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Cardarelli, US

Donato Cardarelli, Medfield, MA US

Patent application numberDescriptionPublished
20090007667GRA MEMS ACCELEROMETER - An accelerometer that lies generally in a plane, for detecting acceleration along an input axis. There is a substrate, a generally planar Servo Member (SM) flexibly coupled to the substrate such that it is capable of oscillatory motion about a servo axis that lies in the plane, a generally planar Torque Summing Member (TSM) coplanar with and flexibly coupled to the SM such that the TSM is capable of rotary motion relative to the SM about an output axis that is in the plane and orthogonal to the servo axis, wherein the TSM is mass-imbalanced relative to the output axis, and a generally planar rotor coplanar with and flexibly coupled to the TSM such that it is capable of rotary oscillatory motion relative to the TSM about a rotor axis that is orthogonal to the plane of the members. There are drives for oscillating the rotor about the rotor axis and for oscillating the SM about the servo axis. Output sensors detect oscillation of the rotor about the rotor axis and of the SM about the servo axis. Output sensors detect rotation of the TSM about the output axis.01-08-2009
20090019932Mems Gyroscope with output oscillation about the normal to the plane - A gyroscope that lies generally in a plane, for detecting rotation rate about a gyro input axis. The gyroscope has a substrate, and a generally planar outer member flexibly coupled to the substrate such that it is capable of oscillatory motion about a drive axis that is orthogonal to the input axis. There is also a generally planar inner member coplanar with and flexibly coupled to the outer member such that it is capable of rotary oscillatory motion relative to the outer member about an output axis that is orthogonal to the plane of the members. There are one or more drives for directly or indirectly oscillating the outer member about the drive axis, and one or more sensors that detect oscillation of the inner member about the output axis.01-22-2009
20100024548Scale Factor Measurement For Mems Gyroscopes And Accelerometers - An inertial instrument such as an accelerometer or gyroscope having scale factor functionality, and that lies generally in a plane. The gyro detects rotation rate about a gyro input axis. The gyroscope has a substrate, a generally planar scale factor gimbal flexibly coupled to the substrate such that it is capable of oscillatory motion about the input axis, a generally planar support member coplanar with and flexibly coupled to the scale factor gimbal such that the support member is capable of oscillatory motion about a drive axis that is orthogonal to the input axis, and a generally planar gyro member coplanar with and flexibly coupled to the support member such that it is capable of rotary oscillatory motion relative to the support member about an output axis that is orthogonal to the plane of the members. There are one or more first drives for oscillating the support member about the drive axis, and one or more second drives for oscillating the scale factor gimbal about the input axis. One or more gyro output sensors that detect oscillation of the gyro member about an output axis that is orthogonal to both the input axis and the drive axis.02-04-2010

Patent applications by Donato Cardarelli, Medfield, MA US

Josephine Cardarelli, San Carlos, CA US

Patent application numberDescriptionPublished
20100104509HUMAN ANTIBODIES THAT BIND CD19 AND USES THEREOF - Human monoclonal antibodies that specifically bind to CD19 with high affinity are disclosed The antibodies are capable of internalizing into CD19-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies are also provided Also provided are methods for detecting CD19, as well as methods for treating cancers, such as B cell malignancies, for example, non-Hodgkin's lymphoma, chronic lymphocytic leukemias, follicular lymphomas, diffuse large cell lymphomas of B lineage, and multiple myelomas using an anti-CD 19 anti-body04-29-2010
20100104564Altered Antibody Fc Regions and Uses Thereof - The present invention relates to altered antibody Fc regions and uses thereof.04-29-2010
20100150950HUMAN ANTIBODIES THAT BIND CD70 AND USES THEREOF - The present disclosure provides isolated monoclonal antibodies that specifically bind to CD70 with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human CD70. In certain embodiments, the antibodies are capable of being internalized into CD70-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD70, as well as methods for treating cancers, such as renal cancer and lymphomas, using an anti-CD7Q antibody of this disclosure.06-17-2010

Josephine M. Cardarelli, Milpitas, CA US

Patent application numberDescriptionPublished
20100158902MONOCLONAL ANTIBODIES AGAINST STROMAL DERIVED FACTOR-1 (SDF-1) - The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed.06-24-2010

Marcelo G. Cardarelli, Lutherville, MD US

Patent application numberDescriptionPublished
20110179361PREDETERMINED PRESENTATION OF PATIENT DATA AT BEDSID - Techniques for presenting patient data at the patient's bedside include receiving predetermined presentation style data that indicates a subset of fewer than all parameters available from an electronic medical records (EMR) system and a first arrangement on a display device of related parameters in the subset. Without human intervention, the most recent values from the EMR system are received. The most recent values are associated in the EMR system with the particular patient for corresponding parameters of the subset. A first most recent value is presented according to the first arrangement at the particular bedside display device without human intervention. In some embodiments, the most recent values are also received or presented in response to a single stroke from a human user at an input for the particular display device.07-21-2011

Pina M. Cardarelli, San Carlos, CA US

Patent application numberDescriptionPublished
20090136980CD10-activated prodrug compounds - The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing the prodrug are also disclosed.05-28-2009