Patent application number | Description | Published |
20090128978 | Hybrid surge protector for a network interface device - A hybrid surge protector for a network interface device (NID) is disclosed. The hybrid surge protector includes a fail-safe spring connected to the ground electrode of a three-electrode gas tube. Tabs on the fail-safe spring are held away from the gas-tube end electrodes by a fusible element. The hybrid surge protector also includes metal-oxide varistor elements (“MOVs”) in contact with the gas-tube end electrodes and with the ground electrode via an MOV spring. This arrangement provides for two initial paths to ground-one path from the gas-tube end electrodes to the ground electrode through the gas tube, and another from the gas-tube end electrodes to the ground electrode through the MOVs and the MOV spring. The dominant path to ground starts as the MOV ground path but switches to the gas-tube path as the gas tube becomes activated. Another path to ground via the fail-safe spring is also available should the gas tube overheat. A surge protection module that includes the hybrid surge protector is also disclosed. | 05-21-2009 |
20110268452 | DIGITAL DATA SERVICES AND/OR POWER DISTRIBUTION IN OPTICAL FIBER-BASED DISTRIBUTED COMMUNICATIONS SYSTEMS PROVIDING DIGITAL DATA AND RADIO FREQUENCY (RF) COMMUNICATIONS SERVICES, AND RELATED COMPONENTS AND METHODS - Embodiments include distribution in optical fiber-based distributed communications systems configured to provide digital data services and radio frequency (RF) communications services, and related components and methods. Embodiments disclosed include units that can be provided in optical fiber-based distributed communications systems that are configured to support RF communication services and digital data services. The units may also be configured to support providing distribution of power. | 11-03-2011 |
20130004136 | FIBER OPTIC EQUIPMENT ASSEMBLIES EMPLOYING NON-U-WIDTH-SIZED HOUSINGS AND RELATED METHODS - Fiber optic equipment assemblies employing non-U-width-sized housings supporting U-sized fiber optic modules, and related methods are disclosed. In one embodiment, the assembly may include the non-U-width-sized housing, at least one fiber optic equipment support member, and at least one U-sized fiber optic module. The non-U-width-sized housing may include an enclosure forming an internal cavity. The at least one fiber optic equipment support member may be disposed within the internal cavity and configured to support at least one U-sized fiber optic module. The at least one U-sized fiber optic module may be disposed within the at least one fiber optic equipment support member which may be disposed within the internal cavity. The at least one U-sized fiber optic module may have a height dimension wherein at least three of the at least one U-sized fiber optic module may be disposed within a U-unit height of unity. | 01-03-2013 |
20130249292 | POWER DISTRIBUTION MODULE(S) CAPABLE OF HOT CONNECTION AND/OR DISCONNECTION FOR DISTRIBUTED ANTENNA SYSTEMS, AND RELATED POWER UNITS, COMPONENTS, AND METHODS - Power distribution modules capable of “hot” connection and/or disconnection in distributed antenna systems (DAS), and related components, power units, and methods are disclosed. The power distribution modules are configured to distribute power to a power-consuming DAS component(s), such as a remote antenna unit(s) (RAU(s)). By “hot” connection and/or disconnection, it is meant that the power distribution modules can be connected and/or disconnected from a power unit and/or a power-consuming DAS component(s) while power is being provided to the power distribution modules. Power is not required to be disabled in the power unit before connection and/or disconnection of power distribution modules. As a non-limiting example, the power distribution modules may be configured to protect against or reduce electrical arcing or electrical contact erosion that may otherwise result from “hot” connection and/or connection of the power distribution modules. | 09-26-2013 |
20140003782 | FIBER-OPTIC-MODULE TRAYS AND DRAWERS FOR FIBER-OPTIC EQUIPMENT | 01-02-2014 |
20140087742 | POWER DISTRIBUTION MODULE(S) FOR DISTRIBUTED ANTENNA SYSTEMS, AND RELATED POWER UNITS, COMPONENTS, SYSTEMS, AND METHODS - A power distribution module can be installed in and connected to a power unit for providing power to a power-consuming DAS component(s), such as a remote unit(s) (RU(s)) as a non-limiting example. The RU may include an antenna, and may sometimes be referred to as a remote antenna unit or RAU. Power from the power distribution module is distributed to any power-consuming DAS components connected to the power distribution modules including but not limited to remote units. The power distribution modules distribute power to the power-consuming DAS components to provide power for power-consuming components in the power-consuming DAS components. In a first configuration, the power distribution module uses two power links to provide power to a single RU. In a second configuration, the power distribution module uses two power links to provide power to two RUs. | 03-27-2014 |
20150063773 | OPTICAL FIBER CABLE MANAGEMENT APPARATUSES WITH STORAGE HUB COMPONENTS - A storage hub component for hanging optical fiber cable that includes a mounting base configured to be mounted within a cable storage housing. A hanging projection extends outwardly from the mounting base. The hanging projection is sized to receive loops of optical fiber cable thereon. A cable retaining feature includes a flexible retaining tab extending outwardly from a peripheral surface of the hanging projection. The flexible retaining tab is configured to bend upon contact with the optical fiber cable. | 03-05-2015 |
20160036536 | POWER DISTRIBUTION MODULE(S) FOR DISTRIBUTED ANTENNA SYSTEMS, AND RELATED POWER UNITS, COMPONENTS, SYSTEMS, AND METHODS - A power distribution module can be installed in and connected to a power unit for providing power to a power-consuming DAS component(s), such as a remote unit(s) (RU(s)) as a non-limiting example. The RU may include an antenna, and may sometimes be referred to as a remote antenna unit or RAU. Power from the power distribution module is distributed to any power-consuming DAS components connected to the power distribution modules including but not limited to remote units. The power distribution modules distribute power to the power-consuming DAS components to provide power for power-consuming components in the power-consuming DAS components. In a first configuration, the power distribution module uses two power links to provide power to a single RU. In a second configuration, the power distribution module uses two power links to provide power to two RUs. | 02-04-2016 |
Patent application number | Description | Published |
20110173169 | Methods To Perform Disk Writes In A Distributed Shared Disk System Needing Consistency Across Failures - Techniques are provided for managing caches in a system with multiple caches that may contain different copies of the same data item. Specifically, techniques are provided for coordinating the write-to-disk operations performed on such data items to ensure that older versions of the data item are not written over newer versions, and to reduce the amount of processing required to recover after a failure. Various approaches are provided in which a master is used to coordinate with the multiple caches to cause a data item to be written to persistent storage. Techniques are also provided for managing checkpoints associated with the caches, where the checkpoints are used to determine the position at which to begin processing recovery logs in the event of a failure. | 07-14-2011 |
20110179169 | Special Values In Oracle Clusterware Resource Profiles - A method and computer-readable storage representing resources in a cluster by a plurality of attribute-value pairs that together are part of a “resource profile,” in which each attribute-value pair defines all, or a portion of, a management policy that applies to the resource. A clusterware manager configures a resource according to the resource profile, and follows a resource profile syntax that specifies a runtime value for the resource in which an actual value is substituted at runtime. | 07-21-2011 |
20110295822 | Methods to Perform Disk Writes in a Distributed Shared Disk System Needing Consistency Across Failures - Techniques are provided for managing caches in a system with multiple caches that may contain different copies of the same data item. Specifically, techniques are provided for coordinating the write-to-disk operations performed on such data items to ensure that older versions of the data item are not written over newer versions, and to reduce the amount of processing required to recover after a failure. Various approaches are provided in which a master is used to coordinate with the multiple caches to cause a data item to be written to persistent storage. Techniques are also provided for transferring data items and locks associated with the data items from one node to another. | 12-01-2011 |
20130007181 | METHOD AND SYSTEM FOR OFFLOADING COMPUTATION FLEXIBLY TO A COMMUNICATION ADAPTER - A method for offloading computation flexibly to a communication adapter includes receiving a message that includes a procedure image identifier associated with a procedure image of a host application, determining a procedure image and a communication adapter processor using the procedure image identifier, and forwarding the first message to the communication adapter processor configured to execute the procedure image. The method further includes executing, on the communication adapter processor independent of a host processor, the procedure image in communication adapter memory by acquiring a host memory latch for a memory block in host memory, reading the memory block in the host memory after acquiring the host memory latch, manipulating, by executing the procedure image, the memory block in the communication adapter memory to obtain a modified memory block, committing the modified memory block to the host memory, and releasing the host memory latch. | 01-03-2013 |
20130185270 | LOCK ACCELERATION - A method for locking resources, including: receiving, by an accelerator, a first request from a first client to lock a first resource; evaluating, by a computer processor of a server, a hash function using an identifier of the first resource as an input to the hash function; identifying, by the computer processor and based on evaluating the hash function, a first hash bucket in a shared memory residing in a physical memory of the server; detecting that the first hash bucket is occupied; and sending the first request to a master lock monitor residing in a user space of the server based at least on detecting that the first hash bucket is occupied. | 07-18-2013 |
20130219036 | ASSIGNING SERVER CATEGORIES TO SERVER NODES IN A HETEROGENEOUS CLUSTER - A cluster management system dynamically assigns a category to a server node based on the server node's attributes. The system can detect a change in value of a server attribute of a first server node. Then, in response to detecting the change in value of the server attribute, the system identifies a plurality of server attributes for the first server node, and dynamically assigns to the first server node a category that matches the server attributes. Further, the system can add the server node to a server pool that has a matching category with the server node. | 08-22-2013 |
Patent application number | Description | Published |
20090103967 | PEN RETENTION APPARATUS - A pen retention bracket for releasably securing a pen tether retracting reel therein is disclosed. The pen retention bracket includes four surfaces that define a rectangular cavity having four sides and a top opening and a bottom opening. A first protrusion and a second protrusion are disposed upon a first surface and extend from the first surface toward a second surface, a distance between the first protrusion and the second protrusion greater than a height of the pen tether retracting reel. The first surface is responsive to an application of force to the pen tether retracting reel to elastically deform and increase a depth between the second surface and at least one of the first protrusion and the second protrusion, thereby releasing the pen tether retracting reel via either of the top opening and the bottom opening. | 04-23-2009 |
20100096514 | BAG HOLDER - A bagging station is provided and includes a bagging station structure including a base and a supportive portion vertically supported on the base, a bag holder, configured to hold bag handles of a bag, to occupy and selectively move between a stowed position, at which the bag holder is stowed, and a plurality of presented positions, at which the bag holder is available for bag holding, and a coupling device to couple the bag holder to the supportive portion such that the bag holder is biased to remain in a currently occupied one of the stowed position or at least one of the presented positions. | 04-22-2010 |
20110312214 | TAMPER PREVENTION AND DETECTION APPARATUS FOR AN ELECTRONIC DEVICE - An apparatus for preventing and detecting tampering of an electronic device is provided. The apparatus may prevent and detect tampering occurring through an aperture in a casing of the electronic device where the aperture is configured for receiving a standoff that couples a communication cable to a communication port of the electronic device. Upon removal of the standoff, visual indicia of tampering may be provided. Additionally, a shield may block entry of the standoff into the aperture if the standoff is removed. | 12-22-2011 |
20120125072 | In situ formation of threads throughout bore of sleeve inserted into substrate hole - Threads are formed in situ throughout a bore of a sleeve inserted into a corresponding hole a substrate. A sleeve having a bore is inserted into a corresponding hole of a substrate. A mandrel is rotated through the sleeve. The mandrel has a threaded ended; the threaded end rotating throughout the bore of the sleeve forms threads throughout the bore. Prior to inserting the sleeve into the corresponding hole of the substrate, the sleeve can be placed onto the mandrel. In this case, the mandrel has an increasing diameter at the threaded end thereof, such that the sleeve rests on the mandrel towards the threaded end thereof where the bore has a smaller diameter than the mandrel. The mandrel is then rotated out of the sleeve in a direction opposite the direction in which the sleeve has been inserted into the corresponding hole of the substrate. | 05-24-2012 |
Patent application number | Description | Published |
20090172955 | STRING TRIMMER HEAD - An improved string trimmer head is described. The trimmer head comprises a housing with a spool and spring assembly enclosed within the housing. The trimmer head further comprises a lid connected to the housing and a bump knob with a base and an intermediate member. The base of the bump knob is located inside the housing. The intermediate member extends outside the housing through the lid. The lid comprises an annulus which surrounds the base. The height of the annulus is greater than a maximum compressing distance of the spool when compressed by the bump knob. A segment of the intermediate member remains outside the lid when the spool is compressed. The bump knob further comprises a finger slot with an outer edge and a recessed portion. A bottom side of the outer edge is positioned farther away from the spool than the recessed portion. | 07-09-2009 |
20090266330 | Monolithic Block and Valve Train for a Four-Stroke Engine - A cylinder crankcase for a four-stroke engine is disclosed. The cylinder crankcase includes a cylinder head, cylinder block, and crankcase which are monolithic. A half-crank crankshaft bears in a crank arm, which is included in the crankcase. The cylinder crankcase includes a belt driven valve train and crank arm that includes a pocket containing a crank gear attached to the crankshaft for driving the belt. | 10-29-2009 |
20090308369 | Laminated Counterweight for Timing Control - A stratified two-stroke engine having a laminated counterweight is disclosed. The laminated counterweight includes a traditional counterweight portion and a laminate portion. The laminate portion has an approximately circular peripheral shape and at least one notch. In operation, the notch may be used to time the opening and closing of a mixture port or a transfer port. | 12-17-2009 |
20100006076 | Breather System for a Four Stroke Engine - A breather system for an engine used to vent combustion, or blow-by, gases. The breather system has an axial breather passage disposed within a camshaft of the engine. A radial opening is in fluid communication with the axial breather passage. A valve is positioned within the radial opening in order to prevent oil from entering the axial breather passage when the engine is not in operation. | 01-14-2010 |
20100145595 | SMALL ENGINE OPERATION COMPONENTS - A low pressure, low cost electronic fuel injection system ( | 06-10-2010 |
Patent application number | Description | Published |
20090077982 | Advance instrumentation methods for pipes and conduits transporting cryogenic materials - A cryogenic material transfer system incorporates a pipe-in-pipe configuration with a nanoporous or microporous insulating layer filling the annulus between the inner and outer pipe. The insulating layer is of sufficient flexibility to absorb and expansion or contraction of the inner pipe due to the flow of cryogenic material therethrough. For longer transfer systems a bulkhead is provided between adjacent pipe joints. Intermediately of the pipe joints an additional bulkhead may be employed to provide additional sealing or water stops and for providing provide additional load transfer. A fiber optic sensor system is installed in the annuals between the inner and outer pipe. | 03-26-2009 |
20100229662 | Instrumentation and Monitoring System For Pipes and Conduits Transporting Cryogenic Materials - An instrumentation and monitoring system for a cryogenic material transfer system incorporates a pipe-in-pipe configuration with either a vacuum or a nanoporous or microporous insulating layer filling the annulus between the inner and outer pipe. The insulating layer is of sufficient flexibility to absorb the expansion or contraction of the inner pipe due to thermal effects from the flow of cryogenic material. The monitoring system typically includes a multitude of fiber optic sensors that measure leaks, temperature, pressure and strain. The invention includes the fiber optic sensors, conventional sensors, cabling, connectors/splice assembles, ingress/egress methods, ruggedization methods, data acquisition and analysis. | 09-16-2010 |
20110219866 | Apparatus to Monitor Flow Assurance Properties in Conduits - A combination of sensors are strategically placed along a pipeline to measure critical properties such as temperature and pressure of the flow product. The sensors are a combination of fiber optic sensing devices that are specifically designed to measure a range of properties within particular bandwidth, with a method to reduce light attenuation over the long pipeline distances. The pipeline is typically subsea and can range widely in diameter. In many cases the pipeline has a coating that acts as a barrier to the corrosive sea water and additional thermal barriers. | 09-15-2011 |
20130287501 | INSTRUMENTED STRAKES AND FAIRINGS FOR SUBSEA RISER AND PIPELINE MONITORING - A VIV suppression device for a subsea riser system includes either a strake or fairing element having at least one fiber optic sensor mounted on the element. The fiber optic sensor on each VIV suppression device associated with the riser includes a plurality of sensor components forming an array, and wherein each fiber optic sensor component in the array produces a sensor component signal. The multiple array signals are combined at a multiplexer associated with that specific array for generating a single VIV suppression device sensor signal. Each fiber optic sensor array produces a unique sensor signal, the subsea riser system further including a multiplexer for combining the unique sensor signals from the fiber optic sensor array for each of the VIV suppression devices, for producing a single cables combined sensor signal to be introduced into the processor. The processed output signal produced by the processor is introduced to a monitor for real time, or near real time monitoring of the processed signal. A database is also associated with the processor for storing the processed signal produced by the processor, for records and for review. Typically, the system will be in communication with a transmission system associated with the processor for transmitting the processed signal to a remote location. | 10-31-2013 |
20140290374 | Apparatus to Monitor Flow Assurance Properties in Conduits - A combination of sensors are strategically placed along a pipeline to measure critical properties such as temperature and pressure of the flow product. The sensors are a combination of fiber optic sensing devices that are specifically designed to measure a range of properties within particular bandwidth, with a method to reduce light attenuation over the long pipeline distances. The pipeline is typically subsea and can range widely in diameter. In many cases the pipeline has a coating that acts as a barrier to the corrosive sea water and additional thermal barriers. | 10-02-2014 |
20140354974 | Apparatus and Method for Monitoring the Mechanical Properties of Subsea Longitudinal Vertical Components in Offshore Drilling and Production Applications - An apparatus to monitor the loads and mechanical behavior of subsea longitudinal vertical components of off shore drilling and production platforms (SLVCs) uses sensors attached directly to the tendons by adhesive or by friction mount. The sensors are typically in a sensor ring assembly which is placed around the perimeter of the SLVC. Ruggedized cables carry the sensor reading from the ring assembly to the SLVC working platform and to a control center for monitoring the action and stresses on the tension legs. The system may be deployed on existing SLVCs or may be installed on new construction during initial assembly and installation. | 12-04-2014 |
20140354975 | Apparatus and Method for Measuring Mechanical Properties of Tendons in Tension Leg Platforms - An apparatus to monitor the loads and mechanical behavior of tendons for a tension leg platform (TLP) uses sensors attached directly to the tendons by adhesive of by friction mount. The sensors are typically in a sensor ring assembly which is placed around the perimeter of the tension leg. Ruggedized cables carry the sensor reading from the ring assembly to the TLP working platform and to a control center for monitoring the action and stresses on the tension legs. The system may be deployed on existing TLPs or may be installed on new construction before while on land. | 12-04-2014 |
Patent application number | Description | Published |
20120209448 | Thermal Management for Integrated Circuits - A method and system for thermal management in integrated circuits and integrated circuit boards is described. In an embodiment, the circuit device board includes circuit devices, temperature sensors, and a thermal management unit. The thermal management unit receives thermal data from the temperature sensors and determines thermal reference points that define thermal regions. The thermal reference points are correlated with the operating characteristics of the circuit devices. When warranted, the thermal management unit makes independent corrective responses to each of the thermal regions. These corrective responses include modifying operating parameters, adjusting workload, and suspending operation of circuit devices within the thermal region. Thus, the disclosed method and system can preserve function in one thermal region while alleviating stress on another thermal region. | 08-16-2012 |
20120209559 | Thermal Management for Integrated Circuits - A method and system for thermal management in integrated circuits and integrated circuit boards is described. In an embodiment, the circuit device board includes circuit devices, temperature sensors, and a thermal management unit. The thermal management unit receives thermal data from the temperature sensors and determines thermal reference points that define thermal regions. The thermal reference points are correlated with the operating characteristics of the circuit devices. When warranted, the thermal management unit makes independent corrective responses to each of the thermal regions. These corrective responses include modifying operating parameters, adjusting workload, and suspending operation of circuit devices within the thermal region. Thus, the disclosed method and system can preserve function in one thermal region while alleviating stress on another thermal region. | 08-16-2012 |
20140149969 | Source code separation and generation for heterogeneous central processing unit (CPU) computational devices - An example method includes obtaining annotated source code and based at least in part on a first annotation, separating the source code into first and second source code portions. The method also includes generating from the first source code portion a first source code stream to be supplied for compilation by a first compiler, the first source code stream augmented, based on the first annotation, to include additional coordination code not present in the obtained source code, and the first compiler specific to the first-type subset of the target CPUs. The method further includes generating from the second source code portion a second source code stream to be supplied for compilation by a second compiler, the second compiler specific to a second-type subset of the target CPUs. The target CPUs of the first- and second-type subsets have one or more different functionalities. | 05-29-2014 |
20150241887 | Thermal Management for Integrated Circuits - A method and system for thermal management in integrated circuits and integrated circuit boards is described. In an embodiment, the circuit device board includes circuit devices, temperature sensors, and a thermal management unit. The thermal management unit receives thermal data from the temperature sensors and determines thermal reference points that define thermal regions. The thermal reference points are correlated with the operating characteristics of the circuit devices. When warranted, the thermal management unit makes independent corrective responses to each of the thermal regions. These corrective responses include modifying operating parameters, adjusting workload, and suspending operation of circuit devices within the thermal region. Thus, the disclosed method and system can preserve function in one thermal region while alleviating stress on another thermal region. | 08-27-2015 |
20160085546 | Source Code Separation and Generation for Heterogeneous Central Processing Unit (CPU) Computational Devices - An example method includes obtaining annotated source code and based at least in part on a first annotation, separating the source code into first and second source code portions. The method also includes generating from the first source code portion a first source code stream to be supplied for compilation by a first compiler, the first source code stream augmented, based on the first annotation, to include additional coordination code not present in the obtained source code, and the first compiler specific to the first-type subset of the target CPUs. The method further includes generating from the second source code portion a second source code stream to be supplied for compilation by a second compiler, the second compiler specific to a second-type subset of the target CPUs. The target CPUs of the first- and second-type subsets have one or more different functionalities. | 03-24-2016 |
Patent application number | Description | Published |
20120238490 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC DISORDERS - Embodiments described herein are directed to methods for the treatment and control of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of conditions and sequelae that are associated with these diseases, including atherosclerosis and non-insulin dependent diabetes. In addition, embodiments are directed to methods of treating coronary heart disease and metabolic syndrome. Embodiments are also directed to neurotensin analogs. In embodiments, the neurotensin analogs may be capable of binding to neurotensin receptors and, upon binding, may modulate the levels of lipids in subjects. | 09-20-2012 |
20130296226 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC DISORDERS - Embodiments described herein are directed to methods for the treatment and control of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of conditions and sequelae that are associated with these diseases, including atherosclerosis and non-insulin dependent diabetes. In addition, embodiments are directed to methods of treating coronary heart disease and metabolic syndrome. Embodiments are also directed to neurotensin analogs. In embodiments, the neurotensin analogs may be capable of binding to neurotensin receptors and, upon binding, may modulate the levels of lipids in subjects. | 11-07-2013 |
Patent application number | Description | Published |
20100143948 | CHEMO-SENSITIVITY ASSAYS USING TUMOR CELLS EXHIBITING PERSISTENT PHENOTYPIC CHARACTERISTICS - The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring the progression of an individual patient malignancy. The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring and for identifying cellular and secreted markers, for screening cells to detect phenotypic and genotypic drift and for predicting chemotherapeutic response of patient tumor cells to at least one therapeutic agent. The assays, methods, tools and systems discussed herein also represent an improved and unified system for monitoring and for screening multiple pharmaceutical agents for efficacy and long term effect as to a specific patient. | 06-10-2010 |
20100216168 | METHODS FOR EVALUATING ANGIOGENIC POTENTIAL IN CULTURE - The present invention provides a method of evaluating the angiogenic potential of a tumor, and for predicting the efficacy of anti-angiogenic therapies on an individualized basis. The method of the invention involves preparing an angiogenic signature for malignant cells in culture by assaying for the presence or level of one or more angiogenesis-related factors selected from VEGF/VPF, IL8/CXCL8, TGF-β1, TGF-β2, TGF-β3, bFGF/FGF-2, EGF, PDGF-AA, PDGF-AA/BB, IP-10, and Flt-3 ligand. The angiogenic signature may be prepared from cultures maintained under normoxic and/or hypoxic environments. The invention may be used in conjunction with chemoresponse testing of anti-tumor agents, to predict or suggest a combination therapy for cancer patients. | 08-26-2010 |
20100311084 | METHODS FOR PREDICTING A PATIENT'S RESPONSE TO EGFR INHIBITORS - The present invention provides methods for individualizing chemotherapy for cancer treatment, and particularly for evaluating a patient's responsiveness to one or more epidermal growth factor receptor (EGFR) inhibitors prior to treatment with such agents. Particularly, the invention provides an in vitro chemoresponse assay for predicting a patient's response to a monoclonal EGFR antibody, such as cetuximab. The method generally comprises culturing malignant cells from a patient's specimen (e.g., biopsy specimen), contacting the cultured cells with a monoclonal EGFR antibody that is a candidate treatment for the patient, and evaluating the cultured cells for a response to the drug. In certain embodiments, monolayer(s) of malignant cells are cultured from explants prepared by mincing tumor tissue, and the cells of the monolayer are suspended and plated for chemosenstivity testing. The in vitro response to the drug as determined by the method of the invention is correlative with the patient's in vivo response upon receiving the monoclonal EGFR antibody during chemotherapeutic treatment (e.g., in combination with other standardized or individualized chemotherapeutic regimen). | 12-09-2010 |
20120329086 | CHEMO-SENSITIVITY ASSAYS USING TUMOR CELLS EXHIBITING PERSISTENT PHENOTYPIC CHARACTERISTICS - The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring the progression of an individual patient malignancy. The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring and for identifying cellular and secreted markers, for screening cells to detect phenotypic and genotypic drift and for predicting chemotherapeutic response of patient tumor cells to at least one therapeutic agent. The assays, methods, tools and systems discussed herein also represent an improved and unified system for monitoring and for screening multiple pharmaceutical agents for efficacy and long term effect as to a specific patient. | 12-27-2012 |
Patent application number | Description | Published |
20090286276 | METHODS FOR PREDICTING A PATIENT'S RESPONSE TO EGFR INHIBITORS - The present invention provides methods for individualizing chemotherapy for cancer treatment, and particularly for evaluating a patient's responsiveness to one or more epidermal growth factor receptor (EGFR) inhibitors prior to treatment with such agents. Particularly, the invention provides an in vitro chemoresponse assay for predicting a patient's response to an EGFR inhibitor, such as an EGFR tyrosine kinase inhibitor or a molecule targeting the extracellular domain of EGFR. The method generally comprises culturing malignant cells from a patient's specimen (e.g., biopsy specimen), contacting the cultured cells with an EGFR inhibitor that is a candidate treatment for the patient, and evaluating the cultured cells for a response to the drug. In certain embodiments, monolayer(s) of malignant cells are cultured from explants prepared by mincing tumor tissue, and the cells of the monolayer are suspended and plated for chemosenstivity testing. The in vitro response to the drug as determined by the method of the invention is correlative with the patient's in vivo response upon receiving the EGFR inhibitor during chemotherapeutic treatment (e.g., in combination with other standardized or individualized chemotherapeutic regimen). | 11-19-2009 |
20110014644 | METHODS FOR PREDICTING A CANCER PATIENT'S RESPONSE TO ANTIFOLATE CHEMOTHERAPY - The present invention provides methods for individualizing therapy for cancer treatment, and particularly for evaluating a patient's responsiveness to one or more antifolate therapeutic agents prior to treatment with such agents. Particularly, the invention provides an in vitro chemoresponse assay for predicting a patient's response to an antifolate agent, such as pemetrexed or methotrexate. | 01-20-2011 |
20110129822 | MULTI DRUG RESPONSE MARKERS FOR BREAST CANCER CELLS - The present invention provides methods for preparing a gene expression profile of a breast cancer cell, tumor, or cell line, where the gene expression profile may be evaluated for one or more gene expression signatures indicative of multidrug resistance. The signature may be indicative of resistance to one or more chemotherapeutic agents selected from a Taxol (e.g., Docetaxel or Paclitaxel), an antibiotic (e.g., Doxorubicin or Epirubicin), an antimetabolite (e.g., Fluorouracil and/or Gemcitabine), and an alkylating agent (e.g., Cyclophosphamide). Generally, the gene expression profile contains the level of expression for a plurality of genes listed in FIGS. | 06-02-2011 |
20110130302 | BIOLOGICAL PATHWAYS ASSOCIATED WITH CHEMOTHERAPY OUTCOME FOR BREAST CANCER - The present invention provides methods for preparing drug response and/or resistance profiles for breast tumor specimens, or cells derived therefrom. The drug response and/or resistance profiles are useful for determining effective chemotherapeutic agents for treatment of the tumor or cell to thereby individualize patient therapy. In other aspects, the invention provides a method for identifying a pathway or gene expression signature indicative of a breast cancer cell's sensitivity to a chemotherapeutic agent, which is useful for identifying a population response rate, or patient sub-population likely to respond to the drug candidate. | 06-02-2011 |
20110207119 | METHODS FOR PREDICTING A CANCER PATIENT'S RESPONSE TO SUNITINIB - The present invention provides methods for individualizing chemotherapy for cancer treatment, and particularly for evaluating a patient's responsiveness to sunitinib prior to treatment. The method comprises expanding malignant cells in culture from a patient's tumor specimen, contacting the cultured cells with one or more active agents including sunitinib, and evaluating or quantifying the response to the active agent(s). The result of the assay is a dose response curve, which may be evaluated using algorithms described herein, so as to quantitatively assess drug sensitivity. The in vitro response to the drug as determined by the method of the invention is correlative with the patient's in vivo response upon receiving sunitinib during chemotherapeutic treatment, in the course of standardized or individualized chemotherapeutic regimen. | 08-25-2011 |
Patent application number | Description | Published |
20110189143 | FORMULATION AND METHOD FOR TREATING PLANTS TO CONTROL OR SUPPRESS A PLANT PATHOGEN - The present invention provides formulations and methods for preventing, suppressing, treating, or controlling pre- or post-harvest disease or decay in plants. In the inventive method, plants are contacted with a formulation including an antagonistic microorganism and a booster composition. The booster composition generally includes about 3 parts Kaolin clay, about 1 part yeast, about 1 part Yucca plant extract, and about 1 part calcium-source material. The antagonistic microorganism may be included in an amount of between about 0.02 parts and about 0.5 parts by weight of the formulation, with about 0.04 parts antagonistic microorganism being preferred in testing to date. The formulation is typically applied to the above ground structures of the plant, including its leaves, flowers, stems, trunk, blossoms and fruit. | 08-04-2011 |
20140079669 | FORMULATION AND METHOD FOR TREATING PLANTS TO CONTROL OR SUPPRESS A PLANT PATHOGEN - The present invention provides formulations and methods for preventing, suppressing, treating, or controlling pre- or post-harvest disease or decay in plants. In the inventive method, plants are contacted with a formulation including an antagonistic microorganism and a booster composition. The booster composition generally includes about 3 parts Kaolin clay, about 1 part yeast, about 1 part | 03-20-2014 |