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Brough, US
Chris Brough, Austin, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090053315 | Thermo-Kinetic Mixing for Pharmaceutical Applications - Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding. | 02-26-2009 |
Chris Brough, Temple, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20100084787 | Composite Load Bearing Structure - A composite load bearing member is provided comprising an elongated inner structural member and a thick polymeric composite outer member. An apparatus for producing the composite load bearing member is provided including devices for suspending the inner structural member within a mold cavity prior to and during injection of the polymeric composite outer member. A method of using the apparatus to produce the composite load bearing member is provided. | 04-08-2010 |
Douglas E. Brough, Gaithersburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080233650 | Method for propagating adenoviral vectors encoding inhibitory gene products - The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector. | 09-25-2008 |
| 20090018100 | MATERIALS AND METHODS FOR TREATING OCULAR-RELATED DISORDERS - The present invention is directed to a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder, e.g., ocular neovascularization or age-related macular degeneration. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and the same or different nucleic acid sequence encoding a neurotrophic agent. The method also can comprise contacting an ocular cell with different expression vectors, each comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a nucleic acid sequence encoding a neurotrophic agent. In addition, the present invention provides a viral vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) or a therapeutic fragment thereof. | 01-15-2009 |
| 20090041759 | Materials and methods for treating ocular-related disorders - The invention is directed to a method of delivering a gene product to an animal. The method comprises administering an expression vector comprising a nucleic acid sequence operably linked to a promoter and encoding a gene product, and upregulating transcription of the nucleic acid sequence in the ocular cell. The expression vector can be an adenoviral vector. The invention further provides a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a neurotrophic agent. In one aspect, the method further comprises upregulating transcription of the nucleic acid sequence. Preferably, if 2×10 | 02-12-2009 |
| 20090264509 | Adenoviral vector-based foot-and-mouth disease vaccine - The invention is directed to an adenoviral vector comprising at least one nucleic acid sequence encoding an | 10-22-2009 |
| 20100222234 | Malaria antigen screening method - The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo. | 09-02-2010 |
Farrell Lynn Brough, West Jordan, UT US
| Patent application number | Description | Published |
|---|---|---|
| 20110208778 | MANAGING DIGITAL IDENTITY INFORMATION - A basic architecture for managing digital identity information in a network such as the World Wide Web is provided. A user of the architecture can organize his or her information into one or more profiles which reflect the nature of different relationships between the user and other entities, and grant or deny each entity access to a given profile. Various enhancements which may be provided through the architecture are also described, including tools for filtering email, controlling access to user web pages, locating other users and making one's own location known, browsing or mailing anonymously, filling in web forms automatically with information already provided once by hand, logging in automatically, securely logging in to multiple sites with a single password and doing so from any machine on the network, and other enhancements. | 08-25-2011 |
Hans Brough, San Carlos, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120066618 | CAROUSEL OF THE NEW - In a method of ranking or filtering new content items for presentation to members of a group of users of a social-networking service, content items that are candidates for presentation to the members are received. A user of the social-networking service is enabled to serve as a curator of the candidates, with the enabling including enabling the user to scroll through subsets of the candidates in a carousel user interface to indicate an opinion of the user with respect to an importance to the group of each of one or more candidates. One or more of the candidates are presented to the members of the group based on the opinion of the user with respect to the candidates. | 03-15-2012 |
Richard A. Brough, Wingdale, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080230154 | ABSORBER LAYER FOR DSA PROCESSING - A method of processing a substrate comprising depositing a layer comprising amorphous carbon on the substrate and then laser annealing the substrate is provided. Optionally, the layer further comprises a dopant selected from the group consisting of nitrogen, boron, phosphorus, fluorine, and combinations thereof. In one aspect, the layer comprising amorphous carbon is an anti-reflective coating and an absorber layer that absorbs electromagnetic radiation emitted by the laser and anneals a top surface layer of the substrate. | 09-25-2008 |
Thomas Charles Brough, High Point, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090221408 | RAPID FILM BONDING USING PATTERN PRINTED ADHESIVE - Various processes for the creation of a film to film bond using printed patterns of adhesive traces. In some implementations of the process, control of the process including control of the temperature of the adhesive and film to a temperature approaching the heat distortion temperature for the film will vary the strength of the bond from a frangible bond to a bond the tears the film, (a film-tearing bond). Some implementations of the process may be used to produce bonded films at web speed rates that are significantly higher than commercial rates for heat seal processes. | 09-03-2009 |