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Chari, US
Anand K. Chari, Bartlett, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20080274734 | SYSTEM FOR PROVIDING HIGH SPEED COMMUNICATIONS SERVICE IN AN AIRBORNE WIRELESS CELLULAR NETWORK - The present Broadband Link System supplements the existing Air-To-Ground Radio Frequency communications link with an additional, separate high speed Broadband Ground-To-Air Data Channel to provide additional data communication capacity for aircraft. This Broadband Ground-To-Air Data Channel is typically a uni-directional (Ground-To-Air) link directed via a focused beam to selected aircraft which are operational in the coverage area of the Broadband Ground-To-Air Data Channel. The routing of the various data transmissions on both the Air-To-Ground Radio Frequency communications link and the Broadband Ground-To-Air Data Channel are managed in a unified manner to maximize the utilization of the two transmission facilities. | 11-06-2008 |
| 20110263199 | SPECTRUM SHARING BETWEEN AN AIRCRAFT-BASED AIR-TO-GROUND COMMUNICATION SYSTEM AND EXISTING GEOSTATIONARY SATELLITE SERVICES - The present Spectrum Sharing System implements spectrum reuse between aircraft-based Air-To-Ground (ATG) communication systems and Geostationary Satellite Service systems. This is accomplished by managing the radio frequency transmissions in the volume of space in which the aircraft operates, with interference between the Spectrum Sharing System and the Geostationary Satellite Service system being reduced by implementing reversed uplink and downlink radio frequency paths in the common spectrum. The Spectrum Sharing System also avoids interfering with Geostationary Satellite Services' earth stations which are pointed towards the satellites' orbital arc by relying upon a combination of the earth stations' highly directive antenna patterns and the Spectrum Sharing System ground station antenna pattern, and to avoid interfering with satellites in their orbital arc by assuring that power levels radiated in that direction by the Spectrum Sharing System ground stations are below the level that would create interference. | 10-27-2011 |
Jayasri R. Chari, Fenton, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20100018300 | Method of Aligning Properties for Dynamometer Testing - A method of aligning a property for testing in a dynamometer cell is provided, including the steps of: mounting a laser travel car to each of four risers in a repositionable manner; mounting a laser to each of the laser travel cars in a repositionable manner; securing a dyno cart into a cart receiving station between the four risers; calibrating each of the lasers; preparing the dyno cart to receive the property; mounting the property to the dyno cart; orienting the various lasers based, at least in part, upon predetermined optimal alignment dimensions to thereby provide a set of target locations; orienting the property such that predetermined locations of the property align with the set of target locations to ensure appropriate property orientation during testing; and removing the dyno cart from the cart receiving station for delivery to the dynamometer cell. | 01-28-2010 |
Manoj Keshavmurthi Chari, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100049535 | Computer-Implemented Marketing Optimization Systems And Methods - Computer-implemented systems and methods are provided for determining an action item from a global set of action items for a plurality of customers based on an objective function, a plurality of individual constraints, and a plurality of aggregate constraints. A plurality of offer sets is generated for each customer. An approximate highest reduced adjusted objective for each of the offer sets for each customer is calculated, and the customers are bucketed based on the highest adjusted objective value associated with each customer. The buckets are collapsed into a single bucket record containing a plurality of aggregate offer set columns, and an aggregate offer set column is selected from each bucket record for each bucket. Each bucket associated with a selected offer set is disaggregated, and the action item included in the selected offer set is stored in a computer-readable memory. | 02-25-2010 |
| 20100082469 | Constrained Optimized Binning For Scorecards - Computer-implemented systems and methods are provided for generating bins for a scorecard. An approximate set of bins is generated by applying an optimization model to binning data. The optimization model includes an objective function, constraints, and surrogate weight of evidence metric(s). The approximated set of bins are then used in scorecard operations. | 04-01-2010 |
Ravi Chari, Netwon, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100203007 | NOVEL BENZODIAZEPINE DERIVATIVES - The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. | 08-12-2010 |
Ravi Chari, Worcester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110256135 | ANTI-NERVE GROWTH FACTOR (NGF) ANTIBODY COMPOSITIONS - The present invention relates to stable compositions of anti-NGF antibodies, and antigen-binding fragments thereof, and their uses in the prevention and/or treatment of various diseases and disorders in which NGF activity is detrimental, e.g., pain disorders. | 10-20-2011 |
Ravi Chari, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110166319 | PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES - The invention provides processes for preparing a cell-binding agent chemically coupled to a drug. A first process comprises covalently attaching a linker to a cell-binding agent, an optional purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, and optional holding steps. A second process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, holding steps, and optionally a tangential flow filtration (TFF) step. | 07-07-2011 |
Ravi S. Chari, Nashville, TN US
| Patent application number | Description | Published |
|---|---|---|
| 20090292211 | Methods and Apparatus for Optical Spectroscopic Detection of Cell and Tissue Death - A method for detecting death process of a cell or tissue of a living subject. In one embodiment, the method includes the steps of illuminating the cell or tissue of the living subject with a coherent light, collecting fluorescent light returned from the illuminated cell or tissue of the living subject, identifying a NAD(P)H peak of a spectrum of the collected fluorescent light with a wavelength, λ | 11-26-2009 |
| 20110295125 | Apparatus and method for radio frequency ablation of a liver tumor in liver tissues - A method for detecting death process of a cell or tissue of a living subject. In one embodiment, the method includes the steps of illuminating the cell or tissue of the living subject with a coherent light, collecting fluorescent light returned from the illuminated cell or tissue of the living subject, identifying a NAD(P)H peak of a spectrum of the collected fluorescent light with a wavelength, λ | 12-01-2011 |
Ravi V. J. Chari, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090274713 | CROSS-LINKERS AND THEIR USES - Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same. | 11-05-2009 |
| 20100092495 | POTENT CELL-BINDING AGENT DRUG CONJUGATES - The present invention relates to the use of about 2 to about 8 drug molecules, for example, maytansinoid, per cell binding agent, such as an antibody, and maximal efficacy as compared to a drug load of lesser or higher number of drugs linked to such a cell binding agent. | 04-15-2010 |
| 20110003969 | CONJUGATION METHODS - This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups. This conjugation method provides in high yields conjugates of high purity and homogeneity that are without inter-chain cross-linking and inactivated linker residues | 01-06-2011 |
| 20110280890 | PRODRUGS OF CC-1065 ANALOGS - The present invention provides prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group containing a sulfonic acid containing phenyl carbamate, in which the protecting group confers enhanced water solubility upon the prodrug, and in which the prodrug also has a moiety, such as a sulfide or a disulfide, that can conjugate to a cell binding reagent such as an antibody, and for the therapeutic use of such prodrug and conjugates, and for processes for preparing such prodrugs and conjugates. | 11-17-2011 |
| 20110281856 | METHOD OF TARGETING SPECIFIC CELL POPULATIONS USING CELL-BINDING AGENT MAYTANSINOID CONJUGATES LINKED VIA A NON-CLEAVABLE LINKER, SAID CONJUGATES AND METHODS OF MAKING SAID CONJUGATES - The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population. | 11-17-2011 |
Santhana Chari, Mableton, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20110096846 | ADVERTISEMENT INSERTION FOR VIDEO - Methods for performing ad insertion prior to performing statistical multiplexing on one or more digital video streams including programs are disclosed. Select coded frames of a program and an advertisement are decoded and re-encoded at a predetermine bit rate to obtain a revised program representing the original program with the advertisement inserted at a select time. | 04-28-2011 |
Srinivas Chari, Winter Springs, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20080298600 | AUTOMATED REAL SPEECH HEARING INSTRUMENT ADJUSTMENT SYSTEM - A method for fitting a hearing instrument comprises placing the hearing instrument in situ includes receiving an audiogram of the user, determining a target gain for the hearing instrument as a function of the audiogram, exposing a reference sensor located adjacent the hearing instrument to an external speech signal, measuring an external sound pressure level (SPL) via the reference sensor, exposing a probe sensor coupled to the inside of the ear to the output of the hearing instrument while the hearing instrument is in situ, measuring an internal sound pressure level (“SPL”) inside the ear of the user via the probe sensor, determining an offset gain as a function of the external SPL, the target gain and the internal SPL, and automatically adjusting a gain of the hearing instrument according to the offset gain. A system for automatically fitting a hearing impaired person with a digital hearing aid in situ includes a digital hearing aid, a reference volume sensor, a probe sensor, a sound mapping module and a parameter control module. | 12-04-2008 |
| 20120140937 | Automated real speech hearing instrument adjustment system - A method for adjusting a hearing instrument to reduce feedback by placing a hearing instrument having an adjustable frequency response in a wearer's ear, providing a probe microphone for measuring the sound pressure level inside the ear and a reference microphone for measuring the sound pressure level outside the ear, exposing the ear to a stimulus and a dynamic event, determining the gain as a function of frequency from the difference in sound pressure level measured by the probe microphone and the reference microphone, identifying a feedback peak where the frequency is in the center of a range of frequencies and corresponds to the maximum gain in that range of frequencies and adjusting the hearing instrument to reduce the gain at a frequency corresponding to the frequency of the feedback peak. | 06-07-2012 |
Venkatesh R. Chari, North Andover, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090009630 | DIRECT INTERFACE OF CAMERA MODULE TO GENERAL PURPOSE I/O PORT OF DIGITAL BASEBAND PROCESSOR - In a mobile wireless device, a camera module can be connected directly to a digital baseband processor that does not have a special interface, without the need for an external coprocessor. The data interface of the camera module is directly connected to pins of a general purpose input/output port on the digital baseband processor to enable the baseband processor to capture the synchronous parallel data stream from the camera module. A clock signal from the camera module can be used to trigger DMA transfers of the image data captured by the general purpose input/output port of the baseband processor. | 01-08-2009 |
Venkatesh Rajagopalan Chari, North Andover, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120154561 | COMPACT ASSISTIVE READING DEVICE - A compact assistive reading device. A compact form factor is achieved through the use of an optical system with a pin hole aperture, which also obviates the needs for mirrors. One or more light sources are positioned outside the field of view of the optical system. A structure such as a prism film, patterned reflector or light pipe may be used to provide an illumination pattern that enhances the quality of images formed with the optical system. Additionally, processing components to recognize text, numbers or other information on an item placed in the imaging area of the optical system may be incorporated into a housing with the optical system. The housing contains features to facilitate easy insertion of an object into the imaging area and sensors to indicate when the object is properly positioned. The device may function as a currency reader. | 06-21-2012 |
Vic Chari, Houston, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20110088398 | GAS TURBINE ENGINE EXHAUST DIFFUSER AND COLLECTOR - Systems are provided that may be used to diffuse and deflect the flows of gas into a plurality of gas flows. A gas flow, for example, exhaust gas, may be diffused, that is, spread out by the diffuser. A flow deflector may be coupled to the diffuser so that the gas flow may be result in a plurality of gas flows. By diffusing and allowing a plurality of gas flows, improved gas flows may be achieved. | 04-21-2011 |