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Chen, Cambridge
Alice A. Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090317802 | Compositions and Methods to Monitor RNA Delivery to Cells - Methods and compositions for tracking or monitoring uptake of siRNA by mammalian cells are provided. The methods and compositions may be used to monitoring the silencing activity of the internalized siRNA. The compositions contain an siRNA, an optically or magnetically detectable nanoparticle such as a quantum dot and, optionally, a transfection reagent. Cells are contacted with an siRNA and an optically or magnetically detectable nanoparticle, optionally in the presence of a transfection reagent. Detection of internalized nanoparticles is indicative of siRNA uptake. The invention allows analysis, identification, processing, etc., of cells that have efficiently taken up siRNA. In one embodiment, cells are sorted into at least two populations based on the amount of siRNA taken up. | 12-24-2009 |
Christine Hiu-Tung Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110015232 | Pyrrolydine Derivatives as IAP Inhibitors - The present invention relates to novel IAP inhibitor compounds of: Formula (I). | 01-20-2011 |
| 20110065726 | Organic Compounds - The present invention is directed to a compound of the formula: | 03-17-2011 |
| 20110183964 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B - The present teachings relate to compounds of Formula I: | 07-28-2011 |
| 20120101064 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES - The invention provides compounds of the formula (I): | 04-26-2012 |
Chunquan Chen, Cambridge CA
| Patent application number | Description | Published |
|---|---|---|
| 20090305895 | Isoflavonoid compounds and use thereof - The use of a one or more Isoflavonoid compound Signals which may be with an agriculturally acceptable carrier, applied prior to planting, up to 365 days or more, either directly to the seed or transplant of a non-legume crop or a legume crop, or applied to the soil that will be planted either to a non-legume crop or a legume crop, for the purpose of increasing yield and/or improving seed germination and/or improving carrier seed emergence and/or improving modulation and/or increasing crop stand density and/or improving plant vigour and/or improving plant growth, and/or increasing biomass, and/or earlier fruiting, all including in circumstances of seeding and plant transplanting. | 12-10-2009 |
Fred F. Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120207196 | High-Speed Signaling Systems with Adaptable Pre-Emphasis and Equalization - A signaling system includes a pre-emphasizing transmitter and an equalizing receiver coupled to one another via a high-speed signal path. The receiver measures the quality of data conveyed from the transmitter. A controller uses this information and other information to adaptively establish appropriate transmit pre-emphasis and receive equalization settings, e.g. to select the lowest power setting for which the signaling system provides some minimum communication bandwidth without exceeding a desired bit-error rate. | 08-16-2012 |
Hailong Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20130089486 | CARBOPHOSPHATES AND RELATED COMPOUNDS - The present invention generally relates to carbophosphates and other compounds. Such compounds may be used in batteries and other electrochemical devices, or in other applications such as those described herein. One aspect of the invention is generally directed to carbophosphate compounds, i.e., compounds containing carbonate and phosphate ions. For example, according to one set of embodiments, the compound has a formula A | 04-11-2013 |
Harr Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100153318 | Methods and systems for automatically summarizing semantic properties from documents with freeform textual annotations - Some embodiments are directed to identifying semantic properties of documents using free-text annotations associated with the documents. Semantic properties of documents may be identified by using a model that is trained on a corpus of training documents where one or more of the training documents may include free-text annotations. In some embodiments, the model may identify semantic topics expressed only in free-text annotations or only in the body of a document. The model may applied to identify semantic topics associated with a work document or to summarize the semantic topics present in a plurality of work documents. | 06-17-2010 |
Jianxin Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100324120 | LIPID FORMULATION - The invention features a cationic lipid of formula I, | 12-23-2010 |
| 20110311582 | NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS - The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention formula (I) provides lipids having the following structure XXXIII wherein: R | 12-22-2011 |
| 20120183602 | LIPID FORMULATION - The invention features a cationic lipid of formula I, | 07-19-2012 |
Jianzhu Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120157667 | Methods Of Producing Humanized Non-Human Mammals - Provided herein are methods of reconstituting functional human blood cell lineages in a non-human mammal comprising introducing human hematopoietic stem cells (HSCs) and nucleic acid encoding one or more human cytokines into an immunodeficient non-human mammal. The non-human mammal is maintained under conditions in which the nucleic acid is expressed and the human HSCs differentiate into functional human blood cell lineages in the non-human mammal, thereby reconstituting functional human blood cell lineages in the non-human mammal. Also provided are methods of producing human antibodies directed against an immunogen in a non-human mammal, hybridomas that secrete the monoclonal antibodies as well as antibodies (e.g., polyclonal antibodies; monoclonal antibodies) produced by the B cells and non-human mammals produced by the methods. | 06-21-2012 |
Kailiang Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100033228 | Analog Logic Automata - A distributed, reconfigurable statistical signal processing apparatus comprises an array of discrete-time analog signal processing circuitry for statistical signal processing based on a local message-passing algorithm and digital configuration circuitry for controlling the functional behavior of the array of analog circuitry. The input signal to the apparatus may be expressed as a probabilistic representation. The analog circuitry may comprise computational elements arranged in a network, with a receiving module that assigns probability values when an input signal arrives and communicates the probability values to one of the computational elements, the computational elements producing outputs based on the assigned probability values. The signal processing apparatus may be an analog logic automata cell or an array of cells, wherein each cell is able to communicate with all neighboring cells. | 02-11-2010 |
| 20100102848 | Asynchronous Logic Automata - A family of reconfigurable, charge-conserving asynchronous logic elements that interact with their nearest neighbors permits design and implementation of circuits that are asynchronous at the bit level, rather than at the level of functional blocks. These elements pass information by means of charge packets (tokens), rather than voltages. Each cell is self-timed, and cells that are configured as interconnect perform at propagation delay speeds, so no hardware non-local connections are needed. An asynchronous logic element comprises a set of edges for asynchronous communication with at least one neighboring cell, each edge having an input for receiving tokens from neighboring cells and an output for transferring an output charge packet to at least one neighboring cell, and circuitry configured to perform a logic operation utilizing received charge packets as inputs and to produce an output charge packet reflecting the result of the logic operation. | 04-29-2010 |
| 20120025868 | Asynchronous Logic Automata - A family of self-timed, charge-conserving asynchronous logic elements that interact with their nearest neighbors permits design and implementation of circuits that are asynchronous at the bit level. The elements pass information by means of state tokens, rather than voltages. Each cell is self-timed, so no hardware non-local connections are needed. An asynchronous logic element comprises a set of edges for asynchronous communication with at least one neighboring cell, the edges receiving state tokens from neighboring logic elements and transferring output state tokens to neighboring logic elements, and circuitry configured to perform, when the circuitry inputs contain valid tokens and the circuitry outputs are empty, a logic operation utilizing received tokens as inputs, thereby producing an output token reflecting the result of the logic operation. | 02-02-2012 |
Langzhou Chen, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20090099841 | AUTOMATIC SPEECH RECOGNITION METHOD AND APPARATUS - A system for calculating the look ahead probabilities at the nodes in a language model look ahead tree, wherein the words of the vocabulary of the language are located at the leaves of the tree, | 04-16-2009 |
| 20120109651 | DATA RETRIEVAL AND INDEXING METHOD AND APPARATUS - A method of searching a plurality of data files, wherein each data file includes a plurality of features. The method: determines a plurality of feature groups, wherein each feature group includes n features and n is an integer of 2 or more; expresses each data file as a file vector, wherein each component of the vector indicates the frequency of a feature group within the data file, wherein the n features which constitute a feature group do not have to be located adjacent to one another; expresses a search query using the feature groups as a vector; and searches the plurality of data files by comparing the search query expressed as a vector with the file vectors. | 05-03-2012 |
Lihren Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100035957 | Methods for the Use of Inhibitors of Cytosolic Phospholipase A2 - This invention provides methods for the use of substituted indole compounds of the general formula: | 02-11-2010 |
Michael L. Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100124677 | DIRECT OXIDATION FUEL CELL SYSTEM WITH UNIFORM VAPOR DELIVERY OF FUEL - A fuel cell system which includes a fuel distribution structure that uniformly distributes vaporizing fuel to a fuel cell is provided. As the fuel travels in a flow field channel in the fuel distribution structure, it is substantially converted to a vapor by the heat of the fuel cell operation in such a manner that the resulting vapor pressure works to substantially uniformly distribute fuel evenly outwardly across substantially the entire active area of the anode aspect of one or more membrane electrode assemblies in the system, and whereby localized, uneven “hot spots” of fuel at the anode aspects are substantially prevented. A pair of enthalpy exchanger and heat spreader assemblies include a cathode current collector element that also has a heat spreader plate that collects and redirects heat in the fuel cell system, the assembly acting to manage the heat, temperature and condensation in the fuel cell system. | 05-20-2010 |
Thomas D. Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110075865 | Dual Single-Crystal Backplate Microphone System and Method Of Fabricating Same - A dual backplate MEMS microphone system includes a flexible diaphragm sandwiched between two single-crystal silicon backplates. Such a MEMS microphone system may be formed by fabricating each backplate in a separate wafer, and then transferring one backplate from its wafer to the other wafer, to form two separate capacitors with the diaphragm. | 03-31-2011 |
| 20130065343 | METHOD FOR ETCHING MATERIAL LONGITUDINALLY SPACED FROM ETCH MASK - A micromachining process forms a plurality of layers on a wafer. This plurality of layers includes both a support layer and a given layer. The process also forms a mask, with a mask hole, at least in part on the support layer. In this configuration, the support layer is positioned between the mask hole and the given layer, and longitudinally spaces the mask hole from the given layer. The process also etches a feature into the given layer through the mask hole. | 03-14-2013 |
Weiguo Chen, Cambridge CA
| Patent application number | Description | Published |
|---|---|---|
| 20100109928 | FLEXIBLE DIGITAL TRANSPARENT TRANSPONDER - Embodiments disclosed herein relate generally to digital transponders. In one broad aspect, there is provided a digital transponder comprising: (a) an analog to digital converter configured to receive a real analog wideband multi-carrier signal and generate a real digital wideband multi-carrier signal from the real analog wideband multi-carrier signal, the real analog wideband multi-carrier signal spans M element channels, M being an integer greater than or equal to one; (b) a channelizer configured to channelize the real digital wideband multi-carrier signal into 2M channelized digital signals, the 2M channelized digital signals comprising M pairs of channelized digital signals, each pair of channelized digital signals comprising a primary channelized digital signal and a secondary channelized digital signal, the secondary channelized digital signal being an image of the primary channelized digital signal; (c) a switch matrix and signal construction module configured to generate a plurality of intermediate signals from only the primary channelized digital signals, the plurality of intermediate signals comprising pairs of intermediate signals, each pair comprising a primary intermediate signal and a secondary intermediate signal, the secondary intermediate signal being an image of the primary intermediate signal; (d) at least one synthesizer, the at least one synthesizer configured to combine at least one pair of intermediate signals to generate a real digital output signal; and (e) at least one digital to analog converter, the at least one digital to analog converter configured to convert the real digital output signal to an analog output signal. | 05-06-2010 |
| 20110075602 | SYSTEMS AND METHODS FOR DECODING AUTOMATIC IDENTIFICATION SYSTEM SIGNALS - A method of extracting automatic identification system (AIS) message segments from AIS signals received by a satellite. The method includes: (a) receiving AIS signals from satellite antennas; (b) generating multiple versions of the AIS signals; (c) extracting message segments contained within each of the AIS signals using one or more AIS receivers; (d) sorting the message segments by time; and (e) deleting any duplicate message segments. Multiple versions of the AIS signals may be generated by one or more of the following methods: (i) processing the AIS signals multiple times, each time with different AIS receiver parameter settings; (ii) splitting each signal into multiple signals and filtering each of the multiple signals separately; (iii) receiving multiple AIS signals and combining them with different phases and amplitudes to produce a plurality of combined AIS signals; and (iv) removing extracted message segments from the received AIS signals and reprocessing the modified AIS signals. | 03-31-2011 |
| 20110304502 | SYSTEMS AND METHODS FOR SEGMENTING A SATELLITE FIELD OF VIEW FOR DETECTING RADIO FREQUENCY SIGNALS - A satellite system for detecting radio frequency signals from space including at least two sensors, a processing unit and at least one receiver. Each sensor receives a plurality of radio frequency signals containing messages and outputs a sensor signal that is representative of the plurality of radio frequency signals. The processing unit selects a predetermined number of mathematical combinations of the sensor signals and combines the sensor signals into the predetermined number of mathematical combinations to produce a plurality of zone signals. The characteristics of each zone signal are undefined at the time the predetermined number of mathematical combinations is selected. The receiver extracts the messages contained in the zone signals. | 12-15-2011 |
Xiaoji Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120159298 | GENERATING CUSTOMIZED DATA BOUND VISUALIZATIONS - Descried herein are various technologies to visualizing data in a spreadsheet application. Customized visualizations are generated by binding a user-defined equation with a parameter of a primitive visual shape that has been selected by the user to visualized a dataset. The user-defined equation takes as input a value of data in a cell of the spreadsheet application, and the primitive visual shape is displayed to the user as a function of the output of the user-defined equation. | 06-21-2012 |
Yiwei Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120303411 | DEMAND MODELING AND PREDICTION IN A RETAIL CATEGORY - System, method and computer program product for demand modeling and prediction in retail categories. The method uses time-series data comprising of unit prices and unit sales for a designated choice set of related products, with the time-series data obtained over a given sequence of sales reporting periods, and over a collection of stores in a market geography. Other relevant data sets from participating retail entities that include additional product attribute data such as market and consumer factors that affect retail demand are further used. A demand model for improved accuracy is achieved by individual sub-modeling method steps of: estimating a model for price movements and price dynamics from the time series data of unit-prices in the aggregated sales data; estimating a model for market share of each product in the retail category using the aggregated sales data and integrated additional product attribute data; and, estimating generating a model for an overall market demand in the retail category from the aggregated sales data. | 11-29-2012 |
Yongdeng Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090030685 | USING SPEECH RECOGNITION RESULTS BASED ON AN UNSTRUCTURED LANGUAGE MODEL WITH A NAVIGATION SYSTEM - Speech recorded by an audio capture facility of a navigation facility is processed by a speech recognition facility to generate results that are provided to the navigation facility. When information related to a navigation application running on the navigation facility are provided to the speech recognition facility, the results generated are based at least in part on the application related information. The speech recognition facility uses an unstructured language model for generating results. The user of the navigation facility may optionally be allowed to edit the results being provided to the navigation facility. The speech recognition facility may also adapt speech recognition based on usage of the results. | 01-29-2009 |
Yuanyu Chen, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120203270 | FLEXURAL LAPARASCOPIC GRASPER - A flexural grasper for use in laparoscopic procedures and the like includes an end effector with digits having rigid elements coupled by flexural bearings. The flexural bearings can be controlled to flex and straighten using cables deployed through the digits and tensioned remotely from a handle for the flexural grasper. | 08-09-2012 |
Zhuoying Chen, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20100135937 | METAL OXIDE NANOCRYSTALS: PREPARATION AND USES - Nanocrystalline forms of metal oxides, including binary metal oxide, perovskite type metal oxides, and complex metal oxides, including doped metal oxides, are provided. Methods of preparation of the nanocrystals are also provided. The nanocrystals, including uncapped and uncoated metal oxide nanocrystals, can be dispersed in a liquid to provide dispersions that are stable and do not precipitate over a period of time ranging from hours to months. Methods of preparation of the dispersions, and methods of use of the dispersions in forming films, are likewise provided. The films can include an organic, inorganic, or mixed organic/inorganic matrix. The films can be substantially free of all organic materials. The films can be used as coatings, or can be used as dielectric layers in a variety of electronics applications, for example as a dielectric material for an ultracapacitor, which can include a mesoporous material. Or the films can be used as a high-K dielectric in organic field-effect transistors. In various embodiments, a layered gate dielectric can include spin-cast (e.g., 8 nm-diameter) high-K BaTiO | 06-03-2010 |