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Burden, GB
Adrian Paul Burden, Malvern GB
| Patent application number | Description | Published |
|---|---|---|
| 20100294024 | ENCAPSULATED DEVICE WITH INTEGRATED GAS PERMEATION SENSOR - An encapsulated device comprising an integrated gas permeation sensor is provided, comprising a base substrate with an electronic component arranged thereon being enclosed within an encapsulation for protecting the electronic component from moisture and/or oxygen; at least one sensor is arranged within the encapsulation to measure the permeation of gas into the encapsulation; each sensor comprises an electrically conductive sensing element comprising a moisture and/or oxygen sensitive material, wherein the reaction of said material with moisture and/or oxygen results in a change in the electrical resistance/conductivity of the sensor. | 11-25-2010 |
| 20100327060 | READING DEVICE FOR IDENTIFYING A TAG OR AN OBJECT ADAPTED TO BE IDENTIFIED, RELATED METHODS AND SYSTEMS - A reading device for identifying a tag or an object adapted to be identified is disclosed. The reading device includes a first reading element for reading a first set of identification features located in the tag or the object adapted to be identified, wherein the first reading element is a magneto-optical reading element; and a second reading element for reading a second set of identification features located in the tag or the object adapted to be identified; wherein the reading device is configured such that a first signal generated from reading the first set of identification features and a second signal generated from reading the second set of identification features are independently used to derive a first signature and a second signature for identifying the tag or object. | 12-30-2010 |
Christopher J. Burden, Chepstow GB
| Patent application number | Description | Published |
|---|---|---|
| 20100202855 | ASSEMBLY - An assembly comprises first and second components provided with holes receiving a retaining element in the form of a pin, in order to retain the components together. The pin is made from a shape memory effect material, and is inserted into the holes in a straight configuration, following which a change in temperature causes a retaining portion of the pin to deform into a second configuration, in which withdrawal of the pin is prevented. | 08-12-2010 |
| 20100288376 | TEMPERATURE RESPONSIVE FLUID FLOW CONTROL DEVICE - A fluid flow control device for regulating the flow of fluid in a passage comprises an annular fixed body having at least one aperture in an annular surface thereof, through which fluid is arranged to flow in use, and a thermally responsive annular valve element mounted concentrically with respect to the fixed body and whose configuration is changeable with temperature so as to control the flow of fluid through the at least one aperture. | 11-18-2010 |
Michael Nail Burden, Hertfordshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20090274726 | SYNTHETIC GENE - The present invention relates to synthetic genes, processes for designing said synthetic genes and their uses in gene therapy and improved DNA vaccination. The novel synthetic genes and processes are codon shuffled so that they have reduced homology relative to a naturally occurring gene encoding the same protein without altering the overall codon usage frequency of the gene. In particular the present invention relates to improved polynucleotides and methods for the treatment or prevention of disease comprising codon-shuffled GM-CSF nucleic acid sequences. Nucleic acid vaccines of the present invention may comprise a combination of a nucleotide sequence encoding codon-shuffled GM-CSF, a nucleotide encoding an antigen against which it is desired to raise an immune response and a toll-like receptor (TLR) agonist. | 11-05-2009 |
Michael Neil Burden, Hertfordshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20100047243 | NOVEL ANTIBODIES AGAINST IGF-IR - The present invention relates to antibodies or antigen binding fragments thereof which specifically binds to IGF-1R, specifically hIGF-1R. Also disclosed are antibody preparations comprising antibodies or antigen binding fragments of the invention. Methods of producing such antibodies or antigen binding fragments and uses thereof are also included within the scope of the present invention. | 02-25-2010 |
| 20110008345 | ANTIGEN-BINDING CONSTRUCTS - The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof. | 01-13-2011 |
Michael Neil Burden, Stevenage GB
| Patent application number | Description | Published |
|---|---|---|
| 20090148905 | ANTIGEN-BINDING CONSTRUCTS - The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof. | 06-11-2009 |
Paul Burden, Cumbria GB
| Patent application number | Description | Published |
|---|---|---|
| 20080257512 | Single Ply Tissue Products Surface Treated With A Softening Agent - Tissue products are described that have been topically treated with a chemical additive, such as a softener. The softener may be, for instance, a polysiloxane. The polysiloxane is topically applied to a tissue sheet, such as a single ply sheet, so as to form a Z-directional gradient in the sheet. Particular, most of the polysiloxane remains on the surface of the tissue product as opposed to migrating to the center of the sheet. In this manner, tissue sheets are formed with improved softness at lower levels of polysiloxane and without the need for applying any surfactants to the sheet. A system for applying chemical additives to tissue sheets is also described. The system includes a chemical additive applicator, such as a meltblown die that emits the chemical additive through a plurality of orifices. In one embodiment, the system includes a device for periodically cleaning the orifices during application of the chemical additive. The cleaning device may be, for instance, a brush that traverses across the die head when desired. | 10-23-2008 |
Paul Myles Burden, Barrow In Furness GB
| Patent application number | Description | Published |
|---|---|---|
| 20100051217 | Soft single-ply tissue - A soft single-ply tissue sheet is produced by making a textured, high bulk, throughdried tissue sheet and calendering the sheet with a high level of compression energy to substantially reduce the bulk and impart improved properties to the sheet. | 03-04-2010 |
| 20100051218 | Soft Single-Ply Tissue - A soft single-ply tissue sheet is produced by making a textured, high bulk, through dried tissue sheet and calendering the sheet with a high level of compression energy to substantially reduce the bulk and impart improved properties to the sheet. | 03-04-2010 |
Roberta Burden, Belfast GB
| Patent application number | Description | Published |
|---|---|---|
| 20090068198 | Antibody and Uses Thereof - Described are specific binding members e.g. antibodies which may be used in the treatment of diseases associated with cathepsin S activity. The specific binding members binds cathepsin S and inhibits its proteolytic activity. The binding members may be used in the treatment of diseases such as cancer, inflammatory diseases, neurodegenerative disorders, autoimmune disorders, and other diseases associated with excessive, deregulated or inappropriate angiogenesis. | 03-12-2009 |
| 20090269360 | THERAPY - The invention relates to a method of inhibiting chemotherapy induced upregulation of Cathepsin S on the surface of tumour cells, the method comprising the administration of a Cathepsin S inhibitor to said cells. Also provided is a therapy comprising an anti Cathepsin S antibody, in particular an anti-Cathepsin S antibody which does not inhibit the proteolytic effect of Cathepsin S but nevertheless inhibits angiogenesis and a combination treatment comprising a Cathepsin S inhibitor and a therapeutic agent. | 10-29-2009 |
| 20100086551 | ANTIBODY AND USES THEREOF - A method of inhibiting angiogenesis in a group of cells, a tissue or an organ includes administering an antibody molecule or nucleic acid encoding an antibody molecule to the cells, tissue or organ, wherein the antibody molecule specifically binds cathepsin S, but does not inhibit proteolytic activity of cathepsin S. | 04-08-2010 |
| 20100104554 | PEPTIDE AND USES THEREOF - A method of inhibiting activity of a cathepsin L-like protease in cells or tissue and the use of the method in the treatment of disease such as cancer and inflammatory diseases is described. The method comprises administration of a cathepsin propeptide or a nucleic acid encoding a cathepsin propeptide. In particular embodiments, the propeptide is a Cathepsin S propeptide. Further, the use of propeptides having an Fc portion is described. | 04-29-2010 |