Buxbaum
Alexander Buxbaum, Portland, OR US
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20150136977 | Differential Imaging with Pattern Recognition for Process Automation of Cross Sectioning Applications - A method for using differential imaging for applications involving TEM samples by allowing operators to take multiple images during a procedure involving a focused ion beam procedure and overlaying the multiple images to create a differential image that clearly shows the differences between milling steps. The methods also involve generating real-time images of the area being milled and using the overlays of the differential images to show small changes in each image, and thus highlight the ion beam milling location. The methods also involve automating the process of creating differential images and using them to automatically mill subsequent slices. | 05-21-2015 |
Darin Buxbaum, Palo Alto, CA US
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20110245854 | DEVICES AND METHODS TO DELIVER, RETAIN AND REMOVE A SEPARATING DEVICE IN AN INTUSSUSCEPTED HOLLOW ORGAN - The present invention is an improved separating device for providing the malabsorptive component of a minimally invasive weight reduction system. This device may be a sleeve, liner, or tubular sheath that alters absorption of compositions through walls of hollow organs (stomach, intestines). The improvement involves better long-term retention through the ability of the device to engage with the interserosal fibrotic tissue formed in an intussusception. The separating device may be a distal extension of a retaining member that is directly engaged with and retained by intussuscepted tissue. Intussusception shrinks a hollow organ to provide a volume reducing restrictive component of a weight reduction system. Securing the separating device to an intussusception avoids retention problems of reference art devices as interserosal fibrosis helps secure the device. Also provided are an apparatus for retaining the device, a device and method for delivering the separating device, and a method for removing it. | 10-06-2011 |
20120245504 | DEVICES AND METHODS TO DELIVER, RETAIN AND REMOVE A SEPARATING DEVICE IN AN INTUSSUSCEPTED HOLLOW ORGAN - The present invention is an improved separating device for providing the malabsorptive component of a minimally invasive weight reduction system. This device may be a sleeve, liner, or tubular sheath that alters absorption of compositions through walls of hollow organs (stomach, intestines). The improvement involves better long-term retention through the ability of the device to engage with the interserosal fibrotic tissue formed in an intussusception. The separating device may be a distal extension of a retaining member that is directly engaged with and retained by intussuscepted tissue. Intussusception shrinks a hollow organ to provide a volume reducing restrictive component of a weight reduction system. Securing the separating device to an intussusception avoids retention problems of reference art devices as interserosal fibrosis helps secure the device. Also provided are an apparatus for retaining the device, a device and method for delivering the separating device, and a method for removing it. | 09-27-2012 |
Darin Howard Buxbaum, Palo Alto, CA US
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20140276337 | Implantable Devices with Delivery Systems and Methods for Blocking Digestive Neurohormonal Pathways in Mammals - Described herein are implantable devices, delivery systems and surgical methods for creating a barrier that may be deployed into a digestive system organ to block the biochemical and/or neurohormonal systems thereby providing therapeutic benefit ideally treating diabetes mellitus and obesity. The device for creating a barrier in the digestive system organ may include a wall or conduit whether impermeable or porous at varying degrees. Method of surgical delivery for the device described herein may be conducted through open, laparoscopic, minimally invasive, or endoscopic means. The device may be temporarily secured on a novel delivery system enabling the methods described. The device may be secured to the digestive organ allowing natural biomechanical motion (peristaltic motion) of the digestive system without untoward effects. | 09-18-2014 |
20140277241 | COORDINATING MUSCULOSKELETAL AND CARDIOVASCULAR HEMODYNAMICS - The present invention is generally directed to methods, systems, and computer program products for coordinating musculoskeletal and cardiovascular hemodynamics. In some embodiments, a heart pacing signal causes heart contractions to occur with an essentially constant time relationship with respect to rhythmic musculoskeletal activity. In other embodiments, prompts (e.g., audio, graphical, etc.) are provided to a user to assist them in timing of their rhythmic musculoskeletal activity relative to timing of their cardiovascular cycle. In further embodiments, accurately indicating a heart condition during a cardiac stress test is increased. | 09-18-2014 |
David Wayne Buxbaum, Columbus, OH US
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20120247834 | CUTTING ELEMENT HAVING MODIFIED SURFACE - A cutting element including a cutting face and a longitudinal axis passing through the cutting face. The cutting element includes at least a first portion of the cutting face that is angled at an angle of about 81 to about 89 degrees relative to the longitudinal axis of the cutting element. The cutting element can further include a substrate, a superabrasive an interface between the substrate and superabrasive layer. Further, the cutting face is provided with a surface roughness of 40 microinches or less. | 10-04-2012 |
Joseph Buxbaum, New York, NY US
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20120216302 | METHODS AND ASSAYS FOR TREATING SUBJECTS WITH SHANK3 DELETION, MUTATION OR REDUCED EXPRESSION - Methods and assays are disclosed for treating subjects with 22q13 deletion syndrome or SHANK3 deletion or duplication, mutation or reduced expression, where the methods comprise administering to the subject insulin-like growth factor 1 (IGF-1), IGF-1-derived peptide or analog, growth hormone, an AMPAkine, a compound that directly or indirectly enhances glutamate neurotransmission, including by inhibiting inhibitory (most typically GABA) transmission, or an agent that activates the growth hormone receptor or the insulin-like growth factor 1 (IGF-1) receptor, or a downstream signaling pathway thereof | 08-23-2012 |
20130225623 | Methods of Treating Psychiatric or Neurological Disorders with MGLUR Antagonists - Methods for treating a psychiatric or neurological disease or disorder using combinations of Group 1 mGluR antagonists are disclosed. In certain aspects, these methods include the treatment of a patient having a neurological or psychiatric disease or disorder associated with a CYFIP1 gene change. | 08-29-2013 |
Joseph D. Buxbaum, New York, NY US
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20120039812 | GENES ASSOCIATED WITH POSTTRAUMATIC-STRESS DISORDER (PTSD) - The present invention relates to a method of identifying a predisposition for developing posttraumatic stress disorder (PTSD) in a subject comprising assessing in a sample obtained from said subject the expression level of one or more genes selected from the FK506 binding protein 5 (FKBP5) gene, the signal transducer and activator of transcription (STAT5B) gene and the nuclear factor I/A (NFIA) gene, wherein a decrease in the expression level of said one or more genes as compared to the expression level of the corresponding gene(s) of a control is indicative of a predisposition for developing PTSD. Further, the invention relates to a method of identifying a compound capable of preventing or treating PTSD or capable of serving as a lead compound for developing a compound capable of preventing or treating PTSD and also to a method of selecting a therapy to prevent or treat PTSD. | 02-16-2012 |
20140178307 | METHODS AND ASSAYS FOR TREATING SUBJECTS WITH SHANK3 DELETION, MUTATION OR REDUCED EXPRESSION - Methods and assays are disclosed for treating subjects with 22q13 deletion syndrome or SHANK3 deletion or duplication, mutation or reduced expression, where the methods comprise administering to the subject insulin-like growth factor 1 (IGF-1), IGF-1-derived peptide or analog, growth hormone, an AMPAkine, a compound that directly or indirectly enhances glutamate neurotransmission, including by inhibiting inhibitory (most typically GABA) transmission, or an agent that activates the growth hormone receptor or the insulin-like growth factor 1 (IGF-1) receptor, or a downstream signaling pathway thereof. | 06-26-2014 |
Mark Buxbaum, Acton, MA US
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20100211953 | MANAGING TASK EXECUTION - Managing task execution includes: receiving a specification of a plurality of tasks to be performed by respective functional modules; processing a flow of input data using a dataflow graph that includes nodes representing data processing components connected by links representing flows of data between data processing components; in response to at least one flow of data provided by at least one data processing component, generating a flow of messages; and in response to each of the messages in the flow of messages, performing an iteration of a set of one or more tasks using one or more corresponding functional modules. | 08-19-2010 |
20140143760 | DYNAMIC GRAPH PERFORMANCE MONITORING - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for dynamic graph performance monitoring. One of the methods includes receiving multiple units of work that each include one or more work elements. The method includes determining a characteristic of the first unit of work. The method includes identifying, by a component of the first dataflow graph, a second dataflow graph from multiple available dataflow graphs based on the determined characteristic, the multiple available dataflow graphs being stored in a data storage system. The method includes processing the first unit of work using the second dataflow graph. The method includes determining one or more performance metrics associated with the processing. | 05-22-2014 |
Mark Buxbaum, Lexington, MA US
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20140143757 | DYNAMIC COMPONENT PERFORMANCE MONITORING - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for dynamic graph performance monitoring. One of the methods includes receiving input data by the data processing system, the input data provided by an application executing on the data processing system. The method includes determining a characteristic of the input data. The method includes identifying, by the application, a dynamic component from multiple available dynamic components based on the determined characteristic, the multiple available dynamic components being stored in a data storage system. The method includes processing the input data using the identified dynamic component. The method also includes determining one or more performance metrics associated with the processing. | 05-22-2014 |
Martin Buxbaum, Alberschwende DE
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20130041051 | METHOD FOR PRODUCING A METHANE-RICH PRODUCT GAS AND REACTOR SYSTEM USABLE FOR THAT PURPOSE - The invention relates to a method for producing a methane-rich product gas, in which a starting gas containing hydrogen and carbon dioxide is catalytically methanated under the influence of at least one adjustatable parameter in at least two stages and at least one criterion relating to the composition of the product gas is monitored. The criterion is fulfilled under a condition influencing the method and when the condition changes, a change in the parameter setting that preserves fulfilment of the criterion is affected. | 02-14-2013 |
Robert E. Buxbaum, Oak Park, MI US
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20110114285 | COPPER-NIOBIUM, COPPER-VANADIUM, OR COPPER-CHROMIUM NANOCOMPOSITES, AND THE USE THEREOF IN HEAT EXCHANGERS - We propose here a class of new materials for high heat-flux applications including high flux heat exchangers, rocket engines, jet engines, gas turbines, space-plane wings, and fusion reactors. The materials are nano-composites formed from copper and a refractory metal, especially niobium, vanadium, or chromium, but also potentially silver, iron, tantalum, tungsten, or molybdenum. The copper plus refractory mix is fast-melted, e.g. by arc melting, and then fast-cooled and worked. When cast the component metals separate into a fractile metal-metal composite that should have excellent heat-transfer qualities. Working the material makes it a lot stronger by extending the fractile structures into micron, and submicron (nano-scale) filaments and sheets of metal-metal composite. The resulting strong, high thermal-conductivity material should be excellent for demanding heat exchange applications, especially those where the heat flux is so high that ordinary materials of construction would suffer from thermal creep: that is from large forces generated internally by the differential expansion caused by the heat flux. Typical heat exchanger surfaces that might use this material might be tubes or indented flat plates. | 05-19-2011 |
20140026340 | SURFACE CLEANING ARTICLE AND PROCESS FOR MAKING THE SAME - An inventive composition that has utility as an article for cleaning a target surface is provided. Embodiments of the inventive composition are readily applied to a substrate to form a cleaning article or form a free-standing article; the composition upon drying forms a matrix having a coefficient of friction of greater than one, and a glass transition temperature that is between 0° C. and 40° C. The matrix is amenable to loading with various additives illustratively including re-enforcing fibers, abrasives, plasticizers, foaming agents, fragrances, and combinations thereof. Embodiments of the inventive composition operate to clean a substrate such as a vehicle and ideally return the same to the original look and feel without requiring excessive work, or requiring the removal of too much material from the surface. | 01-30-2014 |