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Chan, MA
A. Ken Chan, Framingham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120083740 | Introducer Sheath for Catheters - An introducer sheath includes a tubular body portion having a proximal region and a distal region, and defines an internal lumen configured and dimensioned to slidably receive a catheter. A penetrating portion at a distal end of the tubular body has a first tapered configuration to enlarge an opening in a body tissue during distal advancement of the introducer sheath through the body tissue and a second expanded configuration to enable the passage of a distal end portion of a catheter through the penetrating portion. | 04-05-2012 |
Alex C. Chan, Auburn, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100088733 | DISTRIBUTED AUDIO AND VIDEO PROCESSING - A method of distributing audio and video processing tasks among devices interconnected to a display device via a local network is disclosed. In one embodiment, the display device offloads some processing tasks to a computing device on the local network to achieve improved processing performance. The computing device receives audiovisual data, decodes, processes, encodes and transmits the encoded data to the display device in a suitable data format. The processing in the computing device is complementary to any processing to be performed in the display device. In another embodiment, the display device utilizes a plurality of devices on the local network to perform particular signal processing tasks. The other devices in network perform the processing tasks indicated by the display, and send processed data back to the display device for presentation, which helps improve the overall audiovisual data processing performance. | 04-08-2010 |
Andy Chan, Franklin, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110180426 | Modulating Polarization Voltage of Amperometric Sensors - The service life of amperometric electrochemical oxygen sensors is increased by operating the electrodes of such sensors at a polarization voltage suitable for measuring the oxygen content of samples only during calibration or when measuring such samples and thereafter modulating the polarization voltage to a lower voltage such that substantially no electrical current is produced by the electrodes. | 07-28-2011 |
Andy D. C. Chan, Frenklin, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090045056 | Stable three enzyme creatinine biosensor - The invention provides methods for preparing a stable, multiple-use three enzyme biosensor for the amperometric determination of creatinine in biological liquids that has a useful lifetime that extends significantly beyond that of presently available amperometric biosensors. The biosensor prepared by the methods of the invention encompasses a plurality of immobilized enzymes that are applied to the biosensor as an enzyme-polymer composition. The enzymes, which can include creatinine amidohydrolase, creatine amidinohydrolase and sarcosine oxidase, are immobilized into the enzyme-polymer composition simultaneously as well as applied to the biosensor simultaneously. Prior to being immobilized, the enzymes can be chemically modified by attaching one or more polyethylene glycol (PEG) chains per enzyme monomer. The polymer component can be provided by a polyurethane membrane. The invention also provides a method of preparing a biosensor that limits the diffusion of silver ions emanating the reference electrode, thereby preventing, contact between the silver ions and the enzymes. Related methods of preparing an enzyme-polymer composition for incorporation into a multiple use three enzyme biosensor for the amperometric determination of creatinine in biological liquids also are provided. The invention also provides multiple-use biosensors and enzyme-polymer compositions prepared by the methods disclosed. | 02-19-2009 |
Cathy Chan, Burlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090304019 | METHOD AND DEVICE FOR REDUCING MULTICAST TRAFFICE IN A UPNP NETWORK - Methods and devices for facilitating communications over a Universal Plug and Play (UPnP) network are disclosed. These methods and devices reduce network traffic while maintaining maximum freshness of the UPnP controlled device status. These and other features of the present invention are accomplished by introducing an intermediary proxy device to moderate multicast messages that are transmitted over the network. The proxy device receives unicast messages from a UPnP controlled device and transmits multicast information on behalf of the UPnP controlled device at a lower rate. In addition, the proxy device can detect unexpected unavailability of the UPnP controlled device and promptly alert other control points on the UPnP network. | 12-10-2009 |
Chunkong Barden Chan, Allston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080199426 | Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders - Disclosed herein are methods for treating a vascular inflammatory disorder or endothelial cell disorder using inhibitor compounds that inhibit the expression or biological activity of Tie-1, Tie-1 endodomain, thrombin, VEGFR2, VEGFR2 endodomain, EphA2, and any of the cytokines or kinases that are upregulated by activation of Tie-1 or thrombin, as provided herein. Also disclosed are the use of combinations of inhibitor compounds or the use of an eNOS activator compound in combination with any one or more of the inhibitor compounds. Also disclosed are methods for inhibiting the pro-coagulant activity of thrombin using a Tie-1 or Tie-1 endodomain inhibitor compound or an EphA2 inhibitor compound. Methods for diagnosing and monitoring vascular inflammatory disorders or endothelial cell disorders that include the measurement of any of the polypeptides or nucleic acid molecules of the invention are also disclosed. | 08-21-2008 |
| 20100136001 | Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders - Disclosed herein are methods for treating a vascular inflammatory disorder or endothelial cell disorder using inhibitor compounds that inhibit the expression or biological activity of Tie-1, Tie-1 endodomain, thrombin, VEGFR2, VEGFR2 endodomain, EphA2, and any of the cytokines or kinases that are upregulated by activation of Tie-1 or thrombin, as provided herein. Also disclosed are the use of combinations of inhibitor compounds or the use of an eNOS activator compound in combination with any one or more of the inhibitor compounds. Also disclosed are methods for inhibiting the pro-coagulant activity of thrombin using a Tie-1 or Tie-1 endodomain inhibitor compound or an EphA2 inhibitor compound. Methods for diagnosing and monitoring vascular inflammatory disorders or endothelial cell disorders that include the measurement of any of the polypeptides or nucleic acid molecules of the invention are also disclosed. | 06-03-2010 |
| 20120003227 | METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF VASCULAR INFLAMMATORY DISORDERS OR ENDOTHELIAL CELL DISORDERS - Disclosed herein are methods for treating a vascular inflammatory disorder or endothelial cell disorder using inhibitor compounds that inhibit the expression or biological activity of Tie-1, Tie-1 endodomain, thrombin, VEGFR2, VEGFR2 endodomain, EphA2, and any of the cytokines or kinases that are upregulated by activation of Tie-1 or thrombin, as provided herein. Also disclosed are the use of combinations of inhibitor compounds or the use of an eNOS activator compound in combination with any one or more of the inhibitor compounds. Also disclosed are methods for inhibiting the pro-coagulant activity of thrombin using a Tie-1 or Tie-1 endodomain inhibitor compound or an EphA2 inhibitor compound. Methods for diagnosing and monitoring vascular inflammatory disorders or endothelial cell disorders that include the measurement of any of the polypeptides or nucleic acid molecules of the invention are also disclosed. | 01-05-2012 |
Clement Tsz Chan, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110262949 | GENETIC INCORPORATION OF 3-AMINOTYROSINE INTO REDUCTASES - This invention provides reductase proteins that comprise NH | 10-27-2011 |
Edwin P. Chan, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110062635 | Stimuli-responsive surfaces and related methods of fabrication and use - Biomimetic stimuli-responsive surfaces and articles of manufacture, together with methods of fabrication and related methods of use. | 03-17-2011 |
Elayne Chan, Auburndale, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110256526 | DETECTION OF HUMAN SOMATIC CELL REPROGRAMMING - The methods and kits described herein are based, in part, to the discovery phenotype representing a fully-reprogrammed iPS cell and several reprogramming intermediates. The methods and kits described herein permit identification of fully-reprogrammed iPS cells and further permits one of skill in the art to monitor the emergence of iPS cells during the reprogramming process. The methods/kits can also be performed using real time using live cell imaging. Also described herein are methods for screening candidate reprogramming agents by monitoring the emergence of fully-reprogrammed iPS cells in the presence and absence of such an agent. | 10-20-2011 |
Eugene Y. Chan, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110210272 | Methods and Products for Analyzing Polymers - Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers. | 09-01-2011 |
George Joe-Kueng Chan, Salem, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120107107 | ANTI-ROTATION SHROUD FOR TURBINE ENGINES - A shroud for turbine engines. The shroud has an integrated anti-rotation device that prevents circumferential movement of the shroud during normal engine operation, and which allows for circumferential installation in split annular case designs. Since the anti-rotation device is an integral part of the shroud and/or annular split turbine case, no additional parts are necessary for assembly or disassembly. Moreover, existing annular split turbine cases can be reworked to accept the anti-rotation device and yet still be backwards compatible with original shroud designs. | 05-03-2012 |
Jacky Chi-Hung Chan, Framingham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100206661 | ACOUSTIC WAVEGUIDE VIBRATION DAMPING - An acoustic waveguide with at least two portions coupled by vibration damping structure. The vibration damping structure may be a conformable material such as closed cell foam. The vibration damping structure may further include structure for inhibiting motion in a direction transverse to the interface between the vibration damping structure and a portion of the waveguide. | 08-19-2010 |
| 20110037906 | LOW FREQUENCY ENCLOSURE FOR VIDEO DISPLAY DEVICES - A television includes a flat panel display device for presenting video images, a housing for supporting the flat panel display device, and a first acoustic volume located substantially (a) inside the housing, and (b) behind the display device. Two or more acoustic drivers are provided for acoustically energizing the acoustic volume. The drivers are positioned such that acoustic energy put into the acoustic volume from the drivers is substantially additive and vibrational energy from the drivers substantially cancels out. | 02-17-2011 |
| 20110150259 | PORTABLE AUDIO SYSTEM HAVING WAVEGUIDE STRUCTURE - An apparatus includes a housing. A waveguide is located within the housing. The waveguide includes a first subsection that bends around a first axis and has a first cross-sectional area with an aspect ratio that is substantially different from unity. A second subsection bends around a second axis that is non-parallel to the first axis and includes a second cross-sectional area with an aspect ratio that is substantially different from unity. A third subsection acoustically couples the first subsection to the second subsection. The third subsection includes a third cross-sectional area with an aspect ratio that varies between the first aspect ratio and the second aspect ratio. | 06-23-2011 |
| 20110253473 | Acoustic Waveguide Vibration Damping - An acoustic waveguide with at least two portions coupled by vibration damping structure. The vibration damping structure may be a conformable material such as closed cell foam. The vibration damping structure may further include structure for inhibiting motion in a direction transverse to the interface between the vibration damping structure and a portion of the waveguide. | 10-20-2011 |
Joanne Chan, Medford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090280130 | METHOD FOR THE TREATMENT OF ANTHRAX TOXICITY - is a spore-forming Gram positive bacterium that is the causative agent of anthrax infection. Vascular leakage and pleural effusions are hallmarks of the fulminant phase of human anthrax disease following infection. The present invention provides a method of halting, treating, and preventing the rapid toxic effects of human anthrax disease by blocking the VEGF pathway with chemical inhibitors of the VEGFR signaling pathway. The invention is also applicable as an anti-anthrax therapeutic in bio-warfare defense. | 11-12-2009 |
John K. Chan, Needham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120117789 | Methods of Making a Cell Stack for an Electrical Purification Apparatus - An electrical purification apparatus and methods of making same are disclosed. The electrical purification apparatus may provide for increases in operation efficiencies, for example, with respect to current efficiencies and membrane utilization. | 05-17-2012 |
| 20120118728 | ELECTRICAL PURIFICATION APPARATUS HAVING A BLOCKING SPACER - An electrical purification apparatus and methods of making same are disclosed. The electrical purification apparatus may provide for increases in operation efficiencies, for example, with respect to current efficiencies and membrane utilization. | 05-17-2012 |
| 20120118738 | METHOD OF PROVIDING A SOURCE OF POTABLE WATER - An electrical purification apparatus and methods of making same are disclosed. The electrical purification apparatus may provide for increases in operation efficiencies, for example, with respect to current efficiencies and membrane utilization. | 05-17-2012 |
| 20120118743 | ELECTRICAL PURIFICATION APPARATUS - An electrical purification apparatus and methods of making same are disclosed. The electrical purification apparatus may provide for increases in operation efficiencies, for example, with respect to current efficiencies and membrane utilization. | 05-17-2012 |
Juliana Chan, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090074828 | POLY(AMINO ACID) TARGETING MOIETIES - The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries. | 03-19-2009 |
Juliana M. Chan, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110143993 | ENDOTHELIAL BASEMENT MEMBRANE TARGETING PEPTIDE LIGANDS - Peptides that selectively bind to antigens exposed in vascular disease or dysfunction have been identified by biopanning a phage library. The ligands are useful when attached to a substrate to be in contact with endothelial surfaces, especially those where drug delivery is utilized, such as following angioplasty, with release from a drug delivery reservoir in a medical device such as a stent, or by administration intravenously in the form of nano or microparticles, although the peptides may also be used with other medical devices or substrates, for targeting or to increase adhesion to endothelial surfaces. The nanoparticle technology can be used to treat injured vasculature, a clinical problem of primary importance. The targeted nanoparticles are also useful in the treatment of other diseases and disorders such as oncologic and regenerative diseases and indications where neoangiogenesis is commonly observed. | 06-16-2011 |
Julian M.w. Chan, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100316676 | Bisphosphonate Compounds and Methods for Bone Resorption Diseases, Cancer, Bone Pain, Immune Disorders, and Infectious Diseases - Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as | 12-16-2010 |
Julian M. W. Chan, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080318906 | BISPHOSPHONATE COMPOUNDS AND METHODS FOR BONE RESORPTION DISEASES, CANCER, BONE PAIN, IMMUNE DISORDERS, AND INFECTIOUS DISEASES - Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as | 12-25-2008 |
Kok Ping Chan, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110105515 | TARGETING THE ONCOPROTEIN NUCLEOPHOSMIN - (+)-Avrainvillamide, a naturally occurring alkaloid with antiproliferative activity, is shown to bind to the oncoprotein nucleophosmin. Nucleophosmin is known to regulate the tumor suppressor protein p53 and is overexpressed in many different human tumors. The invention provides methods of modulating nucleophosmin and p53 using (+)-avrainvillamide and analogues thereof. These compounds may provide leads for the development of novel anti-cancer therapies that target nucleophosmin. | 05-05-2011 |
Lana Hiului Chan, Northborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100035427 | METHODS FOR GROWING LOW-RESISTIVITY TUNGSTEN FILM - Improved methods for depositing low resistivity tungsten films are provided. The methods involve depositing a tungsten nucleation layer on a substrate and then depositing a tungsten bulk layer over the tungsten nucleation layer to form the tungsten film. The methods provide precise control of the nucleation layer thickness and improved step coverage. According to various embodiments, the methods involve controlling thickness and/or improving step coverage by exposing the substrate to pulse nucleation layer (PNL) cycles at low temperature. Also in some embodiments, the methods may improve resistivity by using a high temperature PNL cycle of a boron-containing species and a tungsten-containing precursor to finish forming the tungsten nucleation layer. | 02-11-2010 |
| 20100159694 | METHOD FOR DEPOSITING THIN TUNGSTEN FILM WITH LOW RESISTIVITY AND ROBUST MICRO-ADHESION CHARACTERISTICS - Methods of forming low resistivity tungsten films with good uniformity and good adhesion to the underlying layer are provided. The methods involve forming a tungsten nucleation layer using a pulsed nucleation layer process at low temperature and then treating the deposited nucleation layer prior to depositing the bulk tungsten fill. The treatment operation lowers resistivity of the deposited tungsten film. In certain embodiments, the depositing the nucleation layer involves a boron-based chemistry in the absence of hydrogen. Also in certain embodiments, the treatment operations involve exposing the nucleation layer to alternating cycles of a reducing agent and a tungsten-containing precursor. The methods are useful for depositing films in high aspect ratio and/or narrow features. The films exhibit low resistivity at narrow line widths and excellent step coverage. | 06-24-2010 |
| 20100273327 | METHOD FOR IMPROVING UNIFORMITY AND ADHESION OF LOW RESISTIVITY TUNGSTEN FILM - Methods of improving the uniformity and adhesion of low resistivity tungsten films are provided. Low resistivity tungsten films are formed by exposing the tungsten nucleation layer to a reducing agent in a series of pulses before depositing the tungsten bulk layer. According to various embodiments, the methods involve reducing agent pulses with different flow rates, different pulse times and different interval times. | 10-28-2010 |
| 20110223763 | METHODS FOR GROWING LOW-RESISTIVITY TUNGSTEN FOR HIGH ASPECT RATIO AND SMALL FEATURES - The present invention addresses this need by providing methods for depositing low resistivity tungsten films in small features and features having high aspect ratios. The methods involve depositing very thin tungsten nucleation layers by pulsed nucleation layer (PNL) processes and then using chemical vapor deposition (CVD) to deposit a tungsten layer to fill the feature. Depositing the tungsten nucleation layer involves exposing the substrate to alternating pulses of a boron-containing reducing agent and a tungsten-containing precursor without using any hydrogen gas, e.g., as a carrier or background gas. Using this process, a conformal tungsten nucleation layer can be deposited to a thickness as small as about 10 Angstroms. The feature may then be wholly or partially filled with tungsten by a hydrogen reduction chemical vapor deposition process. Resistivities of about 14 μΩ-cm for a 500 Angstrom film may be obtained. | 09-15-2011 |
| 20120015518 | METHOD FOR DEPOSITING THIN TUNGSTEN FILM WITH LOW RESISTIVITY AND ROBUST MICRO-ADHESION CHARACTERISTICS - Methods of forming low resistivity tungsten films with good uniformity and good adhesion to the underlying layer are provided. The methods involve forming a tungsten nucleation layer using a pulsed nucleation layer process at low temperature and then treating the deposited nucleation layer prior to depositing the bulk tungsten fill. The treatment operation lowers resistivity of the deposited tungsten film. In certain embodiments, the depositing the nucleation layer involves a boron-based chemistry in the absence of hydrogen. Also in certain embodiments, the treatment operations involve exposing the nucleation layer to alternating cycles of a reducing agent and a tungsten-containing precursor. The methods are useful for depositing films in high aspect ratio and/or narrow features. The films exhibit low resistivity at narrow line widths and excellent step coverage. | 01-19-2012 |
Lawrence K. Chan, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110028478 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-03-2011 |
| 20110028482 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-03-2011 |
| 20110034437 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-10-2011 |
| 20110274654 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are triazole FASN inhibitors of the formula (I): | 11-10-2011 |
| 20110274655 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are tetrazolone FASN inhibitors of the formula (I): | 11-10-2011 |
Lung Chan, Somerville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110194469 | SYSTEM AND METHOD FOR EXTENDING COMMUNICATION COVERAGE IN A WIRELESS NETWORK - A wireless communication system may include a first base station having a first communication coverage area and operating in an HFDD mode using a first frequency and a second frequency in an alternating pattern. The system may also include a second base station having a second communication coverage area different than the first communication coverage area and also operating in an HFDD mode. The second base station may communicate using the first frequency and the second frequency in an opposite alternating pattern from the first base station. | 08-11-2011 |
Marya L. Chan, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090013559 | Mechanical cushioning system for footwear - An element forming at least part of a midsole for footwear includes a top portion, a bottom portion, and at least two strut members disposed between the top and bottom plates for supporting the top plate a distance away from the bottom plate. The top, bottom and struts may be formed of different materials. Adjacent strut members have a C shaped cross-section facing in the same direction when the midsole resting its top or bottom portion is viewed from the side. The midsole element may further comprise a heel cleft to increase the flexibility of the sole. In a preferred embodiment, the strut members on the medial side are arranged at an angle to the strut members on the lateral side of the sole. The directional design provides flexibility and stiffness anisotropically to the sole in the longitudinal and lateral directions of the sole respectively. | 01-15-2009 |
Michael Tin-Lung Chan, Bedford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120016827 | BIOMETRICS WITH MENTAL/ PHYSICAL STATE DETERMINATION METHODS AND SYSTEMS - Methods and systems for determining whether a particular individual is to be granted, among other things, access to information, access to a particular room or other space, or permission to perform a given act or transaction are disclosed. For example, disclosed is an exemplary method that includes performing multiple biometrics tests on the individual to retrieve multiple biometrics test results, performing at least a first data fusion operation on the multiple biometrics test results to determine an identity result, performing at least one biological state test to determine one or more biological state test results of the individual, and conditionally granting authority to the individual based on the identity result and the one or more biological state results. | 01-19-2012 |
Nicholas Chan, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090265839 | Fluid Safety Liner - A fluid safety liner includes a liner of closed-cell foam that uses a series of channels and reservoirs to spread forces and distribute fluid contained within the liner throughout different areas of the liner. The liner is useable in protective gear such as a helmet and has a shape that conforms to the area of protection. The channel and reservoir system generally includes a mesh of coupled channels and reservoirs in the closed-cell foam. The channel and reservoir system also generally includes an incompressible fluid movable throughout the system for redistributing pressure and absorbing the force of any impact through viscous flow. The reduction in peak force and lengthening of the duration of the force reduces the biomechanical severity (e.g. HIC, Head Injury Criterion) of a blow to the protective gear. | 10-29-2009 |
Randolph W. Chan, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090034057 | COMPONENTS AND METHODS FOR USE IN ELECTRO-OPTIC DISPLAYS - A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described. | 02-05-2009 |
| 20090168067 | COMPONENTS AND METHODS FOR USE IN ELECTRO-OPTIC DISPLAYS - A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described. | 07-02-2009 |
| 20100142030 | COMPONENTS AND METHODS FOR USE IN ELECTRO-OPTIC DISPLAYS - A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described. | 06-10-2010 |
| 20100149630 | COMPONENTS AND METHODS FOR USE IN ELECTRO-OPTIC DISPLAYS - A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described. | 06-17-2010 |
| 20110075248 | COMPONENTS AND METHODS FOR USE IN ELECTRO-OPTIC DISPLAYS - A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described. | 03-31-2011 |
Raymond C. Chan, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080279430 | System and Method for Enabling Selection of an Image Registration Transformation - System and method for enabling intra-operative selection of an image registration transformation for use in displaying a first image dataset and a second image dataset in correspondence with one another. Image dataset acquisition devices ( | 11-13-2008 |
| 20100266220 | FEATURES-BASED 2D-3D IMAGE REGISTRATION - An image registration apparatus comprises: a features detector ( | 10-21-2010 |
Shi-Hong Chan, Ipswich, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080268507 | Recombinant Dna Nicking Endonuclease and Uses Thereof - Recombinant nicking endonucleases and associated methylases have been obtained and sequenced and their specificity has been defined. A mutant form of the nicking endonuclease has been cloned where the mutation includes deletion of amino acid sequences at the C-terminal end of the protein. The nicking enzymes have been used for a number of purposes including: amplifying DNA from as few cells as can be found in a single bacterial colony in the presence of a strand displacing polymerase; and for removing genomic DNA in a biological preparation where it is deemed to be a contaminant. | 10-30-2008 |
Siu-Hong Chan, Ipswich, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090029376 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions include restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 01-29-2009 |
| 20110151450 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-23-2011 |
Thomas Chan, Hopkinton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090214443 | METHOD FOR RETARDING SYSTEMIC DELIVERY RATE FOR EASILY ABSORBABLE ACTIVE AGENTS - Drugs such as hormones, which are easily absorbable through the stratum corneum into the vascular network, are administered to the skin of a patient in an absorption retarding matrix material, thereby retarding the rate at which the drug penetrates into and through the skin. | 08-27-2009 |
Thomas C.k. Chan, Winchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100297075 | COMBINATIONAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER - The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or a pyrroloquinolinyl-pyrrolidine-2,5-dione compound in combination with a therapeutically effective amount of a second anti-proliferative agent. | 11-25-2010 |
| 20110301194 | Method for Determining Treatment Efficacy - The present invention provides a method for determining the efficacy of a c-Met inhibitor in treating a cell proliferative disorder, comprising: a) administering to a subject in need thereof a therapeutically effective amount of the c-Met inhibitor, or a pharmaceutically acceptable salt, prodrug or metabolite thereof, either alone or in combination with a therapeutically effective amount of a second anti-proliferative agent; and b) measuring the concentration of hepatocyte growth factor (HGF) in the serum from the subject, wherein if the concentration of serum HGF does not decrease, or if the concentration of serum HGF increases, the c-Met inhibitor is efficacious in treating the cell proliferative disorder. | 12-08-2011 |
| 20120004191 | Combinational Compositions And Methods For Treatment Of Cancer - The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or a pyrroloquinolinyl-pyrrolidine-2,5-dione compound in combination with a therapeutically effective amount of a second anti-proliferative agent. | 01-05-2012 |
| 20120021432 | Phosphorylated NF45 Biomarkers, Antibodies And Methods Of Using Same - The present invention relates to isolated phosphorylated NF45 peptides and isolated phosphorylation site-specific antibody or antigen-binding portion thereof that specifically binds a phosphorylated NF45 protein. The present invention also relates to methods of utilizing these antibodies to determine the therapeutic efficacy of a candidate compound and methods for screening for candidate compounds that increase the phosphorylation of NF45 protein in a cell. | 01-26-2012 |
Timothy Chan, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110152260 | Indazole derivatives as modulators of interleukin-1 receptor-associated kinase - The present invention relates to modulators of IRAK kinases of formula (I) and provides compositions comprising such modulators, as well as methods therewith for treating IRAK-mediated or IRAK-associated conditions or diseases. | 06-23-2011 |
Walker Chan, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110284059 | THERMOPHOTOVOLTAIC ENERGY GENERATION - Inventive systems and methods for the generation of energy using thermophotovoltaic cells are described. Also described are systems and methods for selectively emitting electromagnetic radiation from an emitter for use in thermophotovoltaic energy generation systems. In at least some of the inventive energy generation systems and methods, a voltage applied to the thermophotovoltaic cell (e.g., to enhance the power produced by the cell) can be adjusted to enhance system performance. Certain embodiments of the systems and methods described herein can be used to generate energy relatively efficiently. | 11-24-2011 |
Yinthai Chan, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090068820 | Microspheres including nanoparticles - A microparticle can include a central region and a peripheral region. The peripheral region can include a nanoparticle, such as a metal nanoparticle, a metal oxide nanoparticle, or a semiconductor nanocrystal. The microparticle can be a member of a monodisperse population of particles. | 03-12-2009 |
| 20100303119 | Microfluidic Lasers - The present invention generally relates to lasers comprising fluidic channels, such as microfluidic channels. In some instances, the channel contains two or more fluids. The fluids may remain non-mixed within the channel, for example, due to immiscibility and/or laminar flow within the channel. The fluids may be arranged in the channel such that light propagating in a first fluid is prevented by the second fluid from exiting the first fluid, for example, due to differences in the indexes of refraction (e.g., causing internal reflection of the fluid to occur). Thus, in one embodiment, a first fluid may be at least partially surrounded by a second fluid having a second index of refraction lower than the index of refraction of the first fluid. In some embodiments, the fluidic channel is used as a laser, for instance, a dye laser, i.e., a laser created by directing light at a dye to produce coherent light. The dye may be present in one or more fluids within the fluidic channel. The incident light (for example, created by another laser) may be directed at the channel from any angle. In some cases, laser light may be produced in a direction substantially aligned with the longitudinal axis of the channel. In some embodiments, the laser is free of mirrors, prisms, or gratings, or the laser may produce coherent light using a non-resonant photonic pathway. However, in other cases, mirrors, prisms, or gratings may be used to reflect light along the channel to enhance stimulated emission of coherent light. Another aspect of the invention includes optical diffractors, such as prisms or gratings, which can contain a fluid. The optical diffractors, in certain embodiments, are positioned to diffract light, such as coherent light, emanating from the fluidic channel. Still other aspects of the invention provide devices, kits, and methods of making and using such lasers. | 12-02-2010 |
Yin Thai Chan, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110089375 | MICROSPHERES INCLUDING NANOPARTICLES - A microparticle can include a central region and a peripheral region. The peripheral region can include a nanoparticle, such as a metal nanoparticle, a metal oxide nanoparticle, or a semiconductor nanocrystal. The microparticle can be a member of a monodisperse population of particles. | 04-21-2011 |