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Buzby, MA
Philip Buzby, Brockton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100190168 | COMPETITOR MOLECULES USEFUL FOR LOWERING NONSPECIFIC ADSORPTION OF DYE LABELED NUCLEOTIDES - Methods are described which enable higher signal/noise when performing surface measurements at the single molecule level. Methods are particularly useful in the field of molecular biology when performing single molecule nucleic acid sequencing by synthesis using dye labeled nucleotides. The method employs using a competitor molecule which blocks nonspecific binding of analog molecules to the surface. | 07-29-2010 |
Philip R. Buzby, Brockton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080227970 | Methods And Compositions For Sequencing A Nucleic Acid - The invention provides a family of tethered nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such tethered nucleotide analogs. | 09-18-2008 |
| 20080246949 | OPTICAL TRAIN AND METHOD FOR TIRF SINGLE MOLECULE DETECTION AND ANALYSIS - In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample. | 10-09-2008 |
| 20090061437 | Nucleotide Analogs - The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids. | 03-05-2009 |
| 20100203524 | POLYMERASES AND METHODS OF USE THEREOF - The invention generally relates to polymerases for efficient and controlled sequencing-by-synthesis reactions. In certain embodiments, the invention provides a polymerase enzyme including at least one mutation that enhances ability of the polymerase as compared to a wild-type polymerase to incorporate a nucleotide into a nascent strand of DNA or cDNA including at least one modified nucleotide. | 08-12-2010 |
Philip R. Buzby, Bedford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100173363 | Use of Single-Stranded Nucleic Acid Binding Proteins in Sequencing - The invention provides methods for stabilizing a nucleic acid sequencing reaction. Generally, methods of the invention include exposing a target nucleic acid to a single-stranded nucleic acid binding protein and performing a sequencing reaction. | 07-08-2010 |
Philip Richard Buzby, Brockton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090061439 | Methods and Compositions for Sequencing A Nucleic Acid - The invention provides nucleotide analogs and methods of using them in sequencing reactions. | 03-05-2009 |
| 20100227321 | METHODS AND DEVICES FOR NUCLEIC ACID SEQUENCE DETERMINATION - Methods of the invention comprise methods and devices for nucleic acid sequence determination. Generally, the invention relates to preparing a substrate for sequencing a target nucleic acid | 09-09-2010 |
| 20110152114 | SHORT CYCLE METHODS FOR SEQUENCING POLYNUCLEOTIDES - The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion. | 06-23-2011 |
Phillip Richard Buzby, Brockton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090191565 | SHORT CYCLE METHODS FOR SEQUENCING POLYNUCLEOTIDES - The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or fill completion. | 07-30-2009 |
| 20110151449 | SHORT CYCLE METHODS FOR SEQUENCING POLYNUCLEOTIDES - The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion. | 06-23-2011 |