| Patent application number | Description | Published |
|---|
| 20080213916 | Allosterically Catalyzed Signal Amplification in Chemical and Biological Sensing - Coordination complexes having at least two structural conformations are disclosed. The coordination complexes contain at least one metal center and at least one hemi-labile ligand, and change structural conformations due to the presence or absence of allosteric effectors. Methods of detecting an analyte using the coordination complexes are also disclosed. | 09-04-2008 |
| 20080225287 | ANALYTE DETECTION USING NANOWIRES PRODUCED BY ON-WIRE LITHOGRAPHY - The present invention relates to methods of detecting analytes using nanowires having nanodisk arrays. In particular, the present invention discloses methods of detecting analytes via surface enhanced Raman scattering (SERS) and employing nanowires prepared using on-wire lithography (OWL). | 09-18-2008 |
| 20080242559 | Protein and peptide arrays - Ultrahigh resolution patterning, preferably carried out by DIP PEN™ nanolithographic printing, can be used to construct peptide and protein nanoarrays with nanometer-level dimensions. The peptide and protein nanoarrays, for example, exhibit almost no detectable nonspecific binding of proteins to their passivated portions. This work demonstrates how DIP PEN™ nanolithographic printing can be used in a method to generate high density protein and peptide patterns, which exhibit bioactivity and virtually no non-specific adsorption. It also shows that one can use AFM-based screening procedures to study the reactivity of the features that comprise such nanoarrays. The method encompasses a wide range of protein and peptide structures including, for example, enzymes and antibodies. Features at or below 300 nm can be achieved. In a preferred embodiment, parallel printing with multipen systems are used. | 10-02-2008 |
| 20080269073 | DIRECT WRITE NANOLITHOGRAPHIC DEPOSITION OF NUCLEIC ACIDS FROM NANOSCOPIC TIPS - The use of direct-write nanolithography to generate anchored, nanoscale patterns of nucleic acid on different substrates is described, including electrically conductive and insulating substrates. Modification of nucleic acid, including oligonucleotides, with reactive groups such as thiol groups provides for patterning with use of appropriate scanning probe microscopic tips under appropriate conditions. The reactive groups provide for chemisorption or covalent bonding to the substrate surface. The resulting nucleic acid features, which exhibit good stability, can be hybridized with complementary nucleic acids and probed accordingly with use of, for example, nanoparticles functionalized with nucleic acids. Patterning can be controlled by selection of tip treatment, relative humidity, and nucleic acid structure. | 10-30-2008 |
| 20080274454 | Reversible and Chemically Programmable Micelle Assembly With Dna Block-Copolymer Amphiphiles - The present invention is directed to amphiphilic block copolymers. More particularly the present invention is directed to amphiphilic block copolymers comprising a polynucleotide block and a hydrophobic polymer block, to micelles formed from the block copolymers, and to methods of using the micelles. | 11-06-2008 |
| 20080293588 | NANODISK CODES - The invention relates to nanodisk codes and methods of using the nanodisk codes in encoding and detection schemes. In one aspect, the invention relates to nanodisk codes having a binary encoding scheme and functionalized such that the encoding of the nanodisk codes is detectable. | 11-27-2008 |
| 20080295646 | Method of Making Metal Nanoprisms Having a Predetermined Thickness - A method of preparing metal nanoprisms having a unimodal size distribution and a predetermined thickness. The present method also allows control over nanoprism edge length. | 12-04-2008 |
| 20080306016 | Nucleic Acid Functionalized Nanoparticles for Therapeutic Applications - Materials and Methods for modulating cellular uptake of functionalized nanoparticles are provided. Also provided are materials and methods for modulating the effectiveness of a therapeutic agent with a functionalized nanoparticle. | 12-11-2008 |
| 20080311669 | SCREENING SEQUENCE SELECTIVITY OF OLIGONUCLEOTIDE-BINDING MOLECULES USING NANOPARTICLE BASED COLORIMETRIC ASSAY - Disclosed herein are methods of screening sequence selectivity of oligonucleotide-binding molecules using a gold nanoparticle based calorimetric assay. | 12-18-2008 |
| 20090025556 | Metal-Organic Framework Materials Based on Icosahedral Boranes and Carboranes - Disclosed herein are metal-organic frameworks of metals and boron rich ligands, such as carboranes and icosahedral boranes. Methods of synthesizing and using these materials in gas uptake are disclosed. | 01-29-2009 |
| 20090130455 | UNIVERSAL PHOSPHORAMIDITE FOR PREPARATION OF MODIFIED BIOMOLECULES AND SURFACES - Reagents useful for attaching biomolecules (e.g., proteins, oligonucleotides, and other biomolecules) to a surface, processes of attaching molecules to a surface to form modified surfaces using these reagents, and methods of detecting a target compound using these modified surfaces are disclosed. | 05-21-2009 |
| 20090133169 | Independently-addressable, self-correcting inking for cantilever arrays - An improved method of loading tips and other surfaces with patterning compositions or inks for use in deposition. A method of patterning is described, the method comprising: (i) providing at least one array of tips; (ii) providing a plurality of patterning compositions; (iii) ink jet printing at least some of the patterning compositions onto some of the tips; and (iv) depositing at least some of the patterning compositions onto a substrate surface; wherein the ink jet printing is adapted to prevent substantial cross-contamination of the patterning composition on the tips. Good printing reproducibility and control of printing rate can be achieved. The surfaces subjected to ink jet printing can be treated to encourage localization of the ink at the tip. The method is particularly important for high density arrays. | 05-21-2009 |
| 20090143246 | Patterning with compositions comprising lipid - Better patterning methods, including for better methods for forming biomolecular arrays, including a method comprising: providing a tip and a substrate surface, disposing a patterning composition at the end of the tip, depositing at least some of the patterning composition from the tip to the substrate surface to form a deposit disposed on the substrate surface, wherein the patterning composition comprises at least one lipid, optionally at least one solvent, and at least one patterning species different from the lipid and the optional solvent. The lipid can be a phospholipid such as DOPC. The patterning species can be an oligonucleotide or a protein. Microarrays and nanoarrays can be prepared including nanoscale resolution of deposits. The lipid can activate patterning or increase the rate of patterning. Simplified tip preparation can be achieved. Nanoscopic, SPM, and AFM tips can be used. | 06-04-2009 |
| 20090145742 | ENERGY TRANSFER THROUGH SURFACE PLASMON RESONANCE EXCITATION ON MULTISEGMENTED NANOWIRES - Disclosed herein is energy transfer on multisegmented nanowires via surface plasmon resonance excitation of visible light, such as solar energy, absorbed by metals sensitive to visible light and transferred to metals insensitive to visible light. The nanowires are prepared with controllable gap sizes between different segments by on-wire lithography (OWL). | 06-11-2009 |
| 20090155587 | Multicomponent Nanorods - Multicomponent nanorods having segments with differing electronic and/or chemical properties are disclosed. The nanorods can be tailored with high precision to create controlled gaps within the nanorods or to produce diodes or resistors, based upon the identities of the components making up the segments of the nanorods. Macrostructural composites of these nanorods also are disclosed. | 06-18-2009 |
| 20090155785 | REAL-TIME COLORIMETRIC SCREENING INHIBITORS OF ENDONUCLEASE WITH GOLD NANOPARTICLE SUBSTRATE - The invention provides methods for screening a compound for its effect on endonuclease activity. The methods comprise providing a compound to be screened utilizing a gold nanoparticle aggregate as the substrate for the endonuclease. The gold nanoparticle aggregate is formed by the hybridization of oligonucleotides attached to the nanoparticles, with or without the presence of a third linker oligonucleotide. The hybridized oligonucleotide duplex serves as a substrate for the endonuclease. A detectable change is brought about in the presence of the endonuclease activity. A decrease in the detectable change reflects the reduced levels of endonuclease activities as a result of the effects of endonuclease inhibitors. The present invention also provides kits for screening an endonuclease inhibitor. | 06-18-2009 |
| 20090166222 | ELECTRICAL NANOTRAPS FOR SPECTROSCOPICALLY CHARACTERIZING BIOMOLECULES WITHIN - A method that combines on-wire-lithography (OWL) nanogaps, an electric field concentrating technique, and surface enhanced Raman spectroscopy (SERS) is disclosed for sensitive detection of analytes with small sample sizes in a chip format. | 07-02-2009 |
| 20090209629 | Nucleic Acid Functionalized Nanoparticles for Therapeutic Applications - Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided. | 08-20-2009 |
| 20090211445 | AMORPHOUS INFINITE COORDINATION POLYMER MICROPARTICLES AND USE FOR HYDROGEN STORAGE - Infinite coordination polymeric (ICP) materials are disclosed. One ICP material has a formula | 08-27-2009 |
| 20090220400 | Gas adsorption and gas mixture separations using carborane-based MOF material - A method of separating a mixture of carbon dioxide and a hydrocarbon gas using a metal-organic framework (MOF) material having a three-dimensional carborane ligand structure. | 09-03-2009 |
| 20090221095 | Colorimetric Screening of DNA Binding/Intercalating Agents with Gold Nanoparticle Probes - Methods are provided to identify and characterize compounds that bind with duplex and triplex polynucleotides. | 09-03-2009 |
| 20090280188 | ASYMMETRIC FUNCTIONALIZATED NANOPARTICLES AND METHODS OF USE - Disclosed herein are asymmetrically functionalized nanoparticles. Further disclosed herein are methods of preparing asymmetrically functionalized nanoparticles. Asymmetrically functionalized nanoparticles can be used in various therapeutic methods. | 11-12-2009 |
| 20090308202 | METHODS OF MAKING NANOPRISMS - The invention is a novel photo-induced method for converting large quantities of silver nanospheres into nanoprisms, the nanoprisms formed by this method and applications in which the nanoprisms are useful. Significantly, this light driven process results in a colloid with a unique set of optical properties that directly relate to the nanoprism shape of the particles. Theoretical calculations coupled with experimental observations allow for the assignment of the nanoprism plasmon bands and the first identification of two distinct quadrupole plasmon resonances for a nanoparticle. Finally, unlike the spherical particles from which they derive and which Rayleigh light scatter in the blue, these nanoprisms exhibit-scattering in the red, permitting multicolor diagnostic labels based not only on nanoparticle composition and size but also on shape. | 12-17-2009 |
| 20090324706 | Nanostructures Suitable for Sequestering Cholesterol and Other Molecules - Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels. | 12-31-2009 |
| 20090325812 | Nanoparticles having oligonucleotides attached thereto and uses therefor - The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids. | 12-31-2009 |
| 20100021894 | Nanoparticle-Based Colorimetric Detection Of Cysteine - The invention provides methods to detect cysteine which employ oligonucleotide functionalized nanoparticles. | 01-28-2010 |
| 20100040847 | METHODS UTILIZING SCANNING PROBE MICROSCOPE TIPS AND PRODUCTS THEREFOR OR PRODUCED THEREBY - The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN). DPN utilizes a scanning probe microscope (SPM) tip (e.g., an atomic force microscope (AFM) tip) as a “pen,” a solid-state substrate (e.g., gold) as “paper,” and molecules with a chemical affinity for the solid-state substrate as “ink.” Capillary transport of molecules from the SPM tip to the solid substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN and kits for performing DPN. | 02-18-2010 |
| 20100048427 | UNIVERSAL MATRIX - A method comprises: (i) providing a tip and a substrate surface, (ii) disposing a patterning composition at the end of the tip, (iii) depositing at least some of the patterning composition from the tip to the substrate surface to form a deposit disposed on the substrate surface, wherein the patterning composition comprises at least one patterning species, at least one carrier that is different from the patterning species, and at least one additive different from the patterning species and the carrier. | 02-25-2010 |
| 20100059475 | METHOD OF NANOSCALE PATTERNING USING BLOCK COPOLYMER PHASE SEPARATED NANOSTRUCTURE TEMPLATES - A method of forming nanostructures using block copolymer nanostructure templates is disclosed herein. The method includes forming a nanostructure template by patterning a block copolymer on a substrate and allowing the block copolymer to phase separate to form the nanostructure template. The nanostructure template can then be loaded with a nanostructure precursor material. The nanostructure template is removed to form the nanostructure. | 03-11-2010 |
| 20100068817 | COLORIMETRIC DETECTION OF METALLIC IONS IN AQUEOUS MEDIA USING FUNCTIONALIZED NANOPARTICLES - Disclosed herein are methods of detecting metal ions in a sample using functionalized nanoparticles. More specifically, functionalized nanoparticles are used to selectively detect metal ions in a sample using changes in melting temperature of hybridized oligonucleotides on functionalized nanoparticles. The melting temperature can be detected using absorbance, color change, or both. In some cases, the concentration of the metal ion in the sample can be determined. Concentrations of metal ion of as little as 20 ppb (about 100 nM) can be detected using the disclosed methods. | 03-18-2010 |
| 20100071098 | SCANNING PROBE EPITAXY - A dual tip probe for scanning probe epitaxy is disclosed. The dual tip probe includes first and second tips disposed on a cantilever arm. The first and second tips can be a reader tip and a synthesis tip, respectively. The dual tip probe further includes a rib disposed on the cantilever arm between the first and second tips. The dual tip probe can also include a strain gauge disposed along the length of the cantilever arm. | 03-18-2010 |
| 20100081134 | BIO-BARCODE BASED DETECTION OF TARGET ANALYTES - The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in a solution. | 04-01-2010 |
| 20100092372 | HALIDE ION CONTROL OF SEED MEDIATED GROWTH OF ANISOTROPIC GOLD NANOPARTICLES - Methods of forming nanoprisms or nanorods from gold seed particles by adding controlled amounts of iodide ion to the growth solution are disclosed. | 04-15-2010 |
| 20100098857 | METHODS UTILIZING SCANNING PROBE MICROSCOPE TIPS AND PRODUCTS THEREFOR OR PRODUCED THEREBY - The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN). DPN utilizes a scanning probe microscope (SPM) tip (e.g., an atomic force microscope (AFM) tip) as a “pen,” a solid-state substrate (e.g., gold) as “paper,” and molecules with a chemical affinity for the solid-state substrate as “ink.” Capillary transport of molecules from the SPM tip to the solid substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN and kits for performing DPN. | 04-22-2010 |
| 20100099858 | Maximizing Oligonucleotide Loading on Gold Nanoparticle - Increasing the amount of DNA loaded onto gold nanoparticles is disclosed. More particularly, methods of maximizing DNA loading, using salting techniques, sonication, temperature and other such procedures are disclosed. | 04-22-2010 |
| 20100115672 | SCANNING PROBE EPITAXY - A dual tip probe for scanning probe epitaxy and a method of forming the dual tip probe are disclosed. The dual tip probe includes first and second tips disposed on a cantilever arm. The first and second tips can be a reader tip and a synthesis tip, respectively. The first tip can remain in contact with a substrate during writing and provide in situ characterization of the substrate and or structures written, while the second tip can perform in non-contact mode to write and synthesis nanostructures. This feature can allow the dual tip probe to detect errors in a printed pattern using the first tip and correct the errors using the second tip. | 05-06-2010 |
| 20100129793 | COMPOSITE PARTICLES - Composite particles and methods of synthesizing a composite particle are disclosed, in particular, methods of synthesizing a composite particle comprising a dielectric component, a magnetic component, and a gold shell are disclosed. Further disclosed herein are methods of detecting a target compound using the composite particles of the present invention. Also disclosed are photonic crystals that can be manipulated with an external magnetic field comprising the composite particles of the present invention. | 05-27-2010 |
| 20100129808 | PARTICLES FOR DETECTING INTRACELLULAR TARGETS - Methods describing the use of nanoparticles modified with binding moieties are provided. | 05-27-2010 |
| 20100133489 | Photoinduced phase separation of gold in two-component nanoparticles to form nanoprisms - Nanoprisms containing silver and gold are disclosed. The nanoprisms exhibit the properties of pure silver nanoprisms, but are less susceptible to silver modification or reaction by a surrounding environment than pure silver nanoprisms due to the presence of the gold. The gold surface of the nanoprisms can be further modified, using known gold-modification techniques. | 06-03-2010 |
| 20100136682 | Polyvalent RNA-Nanoparticle Compositions - The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating RNA to a nanoparticle to achieve increased stability and activity. | 06-03-2010 |
| 20100143666 | REDOX ACTIVATED PATTERNING - A method of forming a target pattern using a redox activated surface is disclosed. The method includes patterning a redox agent on a template layer formed on a substrate, the template layer having a first oxidation state, wherein upon contact with the redox agent, the contacted portion of the template layer changes to a second oxidation state different than the first oxidation state, and a template pattern is formed from the portion of the template layer having either the first oxidation state or the second oxidation state, and exposing the substrate having the template pattern to a target material, wherein the target material selectively binds to the template pattern to form a target pattern. | 06-10-2010 |
| 20100160182 | Metal Ion-Based Immobilization - A method for immobilizing unmodified material using a metal-ion approach is provided wherein the material is immobilized on a surface in an active state on surface features coupled with metal-ions. | 06-24-2010 |
| 20100167290 | MOLECULE ATTACHMENT TO NANOPARTICLES - Disclosed herein are molecule-modified nanoparticles and methods of making and using the same. More specifically, disclosed herein are molecule-modified nanoparticles wherein the molecule is attached to the surface of the nanoparticle via an oligonucleotide. Also disclosed are methods of preparing nanoparticles having oligonucleotides and molecules (e.g., biomolecules, such as proteins, peptides, antibodies, lipids, and/or carbohydrates) attached to the nanoparticle surface, wherein the oligonucleotide and molecule are covalently attached. Further disclosed are methods of detecting an analyte of interest using these disclosed molecule-modified nanoparticles. | 07-01-2010 |
| 20100184844 | Inhibition of Bacterial Protein Production by Polyvalent Oligonucleotide Modified Nanoparticle Conjugates - The present invention is directed to oligonucleotide-modified nanoparticle conjugates and methods of inhibiting bacterial protein production. | 07-22-2010 |
| 20100233270 | Delivery of Oligonucleotide-Functionalized Nanoparticles - The present invention relates to compositions and methods for delivering an oligonucleotide-functionalized nanoparticle. | 09-16-2010 |
| 20100234579 | SILVER NANOPARTICLE BINDING AGENT CONJUGATES BASED ON MOIETIES WITH TRIPLE CYCLIC DISULFIDE ANCHORING GROUPS - The present invention concerns the use of binding agent-functionalized silver nanoparticles for a variety of uses, including molecular diagnostic labels, synthons in programmable materials synthesis approaches, and functional components for nanoelectronic devices. More specifically, the invention provides a new strategy for preparing silver nanoparticle-binding agent conjugates that are based upon moieties with triple cyclic disulfide-anchoring groups. | 09-16-2010 |
| 20100239675 | PLASMON MEDIATED PHOTOINDUCED SYNTHESIS OF SILVER TRIANGULAR BIPYRAMIDS - A method of preparing silver triangular bipyramids having a high shape selectivity and low edge length variation is disclosed. Also disclosed are silver triangular bipyramids prepared by this method. | 09-23-2010 |
| 20100291697 | Coated Colloidal Materials - Coated colloidal materials, methods for making coated colloidal materials, and methods of using coated colloidal materials are disclosed. The method yields coated colloidal materials where the optical characteristics of the core is not adversely affected. The coated colloidal materials can be self-assembled into films, layers, or structures and used in the detection of analytes through detection assays. | 11-18-2010 |
| 20100291707 | Multiplexed Scanometric Assay for Target Molecules - The present invention is directed to compositions and methods of use of a functionalized nanoparticle having a catalytic metal deposit. | 11-18-2010 |
| 20100294952 | CONTROLLED AGENT RELEASE AND SEQUESTRATION - Disclosed are nanostructures having nanoprisms and agents, such as diagnostic and/or therapeutic agents. Nanoprisms with a surface plasmon resonance in the near-infrared convert irradiation, such as from a laser into heat selectively to allow the dissociation, such as dehybridization of oligonucleotide duplexes, of agents associated with the nanoprism surface. These nanostructures show morphological, chemical, and functional stability under hours of irradiation. Further disclosed are methods of selectively releasing agents from nanostructures after directed surface plasmon resonance mediated heating of the nanoprisms. Released agents, such as oligonucleotides, are unharmed by this process and can be repeatedly released and sequestered under spatiotemporal control. | 11-25-2010 |
| 20100304173 | Plasmonic-Driven Synthesis of Nanoprisms from Isotropic and Anisotropic Gold Cores - A nanoprism having a prismatic silver shell formed about a gold core and a process of forming the same are disclosed. The process includes irradiating a mixture of gold and silver nanoparticles with a narrow band of wavelengths capable of exciting the surface plasmon resonance of the gold. | 12-02-2010 |
| 20100330345 | METHODS UTILIZING SCANNING PROBE MICROSCOPE TIPS AND PRODUCTS THEREOF OR PRODUCED THEREBY - The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN). DPN utilizes a scanning probe microscope (SPM) tip (e.g., an atomic force microscope (AFM) tip) as a “pen,” a solid-state substrate (e.g., gold) as “paper,” and molecules with a chemical affinity for the solid-state substrate as “ink.” Capillary transport of molecules from the SPM tip to the solid substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN, including submicrometer combinatorial arrays, and kits, devices and software for performing DPN. The invention further provides a method of performing AFM imaging in air. The method comprises coating an AFM tip with a hydrophobic compound, the hydrophobic compound being selected so that AFM imaging performed using the coated AFM tip is improved compared to AFM imaging performed using an uncoated AFM tip. Finally, the invention provides AFM tips coated with the hydrophobic compounds. | 12-30-2010 |
| 20110033940 | CLICK CHEMISTRY, MOLECULAR TRANSPORT JUNCTIONS, AND COLORIMETRIC DETECTION OF COPPER - Click chemistry is used to construct molecular transport junctions (MTJs) through assembly of a molecular wire across a nanogap formed between two electrodes. Also disclosed are methods of using click chemistry and oligonucleotide-modified nanoparticles to detect the presence of copper in a sample. | 02-10-2011 |
| 20110059156 | Nanostructures Suitable for Sequestering Cholesterol and Other Molecules - Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels. | 03-10-2011 |
| 20110059431 | NON-ENZYMATIC DETECTION OF BACTERIAL GENOMIC DNA - The present invention relates to methods for detecting for the presence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes blocking strands to inhibit target rehybridization to detect double stranded genomic DNA. | 03-10-2011 |
| 20110081526 | PATTERNING OF SOLID STATE FEATURES BY DIRECT WRITE NANOLITHOGRAPHIC PRINTING - The present invention includes a method of fabricating organic/inorganic composite nanostructures on a substrate comprising depositing a solution having a block copolymer and an inorganic precursor on the substrate using dip pen nanolithography. The nanostructures comprises arrays of lines and/or dots having widths/diameters less than 1 micron. The present invention also includes a device comprising an organic/inorganic composite nanoscale region chemically bonded to a substrate, wherein the nanoscale region, wherein the nanoscale region has a nanometer scale dimension other than height. | 04-07-2011 |
| 20110111974 | Short Duplex Probes for Enhanced Target Hybridization - The present disclosure is directed to compositions and methods for detecting or associating with a target polynucleotide. | 05-12-2011 |
| 20110132220 | POLYMER PEN LITHOGRAPHY - The disclosure relates to methods of printing indicia on a substrate using a tip array comprised of elastomeric, compressible polymers. The tip array can be prepared using conventional photolithographic methods and can be tailored to have any desired number and/or arrangement of tips. Numerous copies (e.g., greater than 15,000, or greater than 11 million) of a pattern can be made in a parallel fashion in as little as 40 minutes. | 06-09-2011 |
| 20110160511 | Gas adsorption and gas mixture separations using porous organic polymer - A method of separating a mixture of carbon dioxide and methane using a porous organic polymer material which includes non-planar monomeric building blocks linked by imide linkers wherein the polymer material selectively absorbs CO | 06-30-2011 |
| 20110165329 | Force Feedback Leveling of Tip Arrays for Nanolithography - A method of leveling a polymer pen array includes contacting a pen array with a surface and measuring a total force exerted on the surface by the pen array, the pen array being disposed at a first angle with respect to a first axis of the surface and a second angle with respect to a second axis of the surface; tilting one or both of the pen array and the surface to vary the first and second angles of the pen array with respect to the surface; measuring the total force exerted by the tilted pen array on the surface; and repeating the tilting and measuring steps until a global maximum of the total force exerted on the surface by the pen array is measured, thereby determining first and second angles which correspond to a leveled position of the pen array with respect to the surface. | 07-07-2011 |
| 20110165341 | BLOCK COPOLYMER-ASSISTED NANOLITHOGRAPHY - In accordance with an embodiment of the disclosure, a method for forming submicron size nanostructures on a substrate surface includes contacting a substrate with a tip coated with an ink comprising a block copolymer matrix and a nanostructure precursor to form a printed feature comprising the block copolymer matrix and the nanostructure precursor on the substrate, and reducing the nanostructure precursor of the printed feature to form a nanostructure having a diameter (or line width) of less than 1 μm. | 07-07-2011 |
