Patent application number | Description | Published |
20110184190 | COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS - In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate. Exemplary compounds are of formula (I), (II), or (III): | 07-28-2011 |
20120029213 | INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B - Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided. | 02-02-2012 |
20120289718 | COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS - In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate. Exemplary compounds are of formula (I), (II), or (III): | 11-15-2012 |
20120309988 | INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B - Intermediates and methods of their use in the synthesis of anslogs of halichondrin B are provided. | 12-06-2012 |
20130123519 | COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS - In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate. Exemplary compounds are of formula (I), (II), or (III): | 05-16-2013 |
20130237711 | INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B - Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided. | 09-12-2013 |
20140163242 | INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B - Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided. | 06-12-2014 |
Patent application number | Description | Published |
20090041022 | FRAME RELAY SWITCHED DATA SERVICE - A new type of data transport service which uses a frame relay layer 2 data link connection identifier (DLCI) to select among various service types, feature sets, and/or closed user groups (CUGs). A layer 3 address may be extracted from a layer 2 frame, and the layer 3 address information may be used to route a data packet over a packet-switched network according to the service classes, feature sets, and/or CUGs selected. At the destination, the layer 3 data packet may again be enclosed in a layer 2 frame with a DLCI indicating the service classes, features sets, and/or CUGs. Because the use of conventional permanent virtual circuits (PVCs) is not required in aspects of the invention, new methods of measuring and managing network traffic are presented. | 02-12-2009 |
20100157805 | TRAFFIC MANAGEMENT FOR FRAME RELAY SWITCHED DATA SERVICE - A new type of data transport service which uses a frame relay layer | 06-24-2010 |
20100278177 | TECHNIQUE FOR ETHERNET ACCESS TO PACKET-BASED SERVICES - An Ethernet Metropolitan Area Network ( | 11-04-2010 |
20110317706 | FRAME RELAY SWITCHED DATA SERVICE - A new type of data transport service which uses a frame relay layer | 12-29-2011 |
20140044132 | TECHNIQUE FOR ETHERNET ACCESS TO PACKET-BASED SERVICES - An Ethernet Metropolitan Area Network provides connectivity to one or more customer premises to packet-bases services, such as ATM, Frame Relay, or IP while advantageously providing a mechanism for assuring security and regulation of customer traffic. Upon receipt of each customer-generated information frame, an ingress Multi-Service Platform (MSP) “tags” the frame with a customer descriptor that specifically identifies the recipient customer. In practice, the MSP tags each frame by overwriting the Virtual Local Area Network (VLAN) identifier with the routing descriptor. Using the customer descriptor in each frame, a recipient Provider Edge Router (PER) or ATM switch can map the information as appropriate to direct the information to the specific customer. In addition, the customer descriptor may also include Quality of Service (QoS) allowing the recipient Provider Edge Router (PER) or ATM switch to vary the QoS level accordingly. | 02-13-2014 |
20140241363 | FRAME RELAY SWITCHED DATA SERVICE - A new type of data transport service which uses a frame relay layer 2 data link connection identifier (DLCI) to select among various service types, feature sets, and/or closed user groups (CUGs). A layer 3 address may be extracted from a layer 2 frame, and the layer 3 address information may be used to route a data packet over a packet-switched network according to the service classes, feature sets, and/or CUGs selected. At the destination, the layer 3 data packet may again be enclosed in a layer 2 frame with a DLCI indicating the service classes, features sets, and/or CUGs. Because the use of conventional permanent virtual circuits (PVCs) is not required in aspects of the invention, new methods of measuring and managing network traffic are presented. | 08-28-2014 |
Patent application number | Description | Published |
20090192421 | MOBILE HIGH FREQUENCY CHEST WALL OSCILLATION SYSTEM - A therapy system is operable to deliver at least one respiratory therapy to a patient. For example, therapy system may be operable to deliver any one or more of the following therapies: a high frequency chest wall oscillation (HFCWO) therapy, a positive expiratory pressure (PEP) therapy, a nebulizer therapy, an intermittent positive pressure breathing (IPPB) therapy, a cough assist therapy, a suction therapy, a bronchial dilator therapy, and the like. The therapy system is contained in a housing supported by a mobile stand. | 07-30-2009 |
20140171843 | HIGH FREQUENCY CHEST WALL OSCILLATION SYSTEM - A therapy system is operable to deliver at least one respiratory therapy to a patient. For example, therapy system may be operable to deliver any one or more of the following therapies: a high frequency chest wall oscillation (HFCWO) therapy, a positive expiratory pressure (PEP) therapy, a nebulizer therapy, an intermittent positive pressure breathing (IPPB) therapy, a cough assist therapy, a suction therapy, a bronchial dilator therapy, and the like. The therapy system is contained in a housing supported by a mobile stand. | 06-19-2014 |
Patent application number | Description | Published |
20080235693 | Methods and apparatus for window-based fair priority scheduling - A system provides a task scheduler to define a priority queue with at least one window and a queue-window key. Each window is an ordered collection of tasks in a task pool of the priority queue and is identified by the queue-window key. The task scheduler sets a task-window key equal to a user-window key when the user-window key is greater than the minimum queue-window key. The task scheduler can further set the task-window key equal to the minimum queue-window key when the user-window key is less than the minimum queue-window key. A maximum task limit per user for each window and a priority increment for the user-window key are further applied to ensure fair scheduling. | 09-25-2008 |
20120023306 | USING VERSIONED POINTERS TO FACILITATE REUSING MEMORY WITH A REDUCED NEED TO RECLAIM OBJECTS THROUGH GARBAGE COLLECTION - One embodiment of the present invention provides a system that uses versioned pointers to facilitate reusing memory without having to reclaim the objects solely through garbage collection. The system operates by first receiving a request to allocate an object. Next, the system obtains the object from a pool of free objects, and sets an allocated/free flag in the object to indicate that the object is allocated. The system also increments a version number in the object, and also encodes the version number into a pointer for the object. The system then returns the pointer, which includes the encoded version number. In this way, subsequent accesses to the object through the pointer can compare the version number encoded in the pointer with the version number in the object to determine whether the object has been reused since the pointer was generated. | 01-26-2012 |
20140068555 | FAST DISPATCH PREDICATE FOR OVERLOADED FUNCTIONS WITH GENERIC TYPE HIERARCHIES THAT LACK CONTRAVARIANCE - The disclosed embodiments provide a system that facilitates the development and execution of a software program. During runtime of the software program, the system obtains a function call associated with an overloaded function and a generic type hierarchy that lacks contravariance. Next, the system determines an applicability of an implementation of the overloaded function to the function call. Finally, the system selects the implementation for invocation by the function call based on the determined applicability and a partial order of implementations for the overloaded function. | 03-06-2014 |
20140068556 | DISPATCH PREDICATE FOR OVERLOADED FUNCTIONS USING TYPE INTERVALS - The disclosed embodiments provide a system that facilitates the development and execution of a software program. During runtime of the software program, the system obtains a function call associated with an overloaded function and a generic type hierarchy. Next, the system determines an applicability of an implementation of the overloaded function to the function call. Finally, the system selects the implementation for invocation by the function call based on the determined applicability and a partial order of implementations for the overloaded function. | 03-06-2014 |
20140068574 | TYPE INFERENCE OF GENERIC TYPE PARAMETERS IN OVERLOADED FUNCTIONS USING TYPE INTERVALS AND INFERENCE DIRECTIONS - The disclosed embodiments provide a system that facilitates the development and execution of a software program. During operation, the system obtains a type interval for a generic type parameter of an implementation of an overloaded function. Next, the system selects an inference direction for the generic type parameter based on a variance of the generic type parameter, wherein the inference direction is an upward inference direction or a downward inference direction. Finally, the system uses the type interval and the inference direction to perform type inference on the generic type parameter. | 03-06-2014 |
20150058595 | Systems and Methods for Implementing Dynamically Configurable Perfect Hash Tables - Hardware circuitry may evaluate minimal perfect hash functions mapping keys to addresses in lookup tables. The circuitry may include primary hash function sub-circuits that apply linear hash functions to input key values (using carry-free arithmetic) to produce primary hash values. Each sub-circuit may multiply bit vectors representing key values by a bit matrix and add a constant bit vector to the result. The circuitry may include a secondary hash function sub-circuit that generates secondary hash values by aggregating values associated with multiple primary hash values using signed, unsigned, or modular integer addition, or bit-wise XOR operations. Secondary hash values may be usable to access data values in the lookup table that are associated with particular input key values. The circuitry may determine the validity of input keys and may alter the configuration or contents of the lookup tables. The hash function sub-circuits may include programmable hash tables. | 02-26-2015 |
Patent application number | Description | Published |
20080237934 | Method and Device For Producing Electrospun Fibers and Fibers Produced Thereby - The present invention relates to methods for producing fibers made from one or more polymers or polymer composites, and to structures that can be produced from such fibers. In one embodiment, the fibers of the present invention are nanofibers. The present invention also relates to apparatus for producing fibers made from one or more polymers or polymer composites, and methods by which such fibers are made. | 10-02-2008 |
20080242178 | Flexible Ceramic Fibers and a Process For Making Same - The present invention is generally directed to ceramic fibers, which when employed in sheets to provide flexibility and to methods for making same. In one embodiment, the present invention relates to ceramic fibers that are heat and chemical resistant, and to a method for making same. In another embodiment, the present invention relates to ceramic nanofibers and ceramic nanofiber sheets, and to a method for making same. In still another embodiment, the present invention relates to electrospun ceramic nanofibers and nanofiber sheets, products that include such fibers, and to methods of making same. | 10-02-2008 |
20100200512 | Mixed hydrophilic/hydrophobic fiber media for liquid-liquid coalescence - An immiscible lipophilic or hydrophilic liquid phase separated respectively from a continuous hydrophilic phase or a lipophilic phase liquid. Fibers having hydrophilic and hydrophobic properties are mixed, layered, etc., and formed into a filter. The separation mechanism involves capture of small droplets of the immiscible phase, coalescence of the small droplets into larger droplets as the immiscible liquid flows through the fiber filter, and release of the large immiscible droplets from the filter. With respect to separation of a hydrophilic immiscible fluid such as water in a lipophilic continuous fluid such as oil, the hydrophobic fibers will cause small water droplets to migrate towards the hydrophilic fibers whereby large droplets are formed on hydrophilic surface. The large droplets stay on hydrophilic fiber surface for extended periods of time and continue to coalescence until they are so large that they can no longer be maintained by the hydrophilic fibers and are released and drained off of the filter. In designing such filter, wettability of the filter media is an important parameter. The filter media can be designed by mixing hydrophilic and hydrophobic fibers in various proportions to achieve an optimum wettability range for separation of the immiscible liquid from the continuous phase liquid. The wettability of filter media can be characterized by a modified Washburn Equation. | 08-12-2010 |
20120064186 | METHOD AND DEVICE FOR PRODUCING ELECTROSPUN FIBERS AND FIBERS PRODUCED THEREBY - Electrospinning nozzles include novel constructs for providing spinning pores that define the origin of jets of fiber-forming media. In some embodiments, a film covers relatively large holes in a nozzle body and provides spinning pores aligned with such large holes. In some embodiments, conductive tubes are secured at or about relatively large holes in a nozzle body and provide spinning pores fluidly communicating with fiber-forming media at such large holes. In yet other embodiments, nozzle bodies are provided with circular or semi-spherical surfaces having a plurality of spinning pores. | 03-15-2012 |
20120292252 | TUBULAR SURFACE COALESCERS - Disclosed are tubular surface coalescers, systems, and methods for coalescing a mixture of two phases, namely a continuous phase and a dispersed phase. The disclosed tubular surface coalescers, systems, and methods include or utilize one or more layers of media material having a distinct mean pore size and wettability applied to a surface of a porous tubular support structure. | 11-22-2012 |
20130270192 | MIXED HYDROPHILIC/HYDROPHOBIC FIBER MEDIA FOR LIQUID-LIQUID COALESCENCE - An immiscible lipophilic or hydrophilic liquid phase is separated respectively from a continuous hydrophilic or a lipophilic phase liquid. Fibers having hydrophilic and hydrophobic properties are formed into a filter. The separation mechanism involves coalescence of the small droplets into larger droplets as the immiscible liquid flows through the fiber filter, and release of the large immiscible droplets from the filter. With respect to separation of a hydrophilic immiscible fluid in a lipophilic continuous fluid, the hydrophobic fibers cause small water droplets to migrate towards the hydrophilic fibers whereby large droplets are formed on hydrophilic surface. The large droplets coalescence until they are so large that they are released and drained off of the filter. The filter media can be designed by mixing hydrophilic and hydrophobic fibers in various proportions to achieve an optimum wettability range for separation of the immiscible liquid from the continuous phase liquid. | 10-17-2013 |
20140007771 | LIQUID DRAINAGE FROM COALESCING FILTER MEDIUM WITH DRAINAGE CHANNELS - A coalescing filter includes a coalescing filter medium having an entrance face and an exit face and a surface energy, the coalescing filter also having a drainage channel in the coalescing filter medium, the drainage channel being a woven or non-woven fiber construct having a pore size greater than the pore size of said coalescing filter medium and having a surface energy that is lower than the surface energy of the coalescing filter medium, the drainage channel extending at a downward angle relative to the direction from the entrance face to the exit face. | 01-09-2014 |
20140116947 | MIXED HYDROPHILIC/HYDROPHOBIC FIBER MEDIA FOR LIQUID-LIQUID COALESCENCE - An immiscible lipophilic or hydrophilic liquid phase separated respectively from a continuous hydrophilic phase or a lipophilic phase liquid. Fibers having hydrophilic and hydrophobic properties are formed into a filter. The separation mechanism involves capture of small droplets of the immiscible phase, coalescence of the small droplets into larger droplets as the immiscible liquid flows through the fiber filter, and release of the large immiscible droplets from the filter. Regarding separation of a hydrophilic immiscible fluid such as water in a lipophilic continuous fluid such as oil, the hydrophobic fibers cause small water droplets to migrate towards the hydrophilic fibers whereby large droplets form on hydrophilic surface. The large droplets stay on hydrophilic fiber surface for extended periods of time and continue to coalescence until they are so large that they can no longer be maintained by the hydrophilic fibers and are released and drained off of the filter. | 05-01-2014 |
Patent application number | Description | Published |
20090254288 | Electrospun fibrous nanocomposites as permeable, flexible strain sensors - The present invention generally relates to methods to provide electrospun polymer/nanoparticle composite-fiber structures for use as lightweight, compliant, porous strain sensors for non-cyclic strain sensing. In one embodiment, the fibers in the nanocomposites comprise, for example, poly(∈-caprolactone) (PCL) dielectric polymer matrix with embedded electrically conductive carbon black (CB) nanoparticles. In another embodiment, the composite-fiber structures of the present invention contain at least about 7 weight percent or more of CB and are electrically conducting in the as-spun, un-deformed state, and are thus called conductive polymer composites (CPC). In still another embodiment, the electrical resistance of a nanocomposite structure according to the invention increases with strain, and at sufficiently high strains the structure is rendered non-conductive. | 10-08-2009 |
20100283189 | BUBBLE LAUNCHED ELECTROSPINNING JETS - The invention relates to a novel method for electrospinning fibers wherein the fiber-spinning solution is infused with gas bubbles which travel through the electrospinning fluid, causing the bubbles to be coated with electrospinning solution. The coated bubbles, in turn, in response to an applied electrical force, generate jets of the electrospinning fluid that travel away from the bubble surface. The invention further relates to the fibers formed by this bubble-jet process and to products made therefrom. | 11-11-2010 |
20110052467 | CERAMIC NANOFIBERS CONTAINING NANOSIZE METAL CATALYST PARTICLES AND MEDIUM THEREOF - Ceramic nanofibers contain nanosize metal catalyst particles on the surface thereof. The catalyst-ceramic nanofibers when supported as by larger fibers form a medium that effectively catalyze various reactions as in fluid flow processes. | 03-03-2011 |
20120077280 | NANOFIBERS WITH MODIFIED OPTICAL PROPERTIES - Nanofibers modified to alter their optical properties in the infrared part of the electromagnetic spectrum, which nanofibers can be used in applications ranging from identification technology to energy conversion devices (e.g., thermophotovoltaics) to stealth technology. The desired optical properties can be obtained by modifying the fibers with rare earth and other materials and then can be incorporated into garments or other composite structures or can be applied as coatings on solid surfaces, to be used in a number of applications that benefit from selective emission properties. | 03-29-2012 |
Patent application number | Description | Published |
20090014597 | Supersonic aircraft jet engine - Jet engine inlet structure of a supersonic aircraft comprising the structure having an inlet ramp and an cowl lip spaced outwardly of the ramp so that entering air flows between the ramp and lip, the lip and ramp configured to produce a first oblique shock that extends outwardly from a forward portion of the ramp to pass ahead of the lip, and a terminal shock that extends outwardly from a rearward portion of the ramp to one of the following
| 01-15-2009 |
20090206206 | Highly efficient supersonic laminar flow wing - Improved supersonic laminar flow wing structure, on a supersonic aircraft, having one or more of the following:
| 08-20-2009 |
20100139284 | Jet nozzle plug with varying, non-circular cross sections - In a jet engine having a plug nozzle and a plug extending rearwardly from the nozzle exit, the improvement comprising a plug having successive cross sections spaced apart rearwardly of the nozzle exit, the cross sections transitioning from circular or near circular at the exit plane defined at the nozzle exit, to progressively non-circular, rearwardly. | 06-10-2010 |
20110062290 | Supersonic aircraft jet engine installation - Jet engine inlet structure of a supersonic aircraft comprising the structure having an inlet ramp and an cowl lip spaced outwardly of the ramp so that entering air flows between the ramp and lip, the lip and ramp configured to produce a first oblique shock that extends outwardly from a forward portion of the ramp to pass ahead of the lip, and a terminal shock that extends outwardly from a rearward portion of the ramp to one of the following
| 03-17-2011 |
20110067393 | Aircraft emergency and backup secondary power apparatus - In combination, an aircraft and a rotatively combined electrical power/generator and hydraulic motor/pump configured to provide either hydraulic power from electrical power, or electrical power from hydraulic power, installed in said aircraft. | 03-24-2011 |
20110095137 | Laminar flow wing optimized for supersonic cruise aircraft - A method of providing an aircraft having a fuselage and a wing configured for extensive laminar flow at design cruise conditions, the method characterized by a) providing wing biconvex-type airfoils having values of thickness, chord and shape along the wing span which provide substantially optimal aircraft range at design cruise conditions, considering the influences of wing drag and wing weight; b) providing wing leading edges, which are configured to effect laminar flow; c) providing fuselage and wing contours which, in combination, produce reduced total wave drag and produce extensive areas of laminar boundary layer flow on the wing; and d) providing wing sweep angularity that facilitates provision of a), b) and c). | 04-28-2011 |
20120043429 | Laminar flow wing optimized for transonic cruise aircraft - Aircraft configured to operate at Mach numbers from above 0.80 and up to 1.2 with wing sweep angles defined by the wing outboard leading edge of less than 35 degrees, and incorporating calculated values of the ratio of outboard wing panel aspect ratio raised to an exponent of 0.78, divided by the ratio of maximum thickness divided by chord (t/c), greater than about 45, characterized by one of the following: a) where maximum thickness divided by chord (t/c) is at a location approximately 70% of the distance outboard from the attaching aircraft body to the wing tip, or b) where maximum thickness divided by chord (t/c) is the average value of (t/c)'s located between approximately 50% of the distance outboard from the attaching aircraft body to the wing tip. | 02-23-2012 |
20120043430 | Laminar flow wing optimized for transonic cruise aircraft - On an aircraft designed for maximum efficient cruise speed in the range from about Mach 0.8 to about Mach 1.2, and having fuselage and wings with: (a) less than about 25 degrees of leading edge sweep, in combination with airfoil thickness to chord ratios between about 3% and about 8%, as an average along the wing semi-span outboard from the zone of substantial fuselage influence, and (b) wing leading edge sweep between about 20 degrees and about 35 degrees, in combination with airfoil thickness to chord ratios equal to or below about 3% as an average along the semi-span outboard from the zone of substantial fuselage influence to the wing tip. | 02-23-2012 |
Patent application number | Description | Published |
20120067511 | METHOD FOR MANUFACTURING COMPOSITE COMPONENTS - A slide-room for installation in a recreational vehicle or other structure is disclosed. The slide-room comprises a shell, which can be constructed from fiberglass. The shell comprises an end wall, a ceiling, a floor, two opposing side walls, and a flange extending from the end wall, wherein the end wall, the ceiling, the floor, the side walls and the flange comprise a one-piece, unitary construction. Also disclosed are methods for molding composite components, such as slide-room. In one specific implementation, the shell for a slide-room is formed from fiberglass using a vacuum assisted resin transfer process. | 03-22-2012 |
20120068491 | SLIDE-ROOM FOR RECREATIONAL VEHICLE - A slide-room for installation in a recreational vehicle or other structure is disclosed. The slide-room comprises a shell, which can be constructed from fiberglass. The shell comprises an end wall, a ceiling, a floor, two opposing side walls, and a flange extending from the end wall, wherein the end wall, the ceiling, the floor, the side walls and the flange comprise a one-piece, unitary construction. Also disclosed are methods for molding composite components, such as slide-room. In one specific implementation, the shell for a slide-room is formed from fiberglass using a vacuum assisted resin transfer process. | 03-22-2012 |
20130257080 | SLIDE-ROOM FOR RECREATIONAL VEHICLE - A slide-room for installation in a recreational vehicle or other structure is disclosed. The slide-room comprises a shell, which can be constructed from fiberglass. The shell comprises an end wall, a ceiling, a floor, two opposing side walls, and a flange extending from the end wall, wherein the end wall, the ceiling, the floor, the side walls and the flange comprise a one-piece, unitary construction. Also disclosed are methods for molding composite components, such as slide-room. In one specific implementation, the shell for a slide-room is formed from fiberglass using a vacuum assisted resin transfer process. | 10-03-2013 |
Patent application number | Description | Published |
20080245944 | Furniture-glide assembly - A glide assembly is adapted to be mounted about an existing foot attached to the free end of a leg of a piece of furniture. The glide assembly includes a body defining an exterior surface and a bore extending partially through the body to define a hollow interior, an interior surface, and an open end of the body. An insert assembly is removably mountable about the foot and adapted to be received through the open end and fixedly secured within the hollow interior of the body so as to mount the body about the foot. | 10-09-2008 |
20100187399 | FURNITURE-FOOT ASSEMBLIES - A foot assembly is adapted to be removably attached to the elbow of a sled-type leg of a piece of furniture that is adapted to be supported upon a surface. The furniture-foot assembly includes a body defining a hollow interior adapted to removably receive the elbow of the leg and a bottom exterior portion. A glide is adapted to be removably mounted to the bottom exterior portion of the body and supported upon the surface for gliding movement of the furniture-foot assembly relative to the surface. | 07-29-2010 |
20120240355 | Furniture-Glide Assembly - A glide assembly is adapted to be mounted about an existing foot attached to the free end of a leg of a piece of furniture that is adapted to be supported upon a surface. The glide assembly includes a body defining an exterior surface and a bore extending partially through the body to define a hollow interior, an interior surface, a top, open end of the body, and a bottom, closed end of the body disposed opposite the open end. A cap is designed to be replaceably attached to the closed end of the body and adapted to engage the surface upon which the leg is supported. | 09-27-2012 |
Patent application number | Description | Published |
20100030156 | DRUG DELIVERY PLATFORM INCORPORATING HYDROGEL PUMPING MECHANISM WITH GUIDED FLUID FLOW - A drug delivery platform is provided for delivering a controlled infusion of a drug to an individual. The drug delivery platform includes a reservoir for receiving the drug therein and a hydrogel engageable with the reservoir. The hydrogel is movable between a first configuration and a second configuration wherein the hydrogel exerts a pressure on the reservoir to urge the drug therefrom in response to a predetermined stimulus. A flow guide distributes the predetermined stimulus over the hydrogel in response to activation by an individual. | 02-04-2010 |
20110172609 | MICRONEEDLE COMPONENT ASSEMBLY FOR DRUG DELIVERY DEVICE - A device for delivering a drug to a subject is provided. The device includes a drug reservoir, a conduit coupled to the drug reservoir and a microneedle component. The microneedle component includes a body, an engagement structure coupling the microneedle component to the conduit, a hollow microneedle extending from the body, and a handling feature located on the body. The microneedle component is configured to be releasably coupled to an assembly tool via the handling feature during assembly of the device. | 07-14-2011 |
20110172637 | DRUG DELIVERY DEVICE INCLUDING TISSUE SUPPORT STRUCTURE - A drug delivery device for delivering a drug to a subject includes a microneedle configured to facilitate delivery of the drug to the subject. The microneedle includes a tip portion and is moveable from an inactive position to an activated position. When the microneedle is moved to the activated position, the tip portion of the microneedle is configured to penetrate the skin of the subject. The drug delivery device includes a tissue support structure that includes a channel and an engagement element. The channel has a first end and a second end and is in axial alignment with the microneedle. At least the tip portion of the microneedle extends past the second end of the channel in the activated position. The engagement element is positioned adjacent to the channel, and the engagement element is configured to engage with the skin of the subject such that the engagement element resists downward deformation of the skin caused by the microneedle as the microneedle moves from the inactive position to the activated position. | 07-14-2011 |
20110172638 | DRUG DELIVERY DEVICE INCLUDING MULTI-FUNCTIONAL COVER - An apparatus for delivering a drug to a subject is provided. The apparatus includes a housing, a microneedle coupled to the housing and configured to extend from the housing when activated, an activation control coupled to the housing and an outer shell. The outer shell includes a top wall having an inner surface and a sidewall extending from the top wall, the sidewall having an inner surface. The outer shell includes a first attachment structure configured to attach to the housing. The outer shell covers the activation control when the first attachment structure is attached to the housing. The outer shell includes a second attachment structure configured to attach to the housing. The outer shell covers the activated microneedle when the second attachment structure is attached to the housing. | 07-14-2011 |
Patent application number | Description | Published |
20110172601 | Bladder Arrangement For Microneedle-Based Drug Delivery Device - A bladder arrangement is provided for a microneedle-based drug delivery device. The bladder arrangement includes a flexible membrane having an inner surface, an outer surface and an outer periphery. A bladder member, having a rigidity greater than the flexible membrane, includes an inner surface, an outer surface and an outer periphery. The inner surface of the flexible membrane and the inner surface of the bladder member define a chamber for receiving a drug therein. At least one microneedle is operatively connected to the bladder member. The at least one microneedle has an input and an output receivable within the individual. A valve operatively connects the input of the at least one microneedle and the chamber. | 07-14-2011 |
20110172639 | DEVICE AND METHOD FOR DELIVERY OF MICRONEEDLE TO DESIRED DEPTH WITHIN THE SKIN - A device for delivering a drug into the skin of a subject is provided. The device includes a drug reservoir and a microneedle having a tip, a length, and a tip sharpness. The microneedle is coupled to the reservoir. The device includes a microneedle actuator coupled to the microneedle configured to drive the microneedle into the skin of the subject upon activation. The tip sharpness and the actuator allow the microneedle to pass through an outer layer of the skin upon activation, and the length is limited such that the tip does not extend past a desired depth below the surface of the skin of the subject, wherein the desired depth is located in the papillary dermis or the reticular dermis. | 07-14-2011 |
20110172645 | WEARABLE DRUG DELIVERY DEVICE INCLUDING INTEGRATED PUMPING AND ACTIVATION ELEMENTS - A drug delivery device for delivering a drug to a subject is provided. The drug delivery device includes a housing, a drug reservoir supported by the housing containing the drug and a hollow microneedle supported by the housing. The hollow microneedle is moveable from an inactive position to an activated position, wherein, when the hollow microneedle is moved to the activated position, the tip portion of the hollow microneedle is configured to penetrate the skin of the subject. The drug delivery device includes a channel having an input in communication with the drug reservoir and an output in communication with the hollow microneedle. The channel provides fluid communication between the drug reservoir and the hollow microneedle, such that the drug is permitted to flow from the drug reservoir through the channel and through the hollow microneedle. The channel moves from a first position to a second position as the hollow microneedle moves from the inactive position to the activated position, and the position of the drug reservoir relative to the housing remains fixed as the hollow microneedle moves from the inactive position to the activated position. | 07-14-2011 |
20120109066 | WEARABLE DRUG DELIVERY DEVICE HAVING SPRING DRIVE AND SLIDING ACTUATION MECHANISM - A drug delivery device is provided. The drug delivery device includes a drug reservoir in fluid communication with a microneedle array. The drug delivery device has a sliding actuation mechanism that may be activated by a button or lever. Actuation of the drug delivery device inserts the microneedle array into the skin of a subject and causes a piston to compress the drug reservoir, thereby delivering the drug through the microneedle array to the subject. | 05-03-2012 |
Patent application number | Description | Published |
20080220999 | NOVEL MOLYBDENUM COMPOUNDS - Novel molybdenum compounds are prepared by reacting a hindered amine with a molybdenum source, in the presence of one of (a) water, (b) a diol and water, and (c) the reaction product of a fatty oil and a multifunctional amine, and water. Lubricant compositions containing these new compounds are more stabilized against oxidation and have improved friction reducing properties. Synergy is observed when the novel compounds are combined with a diaryl amine in a lubricant composition. | 09-11-2008 |
20080221000 | LUBRICANT ANTIOXIDANT COMPOSITIONS CONTAINING A METAL COMPOUND AND A HINDERED AMINE - An antioxidant lubricant composition has at least 50 wt % of a lubricating base oil and
| 09-11-2008 |
20100197537 | ASHLESS LUBRICANT COMPOSITION - A lubricant composition with improved antioxidant capability is provided by way of an additive composition containing a metal free sulfur-containing compound, an aromatic amine, and a hindered amine. Particularly effective metal-free sulfur-containing compounds include ashless dithiocarbamates, such as methylenebis(dibutyldithiocarbamate), and sulfurized fatty acids. | 08-05-2010 |
20110077178 | LUBRICANT ANTIOXIDANT COMPOSITIONS CONTAINING A METAL COMPOUND AND A HINDERED AMINE - An antioxidant lubricant composition has at least 50 wt % of a lubricating base oil and
| 03-31-2011 |
20120258896 | ZINC DITHIOCARBAMATE LUBRICATING OIL ADDITIVES - A lubricating oil composition comprising a zinc dithiocarbamate fraction, for use in a gasoline or diesel engine equipped with fluoroelastomer seals, wherein said zinc dithiocarbamate fraction consists essentially of zinc dithiocarbamate molecules per Formula I:
| 10-11-2012 |
20120264666 | MOLYBDENUM DIALKYLDITHIOCARBAMATE COMPOSITIONS AND LUBRICATING COMPOSITIONS CONTAINING THE SAME - A novel molybdenum dithiocarbamate composition is produced by preparing a di-tridecylamine (DTDA) intermediate from a butylene feedstock comprising greater than 50% 2-butylene, and preparing a molybdenum dithiocarbamate composition from the DTDA intermediate. The resulting molybdenum dithiocarbamate composition are according to formula (1), wherein R | 10-18-2012 |
20130123156 | LUBRICANT COMPOSITION - 1-[Di(4-octylphenyl)aminomethyl]tolutriazole is prepared in a mineral oil wherein the reaction also contains between 0.1 and 5% by weight of a polyacrylate polymer dissolved in a mineral oil. The liquid product shows increased storage stability with respect to crystallization of the 1-[di(4-octylphenyl)aminomethyl]tolutriazole when the polyacrylate polymer is added during the reaction to prepare the 1-[Di(4-octylphenyl)aminomethyl]tolutriazole. This product can be utilized in a lubricant composition as an antioxidant and corrosion inhibitor | 05-16-2013 |
20140213493 | ASHLESS LUBRICANT COMPOSITION - A lubricant composition with improved antioxidant capability is provided by way of an additive composition containing a metal free sulfur-containing compound, an aromatic amine, and a hindered amine. Particularly effective metal-free sulfur-containing compounds include ashless dithiocarbamates, such as methylenebis(dibutyldithiocarbamate), and sulfurized fatty acids. | 07-31-2014 |
20140342957 | METHOD FOR REDUCING CRYSTALLIZATION OF 1-[DI(4-OCTYLPHENYL)AMINOMETHYL]TOLUTRIAZOLE - 1-[di(4-octylphenyl)aminomethyl]tolutriazole is prepared in a mineral oil and blended with a liquid alkylated diphenylamine. The liquid product shows increased storage stability with respect to crystallization of the 1-[di(4-octylphenyl)aminomethyl]tolutriazole when the amine is added. This blend product can be stored for a prolonged period of time, and then utilized in a lubricant composition as an antioxidant and corrosion inhibitor | 11-20-2014 |
20150087568 | ASHLESS LUBRICANT COMPOSITION - A lubricant composition with improved antioxidant capability is provided by way of an additive composition containing a metal free sulfur-containing compound, an aromatic amine, and a hindered amine. Particularly effective metal-free sulfur-containing compounds include ashless dithiocarbamates, such as methylenebis(dibutyldithiocarbamate), and sulfurized fatty acids. | 03-26-2015 |
Patent application number | Description | Published |
20100252175 | VEHICLE WHEEL CONSTRUCTION PROCESS - An improved process for permanently attaching an overlay to a wheel disc, wherein the overlay is aligned and spaced apart from the wheel disc. A mold is created by a combination of the overlay, wheel disc and localized nests that engage at predetermined times during foam filling to close the mold. The mold is adequately sealed so that there is no foam leakage as the foam expands to fill the mold and, therefore, no final trimming of excess foam is required. The improved process is capable of accommodating a wheel having turbine openings therein. | 10-07-2010 |
20120198772 | GARAGE DOOR AND FAUX WINDOW FA ADE ASSEMBY - A garage door and faux window façade assembly includes a door panel adapted to be mounted in a garage door opening partially defined by an overhead door structure, a triangularly-shaped clearance area defined by a first line segment substantially coplanar with a forwardly-facing surface of the door panel, and second and third line segments defined by a path of the overhead door structure relative to the door panel as the door panel moves between a closed position and an open position, wherein the second line segment is proximate the upper edge of the door panel and the third line segment is proximate the lower edge of the door panel, the clearance area is adapted to be free from abutment with the overhead door structure as the door panel moves between a closed position and an open position, and wherein the clearance area includes a forward portion area defined by the first and second line segments and a ⅜ inch line that extends perpendicularly from the first line segment and intersecting the second line segment, and a frame including at least a select one of a window aperture extending there through and a window recess formed thereon, wherein the frame extends into the forward portion area of the clearance area at at least one location along a length of the frame. | 08-09-2012 |
Patent application number | Description | Published |
20110263001 | Compositions and Methods for Engineering Cells - The disclosure relates generally to genetic manipulation of stem and primary cells and to reprogramming of somatic cells, more specifically, human cells. In particular, compositions and methods are disclosed for the generation and maintenance of such engineered cells. | 10-27-2011 |
20130040304 | Compositions and Methods for Engineering Cells - The disclosure relates generally to genetic manipulation of stem and primary cells and to reprogramming of somatic cells, more specifically, human cells. In particular, compositions and methods are disclosed for the generation and maintenance of such engineered cells. | 02-14-2013 |
20130164269 | CELL CULTURE SYSTEM FOR BIOREACTOR SCALE-UP OF CELLS - The present invention relates to growing stem cells, for e.g., MSCs, in large-scale under GMP-compliance, using media and reagents that satisfy GMP requirements, while maintaining stemness, for effective downstream therapeutic use, which include but are not limited to, stem cell therapy, production of products, such as beneficial factors, recombinant proteins, etc. obtained from such stem cells. | 06-27-2013 |
Patent application number | Description | Published |
20120010163 | NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF - The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject. | 01-12-2012 |
20130237490 | NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF - The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject. | 09-12-2013 |
Patent application number | Description | Published |
20100185861 | ANONYMOUS KEY ISSUING FOR ATTRIBUTE-BASED ENCRYPTION - The claimed subject matter provides systems and/or methods that establish a decryption key for use with an attribute authority. The system can include components that identify a pseudonym based a global identifier (GID) associated with a user, initiates communication with the attribute authority, and selects a first random value utilized to determine a first value. The system also includes components that select a second random value, employs the first value and the second random value to generate a second value and a third value, receives the second value and the third value, identifies a third random value, and employs the second value, the third value, the first random value, and the third random value to determine a fourth value which is employed to determine a fifth value. The fifth value is employed to derive the decryption key for use with the attribute authority. | 07-22-2010 |
20100191975 | PRIVACY-PRESERVING COMMUNICATION - Anonymous information sharing systems and methods enable communication of information to parties in a privacy-preserving manner such that no one other than the designated parties can know the source, recipient, and content of the information. Furthermore, the communication can be accomplished without requiring trial decryption, and protection can be provided against of sharing of privileges. | 07-29-2010 |
20110138190 | GRAPH ENCRYPTION - A storage system stores information about a graph in an encrypted form. A query module can submit a token to the storage system to retrieve specified information about the graph, e.g., to determine the neighbors of an entity in the graph, or to determine whether a first entity is connected to a second entity, etc. The storage system formulates its reply to the token in a lookup result. Through this process, the storage system gives selective access to information about the graph to authorized agents, yet otherwise maintains the general secrecy of the graph from the perspective of unauthorized agents, including the storage system itself. A graph processing module can produce encrypted graph information by encrypting any representation of the graph, such as an adjacency matrix, an index, etc. | 06-09-2011 |
20110161670 | Reducing Leakage of Information from Cryptographic Systems - A system is described for reducing leakage of meaningful information from cryptographic operations. The system uses a pairwise independent hash function to generate a modified secret key SK′ having individual components. The system forms a modified secret key collection that includes SK′ and its individual components. The system then uses the modified secret key collection to decrypt a message. The decryption involves providing multiple partial operation results in separate respective steps. Leakage of meaningful information is reduced due to difficulty in piecing together meaningful information from information leaked by the separate partial operations. In one example, the hash function has the form H | 06-30-2011 |
20120159180 | Server-side Encrypted Pattern Matching - Server-side encrypted pattern matching may minimize the risk of data theft due to server breach and/or unauthorized data access. In various implementations, a server for performing the server-side encrypted pattern matching may include an interface component to receive an encrypted query token. The server may further include a query component to find a match for the encrypted query token in the encrypted data string. The query component may find such a match without decrypting the encrypted data string and the encrypted query token by using an encrypted dictionary that includes information on the edges of the encrypted suffix tree. | 06-21-2012 |
20120331283 | USER-CONTROLLED DATA ENCRYPTION WITH OBFUSCATED POLICY - An obfuscated policy data encryption system and method for re-encrypting data to maintain the confidentiality and integrity of data about a user when the data is stored in a public cloud computing environment. The system and method allow a user to specify in a data-sharing policy who can obtain the data and how much of the data is available to them. This policy is obfuscated such that it is unintelligible to the cloud operator and others processing and storing the data. In some embodiments, a patient species with whom his health care data should be shared with and the encrypted health care data is stored in the cloud in an electronic medical records system. The obfuscated policy allows the electronic medial records system to dispense the health care data of the patient to those requesting the data without disclosing the details of the policy itself. | 12-27-2012 |
20140281491 | IDENTITY ESCROW MANAGEMENT FOR MINIMAL DISCLOSURE CREDENTIALS - The subject disclosure is directed towards identity escrow management where anonymous online users can be de-anonymized if certain conditions are met. An auditor is configured to control a user's anonymity using a prime-order cryptographic group based encryption scheme. Via an authentication component, the auditor verifies that a pseudonym corresponding to the user's identity was encrypted correctly. If valid, the auditor decrypts encrypted pseudonym data using a private cryptographic key based upon the prime-order cryptographic group | 09-18-2014 |
Patent application number | Description | Published |
20100216256 | NANOBELT-BASED SENSORS AND DETECTION METHODS - A biosensor is provided which includes a substrate, a source electrode on the substrate, a drain electrode on the substrate, and at least one functionalized nanobelt on a surface of the substrate between the source electrode and the drain electrode. Methods for sensing a biological or chemical analyte using the sensor is also provided. | 08-26-2010 |
20120122235 | Devices and Methods for Detection of Biomolecular Interactions - Devices, systems, and methods are provided for the detection of biomolecular interactions. The interactions between one or more target DNA strands, one or more receptor DNA strands, and one or more probe DNA strands, if necessary, are used to detect the one or more target DNA strands. The one or more target DNA strands or the one or more probe DNA strands may be coupled to a magnetic bead, and the one or more receptor strands may be coupled to the Hall device. | 05-17-2012 |
20130149787 | Devices and Methods for Detection of Biomolecular Interactions - Devices, systems, and methods are provided for the detection of biomolecular interactions. The interactions between one or more target DNA strands, one or more receptor DNA strands, and one or more probe DNA strands, if necessary, are used to detect the one or more target DNA strands. The one or more target DNA strands or the one or more probe DNA strands may be coupled to a magnetic bead, and the one or more receptor strands may be coupled to the Hall device. | 06-13-2013 |
Patent application number | Description | Published |
20110021503 | USE AND COMPOSITION FOR TREATING DEMENTIA - There is described a method for increasing the maximal tolerated dose and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia by decreasing concomitant adverse effects by administration of said AChEI in combination with a non-selective, peripheral anticholinergic agent, whereby an enhanced acetyl choline esterase inhibition in the CNS of said patient is achieved and alleviation of the symptoms of Alzheimer type dementia in said patient is thereby improved to a greater extent. The use of a non-selective, peripheral anticholinergic agent (nsPAChA) for the preparation of a pharmaceutical composition for increasing the maximal tolerated dose and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia and pharmaceutical compositions comprising a non-selective peripheral anticholinergic agent of formula II as illustrated in the description and an acetylcholine esterase inhibitor are also described. | 01-27-2011 |
20110071135 | METHOD AND COMPOSITION FOR TREATING ALZHEIMER-TYPE DEMENTIA - There is described a method for increasing the maximal tolerated close and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia by decreasing concomitant adverse effects by administration of said AChEI in combination with a non-anticholinergic antiemetic agent, whereby an enhanced acetyl choline esterase inhibition in the CNS of said patient is achieved and alleviation of the symptoms of Alzheimer type dementia in said patient is thereby improved to a greater extent. The use of a non-anticholinergic antiemetic agent for the preparation of a pharmaceutical composition for the treatment of Alzheimer type dementia in combination with an acetyl choline esterase inhibitor (AChEI) and pharmaceutical compositions comprising (a) a 5HT | 03-24-2011 |
20110201597 | METHOD AND COMPOSITION FOR TREATING ALZHEIMER-TYPE DEMENTIA - There is described a method for increasing the maximal tolerated dose and thus the efficacy of an acetylcholinesterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia by decreasing concomitant adverse effects by administration of said AChEI in combination with a non-anticholinergic antiemetic agent, whereby an enhanced acetylcholinesterase inhibition in the CNS of said patient is achieved and alleviation of the symptoms of Alzheimer type dementia in said patient is thereby improved to a greater extent. The use of a non-anticholinergic antiemetic agent for the preparation of a pharmaceutical composition for the treatment of Alzheimer type dementia in combination with an acetylcholinesterase inhibitor (AChEI) and pharmaceutical compositions comprising (a) a 5HT | 08-18-2011 |
20130158012 | USE AND COMPOSITION FOR TREATING DEMENTIA - There is described a method for increasing the maximal tolerated dose and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia by decreasing concomitant adverse effects by administration of said AChEI in combination with a non-selective, peripheral anticholinergic agent, whereby an enhanced acetyl choline esterase inhibition in the CNS of said patient is achieved and alleviation of the symptoms of Alzheimer type dementia in said patient is thereby improved to a greater extent. The use of a non-selective, peripheral anticholinergic agent (nsPAChA) for the preparation of a pharmaceutical composition for increasing the maximal tolerated dose and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia and pharmaceutical compositions comprising a non-selective peripheral anticholinergic agent of formula II as illustrated in the description and an acetylcholine esterase inhibitor are also described. | 06-20-2013 |
20140219969 | CELL THERAPY FOR THE TREATMENT OF NEURODEGENERATION - Methods are described for the isolation and selection of a heterogeneous bone marrow cell population, called NCS-01, that is effective at treating neurodegeneration. For example, NCS-01 cells are shown to treat neurodegeneration caused by ischemia. In vivo studies demonstrate that selected NCS-01 cell populations treat neurodegeneration in a standard rat middle cerebral artery occlusion (MCAO) animal model under conditions of transient or permanent total arterial occlusion. These studies also disclose that when the neurodegeneration is caused by ischemic stroke, combining the administration of a selected NCS-01 cell population with thrombolytic agents and/or mechanical methods of clot removal leads to a decrease in the volume of infarction caused by acute onset neurodegeneration. The disclosed cell therapy promises to make a significant clinical impact on patient survival after stroke. | 08-07-2014 |
20140275036 | USE AND COMPOSITION FOR TREATING DEMENTIA - There is described a method for increasing the maximal tolerated dose and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia by decreasing concomitant adverse effects by administration of said AChEI in combination with a non-selective, peripheral anticholinergic agent, whereby an enhanced acetyl choline esterase inhibition in the CNS of said patient is achieved and alleviation of the symptoms of Alzheimer type dementia in said patient is thereby improved to a greater extent. The use of a non-selective, peripheral anticholinergic agent (nsPAChA) for the preparation of a pharmaceutical composition for increasing the maximal tolerated dose and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia and pharmaceutical compositions comprising a non-selective peripheral anticholinergic agent of formula II as illustrated in the description and an acetylcholine esterase inhibitor are also described. | 09-18-2014 |
20140288057 | METHOD AND COMPOSITION FOR TREATING ALZHEIMER-TYPE DEMENTIA - There is described a method for increasing the maximal tolerated dose and thus the efficacy of an acetylcholinesterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia by decreasing concomitant adverse effects by administration of said AChEI in combination with a non-anticholinergic antiemetic agent, whereby an enhanced acetylcholinesterase inhibition in the CNS of said patient is achieved and alleviation of the symptoms of Alzheimer type dementia in said patient is thereby improved to a greater extent. The use of a non-anticholinergic antiemetic agent for the preparation of a pharmaceutical composition for the treatment of Alzheimer type dementia in combination with an acetylcholinesterase inhibitor (AChEI) and pharmaceutical compositions comprising (a) a 5HT | 09-25-2014 |
20140356343 | COMPOSITION FOR TREATING PARKINSON'S DISEASE - A composition useful for the treatment of degenerative brain disease. A pharmaceutical composition comprising an effective amount of apamin as an active ingredient and an effective amount of at least another compound including a permeability enhancer and/or carrier molecule. | 12-04-2014 |