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| 20090208473 | COMPOSITIONS AND METHODS TO MODULATE CELL MEMBRANE RESEALING - Disclosed herein are compositions and methods for repairing cell membranes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the repair of cell membranes. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with cell membrane damage. | 08-20-2009 |
| 20090318348 | Proteins, Nucleic Acids Encoding the Same, and Associated Methods of Use - Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins. | 12-24-2009 |
| 20110287004 | MG53 COMPOSITIONS AND METHODS OF USE - Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins. | 11-24-2011 |
| 20110287015 | MG53 COMPOSITIONS AND METHODS OF USE - Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins. | 11-24-2011 |
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| 20080313835 | Oral Care Instrument Including An Oral Care Agent - An oral care instrument includes at least one oral care agent. In one embodiment, the oral care agent can be provided on one or more surfaces of the oral care instrument or included within cavities within the head or in one or more surfaces of a head. In other embodiment, the oral care agent can be provided in or on a thin slab subsequently bonded onto a surface, or applied as a stable coating. The oral care instrument can also be provided with a wear indicator. The oral care agents can be released during one use, during multiple uses, or throughout the life of the instrument. Water, oral secretions and/or chemicals within the mouth can activate the oral care agents. | 12-25-2008 |
| 20090087813 | BIO-ACTIVATED ORAL CARE INSTRUMENT - An oral care instrument, such as a motorized toothbrush, which activates upon exposure to the oral environment of the user, is described. The electrical conductivity of saliva, optionally mixed with toothpaste and water, may be utilized to complete an electrical circuit that powers a motorized device within the instrument. | 04-02-2009 |
| 20090317345 | Antiperspirant/Deodorant Gel Composition With Low Pouring Temperature - Solid stick antiperspirant and deodorant compositions containing both branched and linear N-acyl gelling agents along with dipropylene glycol are provided. Such compositions exhibit advantageous pouring temperatures below about 80° C. | 12-24-2009 |
| 20110283469 | BIO-ACTIVATED ORAL CARE INSTRUMENT - An oral care instrument, such as a motorized toothbrush, which activates upon exposure to the oral environment of the user, is described. The electrical conductivity of saliva, optionally mixed with toothpaste and water, may be utilized to complete an electrical circuit that powers a motorized device within the instrument. | 11-24-2011 |
| 20120045493 | Solid Cosmetic Composition with Structurant and Electrolyte Solution - A water soluble cosmetic or pharmaceutical or pharmaceutical actives in an electrolyte solution which, when impregnated with one or more retentive fillers (such as, for example, silica or hydrophobically modified silica, lamellar filler, crosspolymer, cellulosic, resins, or silicone elastomers) can form stable solid compositions with structurants. Such solid compositions do not require a higher buffer pH or leave residues upon application to the skin. Solid compositions according to the present invention are suitable for cosmetic and pharmaceutical purposes such as antiperspirants, deodorants, lip products, and other topical applications. | 02-23-2012 |
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| 20100111023 | METHOD AND AN APPARATUS FOR PROVIDING CONTROL INFORMATION FOR MULTI-CARRIER UPLINK TRANSMISSION - A method and an apparatus for providing control information for multi-carrier uplink transmission are disclosed. A wireless transmit/receive unit (WTRU) may set a happy bit for enhanced dedicated channel (E-DCH) transmissions on each uplink carrier considering aggregated transmission capability over all uplink carriers. The happy bit is set to “unhappy” if the WTRU is transmitting as much scheduled data as allowed by a current serving grant, the WTRU has enough power available to transmit at a higher rate, and total E-DCH buffer status (TEBS) requires more than a pre-configured period to be transmitted with a current effective data rate aggregated over all uplink carriers. The WTRU may send scheduling information including power headroom measured on the anchor uplink carrier and/or power headroom measured on the supplementary uplink carrier. For power headroom measurements, the WTRU may initiate a short-lived dedicated physical control channel loop on the supplementary carrier. | 05-06-2010 |
| 20100172428 | FAST CONTROL CHANNEL FEEDBACK FOR MULTIPLE DOWNLINK CARRIER OPERATIONS - A method and apparatus for fast control channel feedback for multiple downlink carrier operations are disclosed. A wireless transmit/receive unit (WTRU) receives signals over a plurality of downlink carriers, generates feedback for each of the plurality of downlink carriers based on the received signals, and transmits via a plurality of antennas, the feedback for at least one of the plurality of downlink carriers over a first physical channel and feedback for another of the plurality of downlink carriers over a second physical channel. | 07-08-2010 |
| 20110080972 | METHOD AND APPARATUS FOR MULTI-ANTENNA TRANSMISSION IN UPLINK - Method and apparatus for uplink transmission using multiple antennas are disclosed. A wireless transmit/receive unit (WTRU) performs space time transmit diversity (STTD) encoding on an input stream of a physical channel configured for STTD. Each physical channel may be mapped to either an in-phase (I) branch or a quadrature-phase (Q) branch. The WTRU may perform the STTD encoding either in a binary domain or in a complex domain. Additionally, the WTRU may perform pre-coding on at least one physical channel including the E-DPDCH with the pre-coding weights, and transmitting the pre-coded output streams via a plurality of antennas. The pre-coding may be performed either after or before spreading operation. | 04-07-2011 |
| 20110105174 | METHOD AND APPARATUS FOR TRANSMIT POWER CONTROL FOR MULTIPLE ANTENNA TRANSMISSIONS IN THE UPLINK - Techniques for transmit power control for multiple antenna transmissions in an uplink are disclosed. A wireless transmit/receive unit (WTRU) generates at least one input stream for transmission and applies a gain factor to each channel. The gain factor is determined based on a reference channel power estimate. The WTRU generates at least two data streams from the input stream for transmission via a plurality of antennas and applies weights to the data streams. The gain factor and/or the weights are controlled such that a transmit power on each antenna is within a maximum allowed value. The WTRU may perform power scaling on a condition that a transmit power on any antenna exceeds the maximum allowed value. The WTRU may scale down an enhanced dedicated channel (E-DCH) dedicated physical data channel (E-DPDCH) first before other channels. For multiple E-DCH streams, the WTRU may calculate an E-DPDCH power offset based on an additional power offset factor due to multiple stream transmission. | 05-05-2011 |
| 20110170420 | METHOD AND APPARATUS FOR PERFORMING DISCONTINUOUS RECEPTION AND/OR DISCONTINUOUS TRANSMISSION FOR A MULTI-CARRIER/MULTI-CELL OPERATION - Method and apparatus for multi-carrier/multi-cell discontinuous reception (DRX)/discontinuous transmission (DTX) operations, autonomous deactivation of the secondary carrier(s)/cell(s), and explicit activation/deactivation of DRX/DTX and secondary carriers/cells are disclosed. A user equipment (UE) may configure at least one state variable for controlling DRX and/or DTX on a plurality of cells and perform an DRX and/or DTX operation on a subset of cells based on a state variable associated with the subset of cells on a cell group basis. The UE may activate or deactivate DRX and/or DTX based on an order from a network for all cells, a group of cells, or an individual cell. The UE may deactivate the secondary cells autonomously based on activity on the cell(s). | 07-14-2011 |
| 20110249656 | Sending Feedback for Multiple Downlink Carriers - Feedback information for multiple serving cells are transmitted on high speed dedicated physical control channel (HS-DPCCH). A slot format for transmitting feedback information is determined based on the number of configured secondary serving cells and whether multiple input multiple-output (MIMO) is configured in the serving cells. Spreading factor is reduced to 128 when two secondary serving cells are configured and MIMO is configured in at least one of the two configured secondary serving cells, or when three secondary serving cells are configured. The serving cells are grouped into feedback groups, each feedback group having one or more serving cells. Channel coding may be applied to feedback information for the feedback groups. The resulting encoded feedback information for the feedback groups is concatenated to form composite feedback information. | 10-13-2011 |
| 20110263281 | POWER CONTROL FOR CLOSED LOOP TRANSMIT DIVERSITY AND MIMO IN UPLINK - A method for dynamically controlling the transmit power of transmission streams transmitted via multiple antennas is disclosed. A transmit power level for multiple streams is determined based on a first reference channel. The difference of signal to interface ratios (SIRs) between two reference channels may represent a power offset. The power offset may be used to determine gain factors used to transmit data channels on the secondary stream with reference to the gain factor of the first reference channel. The power offset may be used to determine other parameters, such a serving grant or transport block sizes of channels carried on the secondary stream. The power offset may allow transmission parameters of channels on the secondary stream to be determined based on the transmit power level of the primary stream and a gain factor for a reference channel transmitted via the primary stream. | 10-27-2011 |
| 20120008510 | Method and Apparatus for Performing Uplink Antenna Transmit Diversity - Systems, methods, and instrumentalities are disclosed to provide antenna transmit diversity. A wireless transmit/receiver unit (WTRU) may comprise multiple antennas. A channel condition for each of the antennas may be determined. A probing phase may be used in order to determine the channel conditions. During a period of the probing phase, a probing signal from each antenna may be transmitted during a respective time interval. The WTRU transmit power may or may not be held constant. A Node B may receive each probing signal and determine channel quality information. The Node B may adjust the determined channel quality information if there is a power offset between the signals. The Node B may send the channel quality information to the WTRU. The WTRU may switch an antenna to use for uplink transmission based on the received channel quality information. | 01-12-2012 |
| 20120015657 | MANAGING POWER CONSUMPTION IN BASE STATIONS AND REMOTE ACCESS POINTS - A wireless transmit/receive unit (WTRU) in communication with a wireless network that may include a base station (or base node) and a cell that may be in a dormant mode is contemplated. The WTRU may determine that the WTRU may be within a vicinity of the cell and may generate a report that includes one or more measurements related to a location of the WTRU. The WTRU may transmit the report to the network and may receive an indication to perform one or more measurements related to the cell. The one or more measurements related to the cell may be based on a Common Pilot Channel (CPICH), a Synchronization Channel (SCH), and/or a Broadcast Channel (Primary Common Control Physical Channel) (BCH P-CCPCH) that may be transmitted by the cell upon a command from a base node. | 01-19-2012 |
| 20120082192 | METHOD AND APPARATUS FOR TRANSMITTING PILOT ON MULTIPLE ANTENNAS - Method and apparatus for transmitting pilot on multiple antennas are disclosed. A wireless transmit/receive unit (WTRU) may transmit a primary dedicated physical control channel (DPCCH) and at least one secondary DPCCH via multiple antennas using different channelization codes. The first eight pilot symbols of the secondary DPCCH may be same as pilot symbols of length eight of the primary DPCCH. The secondary DPCCH may include a same number of pilot bits as the primary DPCCH in a normal mode and in a compressed mode, respectively. The transmit power of the secondary DPCCH may be adjusted based on a ratio of a number of pilot symbols in the primary DPCCH and the secondary DPCCH. When a required transmit power exceeds a maximum allowed transmit power of the WTRU, power scaling may be applied equally to the primary DPCCJ and the secondary DPCCH. | 04-05-2012 |
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| 20080310860 | Method and Apparatus for Decision Threshold Control In An Optical Signal Receiver - A method of adjusting a decision threshold in an optical signal receiver. A forward error correction (FEC) decoder provides a feedback signal representative of corrected errors. The decision threshold is adjusted in response to a polarity of the received signal and to balance a number of corrected ones and zeros. | 12-18-2008 |
| 20090269081 | Soft Decision Threshold Control in a Signal Receiver Using Soft Decision Error Correction - A soft decision threshold control system and method may be used with a forward error correction (FEC) scheme to adjust or tune one or more soft decision thresholds in response to one or more bit value averages for the threshold(s) and in response to a bit error rate (BER). The bit value average for a soft decision threshold generally refers to an average number of binary values (e.g., logic ones and/or zeros) occurring in a bit stream detected using the soft decision threshold. For different BER levels in a particular system, for example, one or more of the soft decision thresholds may have a predetermined bit value average, which has been determined to provide a certain level of performance (e.g., an optimum performance). Thus, one or more of the soft decision thresholds may be adjusted such that the bit value averages for the soft decision thresholds are adjusted as a function of the BER. The settings of the soft decision thresholds may also be adjusted in response to changes in a signal amplitude of the input signal being detected. | 10-29-2009 |
| 20100232788 | Dual Stage Carrier Phase Estimation in a Coherent Optical Signal Receiver - A system and method implementing dual stage carrier phase estimation (CPE) in a coherent receiver for an optical fiber communication system. In the first stage, a feed-forward CPE is implemented to make an initial carrier phase estimation of a training sequence. The initial carrier phase estimation is coupled to the second stage which implements a decision-feedback CPE. After a training period, accurate bit decision for system traffic can be achieved using the decision-feedback CPE. | 09-16-2010 |
| 20100232796 | Data Pattern Dependent Distortion Compensation in a Coherent Optical Signal Receiver - A distortion compensation system and method may be used to compensate for data pattern dependent signal distortion in a signal received in a coherent optical signal receiver. In general, the distortion compensation system and method compares a received signal field with stored distorted signal waveforms associated with known data patterns and selects a compensation value associated with the distorted signal waveform that corresponds most closely with the received signal field. The distortion compensation system and method compensates the received signal using the selected compensation value and thus mitigates the effects of data pattern dependent signal distortion. | 09-16-2010 |
| 20100232797 | Detection of Data in Signals with Data Pattern Dependent Signal Distortion - A detection system and method may be used to detect data transmitted in a signal with data pattern dependent signal distortion such as intersymbol interference. In general, a detection system and method compares samples of a received signal with stored samples of distorted signals associated with known data patterns and selects the known data patterns that correspond most closely with the samples of the received signal. The detection system and method may thus mitigate the effects of data pattern dependent signal distortion. | 09-16-2010 |
| 20100232805 | Local Oscillator Frequency Offset Compensation in a Coherent Optical Signal Receiver - A system and method implementing dual stage carrier frequency offset compensation (FOC) in a coherent receiver for an optical communication system. In the first stage, a feed forward FOC function compensates for relatively slowly drifting frequency offsets. In a second stage, a decision-feedback FOC function compensates for relatively quickly drifting frequency offsets. The feed forward frequency offset compensation may be implemented with a feed forward carrier phase estimation function and the decision-feedback frequency offset compensation may be implemented with a decision-feedback carrier phase estimation function. | 09-16-2010 |
| 20100232809 | Detection of Data in Signals with Data Pattern Dependent Signal Distortion - A detection system and method may be used to detect data transmitted in a signal with data pattern dependent signal distortion. In general, a detection system and method compares samples of a received signal with stored samples of distorted signals associated with known data patterns and selects the known data patterns that correspond most closely with the samples of the received signal. The detection system and method may thus mitigate the effects of data pattern dependent signal distortion. | 09-16-2010 |
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| 20090143570 | METHOD FOR ISOLATION OF GENOMIC DNA, RNA AND PROTEINS FROM A SINGLE SAMPLE - The invention provides systems, methods and kits for the separation and/or purification of at least two cellular components selected from genomic DNA, RNA and proteins. The method includes first lysing a biological sample to generate an aqueous solution containing the cellular components; then applying the aqueous solution to a first mineral support under conditions for genomic DNA to bind; and collecting the flowthrough which contains unbound total RNA and proteins. The method further includes applying the flowthrough to a second mineral support under conditions for RNA to bind, and collecting the flowthrough which contains proteins. The genomic DNA and total RNA bound can be eluted while the protein in the flowthrough can be further purified. Further the total RNA isolated could be used to isolate small RNA such as microRNA. | 06-04-2009 |
| 20100105109 | MULTIPLY-PRIMED AMPLIFICATION OF CIRCULAR NUCLEIC ACID SEQUENCES - Improved processes for the amplification of target DNA sequences in the form of single or double stranded circular DNA molecules, especially those present in colony and plaque extracts, using multiple specific and/or random sequence oligonucleotide primers are disclosed. The product of this amplification is used for analysis by restriction enzyme digestion or DNA sequencing and other analyses that involve hybridization. Kits containing components for use in the method are also described. Also described are further uses of this amplified DNA in sequencing, genotyping and haplotyping, and other molecular biology applications. | 04-29-2010 |
| 20110172405 | METHOD FOR SMALL RNA ISOLATION - This invention relates to a simple and rapid method for the extraction and purification of small RNA from a sample solution. Accordingly, a sample is first mixed with an organic solvent to form a mixture containing the solvent. The mixture is applied to a first mineral support for large RNA to bind. The filtrate is collected which contain unbound small RNA, and is mixed with a second organic solvent to form a second mixture containing the second solvent. This second mixture is applied to a second mineral support for small RNA to bind. After a wash step, the small RNA is eluted. Also provided is a method for the isolation of large RNA, by eluting the large RNA from the first mineral support. In addition, total protein is present in the filtrate and can be isolated by a conventional method. | 07-14-2011 |
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| 20090170853 | NOVEL INHIBITORS OF KINASES - The present invention provides compounds of formula I, | 07-02-2009 |
| 20110034416 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER - Disclosed are compounds of Formula (I): | 02-10-2011 |
| 20110052583 | PYRIDINONE COMPOUNDS - The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: | 03-03-2011 |
| 20110294793 | HYDROXYPHENYL SULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS - The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compounds and methods of treating diseases using the compounds. | 12-01-2011 |
| 20110295015 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER - Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed. | 12-01-2011 |
