Patent application number | Description | Published |
20100047179 | TARGETED SPLIT BIOMOLECULAR CONJUGATES FOR THE TREATMENT OF DISEASES, MALIGNANCIES AND DISORDERS, AND METHODS OF THEIR PRODUCTION - The present invention is directed to compositions and methods for the production of split-biomolecular conjugates for the directed targeting of nucleic acids and polypeptides. More preferably, the compositions and methods allow for the use of the split biomolecular conjugates for the treatment of diseases, malignancies, disorders and screening. In some embodiments, the split biomolecular conjugates comprise split effector protein fragments conjugated to a probe, and interaction of both probes with a target nucleic acid or target polypeptide, such as a pathogenic nucleic acid sequence or pathogenic protein, brings a the split-effector fragments together to facilitate the reassembly of the effector molecule. Depending on the effector molecule, the protein complementation results in a cellular effect, in particular for the treatment of diseases, malignancies and disorders. | 02-25-2010 |
20100311046 | METHOD FOR THE DETECTION OF CHROMOSOMAL ANEUPLOIDIES - The non-invasive detection of fetal chromosomal aneuploidies is demonstrated. Alleles of fetal RNA-SNPs present in a biological sample (e.g. maternal blood) containing fetal RNA are detected and quantified in order to determine the ratio of the alleles. This ratio is compared to a standard control consisting of euploid fetuses. Deviation of allele ratio indicates the presence of chromosomal aneuploidy. | 12-09-2010 |
20110105353 | Fetal Genomic Analysis From A Maternal Biological Sample - Systems, methods, and apparatus for determining at least a portion of fetal genome are provided. DNA fragments from a maternal sample (maternal and fetal DNA) can be analyzed to identify alleles at certain loci. The amounts of DNA fragments of the respective alleles at these loci can be analyzed together to determine relative amounts of the haplotypes for these loci and determine which haplotypes have been inherited from the parental genomes. Loci where the parents are a specific combination of homozygous and heterozygous can be analyzed to determine regions of the fetal genome. Reference haplotypes common in the population can be used along with the analysis of the DNA fragments of the maternal sample to determine the maternal and paternal genomes. Determination of mutations, a fractional fetal DNA concentration in a maternal sample, and a proportion of coverage of a sequencing of the maternal sample can also be provided. | 05-05-2011 |
20110172111 | SOLID PHASE SEQUENCING OF BIOPOLYMERS - This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Nucleic acids whose sequences can be determined include DNA or RNA in biological samples such as patient biopsies and environmental samples. Probes may be fixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence. | 07-14-2011 |
20130253844 | IDENTIFYING A DE NOVO FETAL MUTATION FROM A MATERNAL BIOLOGICAL SAMPLE - Systems, methods, and apparatus for determining at least a portion of fetal genome are provided. DNA fragments from a maternal sample (maternal and fetal DNA) can be analyzed to identify alleles at certain loci. The amounts of DNA fragments of the respective alleles at these loci can be analyzed together to determine relative amounts of the haplotypes for these loci and determine which haplotypes have been inherited from the parental genomes. Loci where the parents are a specific combination of homozygous and heterozygous can be analyzed to determine regions of the fetal genome. Reference haplotypes common in the population can be used along with the analysis of the DNA fragments of the maternal sample to determine the maternal and paternal genomes. Determination of mutations, a fractional fetal DNA concentration in a maternal sample, and a proportion of coverage of a sequencing of the maternal sample can also be provided. | 09-26-2013 |
20130323731 | DETERMINATION OF THE DEPTH COVERAGE OF THE FETAL GENOME - Systems, methods, and apparatus for determining at least a portion of fetal genome are provided. DNA fragments from a maternal sample (maternal and fetal DNA) can be analyzed to identify alleles at certain loci. The amounts of DNA fragments of the respective alleles at these loci can be analyzed together to determine relative amounts of the haplotypes for these loci and determine which haplotypes have been inherited from the parental genomes. Loci where the parents are a specific combination of homozygous and heterozygous can be analyzed to determine regions of the fetal genome. Reference haplotypes common in the population can be used along with the analysis of the DNA fragments of the maternal sample to determine the maternal and paternal genomes. Determination of mutations, a fractional fetal DNA concentration in a maternal sample, and a proportion of coverage of a sequencing of the maternal sample can also be provided. | 12-05-2013 |
Patent application number | Description | Published |
20090011435 | ASSAYS FOR DETECTING ANTIBODIES TO THERAPEUTICS - The disclosed invention relates to methods and devices for detecting a biologic in a test sample. In particular, the disclosed assay utilizes EPO as a target to detect endogenous anti-EPO antibodies in a sample and does not manipulate or modify the target EPO antibody. | 01-08-2009 |
20090047686 | METHODS FOR IDENTIFYING AND PRODUCING SPECIFIC AMINO ACID DEPENDENT ANTIBODIES AND USES THEREOF - The present invention relates to methods for producing antibodies that are selective for one or two of the N-terminal amino acid residues of PTH, the antibodies made by such methods, and methods of using them to determine PTH levels while avoiding interference from N-terminally truncated PTH peptides. | 02-19-2009 |
20090142773 | METHODS AND CONTROLS FOR MONITORING ASSAY QUALITY AND ACCURACY IN PARATHYROID HORMONE MEASUREMENT - The present invention relates to the use of control compositions and kits comprising such to evaluate and monitor the consistency of assays utilized to determine parathyroid hormone levels. | 06-04-2009 |
20100021496 | METHODS, KITS, AND ANTIBODIES FOR QUANTITATIVE DETERMINATION OF PARATHYROID HORMONE MOLECULES WITH INTACT C-TERMINUS - The present invention relates to novel methods and compositions useful for detecting whole parathyroid hormone at a physiological level and C-terminal parathyroid fragments in a mammalian sample. Such detections may be useful to different parathyroid diseases or disorders in a subject, such as chronic renal failure, hyperparathyroidism and related bone diseases, from normal or non-disease states. One detects whole or non-fragmented (1 to 84) parathyroid hormone in a biological sample and optionally one or more of a selection of C-terminal parathyroid hormone peptide fragments that may or may not function as a parathyroid hormone antagonists. By either comparing values or using independently the value of either the one or more of a selection of C-terminal parathyroid hormone peptide fragments, the whole parathyroid hormone, or the combination of these values, one is able to differentiate chronic renal failure, parathyroid and bone related disease states, as well as differentiate such states from normal states. | 01-28-2010 |
20100150942 | AFFINITY PURIFIED HUMAN POLYCLONAL ANTIBODIES AND METHODS OF MAKING AND USING THEM - The present invention describes a method for treating, removing or preventing a bacterial infection, which method comprises administering to a human suffering, suspected of suffering or at risk of suffering from | 06-17-2010 |
20110079641 | METHOD AND SYSTEM FOR ACCURATELY LABELING A SPECIMEN AND TREATING A SUBJECT - Methods of accurately labeling a specimen accurately giving a medical treatment to a subject or patient are provided. The methods comprise reading a machine-readable subject identification label associated with a subject using a portable label reader; reading a machine-readable subject identification label associated with a collection receptacle or a machine-readable subject identification label associated with a medical treatment intended to be given to the subject using the portable label reader; and indicating whether the two machine-readable subject identification labels correspond to each other using the portable label reader, wherein a specimen is taken from the subject, deposited in the collection receptacle and/or the label is affixed to the collection receptacle, or the medical treatment is given to the subject when the two machine-readable subject identification labels correspond. Systems and hand-held apparatuses for accurately labeling a specimen and accurately giving a medical treatment to a subject or patient are also provided. | 04-07-2011 |
20110300642 | METHODS FOR DIFFERENTIATING AND MONITORING PARATHYROID AND BONE STATUS RELATED DISEASES - The present invention relates to novel methods and devices for differentiating in a patient parathyroid diseases, such as hyperparathyroidism and related bone diseases, from normal or non-disease states. One detects whole or non-fragmented (1 to 84) parathyroid hormone in a biological sample and also a large non-whole parathyroid hormone peptide fragment that can function as a parathyroid hormone antagonist. By either comparing values or using independently the value of either the large non-whole parathyroid hormone peptide fragment, the whole parathyroid hormone, or the combination of these values, one is able to differentiate parathyroid and bone related disease states, as well as differentiate such states from normal states. | 12-08-2011 |
20120027771 | AFFINITY PURIFIED HUMAN POLYCLONAL ANTIBODIES AGAINST VIRAL, BACTERIAL AND/OR FUNGAL INFECTIONS AND METHODS OF MAKING AND USING THE SAME - The present invention discloses compositions and methods for treating, preventing and/or monitoring viral, bacterial, eukaryotic protist and/or fungal infections. In some embodiments, these compositions and methods involve human polyclonal antibodies affinity purified from human blood using certain viral, bacterial, eukaryotic protist and/or fungal antigens as described herein. Methods of making the antigenic preparations and the affinity-purified human polyclonal antibodies for passive immunization are also provided. | 02-02-2012 |