| Patent application number | Description | Published |
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| 20100155323 | FUNCTIONALIZED NONWOVEN ARTICLE - A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising cationic aminoalkyl(meth)acryloyl monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as oligonucleotides or monoclonal antibodies (MAb), from a fluid mixture. | 06-24-2010 |
| 20100320138 | FUNCTIONALIZED NONWOVEN ARTICLE - A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising anionic monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as monoclonal antibodies (MAb), from a fluid mixture. | 12-23-2010 |
| 20110006007 | COMPOSITE POLYMERIC FILTRATION MEDIA - Provided are filtration media, matrixes, and systems for liquid purification that utilize functional polymer particles. The functional polymer particles can comprise a cationic charge. Exemplary functional polymer particles comprise comprise [3-(methacryloylamino)propyl]-trimethylammonium chloride (MAPTAC) polymerized with trimethylolpropane trimethacrylate (TMPTMA). | 01-13-2011 |
| 20110033633 | METHOD OF MAKING LIGAND FUNCTIONALIZED SUBSTRATES - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 02-10-2011 |
| 20110100916 | SOLID SUPPORT WITH A GRAFTED CHAIN - Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample. | 05-05-2011 |
| 20110201078 | LIGAND FUNCTIONALIZED POLYMERS - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 08-18-2011 |
| 20110217752 | LIGAND FUNCTIONALIZED POLYMERS - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 09-08-2011 |
| Patent application number | Description | Published |
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| 20090054926 | EXTRA-VASCULAR SEALING DEVICE AND METHOD - Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. In one embodiment, the closure device includes a vessel locating member, an anchor and a sealing material. The closure device may be configured to deploy the anchor and the sealing material outside of a hole in a blood vessel to close the hole. The vessel locating member may be used to locate the blood vessel to ensure that the anchor and/or the sealing material are properly placed adjacent to the hole. The closure device may also include a tamper member configured to push or tamp the sealing material against the anchor. The closure device may also include a suture that is used to hold the sealing material and the anchor together adjacent to the hole in the blood vessel. | 02-26-2009 |
| 20090171281 | SYSTEMS AND METHODS FOR LOCATING AND CLOSING A TISSUE PUNCTURE - A vascular closure device includes a main body and an expandable portion that can be selectively expanded and contracted. The vascular closure device may be used to close the hole in a wall of a vessel after a medical procedure. For example, the vascular closure device may be used to close the hole in an artery after a medical procedure that required access to the artery. In one embodiment, the expandable portion may be oriented at an oblique angle relative to the main body. This may be desirable in situations where the vessel puncture is oriented at an angle relative to the vessel. Orienting the expandable portion at an oblique angle relative to the main body may help the expandable portion to cover the hole in the wall of the vessel. | 07-02-2009 |
| 20090171282 | VASCUAR CLOSURE DEVICE HAVING A FLOWABLE SEALING MATERIAL - Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device is configured to safely and accurately deploy a sealing material that undergoes a phase change when deployed inside the tissue tract. The sealing material may be a solid at room temperature and a liquid or gel at body temperature. Also, the sealing material may change from a liquid or gel to a cubic phase when it comes into contact with bodily fluids. | 07-02-2009 |
| 20090171387 | VASCULAR CLOSURE DEVICE HAVING AN IMPROVED PLUG - Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device includes an improved plug that is configured to be positioned adjacent to the hole in the vasculature. The plug may be shaped to prevent the plug from moving away from the hole in the blood vessel due to pulsatile pressure from the blood. In one embodiment, the plug may include a plurality of projections that extend outward from the plug and contact surrounding tissue in the tissue puncture tract to prevent the plug from moving away from the hole in the blood vessel. | 07-02-2009 |
| 20100145366 | THREE-NEEDLE CLOSURE DEVICE - The present invention relates to a three-needle type vascular closure system. The closure system utilizes three needles in the form of a guiding device, an expandable needle, and a hooking device. The guiding device is used to make the initial opening in the vessel, where the opening provides access for a sheath through which a medical procedure is to be performed. The expandable needle is inserted into the vessel in which it expands radially from the needle to form a target. The hooking device is also inserted into the vessel and is used to hook the expandable needle so as to form an internal union between the hooking device and the expandable needle. The needles can then be retracted thereby extending a suture from the hooking device and forming an internal suture pass that can be used to approximate the tissue surrounding the initial opening in the vessel. In one embodiment, the suture is passed across the vessel opening prior to dilation of the vessel opening. | 06-10-2010 |
| 20110077598 | VASCULAR ACCESS TO CLOSURE SHEATH AND METHODS - An insertion sheath and related methods include a tube member and a shape memory feature. The tube member defines an insertion lumen. The shape memory feature is positioned at a distal end portion of the tube member. The shape memory feature provides a monofold shape in the tube member when in a first state, and a radially expanded shape in the tube member in a second state upon application of an expansion force. The shape memory feature returns the monofold shape after removal of the expansion force. The insertion sheath may function as an access to closure sheath that is suitable for use as a procedural insertion sheath when treating the patient and a closure insertion sheath when sealing closed the vascular puncture. | 03-31-2011 |
| 20120004671 | SUTURE LOOP CLOSURE DEVICE - The present invention describes apparatus and methods for tying a filament across subcutaneous punctures. According to some embodiments, the apparatus and methods provide pre-tied knots that are inserted into a bodily lumen. Needles flanking the subcutaneous puncture are inserted into the lumen and grab the pre-tied knots. The pre-tied knots are pulled through tiny holes flanking the subcutaneous puncture by the needles, leaving an internal length of the filament across the subcutaneous puncture. The filament is then externally tied, closing the subcutaneous puncture. | 01-05-2012 |
| 20120071919 | VASCULAR SEALING DEVICE WITH HIGH SURFACE AREA SEALING PLUG - An internal tissue puncture closure method and apparatus. The method and apparatus provide a folded sealing plug that provides more surface area than conventional plugs to more fully cover and seal an external situs of an internal tissue puncture. The folded sealing plug may have a weave pattern that tends to cause the sealing plug to corkscrew into the internal tissue puncture as it is compressed toward an anchor placed inside of the tissue puncture. | 03-22-2012 |
