Patent application number | Description | Published |
20100305197 | Conditionally Active Ribozymes And Uses Thereof - This invention relates, at least in part, to conditionally active ribozymes and uses of such ribozymes. Some aspects of this invention relate to the engineering of conditionally active ribozymes. In some embodiments, the splicing activity of such ribozymes is modulated by at least one regulatory element. Some aspects of this invention relate to uses of conditionally active ribozymes. RNA detection technology, conditional RNA expression technology, cell tagging technology, therapeutic approaches, and synthetic biology are examples of areas in which conditionally active ribozymes according to some aspects of the invention can be employed. RNA folding models useful in the design of conditionally active ribozymes with altered splicing efficiency and/or substrate specificity are provided. Compositions and methods to manufacture medicaments containing conditionally active ribozymes are also described. | 12-02-2010 |
20120064622 | Methods and Systems for Chemoautotrophic Production of Organic Compounds - The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest. | 03-15-2012 |
20150037853 | Methods and Systems for Chemoautotrophic Production of Organic Compounds - The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest. | 02-05-2015 |
Patent application number | Description | Published |
20100130510 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 05-27-2010 |
20110052643 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain fused ring compounds, or pharmaceutically acceptable salts thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 03-03-2011 |
20120283272 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 11-08-2012 |
20130165451 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 06-27-2013 |
20130317032 | THIAZOLE AND THIADIAZOLE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to compounds of structural formula (I): | 11-28-2013 |
20140107132 | SUBSTITUTED PYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds of Formula (I): | 04-17-2014 |
20140135331 | THIAZOLE AND THIADIAZOLE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to compounds of structural formula (I): | 05-15-2014 |
Patent application number | Description | Published |
20140013675 | Abrasive Article and Method Of Forming - An abrasive article including a substrate having an elongated body, a tacking layer overlying the substrate, and a first type of abrasive particle overlying the tacking layer and defining a first abrasive particle concentration at least about 10 particles per mm of substrate. | 01-16-2014 |
20140017984 | Abrasive Article and Method Of Forming - An abrasive article including a substrate having an elongated body, a tacking layer overlying the substrate, a first type of abrasive particle overlying the tacking layer, a second type of abrasive particle different than the first type of abrasive particles overlying the tacking layer, and a bonding layer overlying at least a portion of one of the first type of abrasive particle and the second type of abrasive particle and the tacking layer. | 01-16-2014 |
20140017985 | ABRASIVE ARTICLE AND METHOD OF FORMING - An abrasive article includes a substrate, a tacking layer overlying the substrate, a first type of abrasive particle overlying the tacking layer, at least about 5% and not greater than about 99% of a total amount of the first type of abrasive particle has an exposed surface, and a bonding layer overlying at least a portion of the abrasive particles and the tacking layer. | 01-16-2014 |
20140150766 | ABRASIVE ARTICLE AND METHOD OF FORMING - A method of conducting a cutting operation on a workpiece including providing an abrasive article having a substrate having an elongated body, a tacking layer overlying the substrate, and a first type of abrasive particle contained in the tacking layer, the method further including moving the abrasive article and a workpiece relative to each other, the workpiece including a material selected from the group consisting of a ceramic, a semiconductive material, an insulating material, a glass, a natural material, organic material, and a combination thereof. | 06-05-2014 |
Patent application number | Description | Published |
20090098057 | SILICA-CORED CARRIER PARTICLE - A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core. | 04-16-2009 |
20090169482 | SILICA-CORED CARRIER PARTICLE - A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core. | 07-02-2009 |
Patent application number | Description | Published |
20100144043 | MOLECULAR FLUORESCENCE SENSOR FOR HIGHLY SENSITIVE AND SELECTIVE DETECTION OF MERCURY - A fluorescent sensor compound based on a perylene core is described and disclosed. The fluorescent sensor compound for detecting mercury can have a structure I: | 06-10-2010 |
20100197039 | FLUORESCENT MATERIALS FOR HIGHLY SENSITIVE AND SELECTIVE SENSING OF AMINES AND NANOFIBRIL MATERIALS MADE THEREFROM - A fluorescence sensory material with high sensitivity, selectivity, and photostability has been developed for vapor probing of organic amines. The sensory material is a perylene-3,4,9,10-tetracarboxyl compound having amine binding groups and the following formula | 08-05-2010 |
20120186639 | PARALLEL COAXIAL MOLECULAR STACK ARRAYS - A coaxial molecular stack ( | 07-26-2012 |
20120186648 | COAXIAL MOLECULAR STACK FOR TRANSFERRING PHOTOCURRENT GENERATION - A photovoltaic device ( | 07-26-2012 |
20130065319 | PHOTOCONDUCTIVE SENSOR MATERIALS FOR DETECTION OF EXPLOSIVE VAPOR - A photoconductive sensor compound for detecting explosives can have a structure I: | 03-14-2013 |
20130183766 | OPTOELECTRICAL VAPOR SENSING - A chemical sensor can comprise a nanofiber mass of p-type nanofibers having a HOMO level greater than −5.0 eV. Additionally, the chemical sensor can comprise oxygen in contact with the p-type nanofibers. Further, the chemical sensor can comprise a pair of electrodes in electrical contact across the nanofiber mass, where the p-type nanofibers conduct an electric current that decreases upon contact with an amine compound. | 07-18-2013 |
20130217139 | FLUORESCENT CARBAZOLE OLIGOMERS NANOFIBRIL MATERIALS FOR VAPOR SENSING - A fluorescence based sensor ( | 08-22-2013 |
20130302902 | NANOFIBRIL MATERIALS FOR HIGHLY SENSITIVE AND SELECTIVE SENSING OF AMINES - A sensory material with high sensitivity, selectivity, and photostability has been developed for vapor probing of organic amines. The sensory material is a perylene-3,4,9,10-tetracarboxyl compound having amine binding groups and the following formula | 11-14-2013 |
20140147670 | NANOFIBER-BASED HETEROJUNCTION APPROACH FOR HIGH PHOTOCONDUCTIVITY ON ORGANIC MATERIALS - The present disclosure provides methods and compositions for an organic nanofiber-based heterojunction material, comprising nano fibers of an acceptor molecule, the nano fibers coated with a donor molecule, where the acceptor molecule contains a group and the donor molecule contains a companion group, wherein the group and companion group enables strong binding between the acceptor molecule and donor molecule, the strong binding providing for efficient forward electron transfer between the acceptor molecule and donor molecule, and wherein the group and companion group minimize charge carrier recombination between the acceptor molecule and the donor molecule. | 05-29-2014 |
20150118760 | FLUORESCENT SENSING OF VAPORS USING TUBULAR NANOFIBRIL MATERIALS - A fluorescence-based sensor can comprise a nanofiber mass of nanofibers having tubular morphology and a fluorescence detector, where fluorescence of the nanofibers decreases upon contact with a nitro-containing compound. The nanofibers can comprise carbazole-cornered, arylene-ethynylene tetracyclic macromolecules of formula I: where R1-R4 are alkyl-containing groups. The tubular morphology allows for highly selective detection of trinitrotoluene over other nitro-based compounds and oxidizing organic compounds. | 04-30-2015 |
Patent application number | Description | Published |
20120232083 | FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections. | 09-13-2012 |
20120258948 | N-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives of formula I, | 10-11-2012 |
20140057919 | FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections. | 02-27-2014 |
20140128363 | N-Link Hydroxamic Acid Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections. | 05-08-2014 |
20140343031 | N-Link Hydroxamic Acid Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections. | 11-20-2014 |
20150158864 | PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYR-ROLO[2,3-D]PYRIDINYL ACRYLAMIDES - The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK. | 06-11-2015 |
20150182513 | N-Link Hydroxamic Acid Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections. | 07-02-2015 |