Cappiello

Achille Cappiello, Urbino IT

Patent application number	Description	Published
20110049031	Device for generating micro- and nanoflow mobile phase gradients for high-performance liquid chromatography - A device for generating micro- and nanoflow mobile phase gradients for high performance liquid chromatography includes a generator of micro- and nanoflows of at least two mobile phases in different percentage compositions; an n-position gradient distributor having inlet and outlet ports and n couples of ports for a like number of capillary loops, each selectively connectable at one end with the inlet port and at its other end to the outlet port, which in turn is connectable to an analytical circuit that includes a chromatographic column and a detector; a micro- and nanoflow meter connected to the analytical circuit; a flow deviator having an inlet connected to the outlet of the gradient distributor, one outlet connected to a discharge and another outlet connected to the micro- and nanoflow meter, and a control unit that includes means of control of the generator of micro- and nanoflows such to create the different mobile phase mixture compositions, means for controlling the gradient distributor, means for controlling the position of the flow deviator and means for controlling the throughput of the generator of micro- and nanoflows on the basis of data received from the micro- and nanoflow meter.	03-03-2011

Patent application number	Description	Published
20100083887	AUTOMATIC SYSTEM FOR ANTI-ROLL STABILIZATION OF WATERCRAFT - An automatic system for anti-roll stabilization of watercraft, comprising, a stabilizing fin that can turn about an axis, an actuator assembly, designed to govern rotation of said fin about said axis, and a regulating system, designed to govern said actuator assembly as a function of signals indicating rolling of the watercraft. Said actuator assembly comprises an electric motor connected to said stabilizing fin.	04-08-2010

Patent application number	Description	Published
20100076194	SUBSTITUTED 3-AMINO-1-OXO OR THIOXO-1,2,5,6,7,8-HEXAHYDRO-2,7-NAPHTHYRIDINE-4-CARBONITRILES ARE SELECTIVE ALPHA 2B ANTAGONISTS - The present invention provides compounds which are subtype selective antagonists of the alpha 2B adrenergic receptor and have no or weak antagonist activity at the other alpha adrenergic receptors. These compounds are useful as tool compounds and, in particular, as tool compounds for developing compounds useful in treating diseases that include but are not limited to chronic pain, visceral pain, corneal pain, neuropathic pain, glaucoma, ischemic neuropathies and other neurodegenerative diseases and conditions. These compounds are also useful as compounds for treating myocardial infarction and preventing acute coronary events. The compounds of this invention are 3-amino-1-thioxo or oxo-1,2,5,6,7,8-hexahydro-2,7-naphthyridine-4-carbonitriles or substituted derivatives thereof.	03-25-2010
20100298395	UNSUBSTITUTED AND SUBSTITUTED 4-BENZYL-1,3-DIHYDRO-IMIDAZOLE-2-THIONES ACTING AS SPECIFIC OR SELECTIVE ALPHA2 ADRENERGIC AGONISTS AND METHODS FOR USING THE SAME - Compounds of Formula 1	11-25-2010