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Cardinale
Carolyn Cardinale, Princeton, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100048088 | STUFFED ANIMAL WITH REMOVABLY ATTACHABLE TAIL - The present invention discloses a stuffed animal having a releasably attachable tail. The stuffed animal includes a body, a tail releasably attached to the body and attachment means carried by at least one of the body and the tail. The attachment means releasably attaches the tail to the body and may include a plurality of hook and loop fastener elements. In another embodiment, the attachment means includes at least one attachment ear and at least one corresponding attachment member. The at least one attachment ear is attached to the at least one attachment member via hook and loop fastener elements for releasably securing the tail to the body. A customer or seller can dress the stuffed animal with changeable clothing after removing the tail, which can be handled with ease by even young children. | 02-25-2010 |
Daniela Cardinale, Modena IT
| Patent application number | Description | Published |
|---|---|---|
| 20120302511 | PEPTIDES BINDING TO THE DIMER INTERFACE OF THYMIDYLATE SYNTHASE FOR THE TREATMENT OF CANCER - Provided are peptides that bind to the thymidylate synthase protein, in particular to human thymidylate synthase (hTS) protein, for the treatment of cancer. Further provided are peptides that can bind at a binding site located at the interface of thymidylate synthase protein. These peptides range from 3 to 10, preferably 4-8 amino acids and have a sequence that binds to each subunit of the thymidylate synthase dimer at the level of dimer interface, stabilizing the dimeric inactive form of the thymidylate synthase enzyme. In addition, provided are pharmaceutical compositions including these compounds as active agents, and uses thereof for the treatment of cancer and to reverse or/and be active in cancer drug resistance. | 11-29-2012 |
Dennis Cardinale, Plantation, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20080277586 | Low-Power Fast Infrared Gas Sensor, Hand Held Gas Leak Detector, and Gas Monitor Utilizing Absorptive-Photo-Acoustic Detection - A gas sensor for sensing the presence of a gas includes an IR source, a microphone, a reference gas substantially similar to the gas to be detected, a reference body defining a reference chamber therein, the reference chamber having a pressure port coupled to the microphone, and a broad-band optical window through which at least IR wavelengths corresponding to absorption peaks of the predetermined gas may pass. The window is disposed between the IR source and reference chamber. The reference gas is contained within the reference chamber between the optical window and the microphone. The sensor can be included in a hand-held gas detection instrument having power supply, an outer shell, a circuit board assembly including sensor circuitry, a suction pump, actuation controls and status indicators. A probe defining a lumen therethrough supplies the sample gas. | 11-13-2008 |
| 20110231117 | Electronic Vacuum Gauge and Systems and Methods of Calibration and Operation of Same - An electronic thermistor-based vacuum gauge and systems and methods of calibration and operation of the same that require no calibration against a known vacuum standard to obtain high accuracy through broad vacuum and ambient temperature ranges. Additional features of the invention include a construction and method of improving battery life, a construction and method of detecting faulty vacuum sensors, a method for determining the state of calibration of a vacuum sensor, a method of quantifying vacuum leak rates, and a method of automatically alerting an operator when an evacuation process has concluded. | 09-22-2011 |
Matteo Cardinale, Collegno (torino) IT
| Patent application number | Description | Published |
|---|---|---|
| 20100096372 | OPERATING HEAD, PARTICULARLY FOR A LASER MACHINE - A management method for a redundant axis laser machine of the type comprising a movable structure controlled by actuators and operated according to a first set of variables (X, Y, Z, A) and an operating head operated according to a second set of said variables (W, B, C), said first set of variables (X, Y, Z, A) and second set of variables (W, B, C) identifying one or more redundant variables. Such method envisions a filtering allowing the work trajectory to be decomposed into defined trajectories for a first low dynamic system made up of said first set of variables (X, Y, Z, A) and a second high dynamic system made up of said second set of said variables (W, B, C), respectively. | 04-22-2010 |
Michael Cardinale, Manalapan, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100292710 | SURGICAL FASTENERS, APPLICATOR INSTRUMENTS, AND METHODS FOR DEPLOYING SURGICAL FASTENERS - An applicator instrument for dispensing surgical fasteners includes a housing, an elongated shaft extending from the housing, the elongated shaft having a proximal end coupled with the housing and a distal end remote therefrom, and a firing system for dispensing surgical fasteners from the distal end of the elongated shaft. The firing system includes a firing rod disposed in the elongated shaft, the firing system having a firing cycle with a first stage for advancing the firing rod toward the distal end of the elongated shaft at a first rate of speed and a second stage for advancing the firing rod toward the distal end of the elongated shaft at a second rate of speed that is greater than the first rate of speed. | 11-18-2010 |
| 20100292712 | SURGICAL FASTENERS, APPLICATOR INSTRUMENTS, AND METHODS FOR DEPLOYING SURGICAL FASTENERS - An applicator instrument for dispensing surgical fasteners includes a housing, an elongated shaft extending from the housing, a firing rod disposed inside the elongated shaft and being movable within a first plane between a retracted position and an extended position, an advancer disposed inside the elongated shaft and being moveable within a second plane between a retracted position and an extended position, and a staging assembly located adjacent the distal end of the elongated shaft and being adapted to align surgical fasteners with a distal end of the firing rod. The staging assembly is held below the second plane by the advancer when the advancer is in the extended position and the staging assembly is adapted to move into at least partial alignment with the distal end of the firing rod when the advancer is in the retracted position. | 11-18-2010 |
| 20100292713 | SURGICAL FASTENERS, APPLICATOR INSTRUMENTS, AND METHODS FOR DEPLOYING SURGICAL FASTENERS - A firing system for an applicator instrument adapted to dispense surgical fasteners includes a housing, an elongated shaft extending from the housing, a firing rod disposed within the elongated shaft, a firing rod release engageable with the firing rod for preventing distal movement of the firing rod during at least one stage of a firing cycle, a trigger mounted to the housing, and a firing spring having a first end connected with the firing rod and a second end adapted for being sequentially coupled and decoupled from the trigger during the firing cycle. The firing cycle includes an initial stage in which the trigger is open and decoupled from the energy storing element, and the firing spring is at least partially compressed, and a piloting stage during which the firing rod release is disengaged from the firing rod for enabling distal movement of the firing rod. | 11-18-2010 |
Michael Cardinale, Nottingham, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20130023780 | BULLSEYE DISPLAY FOR ECG DATA - A bullseye chart is comprised of concentric circles, each corresponding to a different level Anterior of the heart in relation to the apex. Each circle is divided into segments, with each segment corresponding to a different circumferential region around the heart. The bullseye chart is filled in with ECG data such as ST elevation data of leads corresponding to the various segments. The bullseye chart may be filled in with numeric ECG data values or qualitative values such as coloring or shading which indicates normal and abnormal segments. The ECG bullseye chart may be compared with an ultrasound bullet scorecard filled in with data derived from ultrasound images. | 01-24-2013 |
Michael Cardinale, Morristown, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20110079627 | APPLICATOR INSTRUMENTS HAVING CURVED AND ARTICULATING SHAFTS FOR DEPLOYING SURGICAL FASTENERS AND METHODS THEREFOR - An applicator instrument for dispensing surgical fasteners includes a housing and a curved shaft. Surgical fasteners are disposed within the curved shaft for being dispensed from the distal end of the curved shaft. An advancer is disposed inside the curved shaft for shifting the surgical fasteners one position closer to the distal end of the curved shaft each time the advancer moves distally. A firing element is disposed inside the curved shaft and is movable between the proximal and distal ends of the curved shaft for dispensing the surgical fasteners from the distal end of the curved shaft. A staging assembly is adapted to receive a leading one of the surgical fasteners from the advancer as the advancer moves distally to shift the leading surgical fastener into substantial alignment with the firing element when the advancer moves proximally. | 04-07-2011 |
Paolo Cardinale, Milan IT
| Patent application number | Description | Published |
|---|---|---|
| 20110107294 | WEB PORTAL APPLICATION CUSTOMIZATION METHOD AND SYSTEM USING PROFILES - Web portal application customization methods and systems using profiles allow developers to expose different functionalities and a different look and feel to users belonging to different user profiles. Specifically, the method allows a developer to define default and profile-specific transitions as well as default and profile-specific states. Upon request of a transition by a workflow engine, the system transparently provides the workflow engine with a profile-specific transition if a profile-specific transition associated with the user is available. If a profile-specific transition is not available, the system provides the application with a default transition. Likewise, the system transparently provides the application with a profile-relevant state according to the profile of the user and the availability of a profile-specific state. Accordingly, the method may implement highly customizable functionalities and look and feel effectively and cost-efficiently. | 05-05-2011 |
Salvatore Cardinale, Mill Valley, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090314786 | Insulated water-tight container - An insulated container for shipping, transporting, or storing warm or cold items is disclosed, useful for maintaining temperature of items stored or shipped within the container, the container assembly consisting of at least one layer of rigid or semi-rigid material, and at least one layer of flexible, thermally insulating, water-resistant material, in the form of a pouch, which pouch is secured to the rigid material at areas which allow easy reconfiguration of the container to form a finished container having desirable insulating and water-resistant characteristics. | 12-24-2009 |
Stefano Cardinale, Scotland GB
| Patent application number | Description | Published |
|---|---|---|
| 20090136924 | RAPID GENERATION OF LONG SYNTHETIC CENTROMERIC TANDEM REPEATS FOR MAMMALIAN ARTIFICIAL CHROMOSOME FORMATION - Methods are described for construction of long synthetic arrays of DNA repeats, such as alphoid repeats or other repeat sequences. The methods include concatamerization of DNA into short repeats (for instance using rolling circle amplification or directional in vitro ligation), followed by assembling the short repeats into long arrays by homologous recombination during transformation into microbe cells. These methods can be described generally as Recombinational Amplification of Repeats (RAR). The long arrays are engineered centromere-like regions that allow one to construct mammalian artificial chromosomes with a predefined centromeric region structure. Artificial chromosomes, including human artificial chromosomes with a regulated centromere, and methods of their use are also provided | 05-28-2009 |