Cao, MI
Bang Kim Cao, Northville, MI US
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20130325255 | TRACTION CONTROL ENABLE/DISABLE FEATURE - A method and system for displaying a traction control ON/OFF menu at a display module in a vehicle upon detection of vehicle characteristics and conditions that may warrant a driver's desire to manually disable the traction control feature. The method and system verify traction control is enabled on the vehicle, verify the traction control ON/OFF menu is not already being displayed at a display module, a controller receives at least one signal indicating an occasion that may warrant manual deactivation of traction control and the controller initiates displaying the traction control ON/OFF menu for the convenience of the driver. | 12-05-2013 |
Boliang Cao, Ada, MI US
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20090155284 | HGF-SF MONOCLONAL ANTIBODY COMBINATIONS - The present invention provides a combination of anti-HGF/SF antibodies that specifically bind HGF/SF and inhibits HGF/SF activity. The present invention further provides a combination of anti-HGF/SF antibodies comprising three or more anti-HGF/SF antibodies selected from the group consisting of: antibody #1 produced from hybridoma 1C10-F1-A11, antibody #4 produced from hybridoma 8H2-F2-B10, antibody #5 produced from hybridoma 13B1-E4-E10, antibody #7 produced from hybridoma 15D7-B2, and antibody #10 produced from hybridoma 31D4-C9-D4. The invention also provides a method of treating cancer in a subject comprising administering to the subject a combination of anti-HGF/SF antibodies whereby the antibodies bind to a hepatocyte growth factor, whereby the binding of the antibodies to a hepatocyte growth factor results in an inhibition of hepatocyte growth factor binding to the hepatocyte growth factor receptor, whereby the inhibition of hepatocyte growth factor binding to receptor causes an inhibition of cancer growth, thereby treating the cancer. | 06-18-2009 |
20090324603 | MET FAB AND SCFV FRAGMENTS AND METHODS OF USE - Antibody fragments (Fabs and scFvs) specific to the Met receptor are disclosed. Compositions and kits including these Fabs and scFvs, and drug and imaging conjugates of these Fabs and scFvs also are disclosed. The novel Fabs and scFvs can be internalized into the interior of a cell. Methods include using the novel Met Fabs and scFvs for diagnosing, prognosing, and treating cancer, and for evaluating chemotherapeutic response. | 12-31-2009 |
20100285504 | MONOCLONAL ANTIBODY WHICH BINDS MET IN FORMALIN-FIXED AND PARAFFIN-EMBEDDED TISSUES AND RELATED METHODS - In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4. The Met4 antibody is particularly useful for detecting Met in formalin-fixed tissue. Methods of using the Met4 antibody for detection, diagnosis, prognosis, and evaluating therapeutic efficacy are provided. | 11-11-2010 |
Changwei Cao, West Bloomfield, MI US
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20080288146 | SYSTEMS AND METHODS FOR DETECTING AND REDUCING HIGH DRIVELINE TORSIONAL LEVELS IN AUTOMOBILE TRANSMISSIONS - The present disclosure provides systems and methods to detect and reduce any high driveline torsional levels, such as due to the cylinder deactivation in variable displacement system engines or aggressive lock-up strategies for fuel efficiency, in automobile transmissions. The present disclosure utilizes a controller in an automobile to operate a computationally thrifty method for quickly detecting noise and vibration disturbances in the transmission. This quick detection enables fuel economic calibrations that aggressively reduce the disturbances by controlling slip in a launch device of the transmission. As problem disturbances arise, they are detected before occupants notice objectionable behavior. Once detected, the disturbances are reduced, such as by increasing launch device slip, which effectively intercepts the objectionable disturbances before they are transferred through the entire drivetrain. The present disclosure can also apply to launch devices in Dual Clutch Transmissions and Electronically-controlled Manual Transmissions. | 11-20-2008 |
20140358388 | INTERACTIVE TRANSMISSION SHIFT TECHNIQUES - A method for interactive transmission garage shifts includes receiving a request for a transmission garage shift; controlling the transmission to bring the vehicle to a stop state based on determining that the vehicle is rolling backwards on a grade above a predetermined grade threshold and at a speed below a predetermined speed threshold; controlling an electric park brake (EPB) to hold the vehicle at the stop state; controlling the transmission to engage a dog clutch so as to place the transmission in a forward drive gear; and controlling the EPB to i) deactivate if the dog clutch is determined to be engaged, or ii) maintain activation to maintain the vehicle at the stop state if the dog clutch is determined to be disengaged. | 12-04-2014 |
Dong Cao, Canton, MI US
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20160099665 | Dynamic IGBT Gate Drive For Vehicle Traction Inverters - A hybrid electric vehicle includes a traction battery, traction motor and power inverter therebetween. The power inverter converts the DC power of the traction battery to AC power to drive each phase of the traction motor. The power inverter includes Insulated Gate Bipolar junction Transistors (IGBTs) to modulate the power to the traction motor. The speed at which the IGBTs are modulated impacts the system performance including power loss, voltage overshoot and current overshoot. Using a dual emitter IGBT to provide a current mirror of the drive current, circuitry may be used with the gate drive circuitry such that the gate drive speed may be dynamically adjusted based on characteristics including temperature and traction motor rotational speed. | 04-07-2016 |
Fang Cao, Ann Arbor, MI US
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20130150309 | CYCLIZED PEPTIDOMIMETIC SMALL MOLECULE INHIBITORS OF THE WDR5 AND MLL1 INTERACTION - Cyclic peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed. | 06-13-2013 |
Feina Cao, Canton, MI US
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20130310505 | Flame Retardant Thermoplastic Polyurethane Compositions - The present invention relates to flame retardant thermoplastic polyurethane (TPU) compositions that are prepared by compounding certain TPU's and with a polyphosphonate homopolymer or copolymer, and more specifically TPU compositions that pass ASTM E84 Class 1 and UL94 V0 ratings. The invention also relates to compositions that further include an inherently dissipative polymer to provide a TPU composition that has flame retardant properties, electrostatic discharge performance, good clarity and/or transparency, or any combination thereof. | 11-21-2013 |
20140031478 | Electrostatic Dissipative Polycarbonate Compositions - The present invention relates to electrostatic dissipative polycarbonate compositions that are prepared by combining an aromatic polycarbonate polymer with a thermoplastic polyurethane based inherently dissipative polymer and a compatibilizer component that comprises a second thermoplastic polyurethane. This second thermoplastic polyurethane is a reaction product of (a) at least one polyol intermediate, (b) at least one diisocyanate, and (c) at least one chain extender, wherein (a), the polyol intermediate comprises a polycaprolactone polyol, a polycarbonate polyol, or combinations thereof. | 01-30-2014 |
20140255792 | Polyurethane Based Electrolyte Systems For Electrochemical Cells - The invention relates to a polymer gel electrolyte system for use in an electrochemical cell having positive and negative electrodes, said electrolyte system comprising: (A) a poly(dialkylene ester) thermoplastic polyurethane composition; (B) an alkali metal salt; and (C) an aprotic organic solvent. The invention also provides an electrochemical cell comprising a positive electrode, a negative electrode, and (I) a polymer electrolyte disposed between said positive and negative electrodes, wherein the polymer electrolyte comprises (A) the poly(dialkylene ester) thermoplastic polyurethane composition; (B) an alkali metal salt; and (C) an aprotic organic solvent. | 09-11-2014 |
20140287323 | Polyurethane Based Membranes And/Or Separators For Electrochemical Cells - The invention relates to a membrane comprising a poly(dialkylene ester) thermoplastic polyurethane composition. The invention also provides an electrochemical cell comprising a positive electrode, a negative electrode, and (I) a separator membrane disposed between said positive and negative electrodes, wherein the said membrane comprises (A) the described poly(dialkylene ester) thermoplastic polyurethane composition. | 09-25-2014 |
20140302398 | Polyurethane-Based Electrode Binder Compositions And Electrodes Thereof For Electrochemical Cells - The invention relates to an electrode binder composition, an electrode made using the described binder composition, and an electrochemical cell made using the described electrode, where the all of these materials are made using a composition of a poly(dialkylene ester) thermoplastic polyurethane composition. The electrode is made using the described thermoplastic polyurethane and an electrode active material. The electrochemical cells can be made using the described electrodes and also using (i) membranes and/or separators made using the described poly(dialkylene ester) thermoplastic polyurethane composition; (ii) an electrolyte system based on the described poly(dialkylene ester) thermoplastic polyurethane composition; or (iii) a combination thereof. | 10-09-2014 |
Keqin Cao, Ann Arbor, MI US
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20130288050 | SYNTHESIS AND USE OF ARAMID NANOFIBERS - Dissociation of a macroscale version of an aramid fiber leads to the nanofiber form of this polymer. Indefinitely stable dispersions of uniform high-aspect-ratio aramid nanofibers (ANFs) with diameters between 3 and 30 nm controlled by the media composition and up to 10 μm in length are obtained. ANFs can be processed in transparent thin films using layer-by-layer assembly (LBL) with superior mechanical performance. | 10-31-2013 |
Ming Cao, Rochester Hills, MI US
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20100018833 | System and Method for Controlling a Clutch Fill Event - A method optimizes a fill event of an apply chamber of a fluid-actuated clutch, and includes determining input values describing the fill event, and then estimating a fill time using the input values. The method includes filling the apply chamber using the estimated fill time (EFT) or within an allowable range of the EFT. The input values can include a command line pressure, command fill stroke pressure, and an estimated viscosity of the fluid, although other values can be used. The input values are processed through a neural network having an input layer, an optional hidden layer, and an output layer. An assembly includes a fluid-actuated clutch having an apply chamber and a controller operable for estimating the fill time required for filling the apply chamber, and for controlling the fill of the apply chamber within the EFT. | 01-28-2010 |
Qi Cao, Ann Arbor, MI US
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20090012031 | EZH2 Cancer Markers - The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer. | 01-08-2009 |
20100222420 | COMPOSITIONS AND METHODS FOR INHIBITING EZH2 - The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer. | 09-02-2010 |
20110207198 | COMPOSITIONS AND METHODS FOR INHIBITING MMSET - The present invention relates to agents that find use in the treatment, management, and/or study of cancer. In particular, the present invention relates to agents (e.g., small molecules, nucleic acids) that affect MMSET expression or activity. | 08-25-2011 |
20110251216 | COMPOSITIONS AND METHODS FOR INHIBITING EZH2 - The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in cancer (e.g., prostate cancer, breast cancer, other solid tumors, multiple myeloma). | 10-13-2011 |
Yue Cao, Ann Arbor, MI US
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20130039558 | PATIENT MODELING FROM MULTISPECTRAL INPUT IMAGE VOLUMES - A computer-implemented method is provided for generating patient models from multiple imaging contrast sources which may be, for example from magnetic resonance imaging without computed tomography. The method includes: acquiring multiple sets of image data representing a volume of a patient using magnetic resonance imaging, wherein each set of image data is acquired in a different manner so as to create contrast amongst tissue types of the patient; classifying tissue in each voxel in the volume using the multiple sets of image data as input to a classification algorithm; and generating a patient model for the volume from probability distributions of the classes of tissue as derived from the classification algorithm. | 02-14-2013 |
20130329973 | SUBVOLUME IDENTIFICATION FOR PREDICTION OF TREATMENT OUTCOME - Physiological imaging-defined subvolumes of tissues/disease are identified to yield spatially-defined prognostic and/or predictive indicators and/or focal therapy targets within such tissues, in particular tumors, for evaluation over time, for example, prior to and after a therapy treatment. Medical image data is analyzed to delineate subvolumes of tissue based upon multiple physiological, metabolic, and biological imaging properties, where those subvolumes are extracted and analyzed in a probabilistic manner to associate with one or more abnormal or disease phenotype conditions. | 12-12-2013 |
Zhengyi Cao, Ypsilanti, MI US
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20090104119 | Dendrimer Based Compositions And Methods Of Using The Same - The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based multifunctional compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor). | 04-23-2009 |
Zhengyi Cao, Ann Arbor, MI US
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20100028433 | IMMUNOGENIC COMPOSITIONS COMPRISING NANOEMULSION AND HEPATITIS B VIRUS IMMUNOGEN AND METHODS OF USING THE SAME - The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides immunogenic compositions and methods of using the same to induce immune responses (e.g., immunity (e.g., protective immunity)) against Hepatitis B virus (HBV)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications. | 02-04-2010 |
Zongliang Cao, Ann Arbor, MI US
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20130105921 | MICROSYSTEM DEVICE AND METHODS FOR FABRICATING THE SAME | 05-02-2013 |