Castle
John Castle, Mainz DE
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20110039732 | cDNA Synthesis Using Non-Random Primers - The present invention provides methods for selectively amplifying a target population of nucleic acid molecules in a population of RNA template molecules (e.g., all mRNA molecules expressed in a cell type except for the most highly expressed mRNA species). The present invention also provides a first population of oligonucleotides including the nucleic acid sequences set forth in SEQ ID NOS:1-749 and a second population of oligonucleotides including the nucleic acid sequences set forth in SEQ ID NOS:750-1498. The first population of oligonucleotides can be used, for example, to prime the synthesis of first strand cDNA molecules complementary to mRNA molecules isolated from mammalian cells without priming the synthesis of cDNA molecules complementary to ribosomal RNA molecules. The second population of oligonucleotides can be used, for example, to prime the second strand synthesis of primer extension products (first strand cDNA) complementary to mRNA molecules isolated from mammalian cells without priming the second strand synthesis of primer extension products synthesized from ribosomal RNA molecules. | 02-17-2011 |
John Castle, Mainz-Kostheim DE
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20100029511 | CDNA SYNTHESIS USING NON-RANDOM PRIMERS - The present invention provides methods for selectively amplifying a target population of nucleic acid molecules in a population of RNA template molecules (e.g., all mRNA molecules expressed in a cell type except for the most highly expressed mRNA species). The invention also provides a method of generating a population of oligonucleotide primers for transcriptome profiling of total RNA from a subject of interest. | 02-04-2010 |
John Christopher Castle, Mainz DE
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20140178438 | INDIVIDUALIZED VACCINES FOR CANCER - The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method. | 06-26-2014 |
20160125129 | PREDICTING IMMUNOGENICITY OF T CELL EPITOPES - The present invention relates to methods for predicting T cell epitopes. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic or not. The methods of the invention are useful, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines. | 05-05-2016 |
Kerstin Castle, Cambridgeshire GB
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20120124740 | MAT - The present invention relates to mats, and in particular, to floor play mats for babies and children. The invention extends to uses of the play mat, and to methods of manufacturing such mats. | 05-24-2012 |
Leona Castle, Cumberland CA
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20130319426 | LEG SUPPORT PILLOW - A leg support pillow apparatus for supporting a lower leg and foot of a person lying in a bed has a base with a first thickness at an upper knee end thereof and an increased second thickness at a lower foot end thereof. Partition walls extend upward from the base and define leg channels extending from the knee end to the foot end of the base. The channels include foot portions at foot ends thereof having a width and depth configured to support the feet in an upright orientation, and upper knee ends of the channels have a width greater than the foot portions. Heel openings in the base under lower ends of each foot portion of the channels are configured such that when the leg is resting on the base inside the channel, the heel extends down into the heel opening and is supported above the bed. | 12-05-2013 |
20150223613 | BED COVER - A mattress cover assembly for covering a mattress includes a waterproof sheet with a bottom surface that is configured to slide readily across a mattress surface on which same is spread, and the waterproof sheet is configured to cover the mattress surface and to extend downward along right and left sides of the mattress. An incontinence pad is fastened to a middle portion of a top surface of the waterproof sheet, and a plurality of loops are spaced about a perimeter of the waterproof sheet. | 08-13-2015 |
Michael Frank Castle, Calne GB
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20090291658 | Low Power Signal Processor - There is disclosed a signal processor for reception of data over a radio link in which one or more signals are processed in separate channels each optimally adapted to the signal in the sub-band being processed. Such a signal processor uses less power and at lower cost than a conventional signal processor to yield the same performance. The signal processor uses a novel combination of both analog and digital signal processing. | 11-26-2009 |
Robert Castle, Bristol GB
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20140087655 | SYSTEMS AND METHODS FOR DETERMINING WHETHER A COMPANION COMMUNICATION DEVICE IS BEYOND A PROXIMITY OF A PRIMARY COMMUNICATION DEVICE - Systems and methods for determining whether a companion communication device is beyond a proximity of a primary communication device are provided. In some aspects, a system includes an analysis module configured to determine whether a wireless transaction between the primary communication device and the companion communication device is at a conclusion. The system also includes a communications module configured to emit a sensing signal based on the determination of whether the transaction is at the conclusion. The sensing signal is insufficient to elicit a response from the companion communication device. The system also includes a detection module configured to detect a present parameter associated with the emitted sensing signal. The analysis module is configured to determine a parameter change between the present parameter and a reference parameter, and to determine whether the companion communication device is beyond the proximity of the primary communication device based on the parameter change. | 03-27-2014 |
Robert John Castle, Bristol GB
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20100321126 | Method of Modulating A Carrier to Transmit Power to a Device, and Modulator Adapted to do the Same - A receiver for recovering timing and data information from a signal, comprising an envelope detector for demodulating the signal; to produce a demodulated signal; a filter for filtering the demodulated signal to remove or attenuate amplitude variations due to the timing information so as to produce a data signal; and a timing recovery circuit for forming a difference between time aligned versions of the demodulated signal and the data signal so as to recover the timing information. | 12-23-2010 |
Robert John Castle, Doncaster GB
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20150129080 | Reform Tub Iris to also include Coil Shear - A combined unit comprises an actuator and a plurality of support members coupled together in series connected to the actuator. Each support member further comprises a retractable shear blade ( | 05-14-2015 |
Thomas Charles Castle, Flintshire GB
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20140141262 | VINYL ALCOHOL POLYMERS WITH SILANE SIDE CHAINS AND COMPOSITIONS COMPRISING THE SAME - A functionalized homopolymer or copolymer of vinyl alcohol of the formula P—(R) | 05-22-2014 |
Thomas Charles Castle, Chester GB
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20100233100 | AMPHIPHILIC COPOLYMERIC MATERIAL - An amphiphilic polymeric material which has a straight or branched chain polymer backbone and a multiplicity of side chains attached to the backbone, wherein the backbone is a copolymer of at least one ethylenically-unsaturated aliphatic hydrocarbon monomer and maleic anhydride, or is a terpolymer of maleic anhydride, ethylene, and a further ethylenically unsaturated monomer. A method of synthesising said polymeric material is also provided, together with chewing gum bases, compositions and emulsions comprising amphiphilic polymeric materials. | 09-16-2010 |
20100266513 | AMPHIPHILIC POLYMERIC MATERIAL - The present invention concerns an amphiphilic polymeric material which comprises a straight or branched chain carbon-carbon backbone and a multiplicity of side chains attached to the backbone, wherein the side chains have formula (I). At least one of R | 10-21-2010 |
20130095047 | COSMETIC COMPOSITION - A cosmetic composition including: (i) at least one amphiphilic copolymer; and (ii) one or more cosmetically acceptable diluents, excipients or carriers; wherein the amphiphilic copolymer is selected from the group consisting of a graft copolymer including a hydrophobic straight or branched chain carbon-carbon backbone having at least one hydrophilic side chain attached thereto; a graft copolymer comprising a hydrophilic straight or branched chain backbone having at least one hydrophobic side chain attached thereto; a block copolymer including at least one hydrophilic block and at least one hydrophobic block in a straight or branched chain backbone; and a cross-linked/network copolymer. | 04-18-2013 |
20160130382 | AMPHIPHILIC POLYMERIC MATERIAL - A amphiphilic polymeric material that includes a straight or branched chain carbon-carbon backbone and a multiplicity of side chains attached to the backbone, wherein the side chains have formula (I): | 05-12-2016 |
Thomas Charles Castle, Flintshire Clwyd GB
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20160130533 | LATEX ADDITIVES - A latex composition including a dispersion of an amphiphilic copolymer in an aqueous medium, wherein the copolymer is: (i) a graft copolymer including a hydrophobic straight or branched chain carbon-carbon backbone having at least one hydrophilic side chain, wherein each chain is independently of formula (I), wherein R1 and R2 are each independently H1-C(O)WR4 or —C(O)Q; provided that at least one of R1 and R2 is the group —C(O)Q; or R1 and R2 together form a cyclic structure together with the carbon atoms to which they are attached. | 05-12-2016 |