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Califano, US
Andrea Califano, New York, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090269772 | SYSTEMS AND METHODS FOR IDENTIFYING COMBINATIONS OF COMPOUNDS OF THERAPEUTIC INTEREST - Systems, methods, and apparatus for searching for a combination of compounds of therapeutic interest are provided. Cell-based assays are performed, each cell-based assay exposing a different sample of cells to a different compound in a plurality of compounds. From the cell-based assays, a subset of the tested compounds is selected. For each respective compound in the subset, a molecular abundance profile from cells exposed to the respective compound is measured. Targets of transcription factors and post-translational modulators of transcription factor activity are inferred from the molecular abundance profile data using information theoretic measures. This data is used to construct an interaction network. Variances in edges in the interaction network are used to determine the drug activity profile of compounds in the subset of compounds. The drug activity profiles are used to form a filter set of compound combinations from the subset of compounds. | 10-29-2009 |
| 20100023273 | Characterization of Phenotypes by Gene Expression Patterns and Classification of Samples Based Thereon - Generally, the present invention applies a transformation to convert a probability distribution of gene expression signals in control samples to a uniform distribution. The uniform distribution allows better comparisons between expression levels for genes. The transformation is derived from gene expression signals of control data, and is applied to gene expression signals of phenotype data. The phenotype data can be represented in a matrix format. A number of gene expression patterns may be determined (in the form of submatrices) that will characterize the phenotype. The uniform distribution helps in this regard, as it allows better comparisons of patterns. The gene expression patterns can then be used to classify samples as belonging to the phenotype set. Preferably, a discriminant function is used to compare a sample with the gene expression patterns that characterize the phenotype. The discriminant function can determine a score that can be used to determine whether the sample belongs to the phenotype. | 01-28-2010 |
| 20100172495 | SEMIOTIC SYSTEM AND METHOD WITH PRIVACY PROTECTION - A method of processing semiotic data includes receiving semiotic data including at least one data set P, selecting a function h, and for at least one of each data set P to be collected, computing h(P), destroying data set P, and storing h(P) in a database, wherein data set P cannot be extracted from h(P). The method further includes selecting a private key/public key (K, k) once for all cases, one of destroying the private key K and sending the private key K to a trusted party, and choosing function h as the public encryption function corresponding to k. | 07-08-2010 |
| 20100197772 | Tissue-Specific MicroRNAs and Compositions and Uses Thereof - The invention provides for isolated nucleic acid sequences of newly discovered micro RNAs that have been identified to exist in normal Human B cells and/or in tumor-related Human B cells, using an integrated bioinformatics method and pipeline described herein. | 08-05-2010 |
| 20100299159 | METHODS AND SYSTEMS FOR MANAGING INFORMED CONSENT PROCESSES - The systems and methods provide a dynamic process for obtaining and managing informed consent documentation. In general, the dynamic informed consent process (DICP) makes use of an intermediary organization, e.g., a trusted intermediary, which: (a) provides ICFs which have been dynamically generated for a specified trial or medical procedure and based on particular state or federal requirements, if any; and (b) archives copies of signed ICFs. In certain preferred embodiments, there may also be a procedure to provide training materials, such as audio or video presentations, to be viewed by prospective participants. In certain preferred embodiments, the process also includes contacting subjects who have signed ICFs in the event that there is a change of circumstance which the subject may deem material to whether s/he would continue to consent, or whether the participant needs to provide a different type of consent to participate in particular event or trial. | 11-25-2010 |
| 20110172929 | SYSTEM AND METHOD FOR PREDICTION OF PHENOTYPICALLY RELEVANT GENES AND PERTURBATION TARGETS - Disclosed herein is a systems biology approach to prediction of phenotypically relevant genes such as oncogenes and perturbation targets. Interactions from a comprehensive cellular network such as the B Cell Interactome (BCI) can be used to identify those that become affected, or dysregulated, by a phenotype (e.g, disease, tumor and cancer) or perturbation (e.g., drug treatment) based on correlation changes between expression profiles of gene pairs in the interactions upon removal or addition of samples showing the phenotype or perturbation. Genes can be ranked based on the affected interactions involving the genes to predict phenotypically relevant genes and/or perturbation targets. | 07-14-2011 |
Christopher J. Califano, Locust Valley, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080318742 | METHOD AND APPARATUS FOR KNEE STRENGTHENING - An exercise device and method of use is provided. The exercise device includes an elongated elastic element having a first end and a second end. The elongated elastic element is stretchable along its length. The exercise device further includes a pulley system comprising a pulley having a channel along its outer circumference through which the elongated elastic element runs. An engagement mechanism removably anchors the pulley to a fixed point while allowing the pulley to rotate as the elongated elastic element passes through the channel. | 12-25-2008 |
Edward A. Califano, N. Massapequa, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100205899 | MASONRY SUB-FLOORING - A device for use in constructing a support surface for pavers and paving bricks comprising a planar tread surface; two elongated complementary mounting members being disposed at respectively opposite ends of the device and extending over substantially the entire width of the device, adapted to overlap and interlock. Thus when two devices are arranged end-to-end the complementary mounting members are fitted together and overlapping one another to define a mounting area. Each mounting member further includes a fastener receiving means, the fastener receiving means being located such that when a portion of the mounting member overlaps a corresponding portion of a complementary mounting member, the fastener receiving means of the portions are aligned to receive a single fastening element. The device further comprises two elongate engagement members disposed at opposite sides of the device and having shapes which are complementary to each other so that two devices can be arranged side-by-side with the complementary engagement members fitted together; and a grid-like area between said members including openings which pack, retain and support fine particulate matter, such as sand, marble dust, etc while simultaneously allowing water to drain through. | 08-19-2010 |
Jean C. Califano, Whitefish Bay, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20100317568 | Anti-Viral Compounds - Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. | 12-16-2010 |
| 20110092415 | Anti-Viral Compounds - Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. | 04-21-2011 |
| 20110207699 | Anti-Viral Compounds - Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. | 08-25-2011 |
Jean-Christophe Califano, Whitefish Bay, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20110237793 | PROCESS FOR PREPARING ANTIVIRAL COMPOUND - This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions. | 09-29-2011 |
Joseph A. Califano, Owings Mills, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110097724 | Detection of Head and Neck Cancer Using Hypermethylated Gene Detection - Methods and kits for detection of a cell proliferative disorder, such as head and neck cancer are provided utilizing analysis of the methylation state of targeted genes or regulatory regions of genes in a saliva or serum sample are described. The presence of hypermethylation of the genes or their regulatory regions is indicative of the presence, or a stronger possibility of recurrence and or a poorer prognosis in subjects with cancer. | 04-28-2011 |
Joseph N. Califano US
| Patent application number | Description | Published |
|---|---|---|
| 20090067361 | Cellular Phone Signal Enhancement Apparatus - A method for guiding radio frequency (RF), this apparatus aids an RF signal for receiving incoming and outgoing RF cellular signals is described. This apparatus facilitates an improved communications link between an outside cellular signal source and a receiving indoor hand held cellular device. This apparatus improves existing communication links by providing a path for RF signal travel using standard building wiring infrastructure. This invention, in its preferred embodiments, is specifically designed to provide channeling of RF communications from local sources of RF signal sources outside of a building or other structure to their interior. This invention uses only passive means to facilitate an RF path and is not electrically activated when plugged into a standard wall outlet, but relies on absorbed RF thru existing building wiring infrastructure to facilitate an improved communications signal to a hand held cellular device inside of said structure. | 03-12-2009 |
Michael J. Califano, Cairo, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20110079287 | SINGLE COMPONENT TWO-STAGE REGULATOR - Disclosed is a cylindrical, single-component two-stage regulator for controlling a pressure and a flow rate of a gas. The regulator includes a housing for holding the two stages having an ingress adapted for connection to a source of gas at a high input pressure and an egress adapted for supplying gas at a lower output pressure than the high input pressure; a first stage for reducing the pressure of the gas from the high input pressure to a fixed intermediate pressure; and a second stage for reducing the pressure of the gas from the fixed intermediate pressure to the lower output pressure and regulating the flow rate of the gas out of the egress. One application of the present invention is for use in SCUBA (Self-Contained Underwater Breathing Apparatus) applications, where it replaces the traditional two-component user-adjustable regulator. The regulator may be made out of stainless steel, and is small enough to fit into a user's mouthpiece. | 04-07-2011 |
| 20110079290 | SINGLE COMPONENT TWO-STAGE REGULATOR - Disclosed is a cylindrical, single-component two-stage regulator for controlling a pressure and a flow rate of a gas. The regulator includes a housing for holding the two stages having an ingress adapted for connection to a source of gas at a high input pressure and an egress adapted for supplying gas at a lower output pressure than the high input pressure; a first stage for reducing the pressure of the gas from the high input pressure to a fixed intermediate pressure; and a second stage for reducing the pressure of the gas from the fixed intermediate pressure to the lower output pressure and regulating the flow rate of the gas out of the egress. One application of the present invention is for use in scuba (Self-Contained Under-water Breathing Apparatus) applications, where it replaces the traditional two-component user-adjustable regulator. The regulator may be made out of stainless steel, and is small enough to fit into a user's mouthpiece. | 04-07-2011 |
Paul Califano, Cairo, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20110162731 | Micro-regulator device - A regulator comprised of a housing having an ingress for connection to a source of gas at a first pressure and an egress adapted for supplying gas at a lower pressure than the first pressure. A fixed member, located within the housing, separates the ingress from the egress and has at least one opening extending therethrough. A throttling tube is located in the housing and extends through the opening in the fixed member to control the flow of gas from the ingress to the egress. The throttling tube has a first end juxtaposed with a compressible disk and a second end juxtaposed with a valve seat. An actuation lever responds to a pressure within the housing to move the throttling tube into and out of engagement with the valve seat. The throttling tube responds to a force provided by the disk when it is out of engagement with valve seat. | 07-07-2011 |
Paul J. Califano, Cairo, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20110079287 | SINGLE COMPONENT TWO-STAGE REGULATOR - Disclosed is a cylindrical, single-component two-stage regulator for controlling a pressure and a flow rate of a gas. The regulator includes a housing for holding the two stages having an ingress adapted for connection to a source of gas at a high input pressure and an egress adapted for supplying gas at a lower output pressure than the high input pressure; a first stage for reducing the pressure of the gas from the high input pressure to a fixed intermediate pressure; and a second stage for reducing the pressure of the gas from the fixed intermediate pressure to the lower output pressure and regulating the flow rate of the gas out of the egress. One application of the present invention is for use in SCUBA (Self-Contained Underwater Breathing Apparatus) applications, where it replaces the traditional two-component user-adjustable regulator. The regulator may be made out of stainless steel, and is small enough to fit into a user's mouthpiece. | 04-07-2011 |
| 20110079290 | SINGLE COMPONENT TWO-STAGE REGULATOR - Disclosed is a cylindrical, single-component two-stage regulator for controlling a pressure and a flow rate of a gas. The regulator includes a housing for holding the two stages having an ingress adapted for connection to a source of gas at a high input pressure and an egress adapted for supplying gas at a lower output pressure than the high input pressure; a first stage for reducing the pressure of the gas from the high input pressure to a fixed intermediate pressure; and a second stage for reducing the pressure of the gas from the fixed intermediate pressure to the lower output pressure and regulating the flow rate of the gas out of the egress. One application of the present invention is for use in scuba (Self-Contained Under-water Breathing Apparatus) applications, where it replaces the traditional two-component user-adjustable regulator. The regulator may be made out of stainless steel, and is small enough to fit into a user's mouthpiece. | 04-07-2011 |