| Patent application number | Description | Published |
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| 20090259027 | Human GM-CSF antibodies - Chimeric antibodies, as well as fusion proteins which comprise chimeric antibodies, are disclosed. The antibodies bind to GM-CSF, CD-30, and G250 antigen. The fusion proteins include biologically active portions of tumor necrosis factor, or full length tumor necrosis factor. Expression vectors adapted for production of the antibodies, as well as methods for manufacturing these, are also disclosed. | 10-15-2009 |
| 20100167395 | Humanized GM-CSF antibodies - Chimeric antibodies, as well as fusion proteins which comprise chimeric antibodies, are disclosed. The antibodies bind to GM-CSF, CD-30, and G250 antigen. The fusion proteins include biologically active portions of tumor necrosis factor, or full length tumor necrosis factor. Expression vectors adapted for production of the antibodies, as well as methods for manufacturing these, are also disclosed. | 07-01-2010 |
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| 20090137782 | SPECIFIC BINDING PROTEINS AND USES THEREOF - The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806. | 05-28-2009 |
| 20100322937 | EGF receptor epitope peptides and uses thereof - The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided. | 12-23-2010 |
| 20110076232 | SPECIFIC BINDING PROTEINS AND USES THEREOF - The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof. | 03-31-2011 |
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| 20090269201 | Air diffuser system for industrial pumps - An air diffuser system for an impeller for a centrifugal pump has least one channel ( | 10-29-2009 |
| 20100111686 | AIR DIFFUSER SYSTEM FOR INDUSTRIAL PUMPS - An air diffuser device suitable for use in an air diffuser system for a centrifugal pump the pump including a pump casing with a pumping chamber therein, an impeller mounted within the pumping chamber for rotation about a rotation axis, the impeller including a front side and a rear side. The air diffuser system comprises one or more passages extending through the impeller from the front side to the rear side, the or each passage having a first opening at the rear side and a second opening at the front side of the impeller. The air diffuser device comprises a main body having a seal side and an impeller side, and at least one channel extending through the main body from the seal side to the impeller side, the or each channel having an intake opening at the seal side, a discharge opening at the impeller side, and a base wall extending through the main body, the base wall having a leading end portion at the seal side, and a trailing end portion at the impeller side, the discharge opening being in fluid communication with the first opening of the passage in the impeller when installed. | 05-06-2010 |
| 20100135765 | PUMPS - A pump assembly and components therefor including an impeller which has flow inducer elements on an inner surface of a front shroud thereof, a flow directing device or strainer having passageways for delivering material to the impeller and at least one flow circulating passageway and a pump casing having an intake section with flow distribution vanes in the region of a feed opening adjacent the intake section. | 06-03-2010 |
| 20110129344 | SLURRY PUMP IMPELLER - A slurry pump impeller which includes a front shroud and a back shroud each having an inner main face with an outer peripheral edge and a central axis, a plurality of pumping vanes extending between the inner main faces of the shrouds, the pumping vanes being disposed in spaced apart relation. Each pumping vane includes a leading edge in the region of the central axis and a trailing edge in the region of the outer peripheral edges of the shrouds with a passageway between adjacent pumping vanes. Each passageway has associated therewith a discharge guide vane, each discharge guide vane being disposed within a respective passageway and located closer to one or the other of the pumping vanes and projecting from the inner main face of at least one of the or each shrouds. | 06-02-2011 |
| 20110142599 | Adjustable side liner for a pump - An adjustment assembly for pump casing of a pump, the pump casing including a main part and a side part having a main axis and a side wall section extending laterally with respect to the main axis. The adjustment assembly is operable to cause relative displacement between the side part and the main part of the pump casing. The adjustment assembly includes a drive device and an actuator which can be activated externally of the pump, the drive device being operable to cause the relative displacement of the side part in response to activation of said actuator, the relative displacement capable of being a combination of axial and rotational movement. | 06-16-2011 |
| 20110142610 | PUMP CASING - A pump casing for a centrifugal pump, which comprises an inlet opening, a discharge outlet, and a transition surface extending between an inner peripheral surface of the main pumping chamber and an inner peripheral surface of the discharge outlet, the transition surface arranged for separating an in use exit flow of material in the discharge outlet from an in use recircula tion flow of material in the main pumping chamber. The transition surface has a cutwater having a profiled section which comprises a protrusion which extends irregularly from an otherwise generally rounded arched or U-shaped transition surface and is configured such that, in use, the velocity and/or turbulence resulting from the in use flow of the material being pumped in the main pumping chamber is reduced. | 06-16-2011 |
| 20110158795 | CENTRIFUGAL PUMP IMPELLERS - A centrifugal pump impeller includes front and back shrouds and a plurality of pumping vanes therebetween, each pumping vane having a leading edge in the region of an impeller inlet and a trailing edge, the front shroud has an arcuate inner face in the region of the impeller inlet, the arcuate inner face having a radius of curvature (R | 06-30-2011 |
| 20110164841 | LUBRICANT RETAINER FOR PUMP SHAFT BEARING ASSEMBLY - A lubricant retainer for use in a pump bearing assembly, the bearing assembly which in a first operating configuration is lubricated by a relatively highly viscous lubricant, and which in a second operating configuration is lubricated by a less-viscous lubricant, the bearing assembly comprising a bearing housing having a bore extending therethrough for receiving a pump drive shaft, spaced-apart bearing mounting zones within said bore with a chamber therebetween, each bearing mounting zone arranged for the in use receipt of a bearing therein. Each zone has associated therewith one lubricant retainer, the lubricant retainer being adapted to be mounted within the bore adjacent the bearing mounting zone with which it is associated so as to form a barrier between the bearing mounting zone and the chamber when the pump bearing assembly is in the first operating configuration, the retainer being removed when the pump bearing assembly is in the second operating configuration. | 07-07-2011 |
