Patent application number | Description | Published |
20090280113 | TARGET FOR REGULATING MULTIPLE SCLEROSIS - Methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). Methods are also provided for screening for agents that find use in treating demyelinating inflammatory disease in a subject. | 11-12-2009 |
20100080816 | TOLEROGENIC POPULATIONS OF DENDRITIC CELLS - Tolerogenic populations of dendritic cells are provided, where the dendritic cells are characterized by expression of select tissue-specific homing receptors including the chemokine receptors CCR9; or CMKLR1; or the integrin CD103. The dendritic cells may be conventional/myeloid or plasmacytoid dendritic cells. The cells may be isolated from lymphoid tissue, from blood, or from in vitro culture, e.g. bone marrow culture, etc. Methods are provided for their identification, isolation and targeting in immunotherapeutic interventions in suppressing inflammatory disorders including autoimmunity, transplantation responses and allergic diseases. In some embodiments dendritic cell populations are fixed to render them immunosuppressive, thus allowing the cells to be typed and banked for future use. | 04-01-2010 |
20100092974 | METHODS FOR SCREENING FOR MODULATORS OF CCRL2 - The invention provides methods and compositions for identifying a modulator of CCRL2 and chemerin. The present invention also provides methods and compositions for treating an inflammatory disease by administering a compound that modulates the interaction of CCRL2 with chemerin. | 04-15-2010 |
20100098714 | Anti-leukocyte recruitment therapy for the treatment of seizures and epilepsy - Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy. | 04-22-2010 |
20120064092 | Novel Target for Regulating Multiple Sclerosis - Methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). Methods are also provided for screening for agents that find use in treating demyelinating inflammatory disease in a subject. | 03-15-2012 |
20130230539 | Anti-Leukocyte Recruitment Therapy for the Treatment of Seizures and Epilepsy - Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy. | 09-05-2013 |
20130266967 | FUNCTION HOMOLOGY SCREENING - A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses. | 10-10-2013 |
20150025153 | Small Molecule CMKLR1 Antagonists in Demyelinating Disease - Compounds and methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). In some embodiments such methods include treating demyelinating inflammatory disease in a subject by administering an agent that antagonizes the activity of chemokine-like receptor 1 (CMKLR1) and/or a CMKLR1 ligand (e.g., chemerin or other endogenous CMKLR1 ligands). Candidate compounds include, without limitation, analogs and variants of 2-(alpha-naphthoyl)ethyltrimethylammonium iodide. | 01-22-2015 |
Patent application number | Description | Published |
20160062464 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |
20160062465 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |
20160062466 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |
20160063825 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |
20160063827 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |
20160063828 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |
20160066124 | ALERT MANAGER - Systems, methods, and computer-readable medium are provided for managing alerts of one or more computing devices. For example, a user device may configure a user interface to present electronic content corresponding to a first category. The user device may also receive a data structure of rules. At least one rule may correspond to an entry of the data structure for an alert category pairing. The user device may receive information that identifies and incoming alert and determine a presentation method for the incoming alert based at least in part on a corresponding rule. The user device may also present the incoming based at least in part on the determined presentation method. | 03-03-2016 |
Patent application number | Description | Published |
20150370529 | USER INTERFACE FOR MANIPULATING USER INTERFACE OBJECTS WITH MAGNETIC PROPERTIES - The present disclosure relates to user interfaces for manipulating user interface objects. A device, including a display and a rotatable input mechanism, is described in relation to manipulating user interface objects. In some examples, the manipulation of the object is a scroll, zoom, or rotate of the object. In other examples, objects are selected in accordance with simulated magnetic properties. | 12-24-2015 |
20160034133 | CONTEXT-SPECIFIC USER INTERFACES - Context-specific user interfaces for use with a portable multifunction device are disclosed. The methods described herein for context-specific user interfaces provide indications of time and, optionally, a variety of additional information. Further disclosed are non-transitory computer-readable storage media, systems, and devices configured to perform the methods described herein. | 02-04-2016 |
20160034148 | CONTEXT-SPECIFIC USER INTERFACES - Context-specific user interfaces for use with a portable multifunction device are disclosed. The methods described herein for context-specific user interfaces provide indications of time and, optionally, a variety of additional information. Further disclosed are non-transitory computer-readable storage media, systems, and devices configured to perform the methods described herein. | 02-04-2016 |
20160034152 | CONTEXT-SPECIFIC USER INTERFACES - Context-specific user interfaces for use with a portable multifunction device are disclosed. The methods described herein for context-specific user interfaces provide indications of time and, optionally, a variety of additional information. Further disclosed are non-transitory computer-readable storage media, systems, and devices configured to perform the methods described herein. | 02-04-2016 |
20160034166 | CONTEXT-SPECIFIC USER INTERFACES - Context-specific user interfaces for use with a portable multifunction device are disclosed. The methods described herein for context-specific user interfaces provide indications of time and, optionally, a variety of additional information. Further disclosed are non-transitory computer-readable storage media, systems, and devices configured to perform the methods described herein. | 02-04-2016 |
20160034167 | CONTEXT-SPECIFIC USER INTERFACES - Context-specific user interfaces for use with a portable multifunction device are disclosed. The methods described herein for context-specific user interfaces provide indications of time and, optionally, a variety of additional information. Further disclosed are non-transitory computer-readable storage media, systems, and devices configured to perform the methods described herein. | 02-04-2016 |
20160048705 | AUTHENTICATED DEVICE USED TO UNLOCK ANOTHER DEVICE - An electronic device having a user-interface locked state and a user-interface unlocked state may be in the locked state. The locked electronic device may detect, via wireless communication, an external device; receive, from the external device, unlocking information for unlocking the electronic device. The locked electronic device may determine whether the external device is authorized to facilitate its unlocking. The locked electronic device may detect user input. In response to the user input, the received unlocking information, and/or a determination that the external device is authorized, the locked electronic device may unlock and enter a normal operating state wherein application programs may be launched and used. | 02-18-2016 |
20160058336 | PHYSICAL ACTIVITY AND WORKOUT MONITOR - The present disclosure relates to devices and processes for monitoring attributes of a user's physical activity (e.g., workout) or inactivity, and to user interfaces (e.g., an activity indicator) for displaying the same. In some examples, a device determines whether physical activity corresponds to a first type based on a first set of criteria, and whether physical activity corresponds to a second type based on a second set of criteria. In some examples, the device controls an inactivity timer that measures user's inactivity. In some examples, the device displays a first visual representation of an attribute or amount of a first type of physical activity, and a second visual representation of an attribute or amount of a second type. In some examples, the device displays a third visual representation of an attribute or amount of a third type of activity. In some examples, the third visual representation corresponds to user's inactivity. | 03-03-2016 |
20160058337 | PHYSICAL ACTIVITY AND WORKOUT MONITOR - The present disclosure relates to devices and processes for monitoring attributes of a user's physical activity (e.g., workout) or inactivity, and to user interfaces (e.g., an activity indicator) for displaying the same. In some examples, a device determines whether physical activity corresponds to a first type based on a first set of criteria, and whether physical activity corresponds to a second type based on a second set of criteria. In some examples, the device controls an inactivity timer that measures user's inactivity. In some examples, the device displays a first visual representation of an attribute or amount of a first type of physical activity, and a second visual representation of an attribute or amount of a second type. In some examples, the device displays a third visual representation of an attribute or amount of a third type of activity. In some examples, the third visual representation corresponds to user's inactivity. | 03-03-2016 |
20160062540 | REDUCED-SIZE INTERFACES FOR MANAGING ALERTS - An electronic device with a display can receive an alert comprising information, and in response to receiving the alert, issue a perceptual output. The device can detect a user input and determine whether the user input was detected within a predetermined time interval after the perceptual output. In accordance with a determination that the user input was detected within the predetermined time interval, the device can display a notification on the display, wherein the notification comprises a first portion of the information. If the device continues to detect the user input after a second predetermined time period, the device can display a second portion of the information, where the second portion is different from the first portion. | 03-03-2016 |
20160062570 | REDUCED-SIZE NOTIFICATION INTERFACE - An electronic device with a touch-sensitive display can obtain a plurality of alerts associated with dates and times. The device can detect a user input, and in response to the input display a notification interface. The notification interface can include a future notification representing a future alert with a date and time after the current date and time, and a past notification representing a past alert with a date and time before the current date and time. The future and past notifications can be separated by a graphical separator that has an indication of the current time. The future and past alerts correspond to different installed applications. | 03-03-2016 |
20160062572 | REDUCED SIZE CONFIGURATION INTERFACE - An electronic device with a camera invokes a wireless communications pairing mode for pairing the electronic device with an external device. The electronic device obtains an image via the camera. The image contains a pattern displayed on a display screen of the external device, and the pattern comprises identifying information of the external device. The electronic device receives data from the external device, determines whether the received data corresponds with the identifying information, and, in response to a determination that the received data corresponds with the identifying information, registers the external device as a paired device. In some examples, the electronic device is a smartphone and the external device is a wearable electronic device. Pairing the electronic device and the external device may allow the devices to exchange information and operate interactively with one another. | 03-03-2016 |
20160062582 | STOPWATCH AND TIMER USER INTERFACES - An electronic device may display a first lap time representation, and may move the first lap time representation in accordance with a first amount of elapsed time. While moving the first lap time representation, the electronic device may detect a lap input. In response to the lap input, the electronic device may cease movement of the first lap time representation, display a second lap time representation, and move the second lap time representation in accordance with a second amount of elapsed time. A relative positioning of the first lap time representation and the second lap time representation may correspond to a difference between a first lap time and a second lap time. In some embodiments, the electronic device may update the timescales of lap time representation(s) in accordance with a rotational input. In some embodiments, the electronic device may update a timer duration setting in accordance with a rotational input. | 03-03-2016 |
20160062589 | REDUCED-SIZE USER INTERFACES FOR DYNAMICALLY UPDATED APPLICATION OVERVIEWS - An electronic device with a touch-sensitive display can detect a contact with the display, and in response to detecting the contact, the device can display a user interface screen representing a corresponding application. The user interface screen can include an affordance for launching the application, and a set of information obtained from the application, where the set of information is updated in accordance with data from the application. | 03-03-2016 |
20160062590 | USER INTERFACE FOR LIMITING NOTIFICATIONS AND ALERTS - The present disclosure relates to systems and processes for limiting notifications on an electronic device. In one example process, data representing a user input can be received by an electronic device. The data representing the user input can include touch data from the touch-sensitive device, ambient light data from an ambient light sensor, intensity data from a contact intensity sensor, and/or motion data from one or more motion sensors. Based on the data, it can be determined whether the user input is a cover gesture over a touch-sensitive display of the electronic device. In response to determining that the user input is a cover gesture over the touch-sensitive display, the electronic device can be put into a DND mode for a predetermined amount of time. While in the DND mode, the electronic device can cease to output some or all notifications. | 03-03-2016 |
20160062598 | MULTI-DIMENSIONAL OBJECT REARRANGEMENT - A method includes displaying, on a touch-sensitive display, a plurality of application icons in a first configuration at locations on a hexagonal grid in relation to an origin. The application icons have corresponding ranks based on their respective locations in relation to the origin. In response to detecting a movement of a user contact from a first position to a second position: the display of a first application icon at a first location is translated to a second position; a second configuration of the application icons is determined based on the first location and the second location; and the display of the application icons is transitioned from the first configuration to the second configuration. In the second configuration, no application icon except the first application icon is displaced by more than one location relative to the first configuration. | 03-03-2016 |
20160065509 | ELECTRONIC MESSAGE USER INTERFACE - The present disclosure relates to electronic message user interfaces. A device, including a display, a touch-sensitive surface, and a rotatable input mechanism, is described in relation to accessing, composing, and manipulating electronic messages. In some examples, a user can provide input through the rotatable input mechanism to access a landing screen of an electronic messages application. The landing screen concurrently displays an affordance for accessing an electronic messages inbox and an affordance for accessing an interface for composing electronic message. | 03-03-2016 |
20160065827 | REMOTE CAMERA USER INTERFACE - At an electronic device with a touch-sensitive display, a remote camera control user interface may be displayed. In some examples, a user may provide input through a gesture at a location corresponding to the touch-sensitive display and/or through a rotation of a rotatable input mechanism to control a camera of an external device. Camera control may include control of the external device's camera features, including image capture, zoom settings, focus settings, flash settings, and timer settings, for example, and may also include access to the external device's library of previously captured images. | 03-03-2016 |