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Brown, MA

A. Leonard Brown, Weston, MA US

Patent application number	Description	Published
20110161981	USING PER TASK TIME SLICE INFORMATION TO IMPROVE DYNAMIC PERFORMANCE STATE SELECTION - Methods and apparatus for using per task time slice information to improve dynamic performance state selection are described. In one embodiment, a new performance state is selected for a process based on one or more previous execution time slice values of the process. Other embodiments are also described.	06-30-2011

Alexander T. Brown, Watertown, MA US

Patent application number	Description	Published
20100009970	COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES - The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.	01-14-2010

Booker T. Brown, Melrose, MA US

Patent application number	Description	Published
20090000198	Mechanical Arm System for Opening a Door - A mechanical arm system for opening a door includes an actuator assembly having an output shaft and an arm driven by the output shaft so as to move the door from a closed position toward an open position. The arm is free from contact with the door when the door moves from the open position to the closed position. The actuator assembly is mounted to a support member adjacent the door. The arm extends between the output shaft and the door. The arm may be moveable between a position in which the arm contacts the door in the open position and a retracted position in which the arm is free from contact with the door in the closed position. The arm may be moved to the retracted position before the door reaches the open position so as to abort the opening of the door.	01-01-2009

Charles H. Brown, Wellesley, MA US

Patent application number	Description	Published
20110141140	VISUALIZATION GUIDED ACL LOCALIZATION SYSTEM - A computerized system provides assistance for placement of localization markers for medical operations such as ACL repair procedures. The system displays, on a graphical user interface, an image of an anatomical structure and allows identification, via an input device on the graphical user interface, of a set of landmark locations identifying respective anatomical positions within the displayed image of the anatomical structure. The system displays a graphical overlay over the image of the anatomical structure. Placement of the graphical overlay is based on the set of landmark locations. The system displays at least one localization marker within the graphical overlay. The localization marker(s) identify a location for performing a surgical operation associated with the anatomical structure, such as ACL repair surgical operations.	06-16-2011

Christopher Todd Brown, Lowell, MA US

Patent application number	Description	Published
20100286071	Finger-1 Peptide Analogs of the TGF-Beta Superfamily - Members of the TGF-β superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.	11-11-2010

Christopher Todd Brown, Chelmsford, MA US

Patent application number	Description	Published
20120046227	DESIGNER OSTEOGENIC PROTEINS - The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.	02-23-2012

Damon J. Brown, Boston, MA US

Patent application number	Description	Published
20090148815	Method and apparatus for tooth whitening - Preconditioning mouth rinse, which pre-treats the teeth to better receive a whitening formula containing a photosensitive compound, and a hand-held consumer light source for tooth whitening, which provides rapid tooth whitening, are disclosed. The light source may use a specific range of visible light and also emit heat sufficient to raise the temperature of the teeth a desired amount at a depth up to about 2 mm in the range of about from 1-5° Celsius over a predetermined period of time. The specified wavelengths of the hand-held consumer operable light will activate the photosensitive substance in the whitening formula. The oxidizing compounds may be transparent to light enabling light energy to activate the oxidizing compounds directly on the tooth surface, or to activate a photosensitizing or photosensitive compound added to produce the desired temperature increase.	06-11-2009
20090325129	Moldable tray, system, and method for whitening teeth - Tooth whitening system includes a moldable dental tray of sufficiently moldable material so that a user can form the tray to substantially match the configuration of the user's teeth, in use. Moldable dental tray includes a raised region and a valley that are adjacent to and free of contact with a corresponding raised region and valley of a user's tooth adjacent a user's gum line. Thus, a tooth provided on the moldable dental tray is free of contact with the user's gingiva, in use. Tooth whitener includes a carrier, a whitening agent, and a sufficiently adhesive so that both the tooth whitener and the moldable dental tray are adhered to a user's tooth for a sufficiently long period of time to achieve a whitening of the user's tooth by the whitening agent. Tooth whitener and tray can be made of organic, natural materials.	12-31-2009
20110281240	METHOD FOR WHITENING TEETH - Tooth whitening compound includes a whitener and a carrier selected for adhering the carrier and whitening composition to a user's teeth. The whitening compound may be applied by the method including painting, washing, sponging, coating, daubing, spraying, wiping, rubbing, and by any movement relative to a horizontal or vertical axis of the user's tooth. The whitening compound may be sufficiently viscous to adhere to a user's teeth, in use, without a mechanical retaining device. The whitening compound may be a semi-solid or a solid compound at ambient temperatures.	11-17-2011

David W. Brown, North Brookfield, MA US

Patent application number	Description	Published
20090136916	METHODS AND MICROARRAYS FOR DETECTING ENTERIC VIRUSES - The present invention relates to methods, microarrays and kits for detecting one or more human astrovirus serotypes in a sample (e.g., a fecal sample) from an individual. The method includes amplifying nucleic acid molecules of the sample with one or more primers, to thereby obtain an amplified nucleic acid product; contacting the amplified nucleic acid product with one or more serotype specific probes having a nucleic acid sequence that is specific for only one astrovirus serotype in the group of astroviruses being assessed, wherein the nucleic acid sequence includes between about 9 and 25 nucleic acid bases (e.g., SEQ ID NO: 5-24); and detecting the hybridization complex. The presence of hybridization complexes with a serotype specific probe indicates the presence of one or more specific astrovirus serotypes, and the absence of hybridization complexes with a serotype specific probe indicates the absence of the specific astrovirus serotype. Identification of the astrovirus serotypes allows for one to diagnose an individual infected with the serotype. The present invention further includes microarrays having any one of the astrovirus specific probe, or kits having microarrays and reagents for carrying out the assay.	05-28-2009

Dean Brown, Boston, MA US

Patent application number	Description	Published
20110160184	Dibenzothiazepine Derivatives and Use Thereof - Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a mood disorder or schizophrenia or other psychotic disorder with said compounds.	06-30-2011

Dennis Brown, Natick, MA US

Patent application number	Description	Published
20100196426	USE OF MICROVESICLES IN DIAGNOSIS AND PROGNOSIS OF MEDICAL DISEASES AND CONDITIONS - The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker in microvesicles isolated from a biological sample from the subject.	08-05-2010
20100316628	AGENTS AND METHODS FOR TREATING RESPIRATORY DISORDERS - The present invention relates to a novel method of preventing and/or treating respiratory disorders and respiratory-related complications in a subject by inhibiting the release of nitric oxide from basal cells in the respiratory tract.	12-16-2010
20110003704	USE OF MICROVESICLES IN DIAGNOSIS AND PROGNOSIS OF MEDICAL DISEASES AND CONDITIONS - The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker in microvesicles isolated from a biological sample from the subject.	01-06-2011
20110053157	USE OF MICROVESICLES IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF MEDICAL DISEASES AND CONDITIONS - The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a′ subject by detecting a biomarker in microvesicles isolated from a biological, sample from the subject. Moreover, disclosed subject matter is directed to methods of diagnosis, monitoring a disease by determining the concentration of microvesicles within a biological sample; methods of delivering a nucleic acid or protein to a target all by administering microvesicles that contain said nucleic acid or protein; methods for performing a body fluid transfusion by introducing a microvesicle-free or microvesicle enriched fluid fraction into a patient.	03-03-2011

Donald J. Brown, Hopkington, MA US

Patent application number	Description	Published
20090285892	METHODS AND SYSTEMS FOR EXPANDING AC133+ CELLS AND DIRECTING DIFFERENTIATION - The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof.	11-19-2009

Donald J. Brown, Hopkinton, MA US

Patent application number	Description	Published
20100183561	Biological therapeutic compositions and methods thereof - Novel uses of Platelet Rich Plasma (PRP) for infection prevention, bone repair and transmyocardial vascularization is disclosed. The present disclosure is directed to methods for preparing concentrated mesenchymal or haematopoietic stem cells, and autologous platelet-rich plasma (PRP) from the blood utilizing the Magallen® System. The stem cells and/or PRP may be combined with secondary biological agents such as antibiotics, fibrinogen and thrombin, and appropriately used in variety of medical conditions, such as, cardiovascular, thoracic, transplantation, head and neck, oral, gastrointestinal, orthopedic, neurosurgical, and plastic surgery.	07-22-2010

Donald Richard Brown, Worcester, MA US

Patent application number	Description	Published
20100103917	System and Method for Synchronizing Phases and Frequencies of Devices in Multi-User, Wireless Communications Systems - A system and method for synchronizing the phases and frequencies of devices in multi-user, wireless communications systems are provided. A primary beacon signal is transmitted by a destination node in a wireless communications network to a plurality of source nodes. Secondary beacon signals are also exchanged between the source nodes. Using the primary and secondary beacon signals, the nodes generate local phase and frequency estimates which are used to control local phases and frequencies of the source nodes. The source nodes then transmit common information to the destination at carrier frequencies based on the estimated local frequencies and phases, so that the phases and frequencies of the transmitted information are synchronized to facilitate coherent combining of the bandpass signals at the destination. Phase and frequency synchronization can be applied to wireless communications systems having any number of source nodes, and effects of Doppler shifts and moving platforms are accounted for. Acoustic and radio-frequency signaling can be utilized.	04-29-2010

Edward M. Brown, Milton, MA US

Patent application number	Description	Published
20120329153	CAR RECEPTOR AS A MEDIATOR OF MIGRATORY CELL CHEMOTAXIS AND/OR CHEMOKINESIS - This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. Specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. The invention also relates to methods for manipulating io hematopoeitic progenitor cells and related products. In particular the invention includes methods and products for using CaR receptor-related compositions to enhance mobilization of hematopoietic progenitor cells, to improve the efficiency of targeting cells to the bone marrow, and/or to modulate hematopoietic progenitor cell function.	12-27-2012

Emery N. Brown, Brookline, MA US

Patent application number	Description	Published
20120016436	SYSTEM AND METHOD FOR DYNAMICALLY CONFIGURABLE DEEP BRAIN STIMULATION - A DBS system and method for predicting future neurological activity in a subject and administering a corrective electrical stimulation signal to prevent anticipated pathological neuronal activity. The DBS system includes an implantable electrode configured to both record neuronal activity from a target brain area in a subject and administer the corrective electric stimulation signal to the target area. The DBS system also includes a controller configured to determine the characteristics of the corrective electrical stimulation signal based on point process models of healthy and pathological neuronal activity in the target area.	01-19-2012

Emery Neal Brown, Brookline, MA US

Patent application number	Description	Published
20120093376	NOISE REDUCTION OF IMAGING DATA - The present invention relates to systems and methods for reducing noise in image data. Preferred embodiments relate to methods for analyzing two-photon in vivo imaging of biological systems. With neuronal population imaging with subcellular resolution, this modality offers an approach for gaining a fundamental understanding of brain anatomy and physiology. Analysis of calcium imaging data requires denoising, that is separating the signal from complex physiological noise. To analyze two-photon brain imaging data, for example, harmonic regression plus colored noise model and an efficient cyclic descent algorithm for parameter estimation. This approach reliably separates stimulus-evoked fluorescence response from background activity and noise, assesses goodness of fit, and estimates confidence intervals and signal-to-noise ratio.	04-19-2012

Eric Brown, Cambridge, MA US

Patent application number	Description	Published
20090277488	Method and structure, using flexible membrane surfaces, for setting and/or maintaining a uniform micron/sub-micron gap separation between juxtaposed photosensitive and heat-supplying surfaces of photovoltaic chips and the like for the generation of electrical power - A near-field energy conversion structure and method of assembling the same, utilizing a sub-micrometer “near field” gap between juxtaposed photocell infrared radiation receiver and heat emitter surfaces, wherein compliant membrane structures, preferably fluid-filled, are interposed in the structure.	11-12-2009
20100319749	Sub-micrometer gap thermophotovoltaic structure (MTPV) and fabrication method therefor - An MTPV thermophotovoltaic chip comprising a photovoltaic cell substrate, micron/sub-micron gap-spaced from a juxtaposed heat or infrared radiation-emitting substrate, with a radiation-transparent intermediate window substrate preferably compliantly adhered to the photovoltaic cell substrate and bounding the gap space therewith.	12-23-2010
20120060883	METHOD AND STRUCTURE FOR PROVIDING A UNIFORM MICRON/SUB-MICRON GAP SEPARATION WITHIN MICRO-GAP THERMOPHOTOVOLTAIC DEVICES FOR THE GENERATION OF ELECTRICAL POWER - A near-field energy conversion method, utilizing a sub-micrometer “near-field” gap between juxtaposed infrared radiation receiver and emitter surfaces, wherein compliant membrane structures, preferably fluid-filled, are interposed in the structure for maintaining uniform gap separation. Thermally resistant gap spacers are also used to maintain uniform gap separation. Means are provided for cooling a receiver substrate structure and for conducting heat to an emitter substrate structure. The gap may also be evacuated for more effective operation.	03-15-2012

Eric L. Brown, Cambridge, MA US

Patent application number	Description	Published
20110315195	Micro-Gap Thermal Photovoltaic Large Scale Sub-Micron Gap Method and Apparatus - The present invention relates to micron-gap thermal photovoltaic (MTPV) technology for the solid-state conversion of heat to electricity. The problem is forming and then maintaining the close spacing between two bodies at a sub-micron gap in order to maintain enhanced performance. While it is possible to obtain the sub-micron gap spacing, the thermal effects on the hot and cold surfaces induce cupping, warping, or deformation of the elements resulting in variations in gap spacing thereby resulting in uncontrollable variances in the power output. A major aspect of the design is to allow for intimate contact of the emitter chips to the shell inside surface, so that there is good heat transfer. The photovoltaic cells are pushed outward against the emitter chips in order to press them against the inner wall. A high temperature thermal interface material improves the heat transfer between the shell inner surface and the emitter chip.	12-29-2011

Eugene L. Brown, Newton Highlands, MA US

Patent application number	Description	Published
20100029500	OLIGONUCLEOTIDE ARRAYS TO MONITOR GENE EXPRESSION AND METHODS FOR MAKING AND USING SAME - The present invention provides an oligonucleotide array capable of identifying genes and related pathways involved with the induction of a particular phenotype by a cell line, e.g., the genes and related pathways involved with the induction of transgene expression by the cell line. The invention is particularly useful when there is little or no information about the genome of the cell line being studied, because it provides methods for identifying consensus sequences for known and previously undiscovered genes, and for designing oligonucleotide probes to the identified consensus sequences. Additionally, when the array is to be used to determine optimal conditions for expression of a transgene by the cell line, the invention teaches methods of including oligonucleotide probes to transgene sequences in the array. The invention also provides methods of using the array to identify genes and related pathways involved with the induction of a particular cell line phenotype. The invention also provides novel polynucleotides of undiscovered genes (i.e., a gene that had not been sequenced and/or shown to be expressed by CHO cells) and novel polynucleotides involved with the induction of a particular cell phenotype, e.g., increased survival when grown under stressful culture conditions, increased transgene expression, decreased production of an antigen, etc. These novel polynucleotides are termed novel CHO sequences and differential CHO sequences, respectively. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides methods of using the polynucleotides of the invention.	02-04-2010

Eugene Lee Brown, Newton, MA US

Patent application number	Description	Published
20090022731	Arthritis-associated B cell gene expression - The invention features methods and compositions benefiting from differential gene expression observed in arthritis-associated B cells.	01-22-2009

George Brown, Boston, MA US

Patent application number	Description	Published
20110125528	SYSTEMS, APPARATUS, AND METHODS FOR DEVELOPING PATIENT MEDICAL HISTORY USING HIERARCHICAL RELATIONSHIPS - An example apparatus provides access to electronic health information for a first patient and one or more patients connected by relationship to the first patient. A first patient indicator represents a first patient and provides a link to electronic health information for the first patient. A second patient indicator represents a second patient and provides a link to electronic health information for the second patient. A connection provides a graphical indication of a relationship between the first patient and the second patient and connects electronic health information for the second patient for access in connection with electronic health information for the first patient. The connection is to provide a graphical indication of a priority of the relationship between the first patient and the second patient based on a defined relationship hierarchy. A graphical indication of a type of relationship between the first patient and the second patient is provided.	05-26-2011

George C. Brown, Southborough, MA US

Patent application number	Description	Published
20120158422	METHODS AND SYSTEMS FOR SCHEDULING APPOINTMENTS IN HEALTHCARE SYSTEMS - Methods and systems for scheduling appointments in healthcare environments are described. An example computer implemented method of automatically scheduling a medical appointment includes enabling a first device associated with a patient to communicate with a provider scheduling system and inputting a patient schedule onto the provider scheduling system. The example method includes identifying a time slot, using a computer, at which both the patient schedule and a provider schedule have an open time slot and identifying a time and a location of a first appointment proximate to the open time slot based on the patient schedule. The example method includes determining an estimated travel time between the location of the first appointment and a location of a second appointment and determining a patient availability to schedule the second appointment in the open time slot based on the time of the first appointment and the estimated travel time between the location of the first appointment and the location of the second appointment.	06-21-2012

Gerard Brown, Melrose, MA US

Patent application number	Description	Published
20110067918	EMI SHIELDING MATERIALS - Corrosion-resistant electromagnetic interference (“EMI”) shielding material. The material is provided as an admixture of an elastomeric polymeric component and a filler component. The filler component is provided as glass or aluminum particles which are electrolessly-plated with a plating of a nickel-phosphorous alloy.	03-24-2011

Jeffrey Brown, Waltham, MA US

Patent application number	Description	Published
20110044998	Stabilized Angiopoietin-2 Antibodies And Uses Thereof - Stabilized antibodies directed to Angiopoeitin-2 and uses of such antibodies are described. Nucleic acid and amino acid sequences, hybridomas or other cell lines for expressing such antibodies are also provided.	02-24-2011

Jeffrey C. Brown, Carlisle, MA US

Patent application number	Description	Published
20110219450	System And Method For Malware Detection - According to one embodiment, a computer-implemented method for execution on one or more processors includes receiving a first file and determining a file type of the first file. The method also includes determining, according to a first policy, a plurality of malware detection schemes to apply to the first file based on the determined file type of the first file. In addition, the method includes scheduling the application of the determined plurality of malware detection schemes to the first file amongst a plurality of detection nodes according to a second policy. Further, the method includes determining, in response to determining the results of applying the plurality of malware detection schemes, that the first file is malware or determining that the first file is suspected malware according to a third policy.	09-08-2011

Jeffrey L. Brown, Arlington, MA US

Patent application number	Description	Published
20080286780	Novel compositions and methods for the identification, assessment, prevention and therapy of human cancers - The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.	11-20-2008
20110104306	NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS - The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.	05-05-2011
20120141604	NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS - The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.	06-07-2012

Jeffrey Lester Brown, Waltham, MA US

Patent application number	Description	Published
20090123474	COMBINATION OF ANGIOPOIETIN-2 ANTAGONIST AND OF VEGF-A, KDR AND/OR FLTL ANTAGONIST FOR TREATING CANCER - The invention relates to agents which possess anti-angiogenic activity and are accordingly useful in methods of treatment of disease states associated with angiogenesis in the animal or human body. More specifically the invention concerns a combination of an antagonist of the biological activity of Angiopoietin-2 and an antagonist of the biological activity of VEGF-A, and/or KDR, and/or Flt1, and uses of such antagonists.	05-14-2009
20110097321	COMBINATION OF ANGIOPOIETIN-2 ANTAGONIST AND OF VEGF-A, KDR AND/OR FLT1 ANTAGONIST FOR TREATING CANCER - The invention relates to agents which possess anti-angiogenic activity and are accordingly useful in methods of treatment of disease states associated with angiogenesis in the animal or human body. More specifically the invention concerns a combination of an antagonist of the biological activity of Angiopoietin-2 and an antagonist of the biological activity of VEGF-A, and/or KDR, and/or Flt1, and uses of such antagonists.	04-28-2011
20120288497	COMBINATION OF ANGIOPOIETIN-2 ANTAGONIST AND OF VEGF-A, KDR AND/OR FLT1 ANTAGONIST FOR TREATING CANCER - The invention relates to agents which possess anti-angiogenic activity and are accordingly useful in methods of treatment of disease states associated with angiogenesis in the animal or human body. More specifically the invention concerns a combination of an antagonist of the biological activity of Angiopoietin-2 and an antagonist of the biological activity of VEGF-A, and/or KDR, and/or Flt1, and uses of such antagonists.	11-15-2012

Jennifer Brown, Waltham, MA US

Patent application number	Description	Published
20100226917	METHODS FOR THE TREATMENT OF HEMATOLOGIC MALIGNANCIES - The present invention discloses, in part, therapies for treating hematologic malignancies, including B cell lymphomas and leukemias or B cell related tumors comprising the administration of a CHK1 inhibitor in combination with a B cell depleting antibody. The present invention further includes treating hematologic malignancies, including B cell lymphomas and leukemias, or B cell related tumors, which are resistant to cancer treatment comprising the administration of a CHK1 inhibitor.	09-09-2010

Jeremy H. Brown, Somerville, MA US

Patent application number	Description	Published
20120239287	COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR CONSTRUCTING VEHICLE GUIDANCE PATHS THAT OBEY DYNAMIC CONSTRAINTS - A computer-implemented method, system, and computer program product are provided for generating a pre-planned vehicle guidance path for a vehicle by transforming an initial piecewise linear path into a path that obeys a minimum vehicle turning radius constraint.	09-20-2012

Keith Brown, Cambridge, MA US

Patent application number	Description	Published
20090211910	DIELECTROPHORETIC TWEEZERS APPARATUS AND METHODS - Dielectrophoretic (DEP) tweezers apparatus and methods for various applications, including particle trapping. Multiple electrodes (e.g., two or three) are disposed on or otherwise constitute an elongated object forming a tip. Exemplary electrode configurations include, but are not limited to, coaxial and triaxial arrangements. A voltage is applied across these electrodes to produce a non-uniform electromagnetic field proximate to the tip thereby creating a dielectrophoretic trap. Once trapped, a particle may be moved to desired locations via manipulation of the elongated object or the medium in which the particle is located. Multiple DEP tweezers apparatus may be arranged to form arrays of tips capable of respectively generating local electromagnetic fields confined to the tips. Such DEP arrays may be employed in nanofabrication processes involving nanolithography or nano-manipulation, as well as data storage and retrieval applications.	08-27-2009

Larry Brown, Newton, MA US

Patent application number	Description	Published
20110033551	NUCLEIC ACID MICROSPHERES, PRODUCTION AND DELIVERY THEREOF - Nucleic acids are prepared by dissolving compounds containing them in a suitable solvent or solvent system and forming microspheres from the resulting solution. The microspheres are administered to an individual as protection from conditions where delivery of nucleic acids is useful, such as in treatment of autoimmune disease.	02-10-2011

Larry K. Brown, Bellingham, MA US

Patent application number	Description	Published
20120215326	Distributed Proportional/Integral/Derivative Tuning - A system and method for implementing a Proportional/Integral/Derivative (PID) tuning cycle in a distributed control system comprising a PID block on a field device collecting loop characteristics of a control loop. The PID block may communicate the collected loop characteristics from the field device to a host computer in the distributed control system. The host computer may calculate a new tuning constant based on the received loop characteristics and communicate the new tuning constant to the PID block on the field device. The PID block on the field device may receive the new tuning constant for the PID block from the host computer. The PID block on the field device may be tuned with the new tuning constant.	08-23-2012
20130054543	Inverted Order Encoding in Lossless Compresssion - A method of compressing an electronic file is provided. The method comprises reading a first electronic file in reverse order sequence from bottom to top, while reading the first file, identifying patterns in a content of the first file and while reading the first file, building a dictionary comprising a plurality of entries, each entry defining an association of a code to one of the patterns identified in the content of the first file. The method further comprises, while reading the first file, building a second electronic file that is a compressed version of the first file, wherein the second electronic file comprises a compressed content portion and a dictionary portion, wherein the compressed content portion comprises codes from the dictionary and wherein the dictionary portion comprises the dictionary.	02-28-2013

Larry R. Brown, Newton, MA US

Patent application number	Description	Published
20080214619	Business method to treat and/or prevent a gastric acid disorder with a proton pump inhibitor (PPI) and a cholinergic agonist to induce rapid onset of PPI action with or without food - Pharmaceutical proton pump inhibitor (PPI) medications and methods are disclosed for preventing and/or treating gastrointestinal disorders characterized by abnormalities in gastric acid secretion at anytime of the day or night without the need for food effect or to be taken with food. The medications comprise a PPI and a cholinergic agonist for inducing rapid onset of PPI action, for increasing the duration of PPI efficacy and for optimizing clinical PPI effectiveness that may be administered at any time of the day or night without food or on an empty stomach, and possibly on an as-needed or on demand basis. In carrying out the methods, a PPI and cholinergic agonist may be administered together as a single unitary dose in the form of a liquid or solid, or administered together, but separately as either liquids or solids or a combination thereof. Preferably, an oral solid dosage form of the present invention allows for release of a proton pump inhibitor at a pH of about 5 or higher, e.g., pH about 5.5, 6, 6.5 or 7, followed by release of a cholinergic agonist within between about 10 minutes and about 60 minutes, preferably within about 15 minutes and about 30 minutes, after release of the proton pump inhibitor from the dosage form, so that it can be administered at any time of the day or night independent of food or food effect. It is believed that the methods and compositions of the present invention will increase the duration of PPI efficacy by between at least about 5 fold and about 10 fold or even about 20 fold, as compared to the duration of PPI efficacy derived from current PPI dosage forms administered alone and without food or a food effect. Kits comprising a PPI, a cholinergic agonist and optionally an antacid are disclosed, such as kits containing each drug in conventional and commercially available dry or liquid dosage forms for simultaneous or concomitant administration or in dry dosage forms to provide for the easy preparation of a liquid composition from the dry dosage forms. These new medications and methods will simplify the traditional continuous PPI regimen and improve patient compliance.	09-04-2008
20090017124	Nucleic Acid Microparticles for Pulmonary Delivery - The present disclosure is related to microparticle compositions, in which the microparticles are made of nucleic acids and non-polymeric cations, which are suitable for administration to moist or aqueous target locations (e.g., the lung tissue), where the substantially spherical nucleic acid microparticles release the nucleic acids through dissolution, allowing the released nucleic acids to freely interact with the target cells.	01-15-2009
20090291145	MICROSPHERE-BASED COMPOSITION FOR PREVENTING AND/OR REVERSING NEW-ONSET AUTOIMMUNE DIABETES - A method is provided that includes using an antisense approach to reverse and/or delay an autoimmune diabetes condition in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.	11-26-2009
20100047903	METHODS OF PROCESSING COMPOSITIONS CONTAINING MICROPARTICLES - Methods for processing microparticles involve providing a composition comprising a plurality of solid microparticles and at least one non-volatile material, providing a non-solvent, and exposing the composition to the non-solvent to remove at least a portion of the non-volatile material from the composition while retaining at least the microparticles.	02-25-2010
20100048483	POLYMERIC BENZYL CARBONATE-DERIVATIVES - The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.	02-25-2010
20100260855	DELIVERY OF AS-OLIGONUCLEOTIDE MICROSPHERES TO INDUCE DENDRITIC CELL TOLERANCE FOR THE TREATMENT OF AUTOIMMUNE TYPE 1 DIABETES - AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.	10-14-2010
20110274758	MICROSPHERE-BASED COMPOSITION FOR PREVENTING AND/OR REVERSING NEW-ONSET AUTOIMMUNE DIABETES - AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to reverse an autoimmune diabetes condition in NOD mice in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.	11-10-2011

Laura Brown, East Sandwich, MA US

Patent application number	Description	Published
20090087855	MARKERS OF ALTERATIONS IN THE Y CHROMOSOME AND USES THEREFOR - Novel sequence tagged sites (STSs), probes and primers useful, e.g., for detecting the presence or absence of an STS in a sample, and methods of using these STSs, probes and primers, e.g., in methods of detecting alterations in the Y chromosome are disclosed. These compositions are also useful in methods of diagnosing or aiding in the diagnosis and/or cause of reduced sperm count and in methods of predicting or aiding in the prediction of the likelihood of success of infertility treatments.	04-02-2009

Liesbeth Brown, West Newton, MA US

Patent application number	Description	Published
20110137418	Aspirating Implants and Method of Bony Regeneration - Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.	06-09-2011

M. E. L. Brown, West Newton, MA US

Patent application number	Description	Published
20090162386	CHONDROCYTE THERAPEUTIC DELIVERY SYSTEM - Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.	06-25-2009
20110171186	CHONDROCYTE THERAPEUTIC DELIVERY SYSTEM - Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.	07-14-2011

M. E. Liesbeth Brown, West Newton, MA US

Patent application number	Description	Published
20080299173	CHONDROCYTE CONTAINER AND METHOD OF USE - Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).	12-04-2008
20120302958	CHONDROCYTE CONTAINER AND METHOD OF USE - Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).	11-29-2012

Michael C. Brown, Raynham, MA US

Patent application number	Description	Published
20130079864	DISTAL DETACHMENT MECHANISMS FOR VASCULAR DEVICES - A system for delivering an expandable implant into the vasculature of a patient, including an elongated core element having a proximal end accessible exterior to the patient and a distal end including at least one feature for engaging a proximal portion of the implant in a collapsed state. The system further includes an expansion limiter having an inner diameter and a length sufficient to cover the proximal portion of the implant and to retain the proximal portion in the collapsed state, and at least one elongated member having a distal end connected to the expansion limiter and a proximal end accessible exterior to the patient to enable proximal movement of the expansion limiter to release the implant.	03-28-2013

Michael F. Brown, Arlington, MA US

Patent application number	Description	Published
20120210043	Systems and Methods for Managing Data Input/Output Operations - Systems and methods for managing data input/output operations are described. In one aspect, a device driver identifies a data read operation generated by a virtual machine in a virtual environment. The device driver is located in the virtual machine and the data read operation identifies a physical cache address associated with the data requested in the data read operation. A determination is made regarding whether data associated with the data read operation is available in a cache associated with the virtual machine.	08-16-2012
20120304171	Managing Data Input/Output Operations - Systems and methods for managing data input/output operations are described that include virtual machines operating with a shared storage within a host. In such a system, a computer-implemented method is provided for dynamically provisioning cache storage while operating system applications continue to operate, including stalling the virtual machine's local cache storage operations, changing the provision of cache storage size; and resuming the operations of the virtual machine.	11-29-2012

Michael G. Brown, Tyngsboro, MA US

Patent application number	Description	Published
20090236506	LIGHT-EMITTING DEVICE ON-WAFER TEST SYSTEMS AND METHODS - On-wafer test systems and methods for light-emitting devices, such as light-emitting diodes (LEDs), are provided. The test system may be designed, for example, to characterize the light output from the LED die (e.g., power in Lumens).	09-24-2009

Michael Gregory Brown, Tyngsboro, MA US

Patent application number	Description	Published
20080290819	LIGHT-EMITTING DEVICE DRIVER CIRCUITS AND RELATED APPLICATIONS - Driver circuits for light-emitting devices (e.g., light-emitting diodes), as well as systems and methods associated therewith are provided.	11-27-2008
20090137072	LIGHT EMITTING DEVICE METHODS - Light-emitting device methods are disclosed.	05-28-2009
20110240961	LIGHT-EMITTING DEVICES FOR LIQUID CRYSTAL DISPLAYS - Light emitting devices, and related components, processes, systems and methods are disclosed.	10-06-2011
20120195068	LIGHT-EMITTING DEVICES FOR LIQUID CRYSTAL DISPLAYS - A lighting system includes a panel having an edge, the edge having a thickness defined between a front surface of the panel and a back surface of the panel, the panel configured to propagate light therein. The lighting system further includes a first light emitting diode (LED) light source and a second LED light source disposed in serrated arrangement along the edge of the panel so that light emitted from respective light emitting surfaces of the light sources impinges on the edge of the panel and enters the panel through the edge and so that the light emitting surfaces lie in respective planes that are not parallel.	08-02-2012
20120261711	ELECTRONIC DEVICE CONTACT STRUCTURES - Electronic devices involving contact structures, and related components, systems and methods associated therewith are described. The contact structures are particularly suitable for use in a variety of light-emitting devices, including LEDs.	10-18-2012

Nancy E. Brown, New Braintree, MA US

Patent application number	Description	Published
20110014467	EXTRUSION COATED NON-TWISTED YARN - The present invention provides a non-twisted yarn and an extrusion coated reinforcement yarn and their methods of manufacture, by coating non-twisted glass filaments with a sizing composition and combining the filaments together side-by-side to provide a sized non-twisted yarn, wherein the sizing composition becomes ductile in a molten thermoplastic resin to free the non-twisted glass filaments for radially inward movement while in the molten thermoplastic resin to provide the non-twisted yarn with an essentially round cross-section suitable for extrusion coating with the molten thermoplastic resin.	01-20-2011

Nancy E. Brown, Braintree, MA US

Patent application number	Description	Published
20120064295	LOW CALIPER GLASS MAT AND BINDER SYSTEM FOR SAME - Cured non-woven fibrous mats, UF-based resinous binders, asphalt coated roofing material and processes for making cured non-woven fibrous mats are provided. A cured non-woven fibrous mat comprising randomly disposed fibers bound together with a resinous adhesive is provided. The mat has a caliper of less than 30 mil, an LOI of less than 18 wt. %, a hot tensile strength of at least about 60 lbs for a sample width of 2.5 inches, and an areal weight of equal to or less than about 1.8 lbs/100 ft	03-15-2012
20120168068	CONTOURABLE CORE FABRIC AND METHOD OF MAKING SAME - A method includes providing an open weave fiber glass scrim, and printing a discontinuous pattern of an ethylene vinyl acetate (EVA) hot melt adhesive on a major surface of the open weave fiber glass scrim, the adhesive having sufficient viscosity at an application temperature used during the printing step to avoid wicking through the scrim.	07-05-2012

Nathan Brown, Cambridge, MA US

Patent application number	Description	Published
20100034849	Recombinant Bicistronic Flavivirus Vectors - This invention relates to bicistronic flavivirus vectors, methods of using such vectors in the prevention and treatment of disease, and methods of making such vectors.	02-11-2010

Paul R. Brown, Andover, MA US

Patent application number	Description	Published
20100172894	METHODS FOR PURIFICATION OF SINGLE DOMAIN ANTIGEN BINDING MOLECULES - Processes and methods of purifying or separating Single Domain Antigen Binding (SDAB) molecules that include one or more single binding domains (e.g., one or more nanobody molecules), substantially devoid of a complementary antibody domain and an immunoglobulin constant region, using Protein A-based affinity chromatography, are disclosed.	07-08-2010

Peter G. Brown, Newton, MA US

Patent application number	Description	Published
20090265025	System and Method for Simulation, Modeling and Scheduling of Equipment Preparation in Batch Process Manufacturing Facilities - A method and system for simulating, modeling and scheduling equipment preparation procedures in the biopharmaceutical production process is described herein. The use of process vessels in batch process manufacturing is optimized through the use of peak load scheduling frames. The system and method includes the steps of identifying soiled process components and their associated equipment preparation procedures. After the soiled process components are identified, a master list of soiled process components and their associated equipment preparation procedures is generated. After the soiled process components and the equipment preparation procedures are identified, the equipment preparation procedures are scheduled out based on preparation equipment protocols to generate a equipment preparation load summary table. Next, the size and capacity of the preparation equipment is determined based on the information in the load summary table. After the size and capacity of the preparation equipment is determined, an equipment preparation time line is generated.	10-22-2009

Peter G. Brown, Brighton, MA US

Patent application number	Description	Published
20090271018	METHOD AND SYSTEM FOR MODELING A BATCH MANUFACTURING FACILITY - A system and method for the modeling of biopharmaceutical batch process manufacturing facilities uses process time lines. The system employs an eleven-field delimited string code which specifies the unit identifier code and the iteration value for each of the ten levels of nested scheduling cycles of the biopharmaceutical drug production process being modeled. The method includes generating a process time line using operational parameters, a block flow diagram, and a set of scheduling cycles for each of a sequence of unit operations. The process time line is used as a tool for batch processing and facility design.	10-29-2009

Richard Brown, East Falmouth, MA US

Patent application number	Description	Published
20120045367	SYSTEM FOR CREATION OF FORMULATIONS AND GENERATION OF DENATURATION GRAPHS - A system for automatically creating a denaturation curve is disclosed. In accordance with certain embodiments, a movement system including a unit having a plurality of cannulas is used. The cannulas are in fluid communication with a fluid system, which allows the cannulas to draw in and dispense fluid. A measurement system is included which draws fluid from a well into a detector to determine a characteristic of the fluid. A controller is used to control these systems and also to create a denaturation graph from the measured characteristics. In another embodiment, a plurality of formulations may be created using the system.	02-23-2012
20120045841	SYSTEM AND METHOD FOR GENERATION OF AUTOMATED DENATURATION GRAPHS - A system and method for creating a plurality of denaturation curves is disclosed. In accordance with certain embodiments, one variable, such as salt content, pH or another parameter, is varied to create a plurality of different buffer solutions. Each is then used to create a denaturation graph. The plurality of denaturation graphs allows analysis of the effect of that variable on protein stability.	02-23-2012
20120045846	SYSTEM AND METHOD FOR pH FORMULATIONS - A system and method for creating a buffer solution having a desired pH value is disclosed. The method uses two known buffer solutions, each with predetermined pH values, and determines a mathematical relationship which defines the amount of each known buffer solution needed to create the buffer solution with the desired pH. This method can then be used to create one or more denaturation graphs, which demonstrate the stability of a protein at a given pH level.	02-23-2012
20120045849	SYSTEM AND METHOD TO MEASURE DISSOCIATION CONSTANTS - A system and method for determining the dissociation constant for a particular ligand is disclosed. In accordance with certain embodiments, the method creates a chemical denaturation curve of a protein in the absence of the ligand. A particular point is selected from this curve, such as the point at which 90% of the protein is unfolded. The molarity of chemical denaturant is determined for this selected point. A one point test is then performed for the protein with a predetermined concentration of the particular ligand. The fraction of protein which is unfolded at this point is then used to determine the dissociation constant for the ligand. This constant is used to quickly determine whether a particular ligard is well suited to be considered a potential drug candidate against that protein target.	02-23-2012

Richard W. Brown, Cambridge, MA US

Patent application number	Description	Published
20090276275	DEMAND BREAKOUT FOR A SUPPLY CHAIN - A system for demand breakout for a supply chain includes a memory operable to store a plurality of orders for at least one product. Each product may be produced using at least one precursor. The memory is also operable to store a production schedule identifying one or more resources in the supply chain, a quantity of each product and precursor scheduled to be produced by the resources, and a time period associated with production of each product and precursor. The system also includes one or more processors collectively operable to identify one or more particular units of the product that correspond to each product order. The one or more processors are also collectively operable to identify one or more particular units of one or more precursors that correspond to each product order.	11-05-2009

Rob Brown, Lexington, MA US

Robert W. Brown, Palmer, MA US

Patent application number	Description	Published
20120137634	System And Method For Manufacturing A Candle With Wax Beads And Solid Wax Topping - The candle uses wax beads produced using existing equipment. The wax beads are transported to a bead hopper and the bead hopper deposits a volume of wax beads into jars prepared with a wick. Concurrently the jars are vibrated using a continuous vibratory motor to settle the wax beads for increased wax bead density. The filled jars are then transported to an in-container wax bead compression system where an automated plunging device compresses the wax beads. Jars are then transported by in-line conveyor to a wide conveyor. The jars are then filled at a liquid wax depositing station where the wax has been heated to its melting point and deposited into the jar to fill the void left by the in-container wax bead Compression system. The filled candle is then cooled to solidification. The finished candle is then ready for packing, distribution, sale, and use.	06-07-2012

R. Quinn Brown, East Longmeadow, MA US

Patent application number	Description	Published
20100185289	INTERBODY FUSION DEVICE AND METHOD OF OPERATION - An interbody fusion device is provided that includes an interbody cage, a fixation system and an actuation mechanism to deploy one or more blades. The cage acts as an intervertebral spacer and provides resistance to the compressive loads in the spinal column. The fixation system includes an anchor and a ramp. These components could be manufactured from various medical grade materials.	07-22-2010

Ryan Brown, Belmont, MA US

Patent application number	Description	Published
20100222338	BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I	09-02-2010
20110118250	BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I	05-19-2011

Stephanie Brown, Peabody, MA US

Patent application number	Description	Published
20110271474	Toothbrush Head - A toothbrush head having a top surface and a bottom surface opposite the top surface is described herein. The head has a first portion, a second portion, and an opening between the first portion and the second portion. The opening extends from the top surface to the bottom surface. A first plurality of contact elements are positioned on the first portion and the second portion. A second plurality of contact elements are positioned on the first portion and the second portion. Each of the second plurality of contact elements has an elastomer.	11-10-2011

Stephen H. Brown, Spencer, MA US

Patent application number	Description	Published
20120315209	METHODS AND SYSTEMS FOR TREATING WATER STREAMS - Methods and systems for treating wastewater and process water streams are provided. In some embodiments, the wastewater and/or process water to be treated contains a target chemical (e.g., ammonia and/or ammonium). The methods and systems described herein may include recovering the target chemical from the water stream and/or producing a desired product (e.g., a fertilizer such as an ammonium salt) from the target chemical. In one set of embodiments, a method of treating wastewater and/or process water involves introducing the water stream into a system that includes a combination of two or more of, or all of, a reverse osmosis system, a reaction and separation system (e.g., a vacuum distillation system or other suitable separation system), and a membrane reactor system.	12-13-2012

Stephenie Brown, Peabody, MA US

Patent application number	Description	Published
20110061189	ORAL CARE PRODUCTS AND METHODS OF USING AND MAKING THE SAME - An oral care implement may include a base portion sized for insertion into an oral cavity and a plurality of flexible, elastomeric elements extending from the base portion, wherein each of the plurality of flexible, elastomeric elements comprises an edge, wherein at least one of the edges comprises a micro edge, and wherein the plurality of flexible, elastomeric elements comprises an element density of less than about 5 mm. Another embodiment of an oral care implement may include a base portion sized for insertion into an oral cavity and a plurality of flexible, elastomeric elements extending from the base portion, wherein at least one of the plurality of flexible, elastomeric elements comprises a first section having a first section edge and a first transverse cross sectional area, and a second section disposed adjacent to the first section along a longitudinal axis of the at least one of the plurality of flexible, elastomeric elements, the second section having a second section edge and a second transverse cross sectional area different from the first transverse cross sectional area. Yet another embodiment of an oral care implement includes a base portion sized for insertion into an oral cavity, the base portion having a base wall and two opposed, side walls connected to the base wall that form a channel for receiving teeth within an oral cavity and a plurality of flexible, elastomeric elements extending into the channel from the base and two opposed, side walls.	03-17-2011

Stephen John Brown, Clinton, MA US

Patent application number	Description	Published
20100229426	Pair of athletic shoes with asymmetric support between the uppers of the pair - A pair of shoes is provided that includes a left and a right shoe. The left shoe includes an upper having a left forefoot portion, the left forefoot portion having a lateral side with a portion thereof made of a first material and a medial side with a portion thereof made of a second material. The right shoe includes an upper having a right forefoot, the right forefoot having a medial side with a portion thereof made of the first material and a lateral side with a portion thereof made of the second material, wherein one of the first material and the second material provides more support than the other. The more supportive first material can include a polyurethane, such as TPU, a non-stretch synthetic material, or ceraprene. The second, less supportable material can be a light weight breathable mesh.	09-16-2010

Steven N. Brown, Hopkinton, MA US

Patent application number	Description	Published
20090121444	VEHICLE SUSPENSION - There is provided a vehicle suspension. More specifically, in one or more embodiments, there is provided an apparatus including an actuator system having a combination of actuators including a linear electromagnetic actuator and a rotary electromagnetic actuator, wherein the actuator system provides force between the sprung mass and an unsprung mass of a vehicle.	05-14-2009
20100059944	Counter-Rotating Motors with Linear Output - An actuator includes a first rotary motor, a second rotary motor, and a transmission coupled to the first and second rotary motors. The transmission converts rotation of the first rotary motor in a first direction and simultaneous rotation of the second rotary motor in a second direction to linear motion of an output shaft in a single direction. The actuator is usable in an active automobile suspension.	03-11-2010
20110193300	Counter-Rotating Motors with Linear Output - An actuator includes a first rotary motor, a second rotary motor, and a transmission coupled to the first and second rotary motors. The transmission converts rotation of the first rotary motor in a first direction and simultaneous rotation of the second rotary motor in a second direction to linear motion of an output shaft in a single direction. The actuator is usable in an active automobile suspension.	08-11-2011
20120181757	Counter-Rotating Motors with Linear Output - An active suspension for a vehicle includes an actuator which incorporates a first rotary motor, a second rotary motor, and a transmission coupled to the first and second rotary motors to convert rotary motion to linear motion. A compensation force is determined to compensate for the rotary inertia of the system. A force feedback loop can be employed to reduce the error between the output force of the actuator and a force command supplied by an active suspension system controller.	07-19-2012

Stuart B. Brown, Needham, MA US

Patent application number	Description	Published
20090152990	APPARATUS FOR IN VIVO ENERGY HARVESTING - An energy harvesting mechanism creates electrical energy from in vivo physiological motion, transforming low frequency, physiological excitation into high frequencies for producing electricity and harvesting energy using an energy collector is deformed from variation of physiologic forces or motion with an input displacement, then captured, and then released to allow the energy collector to move with an output displacement being either faster or has a higher frequency, or both, when compared to the input displacement.	06-18-2009

Todd Brown, Arlington, MA US

Patent application number	Description	Published
20130031870	INTERCHANGEABLE CUTTING ELEMENTS FOR SEALING MACHINE - A sealing machine adapted to support a plurality of different heating/sealing/cutting mechanisms, including tubular heaters and heated cutting blades, is disclosed. The sealing machine utilizes a common interface and mounting system for all side sealers. In addition, in some embodiments, the control system within the sealing machine is adapted to monitor and control the temperature of these various mechanisms automatically so as to create proper seals.	02-07-2013
20130032295	HINGED TUBULAR HEATER FOR SIDE SEALING MACHINE - A tubular heating element which is resistant to damage caused by foreign material is disclosed. The tubular heating element is pivotably attached to the side sealing machine at its leading (upstream) edge. The trailing (downstream) edge of the tubular heating element is moved by means of a compressible force, such as an air cylinder. In this way, the air in the cylinder pushes the tubular heating element downward into the plane of the film. However, a foreign object located on the film can overcome the force of the air cylinder, thereby lifting the tubular heating element out of the path of the film.	02-07-2013

Todd Brown, Boston, MA US

Patent application number	Description	Published
20110251977	Ad Hoc Document Parsing - A system for analyzing investment related documents permits users to upload documents to software hosted on a server. The software identifies the mention of entities and user-defined themes, and calculates the sentiment of the mentions for reporting to the user. The software further analyzes particular documents such as by rating analyst reports.	10-13-2011

Todd Charter Brown, Marlborough, MA US

Patent application number	Description	Published
20110150259	PORTABLE AUDIO SYSTEM HAVING WAVEGUIDE STRUCTURE - An apparatus includes a housing. A waveguide is located within the housing. The waveguide includes a first subsection that bends around a first axis and has a first cross-sectional area with an aspect ratio that is substantially different from unity. A second subsection bends around a second axis that is non-parallel to the first axis and includes a second cross-sectional area with an aspect ratio that is substantially different from unity. A third subsection acoustically couples the first subsection to the second subsection. The third subsection includes a third cross-sectional area with an aspect ratio that varies between the first aspect ratio and the second aspect ratio.	06-23-2011

W. Colby Brown, Brookline, MA US

Patent application number	Description	Published
20100222320	TRIAZOLE DERIVATIVES FOR TREATING ALZHEIMER'S DISEASE AND RELATED CONDITIONS - Compounds of formula I: Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain, in particular Alzheimer's disease.	09-02-2010