Patent application number | Description | Published |
20120149876 | Stable Heterodimeric Antibody Design with Mutations in the Fc Domain - The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) Fc molecule, and increased stability and purity of the resulting variant Fc heterodimers. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics. | 06-14-2012 |
20130089541 | Antibodies with Enhanced or Suppressed Effector Function - Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components. | 04-11-2013 |
20130108623 | Antibodies with Enhanced or Suppressed Effector Function | 05-02-2013 |
20130336973 | Heteromultimer Constructs of Immunoglobulin Heavy Chains with Mutations in the Fc Domain - Provided herein are isolated heteromultimers comprising: at least one single domain antigen-binding construct attached to at least one monomer of a heterodimer Fc region; wherein the heterodimer Fc region comprises a variant CH3 domain comprising amino acid mutations that promote the formation of said heterodimer with stability comparable to that of a native Fc homodimer; and wherein said isolated heteromultimer is devoid of immunoglobulin light chains and optionally devoid of immunoglobulin CH1 region. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics. | 12-19-2013 |
20150284470 | CRYSTAL STRUCTURES OF HETERODIMERIC Fc DOMAINS - Disclosed are the atomic coordinates of compositions comprising Fc heterodimer proteins in crystalline form derived from high resolution x-ray diffraction. Further disclosed are systems and methods for using all or a portion of these atomic coordinates to identify and design improved Fc heterodimer proteins. Further disclosed are compositions comprising a mixture of (i) a solubilized Fc heterodimer protein and (ii) a mother liquor solution. The mother liquor solution comprises between 2% and 10% (v/v) ethylene glycol, between 10% and 25% (w/v) polyethylene glycol having an average molecular weight of between 2000 Daltons and 10000 Daltons, and between 0.05 M and 0.40 M ammonium iodide. Further disclosed are systems and methods of identifying a mutation which promotes heterodimeric Fc chain pair formation in which structure based modeling is performed to identify a candidate mutation to an Fc chain using all or a portion of the disclosed three-dimensional atomic coordinates. | 10-08-2015 |
20160102135 | HETEROMULTIMERS WITH REDUCED OR SILENCED EFFECTOR FUNCTION - Provided herein are heteromultimer constructs with reduced or silenced effector function. In an embodiment is provided a heteromultimer construct comprising an IgG Fc construct having a first and a second Fc polypeptide, each Fc polypeptide comprising a modified lower hinge region wherein: the modified lower hinge region of said first Fc polypeptide comprises at least one amino acid modification, the modified lower hinge region of said second Fc polypeptide comprises at least one amino acid modification which is different from at least one amino acid modification of said first Fc polypeptide, and the IgG Fc construct displays reduced binding to all Fcγ receptors and to C1q protein as compared to a corresponding parent IgG Fc construct. Also provided are methods of producing such heteromultimer constructs, and methods of reducing ADCC for an antibody construct by reducing effector function. | 04-14-2016 |
Patent application number | Description | Published |
20130310056 | INTER-CARRIER DIFFERENTIATION USING ALLOCATION AND RETENTION PRIORITY IN A WIRELESS COMMUNICATION SYSTEM - A method and system for allocating services to a first subscriber of a first home service provider when the first subscriber is visiting a network associated with a visited service provider. A node of the visited network receives a request from the visiting first subscriber to receive a first service from the visited network. In response to the request, the visited network determines whether there are sufficient available resources of a first set of resources to provide the requested first service. When the available resources are insufficient to provide the requested service, then at least one pre-existing service supported by the first set of resources is preempted so that sufficient resources from the first set of resources are made available to provide the requested service, and the requested service is provided to the visiting first subscriber. | 11-21-2013 |
20130329559 | COMMUNICATION NETWORK CONGESTION CONTROL USING ALLOCATION AND RETENTION PRIORITY - A method for managing congestion on a communication network that includes a network node having a congestion level. Congestion pre-emption criteria corresponding to the congestion level is determined. A list of potential service pre-emption candidates associated with a service pre-emption criteria that is at least equal to the congestion pre-emption criteria is created. The list of potential service pre-emption candidates is at least a sub-set of a plurality of services on the node. A determination is made as to whether to pre-empt at least one of the potential service pre-emption candidates on the list based at least on the service pre-emption criteria. | 12-12-2013 |
20150156668 | COMMUNICATION NETWORK CONGESTION CONTROL USING ALLOCATION AND RETENTION PRIORITY - A method for managing congestion on a communication network that includes a network node having a congestion level. Congestion pre-emption criteria corresponding to the congestion level is determined. A list of potential service pre-emption candidates associated with a service pre-emption criteria that is at least equal to the congestion pre-emption criteria is created. The list of potential service pre-emption candidates is at least a sub-set of a plurality of services on the node. A determination is made as to whether to pre-empt at least one of the potential service pre-emption candidates on the list based at least on the service pre-emption criteria. | 06-04-2015 |
20150365273 | WIRELESS COMMUNICATION NETWORK BEARER MANAGEMENT - A method and system for configuring a service at a base station of a wireless communication network are disclosed. According to one aspect, a base station receives from a network node a service identifier that identifies a service to be provided via a plurality of bearers to a user equipment. The base station configures the plurality of bearers according to a service configuration associated with the service identifier. | 12-17-2015 |
Patent application number | Description | Published |
20120245121 | METHODS FOR IMPROVING BONE HEALTH IN INFANTS USING LONG CHAIN POLYUNSATURATED FATTY ACIDS - Disclosed are methods for improving bone health, strength and formation in an infant who may be susceptible to developing bone health issues from conception through adolescence. The methods include administration of a nutritional formulation including at least one LCPUFA to a woman during pregnancy and optionally during lactation and breastfeeding of an infant. | 09-27-2012 |
20120245123 | METHODS FOR IMPROVING BONE HEALTH IN INFANTS USING PREBIOTICS - Disclosed are methods for improving bone health, strength and formation in an infant who may be susceptible to developing bone health issues from conception through adolescence. The methods include administration of a nutritional formulation including a prebiotic to a woman during pregnancy and optionally during lactation and breastfeeding of an infant. | 09-27-2012 |
20140249223 | METHODS FOR IMPROVING BRAIN DEVELOPMENT AND COGNITIVE FUNCTION USING BETA-HYDROXY-BETA METHYLBUTYRATE - Disclosed are methods for enhancing neural function in an individual, such as an older adult. The methods include administering nutritional compositions comprising HMB to the individual. The nutritional compositions provide benefits for individuals that have or may be at risk of having cognitive decline, cognitive impairment, and neural dysfunction, typically resulting from cognitive diseases associated with neurodegenerative diseases. | 09-04-2014 |
20140377404 | USE OF SPECIFIC CARBOHYDRATE SYSTEMS DURING PREGNANCY FOR EFFECTING THE OFFSPRING - The present disclosure is directed to a combination of carbohydrates (a slow rate of digestion simple carbohydrate, a complex carbohydrate, a nonabsorbent carbohydrate, and an indigestible oligosaccharide) for use in a method of treating a pregnant woman wherein the method results in an improvement in the health of the offspring of the pregnant woman. The disclosure is also directed to use of the combination of carbohydrates for the manufacture of a medicament for use in the treatment of a pregnant woman wherein the treatment results in an improvement in the health of the offspring of the pregnant woman. The improvement can be a reduction of at least one long tem adverse health effect and/or an improvement in lean body mass development and formation of the offspring. The combination of carbohydrates may also be administered to the woman during lactation to further the improvement in the health of the offspring. | 12-25-2014 |
20150231159 | METHODS FOR INCREASING BRAIN FUNCTIONALITY USING 2-FUCOSYL-LACTOSE - Disclosed are methods for enhancing learning and/or memory, enhancing memory acquisition, memory retention and recall by inducing a higher long-term potentiation in hippocampal neuronal synapsis in individuals. The methods include administration of 2-fucosyl-lactose to an individual. | 08-20-2015 |
20150238508 | METHODS FOR MODULATING CORTICOSTERONE LEVELS IN PSYCHOLOGICALLY STRESSED INDIVIDUALS - Disclosed are methods of modulating and/or decreasing serum corticosterone levels in an individual affected by stress. Further disclosed are methods of modulating the hypothalamic pituitary adrenal response in an individual. The methods include administration of 2-fucosyl-lactose to an individual. | 08-27-2015 |
20160029679 | USE OF SPECIFIC CARBOHYDRATE SYSTEMS DURING PREGNANCY FOR PREVENTING FAT ACCUMULATION IN PREGNANT WOMEN - Disclosed herein are methods related to the administration of specific carbohydrate systems to a pregnant woman for preventing or limiting fat accumulation. The carbohydrate system may include a slow rate of digestion simple carbohydrate, a complex carbohydrate, a non-absorbent carbohydrate, and/or an indigestible carbohydrate. The compositions may be administered before, during, or after gestation. | 02-04-2016 |
20160030466 | USE OF SPECIFIC CARBOHYDRATE SYSTEMS DURING PREGNANCY FOR IMPROVING BONE DEVELOPMENT AND FORMATION AND/OR FOR IMPROVING COGNITIVE AND CNS DEVELOPMENT IN OFFSPRING - The present disclosure is directed to the administration of specific carbohydrate systems to a pregnant and/or lactating woman for improving one or more characteristics in offspring, for example cognition and/or bone health. The carbohydrate system may include a slow rate of digestion simple carbohydrate, a complex carbohydrate, and a non-absorbent carbohydrate and/or an indigestible carbohydrate. | 02-04-2016 |
Patent application number | Description | Published |
20140377195 | POLYMER COMPOSITION CONTAINING NATURAL BIOACTIVE PRINCIPLES FOR USE IN PHARMACEUTICAL AND COSMETIC FORMULATIONS - The present invention relates to a polymer composition containing natural bioactive principles, in particular propolis extract. The present composition is of value because it exhibits antimicrobial (antibacterial, antifungal, antiviral and antiprotozoal), wound healing, anti-inflammatory, antioxidising and moisturising properties. The composition according to the present invention can be used in pharmaceutical and cosmetic formulations, thus being useful for odontological treatments (of caries, gingivitis, periodontitis, bad breath, aphthae, oral stomatitis) and for the treatment of affections of the skin and mucous membranes. The present composition also contains biocompatible and biodegradable polymers that allow controlled release of the active principles. For this purpose, the product can be provided in the form of different formulations: spray, mouthwash, toothpaste, oral-base cream, lotions, creams, gels, inter alia. | 12-25-2014 |
20150086606 | BIORESORBABLE AND BIOACTIVE THREE-DIMENSIONAL POROUS MATERIAL AND METHOD FOR THE PRODUCTION THEREOF - A bioresorbable and bioactive three-dimensional porous material made from bioresorbable polymers that can be combined with bioactive ceramics, producing a three-dimensional structure of interlinked pores containing additives capable of allowing the regeneration and formation of tissues, and a method for the production thereof is described. | 03-26-2015 |