| Patent application number | Description | Published |
|---|
| 20090286246 | Methods for Identifying Compounds that Affect Expression of Cancer-Related Protein Isoforms - Provided herein are methods for screening compounds for their ability to modulate the expression of certain isoforms of proteins that are associated with cancer, such as isoforms of proteins that participate in Wnt signaling in cancer cells. | 11-19-2009 |
| 20100068708 | Methods for Identifying Compounds that Modulate WNT Signaling in Cancer Cells - Provided herein are methods for screening compounds for their ability to modulate Wnt signaling in cancer cells. | 03-18-2010 |
| 20100203113 | WNT SIGNALLING INHIBITORS, AND METHODS FOR MAKING AND USING THEM - The invention provides dBHD-based compositions and dBHD analog compositions, and pharmaceutical compositions comprising them, e.g., in the form of liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these dBHD analogs are used to inhibit a dysfunctional stem cell and/or a cancer (tumor) stem cell. | 08-12-2010 |
| 20100266675 | LIPOPROTEINS, LIPOPEPTIDES AND ANALOGS, AND METHODS FOR MAKING AND USING THEM - The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them, are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating) and/or tumor associated blood vessels, including endothelial and/or capillary cell growth; including neovasculature related to (within, providing a blood supply to) a tumor. | 10-21-2010 |
| 20110108422 | EX VIVO MULTI-DIMENSIONAL SYSTEM FOR THE SEPARATION AND ISOLATION OF CELLS, VESICLES, NANOPARTICLES AND BIOMARKERS - Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of “seamless” sample-to-answer diagnostic systems and devices. The devices and techniques described can also carry out the assisted self-assembly of molecules, polymers, nanocomponents and mesoscale entities into three dimensional higher order structures. | 05-12-2011 |
| Patent application number | Description | Published |
|---|
| 20080280903 | Apoptosis Inhibitors - The present invention provides compounds that act as selective agents to protect against unintentional cell death or tissue damage and can relieve side effects of cancer treatment such as, for example, oral mucositis, hair loss, diarrhea due to damage to the gastrointestinal epithelium, and myelosuppression. In addition, these compounds can be used to prevent premature cell death when the cell death is caused by signals from damaged cells, for example, signals generated as the result of a traumatic incident or an ischemic episode. | 11-13-2008 |
| 20090202626 | TREATMENT OF BLADDER DISEASES WITH A TLR7 ACTIVATOR - The invention provides a method for the treatment of superficial bladder cancer and inflammatory diseases of the bladder which employs certain Toll-like Receptor (TLR)-agonists. | 08-13-2009 |
| 20090324551 | TLR AGONISTS - The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore. | 12-31-2009 |
| 20100086918 | Methods for High Sensitivity Detection of Genetic Polymorphisms - Multiplex PCR-based methods for detecting a variant polynucleotide having a nucleotide sequence differing from the wild-type nucleotide sequence of a nucleic acid molecule, wherein the variant polynucleotide is in a sample containing an excess of the wild-type nucleic acid molecule. The methods are particularly useful for detection of deletions from, or translocations and inversions in, genomic DNA. The susceptibility to, diagnosis of, and progression of a disease clinically related to the occurrence of such polymorphisms in an individual may also be confirmed and monitored using the multiplex PCR-based methods or by detecting RNA fusion transcripts in a sample that correspond to previously identified deletions, translocations or inversions in genomic DNA. | 04-08-2010 |
| 20100210598 | TOLL-LIKE RECEPTOR MODULATORS AND TREATMENT OF DISEASES - Provided herein are small molecule conjugates that are agonists or antagonists of one or more toll-like receptors. | 08-19-2010 |
| 20110098294 | PURINE ANALOGS - The present invention provides a new patentable class of purine analog compounds, as well as compositions and methods of using them, for example, to prevent or treat various diseases and disorders in human and non-human animals. | 04-28-2011 |
| 20110306671 | AMIDE DERIVATIVES OF ETHACRYNIC ACID - The invention provides ethacrynic acid derivatives useful to prevent, inhibit or treat a variety of disorders or diseases including cancer and inflammatory disorders. | 12-15-2011 |
| 20120148660 | CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR - The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma. | 06-14-2012 |
| Patent application number | Description | Published |
|---|
| 20090244079 | Optimizing the Execution of Media Processing Routines Using a List of Routine Identifiers - Methods for analyzing a list of routine identifiers to optimize processing of routines identified in the list. Some embodiments execute a set of routines in multiple passes where each pass comprises each routine in the set processing a single band of its source. The band size of the sources of the set is related to the size of a cache used during execution of the set. A band size of sources of the set is determined so that all data processed by and produced by any routine in the set can be stored to the cache while the routine processes one band of its source. Some embodiments use the list to combine two or more routines into a single routine where the list is modified accordingly. Some embodiments use the list for grouping and re-ordering routines identified in the list to send particular routines to an alternative processor for processing. | 10-01-2009 |
| 20120198319 | Media-Editing Application with Video Segmentation and Caching Capabilities - For a media-editing application that creates a composite media presentation, some embodiments of the invention provide a method for reducing rendering operations by dividing the composite presentation into several segments and rendering the segments in a manner that allows for these segments to move with respect to each other without losing the rendered results. The media-editing application defines portions of a media presentation as segments. When the media-editing application renders a segment of the media presentation, the application computes an identifier that uniquely identifies the segment and then uses this identifier to store and later retrieve the rendered result for the segment. The application in some embodiments computes the identifier based on a set of attributes of the segment, and stores the results of rendering the segment at a location that is uniquely identifiable in a storage structure by the identifier. | 08-02-2012 |
| 20120209815 | Media Clip Management - Some embodiments provide a method for editing a composite presentation in a media-editing application. The method receives a media file to import into the media-editing application from an external device. The method creates a set of media clip data structures to represent the media file. At least one of the data structures references the media file on the external device. Before the media file is imported from the external device, the method uses the media clip data structure to edit a composite presentation with the media file. After the media file is imported from the external device, automatically modifying the data structure to refer to a copy of the media file on a local device. | 08-16-2012 |
| 20120209889 | Data Structures for a Media-Editing Application - Some embodiments provide a method for defining a data structure for representing a media file imported into a media-editing application. The method defines a reference to an original version of a media file. The method defines references to one or more transcoded versions of the media file. Each of the transcoded versions has a different resolution. The method defines a set of metadata storing information regarding the media file. In some embodiments, the media file includes both audio and video. The method defines a video clip data structure for the media file that references the first data structure and an audio clip data structure for the media file that also references the asset data structure. The method defines a media clip data structure that contains the video clip data structure and the audio clip data structure. The media clip data structure is for editing into a composite video presentation. | 08-16-2012 |
| 20120210217 | Media-Editing Application with Multiple Resolution Modes - For a media-editing application, some embodiments provide a method for creating a media presentation that combines several media clips. During an editing process to define a particular media project, the method receives a first set of edits to the particular media project while the media-editing application is in a first resolution mode that uses content stored at a first resolution to generate the particular media project. The method receives a selection of a user interface tool to modify the resolution mode. The method switches to a second resolution mode that uses content stored at a second resolution to generate the particular media project without interrupting the editing process. After switching to the second resolution mode, the method receives a second set of edits to the same particular media project during the same editing process to define the particular media project. | 08-16-2012 |
| 20120210221 | Media-Editing Application with Live Dragging and Live Editing Capabilities - Some embodiments of the invention provide a media-editing application for creating and editing a media presentation that displays the results of edits as the edits are made to the media presentation. The media-editing application displays the movement of media clips of the media presentation as the media clips are being moved within the media-editing application to change the media presentation. Also, the media editing application in some embodiments can dynamically display the results of edits in a preview display area. That is, the media editing application has a preview generator that can generate previews of the media presentation on the fly as media clips are being dragged into and within the timeline. This allows the user of the media-editing application to see and hear the results of the operation while performing them. | 08-16-2012 |
| Patent application number | Description | Published |
|---|
| 20100057563 | DEPLOYMENT AND DISTRIBUTION MODEL FOR IMPROVED CONTENT DELIVERY - A deployment and distribution model improves content delivery with a business incentive for placement of kiosks with one or more wireless access points in public locations so that portable media players (PMPs) can receive media content (e.g., audio, video, text, haptic content, etc.). In addition, coordination between subscribing users of PMPs, vendors who provide kiosks, and a network central controller of a content distribution system allow for prepositioning of video content at the kiosks through economically desirable low data rate communication links from the network (e.g., dial-up modem, DSL, etc.); coordinated queuing of downloads (e.g., partial downloads) between kiosk to PMP, peer-to-peer (P2P) downloading between PMPs, and uploads from PMP to kiosk; billing/crediting to correspond with such participation in the distribution; and changing priority/selection of prepositioning of content at kiosks to reflect a clientele profile. | 03-04-2010 |
| 20100057924 | ACCESS POINT FOR IMPROVED CONTENT DELIVERY SYSTEM - A deployment and distribution model improves content delivery with a business incentive for placement of kiosks with one or more wireless access points in public locations so that portable media players (PMPs) can receive media content (e.g., audio, video, text, haptic content, etc.). In addition, coordination between subscribing users of PMPs, vendors who provide kiosks, and a network central controller of a content distribution system allow for prepositioning of video content at the kiosks through economically desirable low data rate communication links from the network (e.g., dial-up modem, DSL, etc.); coordinated queuing of downloads (e.g., partial downloads) between kiosk to PMP, peer-to-peer (P2P) downloading between PMPs, and uploads from PMP to kiosk; billing/crediting to correspond with such participation in the distribution; and changing priority/selection of prepositioning of content at kiosks to reflect a clientele profile. | 03-04-2010 |
| 20100058377 | METHODS AND APPARATUS FOR AN ENHANCED MEDIA CONTEXT RATING SYSTEM - Methods, apparatus, systems and computer program products are provided for an improved media content rating system. The rating system herein disclosed is highly-granular in nature, in that, the rating system allows for ratings to be based on the number of times that portions, segments, clips of the media file are played or otherwise executed, as opposed to basing the media content rating solely on the number of times that the media file is played. In this regard, the aspects herein described may further provide for ratings of the portions, segments, clips of the media content as opposed to limiting the rating to a rating for the overall media content file. | 03-04-2010 |
