Chaplin
Andrew Chaplin, Reading GB
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20140012896 | TECHNIQUE FOR IMPLEMENTING SEAMLESS SHORTCUTS IN SHAREPOINT - A system and method for creating shortcuts within a database for archived items. A client computer sends a retrieval request for a given item to a web server. The given item may be an electronic document. A custom HTTPModule within the web server intercepts the request. The HTTPModule uses a uniform resource locator (URL) provided in the request to locate a record associated with the given item. If a given fixed string value is read from the record in place of the original content data, then the web server requests original content data for the given item from an archive store. The record still maintains identification information, such as a document identifier and the URL in order to maintain links and workflows. The retrieval request is not rerouted to an alternate path, and the client computer receives the original content data, rather than an indication of a shortcut. | 01-09-2014 |
Ben Chaplin, London GB
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20120020678 | EMPTY BOTTLE DETECTION USING A ONE TIME FOIL SEAL - An image forming apparatus comprises a controller that stores instructions, which cause the image forming apparatus to determine a characteristic measurement in response to a toner cartridge being partially inserted into the image forming apparatus. A pair of spaced apart sensors included on the image forming apparatus each contact an outer cross-sectional surface of a film on a delivery aperture of the toner cartridge. The image forming apparatus further includes an auger having at least one sensor for conducting a characteristic measurement on the film. The characteristic measurement corresponds to criteria programmed in the image forming apparatus for determining if the toner cartridge has a full toner level or a partially full (or low) toner level. | 01-26-2012 |
20120106989 | TONER BOTTLE PRESENCE AND LEVEL SENSING USING WEIGHT - An image forming apparatus is adapted to distinguish a presence between a full and a partially-full toner cassette. The image forming apparatus includes a load cell positioned in a developer station. The load cell is adapted to sense a mass of a toner cassette at least during an insertion of the toner cassette into the apparatus. A processor is adapted to determine a toner volume contained in the toner cassette based on a mass differential. A controller is adapted to drive or suspend a motor in the developer station to control an operation of the image forming apparatus. The controller controls the operation based on the toner volume. | 05-03-2012 |
Benjamin R. Chaplin, London GB
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20120091654 | ROLL NIP STRUCTURE HAVING ADAPTIVE PIVOT POSITION - A printing apparatus comprises a marking device, a media path positioned to supply sheets of media to the marking device, and a media supply tray positioned to supply the sheets of media to the media path. Further, a pair of rollers forms a nip adjacent the media supply tray. The rollers rotate in opposite directions to cause the sheets of media to move from the media supply tray to the media path. Additionally, a first frame structure supports a first roller of the pair of rollers. The first frame structure can be in a fixed position and holds the first roller in a fixed location. A second frame structure supports a second roller of the pair of rollers. The second frame structure is adjustable in a first direction toward the first roller and has a variable pivot position allowing the second frame structure to move in a second direction perpendicular to the first direction. | 04-19-2012 |
Craig Chaplin, North Vancouver CA
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20140082047 | Business Application Platform With Embedded Business Intelligence Server - A system is provided in which at least one first server comprises at least one data processor executing a business application platform providing various business applications for access by at least one remote client. In addition, at least one second server comprises at least one data processor executing an embedded business intelligence server (EBIS). The EBIS provides an interface to the platform to at least one business intelligence applications providing business intelligence functionality. With such a system, a unified interface can be rendered on the at least one remote client concurrently provides functionality from the platform and the at least one business intelligence client. Related apparatus, systems, techniques and articles are also described. | 03-20-2014 |
David Chaplin, Wtlington GB
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20090192098 | METHOD FOR TREATING HEMATOPOIETIC NEOPLASMS - This invention relates to methods for treating a hematopoietic neoplasm comprising administering a therapeutically effective amount of a combretastatin compound, or a pharmaceutically acceptable salt thereof, to a subject having a hematological malignancy, wherein the combretastatin compound comprises a catechol or quinone moiety and is capable of forming a reactive oxygen species (ROS) in vivo. The method may further comprise co-administering a second chemotherapeutic agent. | 07-30-2009 |
David Chaplin, Watlington GB
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20090264382 | Methods for Treating Hematopoietic Neoplasms - This invention relates to methods for treating, preventing and/or managing hematopoietic neoplasm in a subject by administering to the subject combretastatin A-4 phosphate, or a pharmaceutically acceptable salt thereof. The method may further comprise co-administering a chemotherapeutic agent. | 10-22-2009 |
20120270831 | METHOD FOR TREATING HEMATOPOIETIC NEOPLASMS - This invention relates to methods for treating a hematopoietic neoplasm comprising administering a therapeutically effective amount of a combretastatin compound, or a pharmaceutically acceptable salt thereof, to a subject having a hematological malignancy, wherein the combretastatin compound comprises a catechol or quinone moiety and is capable of forming a reactive oxygen species (ROS) in vivo. The method may further comprise co-administering a second chemotherapeutic agent. | 10-25-2012 |
David Chaplin, Oxfordshire GB
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20090137687 | Compositions and Methods With Enhanced Therapeutic Activity - This invention relates to novel tricyclic quinone and catechol compositions, compositions containing prodrugs of tricyclic quinone and catechol compositions, and methods of use for the treatment of solid tumor cancers and other vascular proliferative disorders. In certain aspects, the compositions of the invention are capable of generating both a vascular targeting effect and tumor cell cytotoxicity (e.g., by oxidative stress) in order to achieve an enhanced anti-tumor response in a patient. | 05-28-2009 |
20090209496 | METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY OF RTK INHIBITORS - This invention relates to methods for treating, preventing and/or managing cancer in a subject including enhancing the efficacy of a Receptor Tyrosine Kinase inhibitor (e.g., a small molecule RTK inhibitor, e.g., Sorafenib or Erlotinib) by administering to the subject a Vascular Disrupting Agent (e.g., a Combretastatin or derivative thereof) sequentially or simultaneously in combination with said RTK inhibitor. Pharmaceutical compositions comprising a combination of a RTK inhibitor and a VDA are also provided. | 08-20-2009 |
20090258937 | Methods for Modulating Tumor Growth and Metastasis - Methods and pharmaceutical compositions for modulating tumor growth or metastasis are provided. | 10-15-2009 |
David J. Chaplin, Watlington GB
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20130296605 | Compositions and Methods for Inhibition of Cathepsins - This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful. | 11-07-2013 |
20150031915 | Compositions and Methods for Inhibition of Cathepsins - This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful. | 01-29-2015 |
Derek Chaplin, Bollington GB
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20090139679 | FORMING SCREEN FOR USE IN A PAPER MACHINE - The invention relates to a forming screen for use in the forming section of a paper machine, comprising a paper and a machine side as well as longitudinal threads extending in the intended running direction and binding cross threads extending transversely thereto, wherein the longitudinal threads are divided in the ratio of the number of threads of 1:1 in a longitudinal thread layer on the machine side and a longitudinal thread layer on the paper side, and the binding cross threads bind in both longitudinal thread layers, which is characterized in that the forming screen has a fiber support index (FSI) which is in the range of 230 to 250 and has an air permeability which is in the range of 5700 to 10600 m | 06-04-2009 |
Derek Chaplin, Ottawa CA
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20140231039 | TEN-SHED SEMI-DUPLEX THROUGH-AIR DRYER FABRIC - A papermaker's through-air dryer (TAD) fabric for use in the production of tissue and towel products. The fabric is woven according to a 10-shed, semi-duplex weave design in which the warp and weft yarns are arranged so as to form pockets of at least two differing sizes in a first planar fabric surface. The pockets are designed and arranged to impart a measure of bulk and absorbency to the paper products conveyed thereon by providing MD oriented recesses in the PS fabric surface into which a portion of the component fibers of the paper products formed on the fabric are deflected during manufacture. | 08-21-2014 |
Derek Chaplin, Kanata CA
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20120175009 | METHOD OF MANUFACTURING INDUSTRIAL TEXTILES BY MINIMIZING WARP CHANGES AND FABRICS MADE ACCORDING TO THE METHOD - A method of weaving industrial textiles to a single warp platform, and textiles made thereby. The method comprises identifying optimal fabric characteristics for selected uses to determine groups of suitable fabrics; selecting a first group, identifying fabric properties for optimal characteristics, and identifying optimal properties for warp yarns to be used for all fabrics in the group; selecting a structure type and weave design for each fabric of the group; providing a loom with selected shedding options and installing warp yarns having the identified optimal properties. Thereafter, each fabric in the group can be woven without changing the warp yarns, simply by identifying properties for weft yarns to correspond with the weave design of the respective fabric, setting the loom accordingly and weaving the fabrics as required, adjusting only the weft parameters between successive fabrics, resulting in increased efficiency of manufacturing and avoiding time consuming warp changes between fabrics. | 07-12-2012 |
20150068698 | SINGLE LAYER PAPERMAKING FABRICS FOR MANUFACTURE OF TISSUE AND SIMILAR PRODUCTS - A woven single layer papermakers' fabric, having a sheet support surface and a machine side surface, comprises a set of monofilament machine direction (MD) oriented warp yarns interwoven with a set of monofilament weft yarns in a ten shed repeating weave pattern, wherein in each repeat of the repeating weave pattern, at least 50% of the warp yarns each forms in the sheet support surface at least one long float over nine consecutive weft yarns. Adjacent long floats define elongated MD oriented pockets in the sheet support surface. The fabrics provide improved properties for forming and conveying topographically patterned products such as tissue. | 03-12-2015 |
Jason Hugh Chaplin, Western Australia AU
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20100087430 | NOVEL BENZOFURAN POTASSIUM CHANNEL BLOCKERS AND USES THEREOF - The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of K | 04-08-2010 |
20100297077 | NOVEL ARYL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF - The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation. | 11-25-2010 |
Jason Hugh Chaplin, Victoria AU
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20090298931 | NOVEL CHROMENONE POTASSIUM CHANNEL BLOCKERS AND USES THEREOF - The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation. | 12-03-2009 |
20100004208 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS - The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors. | 01-07-2010 |
20100292190 | NOVEL TUBULIN POLYMERISATION INHIBITORS - The present invention relates to compounds of general formula (I) as tublin polymerisation inhibitors and methods for preparing such compounds. | 11-18-2010 |
Jason Hugh Chaplin, Thornbury AU
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20100048591 | CHEMICAL COMPOUNDS AND PROCESSES - The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which may possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds. | 02-25-2010 |
20120214770 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS - The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors. | 08-23-2012 |
20120309768 | NOVEL TUBULIN POLYMERISATION INHIBITORS - The present invention relates to compounds of general formula (I) as tublin polymerisation inhibitors and methods for preparing such compounds. | 12-06-2012 |
20130053351 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS - The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors. | 02-28-2013 |
20140171642 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS - The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors. | 06-19-2014 |
Kenneth Robert Chaplin, Deep River CA
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20140076053 | PROFILING TOOL FOR DETERMINING MATERIAL THICKNESS FOR INSPECTION SITES HAVING COMPLEX TOPOGRAPHY - A phased array ultrasonic probe may be mounted to a component to be inspected for wall thickness on an apparatus that includes a split ring adapted to be magnetically held in place on the component. In particular, the probe may be mounted to a carriage connected to the split ring in a manner that allows the carriage to rotate around the split ring while the probe is in operation. Between the probe and the component, a transducer shoe defining, by a flexible membrane, a cavity and an aperture. Conveniently, the construction of the flexible membrane allows wall thickness measurements to be acquired in portions of the component that have complex topography, such as welds. The apparatus is installed on an adaptor assembly for inspection of straight section of pipes. This adaptor assembly is not used in absence of straight section. By acquiring data from multiple output pulse transmitted at multiple incidence angles, processing software may conveniently produce an accurate wall thickness map of the area of interest on the component. | 03-20-2014 |
Kenneth Robert Chaplin, Toronto CA
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20150106055 | SUPPORT STRUCTURE DETECTION - While the typically-collected diameter data contains information for detecting some garter springs, many garter springs may not be detected without processing the diameter data. Responsively, a method for processing the diameter data to detect the garter springs has been developed. In particular, the processing involves fitting of the diameter data to a shape, determining residual errors and using the residual errors to locate garter springs. | 04-16-2015 |
Kevin Chaplin, Vancouver CA
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20100087836 | Surgical Instrument and Method for Tensioning and Securing a Flexible Suture - A surgical instrument may be used to apply tension to a flexible suture to close and secure a broken or cut bone (e.g. a sternum following a sternotomy). The device preferably applies an adjustable tension to the flexible suture in order to secure the bone together. Multiple instruments may be used together to ensure the desired tension is applied to the entire bone structure being secured with the flexible sutures. Once the desired tension is achieved, the device preferably provides a mechanism to apply a uniform twist to the flexible suture to lock the flexible suture in place and maintain the tension previously achieved. The device may automatically cut the flexible suture, or the flexible suture may be cut by the surgeon once the twisting action has been performed. | 04-08-2010 |
20100087837 | Surgical Instrument and Method for Tensioning and Securing a Flexible Suture - A surgical instrument may be used to apply tension to a flexible suture to close and secure a broken or cut bone (e.g. a sternum following a sternotomy). The device preferably applies an adjustable tension to the flexible suture in order to secure the bone together. Multiple instruments may be used together to ensure the desired tension is applied to the entire bone structure being secured with the flexible sutures. Once the desired tension is achieved, the device preferably provides a mechanism to apply a uniform twist to the flexible suture to lock the flexible suture in place. The instrument preferably decreases the upward tension applied to the flexible sutures over the duration of the application of twisting.. The device may automatically cut the flexible suture, or the flexible suture may be cut by the surgeon once the twisting action has been performed. | 04-08-2010 |
20150080902 | SURGICAL INSTRUMENT AND METHOD FOR TENSIONING AND SECURING A FLEXIBLE SUTURE - A surgical instrument may be used to apply tension to a flexible suture to close and secure a broken or cut bone (e.g. a sternum following a sternotomy). The device preferably applies an adjustable tension to the flexible suture in order to secure the bone together. Multiple instruments may be used together to ensure the desired tension is applied to the entire bone structure being secured with the flexible sutures. Once the desired tension is achieved, the device preferably provides a mechanism to apply a uniform twist to the flexible suture to lock the flexible suture in place. The instrument preferably decreases the upward tension applied to the flexible sutures over the duration of the application of twisting. The device may automatically cut the flexible suture, or the flexible suture may be cut by the surgeon once the twisting action has been performed. | 03-19-2015 |
Matthew David Chaplin, Calgary CA
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20140290812 | BARBEQUE COVER - A structurally reinforced barbeque cover having ribs is provided for use in combination with a barbeque having a retaining bracket, to provide convenient storage of the cover while the barbeque is in operation. | 10-02-2014 |
Michael J. Chaplin, Warwickshire GB
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20130104641 | APPARATUS AND METHODS FOR ORIENTING, STABILIZING, OR STABLY OPERATING A LOGGING TOOL | 05-02-2013 |
Michael John Chaplin, Nr Nuneaton GB
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20100108332 | Valve Assembly - A valve assembly ( | 05-06-2010 |
Michael John Chaplin, Warwickshire GB
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20150068737 | LOGGING TOOL AND METHOD OF USE - A logging tool or logging tool sub ( | 03-12-2015 |
Richard R. G. Chaplin, Cambridge CA
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20090094734 | SYSTEM AND APPARATUS FOR BACKLIGHTING SWIMMING POOLS - Lighting systems and apparatus for a swimming pool, having a sidewall sized and shaped to define a perimeter of the swimming pool, a liner for covering the sidewall and a bottom of the swimming pool so as to create a watertight cavity for receiving water, the liner including a light-transmitting portion, and a backlighting apparatus for mounting to a generally continuous surface of the sidewall between the liner and the sidewall and configured to transmit light through the light-transmitting portion of the liner to illuminate the swimming pool. In some embodiments, the backlighting apparatus includes a housing configured for mounting on the surface of the sidewall between the liner and the sidewall, the housing having a light-transmitting front cover configured to align with the light-transmitting portion of the liner, and at least one light source sized and shaped to fit within the housing for emitting light through the front cover to illuminate the pool. In other embodiments, the backlighting apparatus includes a rear sheet portion for mounting on the surface of the sidewall between the liner and the sidewall, a light-transmitting cover sheet portion connected to the rear sheet portion, and at least one light source provided between the rear sheet portion and the cover sheet portion for emitting light through the cover sheet portion and the light-transmitting portion of the liner to illuminate the swimming pool. | 04-16-2009 |