Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


Casebier, MA

David Casebier, Carlisle, MA US

Patent application numberDescriptionPublished
20110312916NOVEL PRODRUGS OF STEROIDAL CYP17 INHIBITORS/ANTIANDROGENS - Prodrugs of C-17-heterocyclic-steroidal drugs providing improved oral bioavailability and pharmacokinetics are described. The drugs are inhibitors of human CYP 17 enzyme, as well as potent antagonists of both wild type and mutant androgen receptors (AR), and are useful for the treatment of urogenital and/or androgen-related cancers, diseases and/or conditions, such as human prostate cancer, breast cancer, and prostate hyperplasia. The disclosure describes methods of synthesizing and using the prodrugs in cancer therapy.12-22-2011
20110312924NOVEL STEROIDAL CYP17 INHIBITORS/ANTIANDROGENS - Steroidal C-17 nitrogen-containing heterocycles of Formula I:12-22-2011

David S. Casebier, Carlisle, MA US

Patent application numberDescriptionPublished
20090104118CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING - The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.04-23-2009
20090252676N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS - The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.10-08-2009
20100022594HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION - Compounds of Formula (I),01-28-2010
20100221182LIGANDS FOR IMAGING CARDIAC INNERVATION - Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 09-02-2010
20110034513Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production - Compounds of Formula (I),02-10-2011
20110091374CONTRAST AGENTS FOR APPLICATIONS INCLUDING PERFUSION IMAGING - The present invention is directed, in part, to compounds and methods for imaging the central nervous system or cancer, comprising administering to a subject a contrast agent which comprises a compound that binds MC-I, and an imaging moiety, and scanning the subject using diagnostic imaging.04-21-2011

Patent applications by David S. Casebier, Carlisle, MA US

David Scott Casebier, Carlisle, MA US

Patent application numberDescriptionPublished
20100120725Substituted Phenylsulfonamide Inhibitors of Beta Amyloid Production - Compounds of Formula I,05-13-2010
20110034428Treatment of Prostate Cancer - Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat androgen receptor mediated diseases or conditions. The present invention provides therapies and therapeutic regimens for the treatment of prostate cancer.02-10-2011

Patent applications by David Scott Casebier, Carlisle, MA US