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Chakrabartty
Avijit Chakrabartty, Vaughan CA
| Patent application number | Description | Published |
|---|---|---|
| 20080206251 | Methods and Compositions to Treat and Detect Misfolded-SOD1 Mediated Diseases - The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and macular degeneration, glaucoma, ischemia, cerebral infarction, myocardial infarction, atherosclerosis, multiple sclerosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease or necrotizing enterocolitis using disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention. | 08-28-2008 |
| 20110020358 | Methods and Compositions for Detecting Amyotrophic Lateral Sclerosis - The invention provides binding proteins that bind to misfolded or monomeric SOD1, and not to native homodimeric SOD1. The invention also includes methods of diagnosing, detecting or monitoring amyotrophic lateral sclerosis in a subject. In addition, the invention provides methods of identifying substances for the treatment or prevention of amyotrophic lateral sclerosis and kits using the binding proteins of the invention. | 01-27-2011 |
Avijit Chakrabartty, Toronto CA
| Patent application number | Description | Published |
|---|---|---|
| 20090280125 | Prion epitopes and methods of use thereof - Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease. | 11-12-2009 |
Avijit Chakrabartty, Vaughn CA
| Patent application number | Description | Published |
|---|---|---|
| 20110212097 | Methods and Compositions to Treat and Detect Misfolded-SOD1 Mediated Diseases - The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and macular degeneration, glaucoma, ischemia, cerebral infarction, myocardial infarction, atherosclerosis, multiple sclerosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease or necrotizing enterocolitis using disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention. | 09-01-2011 |
Shantanu Chakrabartty, Williamston, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20090120200 | SELF-POWERED SENSOR - A self-powered sensor is provided for strain-rate monitoring and other low power requirement applications. The self-powered sensor is comprised of: a piezoelectric transducer; a non-volatile memory comprised of at least one floating gate transistor; a current reference circuit adapted to receive a voltage signal from the piezoelectric transducer and operable to output a reference current into the non-volatile memory; an impact-monitoring circuit having a triggering circuit and a switch; the triggering circuit adapted to receive the voltage signal from the piezoelectric transducer and operable to control the switch based on the rate of change of the voltage signal. | 05-14-2009 |