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Calos
Matthew Calos, Marina Del Rey, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110281653 | INTERACTIVE BROADCAST SPORTS GAMING - A method of interactive gaming includes identifying a broadcast event, generating interactive questions for the broadcast event based upon a subject of the broadcast event, organizing the generated questions based on a structure of the broadcast event, and providing the organized questions to a user during a broadcast of the broadcast event through an interactive gaming interface based on the structure of the broadcast event. | 11-17-2011 |
Michele P. Calos, Menlo Park, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100190178 | Altered Recombinases for Genome Modification - The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also includes methods of modifying the genomes of cells using the altered recombinases, including methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell. | 07-29-2010 |
Michele P. Calos, Woodside, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090035862 | METHODS AND COMPOSITIONS FOR GENOMIC MODIFICATION - The present invention provides methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell, as well as, enzymes, polypeptides, and a variety of vector constructs useful therefore. In the method, a targeting construct comprises, for example, (i) a first recombination site and a polynucleotide sequence of interest, and (ii) a site-specific recombinase, which are introduced into the cell. The genome of the cell comprises a second recombination site. Recombination between the first and second recombination sites is facilitated by the site-specific recombinase. The invention describes compositions, vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy techniques. | 02-05-2009 |
Michele P. Calos, Burlingame, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080241116 | Hybrid Recombinases for Genome Manipulation - The present invention provides methods to site-specifically manipulate genomes by using hybrid recombinases. Hybrid recombinases comprise a modified catalytic domain from a unidirectional serine phage integrase, fused to a foreign DNA recognition domain. | 10-02-2008 |
| 20110177600 | PROTEIN PRODUCTION USING EUKARYOTIC CELL LINES - The subject invention provides a site-specific integration system and methods for generating eukaryotic cells lines for protein production. The provided system includes a first site-specifically integrating target vector and a second site-specifically integrating donor vector comprising a gene of interest. Also provided are mammalian cell lines produced by the subject methods and systems, as well as kits that include the subject systems. | 07-21-2011 |