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Burgard, US
Anthony P. Burgard, State College, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100173318 | METHOD AND SYSTEM FOR MODELING CELLULAR METABOLISM - This invention relates to methods and systems for in silico or bioinformatic modeling of cellular metabolism. The invention includes methods and systems for modeling cellular metabolism of an organism, comprising constructing a flux balance analysis model, and applying constraints to the flux balance analysis model, the constraints selected from the set consisting of: qualitative kinetic information constraints, qualitative regulatory information constraints, and differential DNA microarray experimental data constraints. In addition, the present invention provides for computational procedures for solving metabolic problems. | 07-08-2010 |
| 20110015867 | METHOD FOR REDESIGN OF MICROBIAL PRODUCTION SYSTEMS - A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifying at least one stoichiometrically balanced pathway at least partially based on the reactions and a substrate to minimize a number of non-native functionalities in the production host, and incorporating the at least one stoichiometrically balanced pathway into the host to provide the desired biotransformation. A representation of the metabolic network as modified can be stored. | 01-20-2011 |
Anthony P. Burgard, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110045575 | MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO. | 02-24-2011 |
| 20110129904 | METHODS AND ORGANISMS FOR CONVERTING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL TO 1,3-BUTANEDIOL - A non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway includes at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme or protein expressed in a sufficient amount to produce 1,3-BDO. A method for producing 1,3-BDO that includes culturing the this non-naturally occurring microbial organism under conditions and for a sufficient period of time to produce 1,3-BDO. | 06-02-2011 |
| 20110201089 | METHODS FOR INCREASING PRODUCT YIELDS - A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product. | 08-18-2011 |
| 20110207189 | METHODS FOR INCREASING PRODUCT YIELDS - A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product. | 08-25-2011 |
| 20110212507 | METHODS FOR INCREASING PRODUCT YIELDS - A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includesculturing this organism for a sufficient period of time to produce a product. | 09-01-2011 |
Anthony P. Burgard, Bellafonte, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20120021478 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF AROMATICS, 2,4-PENTADIENOATE AND 1,3-BUTADIENE - The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene pathway. The invention additionally provides methods of using such organisms to produce toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene. | 01-26-2012 |
Anthony R. Burgard, State College, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20110301930 | METHOD FOR DETERMINING GENE KNOCKOUTS - A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate. | 12-08-2011 |
Clark Burgard, Greenwich, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20090319574 | USER PROGRAMMABLE INTERNET BROADCAST STATION - An apparatus and method for creating a personal radio or television station for broadcasting over the Internet includes a user logging onto a dedicated server on the Internet, creating a personal account associated with memory storage and a unique companion webpage address, selecting audio and or video content from predetermined server play lists including news, music, sports, weather, traffic, emergency and civic announcements. The server operator secures licenses from content providers for rebroadcast rights. The user may also upload personal audio or video content to the server. The user creates his own playlist for broadcast which may include server content or his own personal content. A ‘live mode’ is also presented where a user may stream live audio and or video content from his own broadcast studio to the server for rebroadcast over the webpage. Streaming protocols are used to broadcast content to multiple listeners and prevent copyright violations. | 12-24-2009 |
Daniel Burgard, Wauseon, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20100220766 | Wireless Temperature Profiling System - A wireless temperature profiling system and the methods of making it are disclosed. The wireless temperature profiling system can include a photovoltaic substrate, a transponder, and a reader. | 09-02-2010 |
| 20120000247 | HIGH-TEMPERATURE ACTIVATION PROCESS - A method for processing a coated glass substrate may include a high-temperature activation process. | 01-05-2012 |
Daniel J. Burgard, Wauseon, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20120027923 | SEAL FOR PHOTOVOLTAIC MODULE - A seal can be included in a photovoltaic module to improve reliability and durability. | 02-02-2012 |
Edward C. Burgard, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080275080 | Methods for treating lower urinary tract disorders using alpha2delta subunit channel modulators with smooth muscle modulators - A method is provided for using α | 11-06-2008 |
| 20090203792 | METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING ALPHA2DELTA SUBUNIT CALCIUM CHANNEL MODULATORS - A method is provided for treatment of non-painful bladder disorders, particularly non-painful overactive bladder without loss of urine. The method comprises administration of an α | 08-13-2009 |
| 20110294881 | METHODS FOR TREATING LOWER URINARY TRACT DISORDERS USING alpha2delta SUBUNIT CALCIUM CHANNEL MODULATORS WITH SMOOTH MUSCLE MODULATORS - A method is provided for using α | 12-01-2011 |
Jeffrey E. Burgard, Lombard, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20090110615 | Segmented Outer Catalyst Retention Screen for Stacked Radial Flow Reactors - A radial flow reactor design is presented. The reactor has individual and interchangeable screens that are arrayed circumferentially around the inside of the reactor. The reactor includes a plurality of screens held out from the reactor wall to form a circumferential screen, with channels defined between the reactor wall and the circumferential screen. | 04-30-2009 |
Phillip Burgard, Kinnelon, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100325410 | SYSTEM AND METHOD FOR MANAGEMENT AND INSTALLATION OF OPERATING SYSTEM IMAGES FOR COMPUTERS - Shown is a method and system for provisioning a target computer with an operating system, which calls for booting the target computer in a pre-operating system environment, collecting configuration information for the target computer, and transmitting the configuration information to a predetermined server. The approach shown also provides for searching a database in the server for a pre-existing operating system image corresponding to the configuration information from the target computer. If a corresponding operating system image is found, then the present approach involves transferring the pre-existing operating system image to the target computer and installing the pre-existing operating system image on the target computer. | 12-23-2010 |
Robert Burgard, Auburn, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090288598 | Doctor blade supply system with intelligent viscosity logic - A supply system for a chambered doctor blade assembly makes possible the sequential use of water-based and non-water-based coating materials through automated functions programmed in a PLC that controls the system. A pair of pneumatically driven diaphragm pumps serve as supply pump and return pump between the doctor blade chamber and a coating reservoir A PLC controls the pulse rate of pneumatic pressure to the pumps to control the rate of flow of the coating material into, and out of the doctor blade chamber. An ultrasonic sensor mounted detects the liquid level in the trough collection area. The PLC is programmed to modify the pulse rate of the supply pump and return pump to maintain the liquid level in the trough collection area above the drain thereof and below the maximum tolerance. | 11-26-2009 |
| 20090291217 | Doctor blade supply system with intelligent viscosity logic - A supply system for a chambered doctor blade assembly makes possible the sequential use of water-based and non-water-based liquid inks through automated functions programmed in a PLC that controls the system. A pair of pneumatically driven diaphragm pumps serve as supply pump and return pump between the doctor blade chamber and an ink reservoir A PLC controls the pulse rate of pneumatic pressure to the pumps to control the rate of flow of the liquid into, and out of the doctor blade chamber. A capacitive sensor detects a high liquid level in the ink reservoir. The PLC is programmed to modify the pulse rate of the supply pump and return pump to maintain the liquid level in the reservoir above the drain thereof and below the maximum level. | 11-26-2009 |