there along a passageway traversed by the tissue-penetrating member. | 04-21-2011 |
Steve Chen, Carmel, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20080248079 | TISSUE AUGMENTATION DEVICES AND METHODS - Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract. | 10-09-2008 |
Steve Kaipin Chen, Carmel, IN US
Steven K. Chen, Westfield, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20080306441 | NON-BUCKLING BALLOON CATHETER WITH SPRING LOADED FLOATING FLEXIBLE TIP - A balloon catheter including an inflatable balloon affixed to a catheter. The proximal end of the balloon is affixed to the distal end of the catheter so as to provide an air tight seal there between. A stiffening member extends distally of the distal end of the catheter and forms a slip joint connection with the distal end of the balloon to permit the distal end of the balloon to axially move or translate relative to the distal end of the catheter. The slip joint allows the axial length of balloon to change during inflation or deflation without transferring tensile or compressive forces between the balloon and the catheter, thereby preventing transverse creases from forming in the surface of the balloon and preventing the catheter from bowing. The stiffening member provides alignment and lateral support to the distal end of the balloon. | 12-11-2008 |
Wo-Hsing Chen, Fishers, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20090069677 | SYSTEM AND METHOD FOR TISSUE CHANGE MONITORING DURING HIFU TREATMENT - A method and apparatus is disclosed for determining the presence of tissue change due to exposure to HIFU Therapy. | 03-12-2009 |
| 20100022921 | ULTRASOUND PHASED ARRAYS - Ultrasound transducers are disclosed which focus acoustic energy at various focal locations while minimizing focal spot degradation and the generation of unwanted on-axis or off-axis energy concentrations through using a generally constant f-number at the various focal locations. | 01-28-2010 |
| 20100092424 | Method of diagnosis and treatment of tumors using high intensity focused ultrasound - A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a tumor to high intensity focused ultrasound (HIFU) to cause the tumor cells to release cellular material and evaluating the cellular material for a tumor marker. The method of treating a tumor in a patient can also comprise the step of subjecting a tumor to high intensity focused ultrasound (HIFU) to provoke an immune response. | 04-15-2010 |
| 20110201976 | LAPAROSCOPIC HIFU PROBE - A high-intensity focused ultrasound ablation of tissue using minimally invasive medical procedures is provided. | 08-18-2011 |
| 20120035473 | LAPAROSCOPIC HIFU PROBE - A high-intensity focused ultrasound ablation of tissue using minimally invasive medical procedures is provided. | 02-09-2012 |
Yaobin Chen, Carmel, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20100185336 | INTEGRATED AND OPTIMIZED DISTRIBUTED GENERATION AND INTERCONNECT SYSTEM CONTROLLER - Systems and methods for designing and controlling distributed generation resources are disclosed. Monolithic or distributed controllers control the power requests sent to each distributed generation resource to achieve optimal efficiency using rule-based and/or fuzzy logic-based control techniques. High-impedance fault (HIF) detection circuitry allows power export to the utility grid in normal operating circumstances, and when an islanding condition is detected, ceases that export within two seconds and prevents further export until the condition is cleared. | 07-22-2010 |
| 20110166716 | INTEGRATED AND OPTIMIZED DISTRIBUTED GENERATION AND INTERCONNECT SYSTEM CONTROLLER - Systems and methods for designing and controlling distributed generation resources are disclosed. Monolithic or distributed controllers control the power requests sent to each distributed generation resource to achieve optimal efficiency using rule-based and/or fuzzy logic-based control techniques. High-impedance fault (HIF) detection circuitry allows power export to the utility grid in normal operating circumstances, and when an islanding condition is detected, ceases that export within two seconds and prevents further export until the condition is cleared. | 07-07-2011 |
Yin-Yu Chen, Kokomo, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20110163767 | OCCUPANT DETECTION SYSTEM AND METHOD - An occupant detection system and method are provided. The system includes a capacitive sensor having an electrode arranged in a seat proximate to an expected location of an occupant for sensing an occupant presence approximate thereto. The capacitive sensor is configured to provide an output indicative of the sensed occupant presence. The system also includes a force sensor arranged within the seat providing an output indicative of a sensed force applied to the seat. The system further includes occupant detection circuitry for processing the capacitive sensor output and force sensor output and detecting a state of occupancy of the seat based on the capacitive sensor output and the force sensor output. | 07-07-2011 |
Yong-Ching Chen, Columbus, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20100322778 | Method and apparatus for improving turbocharger components - In one form, a turbocharger component, such as a compressor wheel or an impeller, formed of a cast material or a material made using a powder metal process, includes a surface having at least a portion thereof treated by a thermo-mechanical treatment process, such as friction stir processing. At the treated portion, the material forming the component includes a microstructure that is different than the microstructure of the material throughout the rest of the component. For example, in one form the material at the treated portion includes a homogenous microstructure while the material throughout the rest of the component includes a cast microstructure. In one or more forms, the treated portion exhibits at least one of increased strength, ductility and fatigue-resistant properties. In another form, a method is directed to providing components for a turbocharger which exhibit enhanced structural properties. However, other embodiments, forms and applications are also envisioned. | 12-23-2010 |
Zhaogen Chen, Indianapolis, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20100022560 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS - The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and the use of such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome. | 01-28-2010 |
| 20100222339 | Thiazole pyrazolopyrimidines CRF1 receptor antagonists - The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome. | 09-02-2010 |
Zhaogen Chen, Noblesville, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20080275043 | Cycloalkyl Lactam Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1 - The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Fomula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia. | 11-06-2008 |
| 20090306110 | N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR - The present invention provides compounds of formula (I), which are antagonists of the 5-HT | 12-10-2009 |
Zhaogen Chen, Carmel, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20100184764 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 - The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia. | 07-22-2010 |
Zheng-Dao Chen, West Lafayette, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20090246857 | STABLE RECOMBINANT YEASTS FOR FERMENTING XYLOSE TO ETHANOL - Described are recombinant yeast which ferment xylose to ethanol and which maintain their ability to do so when cultured for numerous generations in non-selective media. The preferred yeast contain multiple copies of integrated genes encoding xylose reductase, xylitol dehydrogenase, and xylulokinase fused to promoters which are non-glucose inhibited and which do not require xylose for induction. Also described are preferred methods for integrating multiple copies of exogenous DNA into host cells by transforming cells with replicative/integrative vectors, and then replicating the cells a number of times under selective pressure to promote retention of the vector in subsequent generations. The replicated vectors thus serve to integrate multiple copies of the exogenous DNA into the host cells throughout the replication/selection phase. Thereafter the selective pressure can be removed to promote loss of the vector in subsequent generations, leaving stable integrants of the exogenous DNA. | 10-01-2009 |