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Chaplin

Ben Chaplin, London GB

Patent application numberDescriptionPublished
20120020678EMPTY BOTTLE DETECTION USING A ONE TIME FOIL SEAL - An image forming apparatus comprises a controller that stores instructions, which cause the image forming apparatus to determine a characteristic measurement in response to a toner cartridge being partially inserted into the image forming apparatus. A pair of spaced apart sensors included on the image forming apparatus each contact an outer cross-sectional surface of a film on a delivery aperture of the toner cartridge. The image forming apparatus further includes an auger having at least one sensor for conducting a characteristic measurement on the film. The characteristic measurement corresponds to criteria programmed in the image forming apparatus for determining if the toner cartridge has a full toner level or a partially full (or low) toner level.01-26-2012

Benjamin R. Chaplin, London GB

Patent application numberDescriptionPublished
20120091654ROLL NIP STRUCTURE HAVING ADAPTIVE PIVOT POSITION - A printing apparatus comprises a marking device, a media path positioned to supply sheets of media to the marking device, and a media supply tray positioned to supply the sheets of media to the media path. Further, a pair of rollers forms a nip adjacent the media supply tray. The rollers rotate in opposite directions to cause the sheets of media to move from the media supply tray to the media path. Additionally, a first frame structure supports a first roller of the pair of rollers. The first frame structure can be in a fixed position and holds the first roller in a fixed location. A second frame structure supports a second roller of the pair of rollers. The second frame structure is adjustable in a first direction toward the first roller and has a variable pivot position allowing the second frame structure to move in a second direction perpendicular to the first direction.04-19-2012

David Chaplin, Oxfordshire GB

Patent application numberDescriptionPublished
20090137687Compositions and Methods With Enhanced Therapeutic Activity - This invention relates to novel tricyclic quinone and catechol compositions, compositions containing prodrugs of tricyclic quinone and catechol compositions, and methods of use for the treatment of solid tumor cancers and other vascular proliferative disorders. In certain aspects, the compositions of the invention are capable of generating both a vascular targeting effect and tumor cell cytotoxicity (e.g., by oxidative stress) in order to achieve an enhanced anti-tumor response in a patient.05-28-2009
20090209496METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY OF RTK INHIBITORS - This invention relates to methods for treating, preventing and/or managing cancer in a subject including enhancing the efficacy of a Receptor Tyrosine Kinase inhibitor (e.g., a small molecule RTK inhibitor, e.g., Sorafenib or Erlotinib) by administering to the subject a Vascular Disrupting Agent (e.g., a Combretastatin or derivative thereof) sequentially or simultaneously in combination with said RTK inhibitor. Pharmaceutical compositions comprising a combination of a RTK inhibitor and a VDA are also provided.08-20-2009
20090258937Methods for Modulating Tumor Growth and Metastasis - Methods and pharmaceutical compositions for modulating tumor growth or metastasis are provided.10-15-2009

David Chaplin, Watlington GB

Patent application numberDescriptionPublished
20090264382Methods for Treating Hematopoietic Neoplasms - This invention relates to methods for treating, preventing and/or managing hematopoietic neoplasm in a subject by administering to the subject combretastatin A-4 phosphate, or a pharmaceutically acceptable salt thereof. The method may further comprise co-administering a chemotherapeutic agent.10-22-2009

David Chaplin, Wtlington GB

Patent application numberDescriptionPublished
20090192098METHOD FOR TREATING HEMATOPOIETIC NEOPLASMS - This invention relates to methods for treating a hematopoietic neoplasm comprising administering a therapeutically effective amount of a combretastatin compound, or a pharmaceutically acceptable salt thereof, to a subject having a hematological malignancy, wherein the combretastatin compound comprises a catechol or quinone moiety and is capable of forming a reactive oxygen species (ROS) in vivo. The method may further comprise co-administering a second chemotherapeutic agent.07-30-2009

Derek Chaplin, Bollington GB

Patent application numberDescriptionPublished
20090139679FORMING SCREEN FOR USE IN A PAPER MACHINE - The invention relates to a forming screen for use in the forming section of a paper machine, comprising a paper and a machine side as well as longitudinal threads extending in the intended running direction and binding cross threads extending transversely thereto, wherein the longitudinal threads are divided in the ratio of the number of threads of 1:1 in a longitudinal thread layer on the machine side and a longitudinal thread layer on the paper side, and the binding cross threads bind in both longitudinal thread layers, which is characterized in that the forming screen has a fiber support index (FSI) which is in the range of 230 to 250 and has an air permeability which is in the range of 5700 to 10600 m06-04-2009

Jason Hugh Chaplin, Western Australia AU

Patent application numberDescriptionPublished
20100087430NOVEL BENZOFURAN POTASSIUM CHANNEL BLOCKERS AND USES THEREOF - The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of K04-08-2010
20100297077NOVEL ARYL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF - The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.11-25-2010

Jason Hugh Chaplin, Victoria AU

Patent application numberDescriptionPublished
20090298931NOVEL CHROMENONE POTASSIUM CHANNEL BLOCKERS AND USES THEREOF - The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.12-03-2009
20100004208SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS - The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.01-07-2010
20100292190NOVEL TUBULIN POLYMERISATION INHIBITORS - The present invention relates to compounds of general formula (I) as tublin polymerisation inhibitors and methods for preparing such compounds.11-18-2010

Jason Hugh Chaplin, Thornbury AU

Patent application numberDescriptionPublished
20100048591CHEMICAL COMPOUNDS AND PROCESSES - The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which may possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.02-25-2010

Kevin Chaplin, Vancouver CA

Patent application numberDescriptionPublished
20100087836Surgical Instrument and Method for Tensioning and Securing a Flexible Suture - A surgical instrument may be used to apply tension to a flexible suture to close and secure a broken or cut bone (e.g. a sternum following a sternotomy). The device preferably applies an adjustable tension to the flexible suture in order to secure the bone together. Multiple instruments may be used together to ensure the desired tension is applied to the entire bone structure being secured with the flexible sutures. Once the desired tension is achieved, the device preferably provides a mechanism to apply a uniform twist to the flexible suture to lock the flexible suture in place and maintain the tension previously achieved. The device may automatically cut the flexible suture, or the flexible suture may be cut by the surgeon once the twisting action has been performed.04-08-2010
20100087837Surgical Instrument and Method for Tensioning and Securing a Flexible Suture - A surgical instrument may be used to apply tension to a flexible suture to close and secure a broken or cut bone (e.g. a sternum following a sternotomy). The device preferably applies an adjustable tension to the flexible suture in order to secure the bone together. Multiple instruments may be used together to ensure the desired tension is applied to the entire bone structure being secured with the flexible sutures. Once the desired tension is achieved, the device preferably provides a mechanism to apply a uniform twist to the flexible suture to lock the flexible suture in place. The instrument preferably decreases the upward tension applied to the flexible sutures over the duration of the application of twisting.. The device may automatically cut the flexible suture, or the flexible suture may be cut by the surgeon once the twisting action has been performed.04-08-2010

Michael John Chaplin, Nr Nuneaton GB

Patent application numberDescriptionPublished
20100108332Valve Assembly - A valve assembly (05-06-2010

Richard R. G. Chaplin, Cambridge CA

Patent application numberDescriptionPublished
20090094734SYSTEM AND APPARATUS FOR BACKLIGHTING SWIMMING POOLS - Lighting systems and apparatus for a swimming pool, having a sidewall sized and shaped to define a perimeter of the swimming pool, a liner for covering the sidewall and a bottom of the swimming pool so as to create a watertight cavity for receiving water, the liner including a light-transmitting portion, and a backlighting apparatus for mounting to a generally continuous surface of the sidewall between the liner and the sidewall and configured to transmit light through the light-transmitting portion of the liner to illuminate the swimming pool. In some embodiments, the backlighting apparatus includes a housing configured for mounting on the surface of the sidewall between the liner and the sidewall, the housing having a light-transmitting front cover configured to align with the light-transmitting portion of the liner, and at least one light source sized and shaped to fit within the housing for emitting light through the front cover to illuminate the pool. In other embodiments, the backlighting apparatus includes a rear sheet portion for mounting on the surface of the sidewall between the liner and the sidewall, a light-transmitting cover sheet portion connected to the rear sheet portion, and at least one light source provided between the rear sheet portion and the cover sheet portion for emitting light through the cover sheet portion and the light-transmitting portion of the liner to illuminate the swimming pool.04-16-2009