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Cameron, PA
Craig Cameron, State College, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100129400 | ATTENUATED VIRUSES, VACCINES AND METHODS OF USE THEREOF - The invention encompasses compositions and methods relating to viral polymerases having one or more substitutions of different amino acids at conserved regions of the polymerase yields enzymes with varying rates and fidelity of replication. A universally applicable, polymerase-mechanism-based strategy for production of attenuated viruses and anti-viral vaccines is disclosed. Attenuated viruses serve as vaccines and were shown to provide protection against poliovirus challenge in vivo. | 05-27-2010 |
Craig E. Cameron, State College, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090215983 | Compounds and methods for inhibiting hepatitis C virus replication - The inventors have discovered that an ATPase-deficient dominant-negative mutant NS3 protein of hepatitis C virus inhibits activity of the wild-type NS3 protein and inhibits replication of hepatitis C virus (HCV). The solved crystal structure of a multi-enzyme NS3 complex on a DNA substrate is also provided. The inventors have tested a peptide matching the sequence of a portion of NS3 that interacts with another NS3 molecule for inhibiting HCV replication. The peptide inhibits HCV replication. Accordingly, the invention provides a method of inhibiting HCV replication in cells infected with HCV involving transforming the cells with a vector expressing a dominant-negative mutant NS3 gene. The invention also provides a method of inhibiting HCV replication in cells infected with HCV involving administering to the cells a dominant-negative mutant NS3 protein. The invention also provides peptides and agents that inhibit HCV replication and methods of identifying agents that inhibit HCV replication. | 08-27-2009 |
Louise M. Cameron, Nazareth, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090082375 | SOLID FORMS COMPRISING 3-(2,5-DIMETHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF USING THE SAME - Provided herein are solid forms comprising 3-(2,5-dimethyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione. Pharmaceutical compositions comprising the solid forms and methods for treating, preventing and managing various disorders are also disclosed. | 03-26-2009 |
| 20100016342 | SOLID FORMS COMPRISING 3-(2,5-DIMETHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF USING THE SAME - Provided herein are solid forms comprising 3-(2,5-dimethyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione. Pharmaceutical compositions comprising the solid forms and methods for treating, preventing and managing various disorders are also disclosed. | 01-21-2010 |
Louise Michelle Cameron, Nazareth, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090048275 | SOLID FORMS COMPRISING 4-[9-(TETRAHYDRO-FURAN-3-YL)-8-(2,4,6-TRIFLUORO-PHENYLAMINO)-9H-PURIN-2-Y- LAMINO]-CYCLOHEXAN-1-OL, COMPOSITIONS THEREOF, AND USES THEREWITH - Solid forms comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9H-purin-2-ylamino]-cyclohexan-1-ol, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders are disclosed. | 02-19-2009 |
Rudolph A. Cameron, Bensalem, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100280266 | Fixed-Bed Hydrosilylation Catalyst Complexes and Related Methods - The invention includes a fixed-bed catalyst complex that includes (i) a metal carbene catalyst, wherein the metal is platinum, and (ii) a catalyst support that includes one or more of silica, alumina and/or glass. The invention provides a fixed-bed catalyst complex that includes a catalyst complex including a carbene chosen from those represented by at least one of Formulae (I), (II), (III), and (IV): | 11-04-2010 |
Scott E. Cameron, Lower Burrell, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090041648 | Radiation detector crystal and method of formation thereof - A radiation detector crystal is made from Cd | 02-12-2009 |
Vernon B. Cameron, Greensburg, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100052407 | ROTATABLE CUTTING TOOL WITH SUPERHARD CUTTING MEMBER - A rotatable cutting tool that is useful for impingement upon a substrate and is adapted to be rotatably retained within the bore of a holder. The rotatable cutting tool includes an elongate cutting tool body, which has an axial forward end and an axial rearward end, as well as a socket at the axial forward end thereof. The rotatable cutting tool also includes a hard cutting member that is affixed to the cutting tool body within the socket. The hard cutting member has an axial forward end and an axial rearward end. The hard cutting member has a superhard axial forward portion at the axial forward end thereof wherein the superhard axial forward portion has a maximum transverse dimension. The hard cutting member further has a hard axial rearward portion contiguous with and axial rearward of the superhard axial forward portion. The hard axial rearward portion has a maximum transverse dimension. The ratio of the maximum transverse dimension of the superhard axial forward portion to the maximum transverse dimension of the hard axial rearward portion ranges between about 0.35 and about 0.45. | 03-04-2010 |