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Buckler, MA

Alan Buckler, Arlington, MA US

Patent application numberDescriptionPublished
20110092508BIOMARKERS OF TUMOR PHARMACODYNAMIC RESPONSE - The present invention provides novel biomarkers, and methods of using said biomarkers, for assessing the efficacy of a treatment regimen for treating cancer in a subject, particularly for treating cancer via Hsp90 inhibition. The present invention also provides methods of identifying test agents capable of treating cancer, particularly in the case of cancers characterized by high levels of IL-8.04-21-2011

Andrew Buckler, Wenham, MA US

Patent application numberDescriptionPublished
20090043172MULTI-MODAL IMAGING SYSTEM AND WORKSTATION WITH SUPPORT FOR STRUCTURED HYPOTHESIS TESTING - Investigation of in vivo models of disease requires imaging studies involving single subjects in single imaging sessions, serial imaging of individuals or groups of subjects, and integration of data across diverse and heterogeneous experimental methodologies. Each type of experiment is preferably supported by various feature sets that can be rigorously applied to produce quantitative, reproducible results. Current imaging scanners are not equipped with standardized capability that supports an automated and scientifically rigorous workflow suited to hypothesis testing. An imaging system includes a research workstation at which a user can design, execute, study, and report imaging plans. Flexibility that comes along with a modular design of the system allows the user to customize workflow parameters for more robust hypothesis testing.02-12-2009
20090088620QUANTITATIVE CLINICAL AND PRE-CLINICAL IMAGING - In a clinical or preclinical imaging system, an image acquisition subsystem includes a data acquisition and image reconstruction elements generating clinical or preclinical images. A quantitative image processing subsystem generates variability metadata associated with the clinical or preclinical images, and a clinically or preclinically significant result with an associated confidence interval computed based on the variability metadata. A user interface displays the clinically or preclinically significant result together with the associated confidence interval. A phantom for calibrating such an imaging system includes a deformable nonbiological structure approximating structure of a clinical or preclinical subject to be imaged, and fiducial markers detectable by the imaging system disposed on or in the deformable nonbiological structure to move with deformation of the deformable nonbiological structure.04-02-2009
20100172565PRECLINICAL TIME OF FLIGHT IMAGING - A preclinical positron emission tomography (PET) imaging method includes acquiring time-of-flight localized PET imaging data from one or more non-human animal subjects and reconstructing the acquired data to form an image. In an illustrative PET scanner includes: radiation detectors (07-08-2010
20100198047SMALL ANIMAL IMAGING CAPSULE AND BED SYSTEM - In a small animal imaging system (08-05-2010
20100266190SYSTEM FOR QUANTIFICATION OF NEOVASCULATURE IN CT VOLUMES - When quantifying neo-vasculature growth measured using a CT scanner (10-21-2010
20120061576PET DETECTOR SYSTEM WITH IMPROVED CAPABILITIES FOR QUANTIFICATION - A nuclear medical imaging system employing radiation detection modules with pixelated scintillator crystals includes a scatter detector (03-15-2012

Patent applications by Andrew Buckler, Wenham, MA US

Andrew J. Buckler, Wenham, MA US

Patent application numberDescriptionPublished
20090292559MEDICAL WORKFLOW SYSTEMS AND METHODS WITH PROCESS WORKFLOW RECORDATION - A medical information processing and storage system includes a medical images database storing medical images and metadata relevant to the medical images. A processor is configured to perform post-acquisition image processing on medical images. A medical images archiver is configured to store a medical image in the medical images database after the medical image has been processed by the processor. The medical images archiver stores the medical image in the database with processing-descriptive metadata that is descriptive of the post-acquisition image processing performed on the medical image by the processor.11-26-2009

David R. Buckler, Sudbury, MA US

Patent application numberDescriptionPublished
20120114557Methods for Collagen Imaging - Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.05-10-2012

Kenneth Everett Buckler, Methuen, MA US

Patent application numberDescriptionPublished
20100228231FLUID LINE CONNECTOR SAFETY DEVICE - The present application describes devices that use various features to prevent the disconnection of connectors used in medical treatments. For example embodiments prevent disconnection of luer connectors that are incompletely mated.09-09-2010

Mark Buckler, Wenham, MA US

Patent application numberDescriptionPublished
20080218582VIDEO CONFERENCING - A video conferencing system is provided, in which at least two cameras are used to capture images of people at a first location participating in a video conference. One or more active speakers are identified among the people at the location, and one of the at least two cameras is automatically selected based on a position or positions of the one or more active speakers. Images from the selected camera are provided to a person at a second location participating the video conference.09-11-2008