Patent application number | Description | Published |
20100129882 | HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM - Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils. | 05-27-2010 |
20110020882 | AMINOTRANSFERASE AND OXIDOREDUCTASE NUCLEIC ACIDS AND POLYPEPTIDES AND METHODS OF USING - The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and oxidoreductase nucleic acids and polypeptides. | 01-27-2011 |
20110033391 | Transferases and Oxidoreductases, Nucleic Acids Encoding them and methods for making and using them - This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine+2-oxoglutarate<=>pyruvate+D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid+H | 02-10-2011 |
20110045547 | ISOMERASES AND EPIMERASES AND METHODS OF USING - The invention provides for isomerase (e.g., racemase) and epimerase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such isomerase (e.g., racemase) and epimerase nucleic acids and polypeptides. | 02-24-2011 |
20110053245 | ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM - This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-, arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermerdiates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention. | 03-03-2011 |
20110277046 | HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM - Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils. | 11-10-2011 |
20120258505 | HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM - Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils. | 10-11-2012 |
20140141491 | Isomerases, Nucleic Acids Encoding Them and Methods for Making and Using Them - This invention relates generally to enzymes, polynucleotides encoding the enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. | 05-22-2014 |
20140165221 | Transferases and Oxidoreductases, Nucleic Acids Encoding Them and Methods for Making and Using Them. - This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., d-amino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine+2-oxoglutarate<=>pyruvate+D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid+H | 06-12-2014 |
Patent application number | Description | Published |
20080237470 | Polymeric composite scintillators and method for making same - A scintillation detector comprising nano-scale particles of a scintillation compound embedded in a plastic matrix is provided. The nano-scale particles may be made from metal oxides, metal oxyhalides, metal oxysulfides, or metal halides. Methods are provided for preparing the nano-scale particles. The particles may be coated with organic compounds or polymers prior to incorporation in the plastic matrix. A technique for matching the refractive index of the plastic matrix with the nano-scale particles by incorporating nano-scale particles of titanium dioxide is also provided. The scintillator may be coupled with one or more photodetectors to form a scintillation detection system. The scintillation detection system may be adapted for use in X-ray and radiation imaging devices, such as digital X-ray imaging, mammography, CT, PET, or SPECT, or may be used in radiation security detectors or subterranean radiation detectors. | 10-02-2008 |
20080298545 | CARGO CONTAINER INSPECTION SYSTEM AND APPARATUS - A cargo container inspection radiation detector apparatus is disclosed. The apparatus includes a support, and a plurality of area radiation detectors disposed upon the support arranged corresponding to a height of the cargo container, each area radiation detector comprising an active area defined by a matrix of pixels. | 12-04-2008 |
20080298546 | CARGO CONTAINER INSPECTION METHOD - A method of improving a signal to noise ratio of an image data set of a cargo container is disclosed. The method includes transmitting a radiation beam toward the cargo container, detecting the transmitted radiation beam via a plurality of area radiation detectors, each area radiation detector comprising an active area defined by a matrix of pixels, thereby defining enhanced radiation data, processing the enhanced radiation data and reconstructing the image data set representative of contents of the cargo container, combining image attributes of the image data set to improve the signal to noise ratio, thereby defining an enhanced image data set, and displaying on a display the enhanced image data set comprising an improved signal to noise ratio. | 12-04-2008 |
20090078892 | COMPUTED RADIOGRAPHY SYSTEM AND METHOD FOR MANUFACTURING THE SAME - A computed radiography system is provided. The computed radiography system includes an imaging plate configured to store a radiation energy pattern of an object or emit multiple prompt emission photons of the radiation energy pattern upon irradiation or a combination thereof. The computed radiography system also includes at least one light source configured to illuminate at least a sub-area of the imaging plate for a time period of less than about a second. The at least one light source is configured to stimulate at least one of an emission of multiple photons of the radiation energy pattern stored in the imaging plate. The computed radiography system further includes a two dimensional imager configured to capture at least one two dimensional image from the at least a sub-area of the imaging plate using one of an image emitted from the radiation energy pattern stored or an image emitted from prompt emission or a combination thereof. | 03-26-2009 |
20090146079 | SYSTEM AND METHOD FOR CORRECTING SPATIAL LUMINANCE VARIATION OF COMPUTED RADIOGRAPHY IMAGE PLATES - A computed radiography plate including a substrate is provided. The computed radiography plate also includes at least one phosphor layer disposed above the substrate. The computed radiography plate also includes a protective layer disposed above the phosphor layer. The computed radiography plate further includes multiple patterns inscribed within at least one of the phosphor layer, the protective layer or the substrate. | 06-11-2009 |
20090232277 | SYSTEM AND METHOD FOR INSPECTION OF ITEMS OF INTEREST IN OBJECTS - An inspection system is provided. The inspection system includes at least one radiation source including single or multiple energies and configured to transmit a radiation beam through an object under inspection. The inspection system further includes an array of detectors configured to receive multiple radiation beams transmitted through the object, wherein the array of detectors are oriented at different angles with respect to the radiation beam and wherein at least one of the radiation source, and the array of detectors or the object is configured to be actuated in a translational direction relative to each other. The inspection system further includes processing circuitry coupled to the array of detectors and configured to generate a three dimensional image of the object. | 09-17-2009 |
20110170654 | NUCLEAR FUEL PELLET INSPECTION - A system for inspecting nuclear fuel pellets is provided. The inspection system is configured to use X-ray radiation at one or more energies to probe nuclear fuel pellets disposed within a nuclear fuel rod for nuclear fuel pellet defects. In some implementations of the inspection system, a nuclear fuel rod manufacturing facility may be able to integrate the inspection system for fully or partially automated inspection of all fuel rods produced within the facility. | 07-14-2011 |
20110170661 | INSPECTION SYSTEM AND METHOD - An inspection system is provided. The inspection system includes at least one source configured to emit a beam of radiation onto an object. The inspection system also includes at least two area detectors having different characteristics configured to receive a reflected beam of radiation from the object and output a plurality of image data streams corresponding to the different characteristics, wherein the at least two area detectors disposed in at least one of a cascaded arrangement or separated by a pre-determined distance along a direction parallel or perpendicular to a scan direction of the object. | 07-14-2011 |
20110299653 | METHOD AND APPARATUS FOR LAMINOGRAPHY INSPECTION - Imaging systems including a multiple focal spot x-ray source adapted to irradiate an object with a series of angularly displaced x-ray beams, one at a time, without substantial rotation or translation of the multiple focal spot x-ray source are provided. Such systems also includes a detector adapted to receive at least a fraction of the angularly displaced x-ray beams after being attenuated by the object to produce at least two x-ray projection images of the object. The imaging systems also include a processor adapted to shift and add the at least two x-ray projection images to bring at least two planes of the object into focus, one at a time. | 12-08-2011 |
20120163695 | INTRA-DETECTOR SCATTER CORRECTION - Intra-detector scatter correction methods to improve X-ray images. The method of correcting an X-ray image includes: receiving an original two-dimensional X-ray image; calculating a theoretical scattered image for a array of detector pixels by generating a theoretical point spread (TPS) function of a single pixel for a single line array of detector pixels, based on a system parameter; aggregating the TPS function into a full rotation of line arrays, so as to generating a TPS function for a 2-dimensional array of pixels; and applying the TPS function for a 2-dimensional array of pixels to a plurality of pixels in the detector; and then subtracting the theoretical scattered image from the original two-dimensional X-ray image, so as to create an improved X-ray image. | 06-28-2012 |
20130015371 | THERMOLUMINESCENT COMPUTED RADIOGRAPHY READER AND METHOD FOR USING SAMEAANM Bueno; CliffordAACI Clifton ParkAAST NYAACO USAAGP Bueno; Clifford Clifton Park NY USAANM Venugopal; ManoharanAACI BangaloreAACO INAAGP Venugopal; Manoharan Bangalore INAANM Shaw; Jeffrey JonAACI Ballston LakeAAST NYAACO USAAGP Shaw; Jeffrey Jon Ballston Lake NY USAANM Osterlitz; Mark JohnAACI SchenectadyAAST NYAACO USAAGP Osterlitz; Mark John Schenectady NY US - A computed radiography reading system and method. The system includes an exposed computed radiography plate, a two-dimensional pixelized array, and a heating element. The heating element conducts heat to the computed radiography plate and the computed radiography plate releases entrained light signals to the two-dimensional pixelized array in response to the conducted heat. | 01-17-2013 |
Patent application number | Description | Published |
20090104617 | Diagnostic and Prognostic Tests - The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from tissue samples, such as cancer tissue samples. The invention also provides sets of genes that are expressed differentially in malignant pleural mesothelioma. These sets of genes can be used to discriminate between normal and malignant tissues, and between classes of malignant tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression also are provided. | 04-23-2009 |
20100028876 | DIAGNOSTIC TESTS USING GENE EXPRESSION RATIOS - The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from cell or tissue samples, such as cancer cell or tissue samples. The invention also provides sets of genes that are expressed differentially in normal and cancer lung cells and tissues. These sets of genes can be used to discriminate between normal and malignant cells or tissues, and between classes of malignant cells or tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumour progression/regression also are provided. | 02-04-2010 |
20100196898 | DISEASE-ASSOCIATED GENETIC VARIATIONS AND METHODS FOR OBTAINING AND USING SAME - The invention provides a comprehensive, rapid, unbiased, and accurate method for identifying and/or discovering disease-associated genetic variations, e.g., disease-associated variations. The present invention further provides novel disease-associated genetic variations for use as genetic markers of disease, e.g., cancer. The invention further provides methods for assessing an individual's risk for developing a disease, e.g., cancer, by detecting the presence the novel disease-associated genetic variations of the invention. | 08-05-2010 |
20110059854 | DIAGNOSTIC AND PROGNOSTIC TESTS - The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from tissue samples, such as cancer tissue samples. The invention also provides sets of genes that are expressed differentially in malignant pleural mesothelioma. These sets of genes can be used to discriminate between normal and malignant tissues, and between classes of malignant tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression also are provided. | 03-10-2011 |
20120214163 | DISEASE-ASSOCIATED GENETIC VARIATIONS AND METHODS FOR OBTAINING AND USING SAME - The invention provides a comprehensive, rapid, unbiased, and accurate method for identifying and/or discovering disease-associated genetic variations, e.g., disease-associated variations. The present invention further provides novel disease-associated genetic variations for use as genetic markers of disease, e.g., cancer. The invention further provides methods for assessing an individual's risk for developing a disease, e.g., cancer, by detecting the presence the novel disease-associated genetic variations of the invention. | 08-23-2012 |
20130296198 | DIAGNOSTIC TESTS USING GENE EXPRESSION RATIOS - The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from cell or tissue samples, such as cancer cell or tissue samples. The invention also provides sets of genes that are expressed differentially in normal and cancer lung cells and tissues. These sets of genes can be used to discriminate between normal and malignant cells or tissues, and between classes of malignant cells or tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression also are provided. | 11-07-2013 |
20140038180 | DISEASE-ASSOCIATED GENETIC VARIATIONS AND METHODS FOR OBTAINING AND USING SAME - The invention provides a comprehensive, rapid, unbiased, and accurate method for identifying and/or discovering disease-associated genetic variations, e.g., disease-associated variations. The present invention further provides novel disease-associated genetic variations for use as genetic markers of disease, e.g., cancer. The invention further provides methods for assessing an individual's risk for developing a disease, e.g., cancer, by detecting the presence the novel disease-associated genetic variations of the invention. | 02-06-2014 |
20140294993 | METHOD FOR TREATMENT OF MESOTHELIOMA - The present invention provides that Ras-like, estrogen-regulated, growth inhibitor (RERG) is a malignant mesothelioma biomarker of clinical course and treatment sensitivity and, itself a target for mesothelioma treatment. A low RERG level in a mesothelioma subject indicates poor prognosis. Analyzing RERG expression level along can help mesothelioma patients make treatment choices. Furthermore, mesothelioma can be treated by modulating RERG activity, for example, with treatment with estrogen or estrogen-like agents. | 10-02-2014 |
20140296327 | DIAGNOSIS AND TREATMENT OF MESOTHELIOMA - This disclosure provides methods for surveillance, early detection and diagnosis, subtype classification, prediction of recurrence, prognosis and therapy of malignant mesothelioma based on profiles of indicator mutations in disclosed genes. | 10-02-2014 |