Patent application number | Description | Published |
20090137039 | TARGETING OPPOSITE STRAND REPLICATION INTERMEDIATES OF SINGLE-STRANDED VIRUSES BY RNAI - The invention relates to methods and compositions for modulating viral replication through double-stranded RNA-mediated gene silencing (RNAi), wherein the antiviral methods and compositions preferentially target opposite strand replication intermediates of single-stranded RNA viruses. | 05-28-2009 |
20090311788 | MULTIPLE-COMPARTMENT EUKARYOTIC EXPRESSION SYSTEMS - Method and constructs for expressing heterologous sequences of interest in eukaryotic cells using multiple-compartment expression systems. These systems, which may be comprised of a single construct or multiple constructs, utilize at least two different promoters which are each active within a different subcellular compartment of the same eukaryotic cell. The system and constructs of the invention are particularly useful for achieving enhanced in vivo expression of RNA molecules capable of modulating the expression of target genes. | 12-17-2009 |
20100323001 | In Vivo Delivery Of Double Stranded RNA To a Target Cell - The invention encompasses methods of delivering nucleic acids, including dsRNA, to mammalian target cells in vivo via intercellular transfer, wherein the dsRNA is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsRNA to the target cell. | 12-23-2010 |
20130302403 | Vivo Delivery of Double Stranded RNA to an Interleukin-12 Producing Organ or Tissue - The invention encompasses methods of delivering nucleic acids, including dsRNA, to mammalian target cells in vivo via intercellular transfer, wherein the dsRNA is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsRNA to the target cell. | 11-14-2013 |
20130344133 | In Vivo Delivery of Nucleic Acids to the Liver or Liver Tissue - The invention encompasses methods of delivering nucleic acids, including dsRNA, to mammalian target cells in vivo via intercellular transfer, wherein the dsRNA is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsRNA to the target cell. | 12-26-2013 |
20140348882 | IN VIVO DELIVERY OF NUCLEIC ACIDS TO THE LIVER OR LIVER TISSUE - The invention encompasses methods of delivering nucleic acids, including dsRNA, to mammalian target cells in vivo via intercellular transfer, wherein the dsRNA is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsRNA to the target cell. | 11-27-2014 |
20140349390 | IN VIVO DELIVERY OF NUCLEIC ACIDS TO THE LIVER OR LIVER TISSUE - The invention encompasses methods of delivering nucleic acids, including dsRNA, to mammalian target cells in vivo via intercellular transfer, wherein the dsRNA is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsRNA to the target cell. | 11-27-2014 |
20150297625 | In Vivo Delivery of Nucleic Acids to the Liver or Liver Tissue - The invention encompasses methods of delivering nucleic acids, including dsRNA, to mammalian target cells in vivo via intercellular transfer, wherein the dsRNA is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsRNA to the target cell. | 10-22-2015 |