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Buschmann
Michael Buschmann, Montreal CA
| Patent application number | Description | Published |
|---|---|---|
| 20090202430 | COMPOSITION FOR CYTOCOMPATIBLE, INJECTABLE, SELF-GELLING POLYSACCHARIDE SOLUTIONS FOR ENCAPSULATING AND DELIVERING LIVE CELLS OR BIOLOGICALLY ACTIVE FACTORS - The present invention provides compositions and methods for tissue repair using a cytocompatible self-gelling cross-linked hydrogel. The composition comprises a biocompatible mixture of chitosan, bifunctional dialdehyde, and hydroxylated polymer, which can be used to immobilize or encapsulate viable cells, or bioactive substances. The method includes the process of mixing bioactive substances, live cells, and/or extracellular matrix components with a cross-linking solution comprising a bifunctional aldehyde-treated hydroxylated polymer such as hydroxyethyl cellulose. The cross-linking solution is then mixed homogenously with a neutral isotonic chitosan solution. The chitosan becomes cross-linked by the bifunctional aldehyde, while the cells are protected from potentially nocive effects of the aldehyde cross-linker by the hydroxylated polymer. The injectable solution retains cell viability and bioactivity, and immobilizes cells at the site of injection or delivery. Depending on the particular application, mixtures of chitosan and bifunctional dialdehyde may be employed. The injectable solution also liberates bioactive substances with controlled release kinetics from the site of injection. | 08-13-2009 |
| 20110034797 | NON-INVASIVE MEASURING OF LOAD-INDUCED ELECTRIC POTENTIALS IN DIARTHROIDIAL JOINTS - There is described a method for non-invasively measuring electrical activity in a joint of a subject, the method comprising: removably attaching in a non-invasive manner at least two electrodes to a skin surface around an articulation comprising the joint; generating electroarthrographic potentials within the joint by loading the articulation; capturing the electroarthrographic potentials using the at least two electrodes; discriminating between electroarthrographic potentials originating from joint tissue activity and those from other sources; and generating measurement signals representing the electrical activity of joint tissue. | 02-10-2011 |
Michael D. Buschmann, Montreal CA
| Patent application number | Description | Published |
|---|---|---|
| 20090075383 | COMPOSITION AND METHOD FOR EFFICIENT DELIVERY OF NUCLEIC ACIDS TO CELLS USING CHITOSAN - There is disclosed a composition and a method for the efficient non-viral delivery of nucleic acids to cells using chitosan. In order to achieve high efficiency of transfection, the composition contains a nucleic acid and a chitosan that has the following physico-chemical properties: a combination of a number-average molecular weight between 8 kDa and 185 kDa and a degree of deacetylation between 72% and 92%. The chitosan molecule can also present additional physiochemical properties such as a block distribution of acetyl groups obtained by a heterogeneous treatment of chitin, and/or a polydispersity index between 1.4 and 7.0. By correctly controlling these parameters, efficient delivery systems may be produced that are effective when optimized for different conditions such as the pH of transfection media and amine-to-phosphate ratio. | 03-19-2009 |
| 20090149421 | GEL FORMATION OF POLYELECTROLYTE AQUEOUS SOLUTIONS BY THERMALLY INDUCED CHANGES IN IONIZATION STATE - There is disclosed aqueous solutions of polyelectrolytes that can be neutralized by increasing temperature, under suitable polyelectrolyte charge state conditions, in order to obtain a homogeneous gel. This can be achieved by adding an appropriate weak electrolyte to the polyelectrolyte so that an increase of temperature will lead to a spatially homogeneous neutralization of the polyelectrolyte via proton transfer between the polyelectrolyte and the weak electrolyte. The ability of such a system to be thermally sensitive and to gel upon heating relies on the temperature dependence of the ionization equilibrium for the two components. This thermally induced neutralization reduces electrostatic repulsion between polyelectrolyte molecules allowing the manifestation of attractive polyelectrolyte-polyelectrolyte hydrophobic interactions and hydrogen bonding that result in gel formation. These new kinds of thermo sensitive gels can be used for biomedical applications. | 06-11-2009 |
| 20110034930 | DRILL BURR AND METHOD FOR PERFORMING HOLES IN SUBCHONDRAL BONE TO PROMOTE CARTILAGE REPAIR - A method for performing holes in subchondral bone to promote cartilage repair comprises selecting a drill burr having a drilling head and an axial stop, as a function of the distance between the tip of the drilling head and the axial stop and of a desired depth to reach a desired subchondral bone marrow compartment of a patient; drilling a hole through a base of a cartilage lesion with the drill burr to reach the desired subchondral bone marrow compartment of the patient; abutting the base of the cartilage lesion defining a periphery of the hole with the axial stop while drilling; and withdrawing the drill burr from the hole; whereby the hole has the desired depth and reaches the desired subchondral bone marrow compartment to promote cartilage repair. | 02-10-2011 |
| 20110086008 | COMPOSITION AND METHOD FOR THE REPAIR AND REGENERATION OF CARTILAGE AND OTHER TISSUES - The present invention relates to a new method for repairing human or animal tissues such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, and ulcers. The method comprises the step of introducing into the tissue a temperature-dependent polymer gel composition such that the composition adhere to the tissue and promote support for cell proliferation for repairing the tissue. Other than a polymer, the composition preferably comprises a blood component such as whole blood, processed blood, venous blood, arterial blood, blood from bone, blood from bone-marrow, bone marrow, umbilical cord blood, placenta blood, erythrocytes, leukocytes, monocytes, platelets, fibrinogen, thrombin and platelet rich plasma. The present invention also relates to a new composition to be used with the method of the present invention. | 04-14-2011 |
Nicole Buschmann, Basel CH
| Patent application number | Description | Published |
|---|---|---|
| 20100125064 | 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases - The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula I, | 05-20-2010 |