Calabrese
Andrew Anthony Calabrese, Kent GB
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20100267769 | Substituted Bicyclocarboxyamide Compounds - This invention provides a compound of the formula | 10-21-2010 |
Andrew Antony Calabrese, Kent GB
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20100222365 | SUBSTITUTED TRIAZOLE DERIVIATIVES AS OXYTOCIN ANTAGONISTS - The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.). | 09-02-2010 |
20110021514 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME - Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others. | 01-27-2011 |
20110092529 | 1,2,4-Triazole Derivatives and Their Use as Oxytocin Antagonists - The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.). | 04-21-2011 |
Andrew Antony Calabrese, Sandwich GB
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20090253674 | Substituted Triazole Derivatives As Oxytocin Antagonists - The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction. | 10-08-2009 |
20130137671 | Substituted Triazole Derivatives As Oxytocin Antagonists - The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction. | 05-30-2013 |
20150322042 | SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS - The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction. | 11-12-2015 |
David Calabrese, Lausanne CH
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20130143264 | HIGH EFFICIENCY GENE TRANSFER AND EXPRESSION IN MAMMALIAN CELLS BY AMULTIPLE TRANSFECTION PROCEDURE OF MAR SEQUENCES - The present invention relates to purified and isolated DNA sequences having protein production increasing activity and more specifically to the use of matrix attachment regions (MARs) for increasing protein production activity in a eukaryotic cell. Also disclosed is a method for the identification of said active regions, in particular MAR nucleotide sequences, and the use of these characterized active MAR sequences in a new multiple transfection method. | 06-06-2013 |
David Calabrese, Plan-Les-Ouates CH
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20120231449 | PRODUCTS AND METHODS FOR ENHANCED TRANSGENE EXPRESSION AND PROCESSING - Disclosed are methods and eukaryotic host cells for transgene expression. The cells may be treated and/or modified to increase homologous recombination (HR), decrease non homologous end joining (NHEJ) and/or to enhance a HR/NHEJ ratio in said cell. Such cells can be transfected with vectors comprising the transgene, which advantageously integrates into the genome of the cell to form a concatemeric structure which may comprise more than 200 transgene copies. Certain expression enhancing elements such as MARs are advantageously provided to further enhance and/or facilitate transgene expression. Disclosed is also a recombinant eukaryotic host cell, in particular a non-primate host cell, comprising a transgenic sequence encoding a protein and/or a RNA, in particular a primate protein and/or RNA, involved in translocation across the ER membrane and/or secretion across the cytoplasmic membrane. | 09-13-2012 |
20150361451 | Enhanced Transgene Expression and Processing - Disclosed are constructs and methods for expressing DNAs of interest in particular in non-primate eukaryotic host cells that display advantages with regard quantity and quality of expression including high stability of expression and, if appropriate, transport of the expression product out of the cell. | 12-17-2015 |
David Calabrese, Perly CH
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20110061117 | MATRIX ATTACHMENT REGIONS (MARS) FOR INCREASING TRANSCRIPTION AND USES THEREOF - Isolated and purified MAR sequences of human and non-human animal origin are disclosed as are nucleotide sequences corresponding to or based on them. In particular, MARs and MAR constructs with high transcription and/or protein production enhancing activities are disclosed and so are methods for identifying such MARs, designing such MAR constructs and employing them, e.g., for high yield production of proteins. | 03-10-2011 |
Davide Calabrese, Torino IT
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20120107034 | WRITING INSTRUMENT WITH RETRACTABLE TIP - A writing instrument is described, composed of a body adapted to contain therein ink or at least one ink cartridge, connected to a delivering tip for this ink, the delivering tip sliding inside the body between a first operating position in which the delivering tip goes out of an opening and a second rest position in which the delivering tip is retracted from the opening and is contained inside the body. | 05-03-2012 |
Diego Calabrese, Roma IT
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20120319892 | Acquisition of SAR images for computing a height or a digital elevation model by interferometric processing - The present invention relates to a method for acquiring SAR images for interferometric processing. The method comprises acquiring, by one or more airborne SAR sensors, SAR images of one and the same area with an acquisition geometry such that to enable interferometric processing of said SAR images. The method is characterized by an acquisition geometry in which each SAR image of the area is acquired in a respective direction of acquisition that defines a respective squint angle with respect to the direction of flight, and in which the squint angles are such that to determine a mean squint angle different from zero. | 12-20-2012 |
20150378018 | Multiple-Swath Stripmap SAR Imaging - A SAR imaging method is provided that performs N SAR acquisitions in stripmap mode of areas of the earth's surface by means of a synthetic aperture radar transported by an aerial or satellite platform and which includes a single, non-partitioned antenna and a single receiver coupled to the single, non-partitioned antenna, N being an integer greater than one. Each SAR acquisition in stripmap mode is performed using a respective squint angle with respect to the flight direction of the synthetic aperture radar and a respective elevation angle with respect to the nadir of the synthetic aperture radar. The method may further generate SAR images of areas of the respective swath observed via the SAR acquisition in stripmap mode. All SAR images have the same azimuth resolution that is equal to half the physical or equivalent length along the azimuth direction of the single, non-partitioned antenna of the synthetic aperture radar. | 12-31-2015 |
Francesco Calabrese, Dublin IE
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20140067251 | HEDGING RISK IN JOURNEY PLANNING - Embodiments of the disclosure include a method for journey planning including receiving a journey planning request, the journey planning request having an origin and a destination in a transportation network. The method also includes calculating an optimized journey plan by identifying a plurality of routes through the transportation network from the origin to the destination and determining an uncertainty associated with each of the plurality of routes. Calculating an optimized journey plan also includes evaluating a robustness of each of the plurality of routes to the uncertainty associated with each of the plurality of routes and selecting the optimized journey plan based on the journey planning request and the robustness of each of the plurality of routes. | 03-06-2014 |
20140067254 | HEDGING RISK IN JOURNEY PLANNING - Embodiments of the disclosure include a computer system for journey planning, the computer system includes a journey planning server configured to perform a method. The method includes receiving a journey planning request, the journey planning request having an origin and a destination in a transportation network. The method also includes calculating an optimized journey plan by identifying a plurality of routes through the transportation network from the origin to the destination and determining an uncertainty associated with each of the plurality of routes. Calculating an optimized journey plan also includes evaluating a robustness of each of the plurality of routes to the uncertainty associated with each of the plurality of routes and selecting the optimized journey plan based on the journey planning request and the robustness of each of the plurality of routes. | 03-06-2014 |
20140067266 | JOURNEY COMPUTATION WITH RE-PLANNING BASED ON EVENTS IN A TRANSPORTATION NETWORK - Embodiments of the disclosure include a method for journey planning including receiving a journey planning request. The request includes an origin and a destination in a transportation network. The method also includes calculating an optimized journey plan based on the journey planning request and a route map corresponding to the transportation network and identifying a potential event in the transportation. The method further includes monitoring the transportation network for the potential event and based on detecting an execution of the potential event, calculating an improved journey plan. | 03-06-2014 |
20140094988 | DE-NOISING SCHEDULED TRANSPORTATION DATA - Embodiments of the disclosure include a method for de-noising data in a scheduled transportation system, the method includes receiving a plurality of digital traces that correspond to a piece of equipment in the scheduled transportation system. The method also includes identifying a plurality of journeys from the plurality of digital traces, wherein each of the plurality of journeys corresponds to the piece of equipment traversing one of a plurality of routes and generating a route map and schedule for the scheduled transportation system from the plurality of journeys and the plurality of digital traces. | 04-03-2014 |
20140094991 | DE-NOISING SCHEDULED TRANSPORTATION DATA - Embodiments of the disclosure include a method for de-noising data in a scheduled transportation system, the method includes receiving a plurality of digital traces that correspond to a piece of equipment in the scheduled transportation system. The method also includes identifying a plurality of journeys from the plurality of digital traces, wherein each of the plurality of journeys corresponds to the piece of equipment traversing one of a plurality of routes and generating a route map and schedule for the scheduled transportation system from the plurality of journeys and the plurality of digital traces. | 04-03-2014 |
20140095065 | ESTIMATION OF ARRIVAL TIMES AT TRANSIT STOPS - Embodiments of the disclosure include a method for providing a consolidated estimated time of arrival in a scheduled transportation system. The method includes receiving at least one of a scheduled time of arrival, a real-time estimated time of arrival and a predictive estimated time of arrival and assigning a weight to each of the scheduled time of arrival, the real-time estimated time of arrival and the predictive estimated time of arrival. The method also includes calculating a confidence level and the consolidated estimated time of arrival based on the weights and the scheduled time of arrival, the real-time estimated time of arrival and the predictive estimated time of arrival. | 04-03-2014 |
20140095066 | ESTIMATION OF ARRIVAL TIMES AT TRANSIT STOPS - Embodiments of the disclosure include a method for providing a consolidated estimated time of arrival in a scheduled transportation system. The method includes receiving at least one of a scheduled time of arrival, a real-time estimated time of arrival and a predictive estimated time of arrival and assigning a weight to each of the scheduled time of arrival, the real-time estimated time of arrival and the predictive estimated time of arrival. The method also includes calculating a confidence level and the consolidated estimated time of arrival based on the weights and the scheduled time of arrival, the real-time estimated time of arrival and the predictive estimated time of arrival. | 04-03-2014 |
20150039363 | REAL-TIME PREDICTION AND CORRECTION OF SCHEDULED SERVICE BUNCHING - A method includes: a computer receiving historical data from at least one service vehicle; the computer receiving network definitions for the least one service vehicle; the computer receiving dynamic data from the at least one service vehicle; and the computer developing predictions and corrective actions to prevent service bunching, based upon the historical data, the network definitions, and the dynamic data. | 02-05-2015 |
20150039372 | REAL-TIME PREDICTION AND CORRECTION OF SCHEDULED SERVICE BUNCHING - A method includes: a computer receiving historical data from at least one service vehicle; the computer receiving network definitions for the least one service vehicle; the computer receiving dynamic data from the at least one service vehicle; and the computer developing predictions and corrective actions to prevent service bunching, based upon the historical data, the network definitions, and the dynamic data. | 02-05-2015 |
Francesco Calabrese, Castlenock IE
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20160063405 | PUBLIC TRANSPORTATION FARE EVASION INFERENCE USING PERSONAL MOBILITY DATA - Embodiments include fare evasion inference using personal mobility data in a public transportation system. Aspects include receiving personal mobility data and constructing a plurality of personal trajectories from the personal mobility data. Aspects also include mapping each of the plurality of personal trajectories to a route and time of the public transportation system and calculating an estimated occupancy for each route and time in the public transportation system based on a number of personal trajectories mapped to each route and time. Aspects further include comparing the estimated occupancy with a paying passenger data received from the public transportation system and assigning a score to each route and time in the public transportation system based on the comparison of the estimated occupancies and the paying passenger data, wherein the score is indicative of a probability of a fare evasion occurring. | 03-03-2016 |
Gaetano Calabrese, Aarau CH
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20140328524 | SURFACE AND IMAGE INTEGRATION FOR MODEL EVALUATION AND LANDMARK DETERMINATION - Embodiments of the present disclosure provide a software program that displays both a volume as images and segmentation results as surface models in 3D. Multiple 2D slices are extracted from the 3D volume. The 2D slices may be interactively rotated by the user to best follow an oblique structure. The 2D slices can “cut” the surface models from the segmentation so that only half of the models are displayed. The border curves resulting from the cuts are displayed in the 2D slices. The user may click a point on the surface model to designate a landmark point. The corresponding location of the point is highlighted in the 2D slices. A 2D slice can be reoriented such that the line lies in the slice. The user can then further evaluate or refine the landmark points based on both surface and image information. | 11-06-2014 |
Giovanni Calabrese, Munich DE
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20110108916 | Semiconductor Devices and Methods - Disclosed herein are Lateral Diffused Metal Oxide Semiconductor (LDMOS) device and trench isolation related devices, methods, and techniques. | 05-12-2011 |
20150380522 | Methods of Forming Low Noise Semiconductor Devices - Disclosed herein are Lateral Diffused Metal Oxide Semiconductor (LDMOS) device and trench isolation related devices, methods, and techniques. In one illustration, a doped region is formed within a semiconductor substrate. A trench isolation region is formed within the doped region. The doped region and the trench isolation region are part of a Lateral Diffused Metal Oxide Semiconductor (LDMOS) device. The trench isolation region or an interface between the trench isolation region and the doped region is configured to reduce low frequency noise in the LDMOS device. | 12-31-2015 |
Nicola Calabrese, Bari IT
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20110111094 | PROCESS FOR THE PREPARATION OF VEGETABLE PRESERVES CONTAINING PROBIOTIC MICROORGANISMS - The present invention relates to a process for the preparation of vegetable preserves, comprising immersing a vegetable in a solution containing darkening inhibitors, half cooking the vegetable in water at a temperate of between 90 and 100° C., immersing the vegetable in a brine solution containing probiotic lactobacilli and/or bifidobacteria in a sterile container and sealing the container. The invention further relates to vegetable and vegetable preserves obtained by means of the process. | 05-12-2011 |
Rafael Januario Calabrese, Sao Paulo BR
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20090126720 | SUGAR CANE JUICE CLARIFICATION PROCESS - A process to clarify raw sugar cane juice, which comprises adding a source of lime, adding an anionic inorganic colloid, and separating of the resulting sugar cane juice, is disclosed. | 05-21-2009 |
20100040747 | SILICA MICROGELS FOR REDUCING CHILL HAZE - The present invention provides a method of reducing chill haze in a protein containing liquid (especially beverages resulting from fermentation such as beer and wine) by contacting the liquid with silica microgels having an average microgel diameter of at least 18 nm, more preferably at least 45 nm, and most preferably at least 70 nm. It has now been discovered that microgels having an average microgel diameter of less than about 18 nm do not adequately reduce chill haze of a protein containing liquid. In particular, while microgels having an average microgel diameter of less than about 18 nm cause the coagulation of haze-forming components, these components remain suspended in liquid and continue to cause haze despite allowing the liquid to settle for long periods of time. Conversely, it has now been discovered that microgels having an average microgel diameter of at least about 18 nm cause the coagulation and precipitation of haze-forming components and the rapid settling thereof without the use of an organic polymer which acts as a flocculating agent. | 02-18-2010 |
20100236492 | METALLIZED ANIMAL HOUSE CURTAIN - An animal house curtain comprising a metallized composite sheet can be made from a sheet layer having two outer surfaces, the sheet layer comprising at least one of a nonwoven fabric, woven fabric, nonwoven fabric-film laminate, woven fabric-film laminate, film and composites thereof, and at least one coating on at least one outer surface of the sheet layer, said coating comprising a metal coating layer having a thickness between about 15 nanometers and about 200 nanometers adjacent the outer surface of the sheet layer and wherein the emissivity of the composite sheet is less than about 0.50. Optionally, an organic coating layer of a composition containing a material selected from the group consisting of compounds, polymers, oligomers and combinations thereof, having a thickness between about 0.2 micrometer and about 2.5 micrometers can be deposited on the metal layer. | 09-23-2010 |
Vincent Calabrese, Lausanne CH
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20100034055 | LARGE DATE CALENDAR DAY MECHANISM FOR A TIMEPIECE - The large date mechanism comprises three superposed indicator discs ( | 02-11-2010 |
20100091617 | TIMEPIECE GEAR TRAIN - The invention concerns a timepiece gear train including at least one pair of circular toothed elements ( | 04-15-2010 |
20100246338 | TIMEPIECE MOVEMENT INCLUDING A KARUSSEL - The timepiece movement includes a barrel, an escapement that has an escape wheel and pinion ( | 09-30-2010 |
20110096635 | TOURBILLON AND TIMEPIECE MOVEMENT INCLUDING THE SAME - The tourbillon mechanism is characterized in that it includes a toothed wheel ( | 04-28-2011 |
20110205857 | OSCILLATING WEIGHT FOR AN AUTOMATIC WINDING WATCH, INCLUDING A POWER RESERVE INDICATOR DEVICE INTEGRATED IN SAID OSCILLATING WEIGHT - The invention concerns an oscillating weight ( | 08-25-2011 |
20120020192 | DUAL DISPLAY TIMEPIECE - Mechanism ( | 01-26-2012 |
20130201801 | TWO-DIRECTIONAL DATE CORRECTOR MECHANISM FOR A DATE MECHANISM, DATE MECHANISM, TIMEPIECE - A two-directional date corrector mechanism controlled by a pull-out piece for a date mechanism. The mechanism includes a 24 hour wheel, a date updating finger pivoting integrally therewith, a date driving star-wheel, and a corrector star-wheel meshing therewith and located between the date driving star-wheel and the finger and configured to be uncouplable from the finger under action of an uncoupling mechanism controlled by the pull-out piece, the uncoupling mechanism having a coupling position where the corrector star-wheel meshes with the finger, and an uncoupling position where it is released from the finger to allow the date to be corrected. A date mechanism can include such a date corrector mechanism and a timepiece can include such a date corrector mechanism. | 08-08-2013 |