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Butte
Atul Butte, Menlo Park, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110117049 | Methods and Compositions for Modulating Adipocyte Function - Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7. | 05-19-2011 |
Atul J. Butte, Menlo Park, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120021414 | DIAGNOSTIC MARKERS OF IMMUNOSENESCENCE AND METHODS OF USE THEREOF - Embodiments of the present invention provide diagnostic markers of immunosenescence and methods of identifying individuals with impaired immune function based on a combination of such markers obtained from various analyses, primarily from blood, testing immune function including the analysis of immune cell subset frequencies, gene expression, cytokine and chemokine levels, and signaling responses to stimulation with cytokines (‘cytokine response’). Particular combinations of markers can predict with high accuracy whether an individual will respond to active vaccination and become protected against recurring diseases. | 01-26-2012 |
Atul J. Butte, Stanford, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120076797 | Modulation of kit signaling and hematopoietic cell development by IL-4 receptor modulation - Methods and compositions are provided for modulating Kit/stem cell factor receptor (SCFR)/CD117 and interleukin 4 receptor (IL-4R) signaling in a cell in vitro and in vivo, and for identifying candidate agents with activity in modulating Kit and IL-4R signaling. These methods find particular use in treating disorders of the hematopoietic system and in modulating hematopoietic stem cell expansion. | 03-29-2012 |
| 20120077689 | Compartment-Specific Non-HLA Targets for Diagnosis and Prediction of Graft Outcome - Methods and composition are provided for diagnosing or predicting the status or the outcome of a graft transplant. In some embodiments, the presence or absence of one or more proteins recognizing a non-HLA/non ABO antigen is determined. The obtained result is then employed to diagnose or predict the status or outcome of the graft transplant. Also provided are compositions, systems and kits that find use in practicing the subject methods. | 03-29-2012 |
Jeffrey C. Butte, Portland, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20120074694 | SELF-ALIGNING SANITARY PIPE JOINTS AND RELATED SYSTEMS - Systems for joining pipes used in the food processing and pharmaceutical industries are disclosed. For example, connections of fluid handling pipes and improved flange-type joints are disclosed. Some disclosed joints comprise a pair of flanges each defining a circumferentially extending channel recessed from an end face A radially extending end wall is positioned radially outward of the end face. Said end faces are retained in axially opposed relationship to each other such that a circumferential groove configured to receive a gasket is defined when the joint is assembled. The groove has a first portion open to the flow passage and a second portion extending radially outward from the first portion. A polymeric gasket can comprise a generally toroidal member axially compressed in the first portion of the groove when the joint is assembled. The radial end walls radially compress the gasket, and the gasket can expand radially outward. | 03-29-2012 |
Manish J. Butte, Stanford, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120087618 | Microfluidic waveguide detector - A microfluidic detection device is provided that includes a planar waveguide, or an ion-exchange planar waveguide, a microfluidic channel disposed on the planar waveguide, a light source, such as a laser, LED or incandescent light, directed through the planar waveguide, a labeled cell disposed in the microfluidic channel, where the labeled cell lies in an evanescent field extending from the planar waveguide, and a light detector disposed to receive light from the light source through the planar waveguide. The evanescent field interacts with the labeled cell, where the light through the planar waveguide is altered according to a presence of the labeled cell in the microfluidic channel. | 04-12-2012 |
Manish J. Butte, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090298191 | Lateral Flow and Flow-through Bioassay Devices Based On Patterned Porous Media, Methods of Making Same, and Methods of Using Same - Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region. | 12-03-2009 |
| 20110189786 | COTTON THREAD AS A LOW-COST MULTI-ASSAY DIAGNOSTIC PLATFORM - Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermediate zone located between the inlet zone and the testing zone, wherein the testing zone does not directly contact the inlet zone. In another aspect, a diagnostic system includes (i) a hydrophilic loading thread that includes an inlet zone at a proximal end and an intermediate zone at a distal end; and (ii) one or more additional hydrophilic threads that contact the intermediate zone of the loading thread. A method of detecting the presence or absence of an analyte in a fluid sample includes applying the sample to an inlet zone of a diagnostic system that includes a hydrophilic loading thread with an inlet zone at a proximal end; an intermediate zone; and a testing zone at a distal end; wherein the testing zone does not directly contact the inlet zone. | 08-04-2011 |
Nancy Butte, Houston, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090062620 | Methods for Estimating the Metabolic Cost of Walking - Methods for determining the metabolic cost for walking are disclosed. In one embodiment, a method for determining metabolic cost per unit time of a walk by an individual is disclosed. The method includes providing a body length of the individual. The method also includes measuring a walking speed of the individual. The metabolic cost per unit time is determined by adding a basal metabolic rate and a metabolic constant for walking to the result of a metabolic coefficient for walking multiplied by the walking speed (squared) and such squared speed divided by the body length of the individual. | 03-05-2009 |
Ronald J. Butte, Tucson, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20100192795 | ADJUSTABLE EXPLOSIVE OUTPUT - An explosive component includes a first storage container holding a fuel, a second storage container holding an oxidizer, a mixer to mix the fuel and the oxidizer together into an energetic mixture, and a third storage container to hold the energetic mixture. | 08-05-2010 |
| 20100224730 | PRESSURE-BASED SEPARATION APPARATUSES - Embodiments of separation apparatuses are generally described herein. Other embodiments may be described and claimed. In an embodiment, a separation apparatus is provided that is configured to be disposed between a first component and a second component associated with an aerospace vehicle. The separation apparatus comprises a sealed cavity filled with gas, and the separation apparatus is configured to expand based on a decrease in atmospheric pressure. This expansion is configured to separate the first component from the second component. | 09-09-2010 |