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Brooks, MA
Clinton Brooks, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100048539 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to beat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFRα and PDGFRβ kinases. Formula (I). | 02-25-2010 |
Clinton A. Brooks, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100105653 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES - The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein. | 04-29-2010 |
| 20110152244 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES - The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein. | 06-23-2011 |
David Brooks, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090134707 | Process Variation Tolerant Circuit With Voltage Interpolation And Variable Latency - A circuit having dynamically controllable power. The circuit comprises a plurality of pipelined stages, each of the pipelined stages comprising two clocking domains, a plurality of switching circuits, each switching circuit being connected to one of the pipelined stages, first and second power sources connected to each of the plurality of pipelined stages through the switching circuits, the first power source supplying a first voltage and the second power source supplying a second voltage, wherein the first and second power sources each may be applied to a pipelined stage independently of other pipelined stages, first and second complementary clocks, and a plurality of latches connected to the first and second complementary clocks and to the plurality of pipelined stages for proving latch-based clocking to control the first and second clocking domains and to enable time-borrowing across the plurality of switching circuits. The first voltage differs from the second voltage and the plurality of pipelined stages interpolates between the first and second voltages to provide differing effective voltages between the first and second voltages. | 05-28-2009 |
David Brooks, Concord, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100215573 | IGF-1R SPECIFIC ANTIBODIES USEFUL IN THE DETECTION AND DIAGNOSIS OF CELLULAR PROLIFERATIVE DISORDERS - The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGf-1R. | 08-26-2010 |
Donald J. Brooks, Andover, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100100015 | ULTRASOUND SYSTEMS AND METHODS FOR TREATNG ISCHEMIC LIMBS OR TISSUE AFFECTED BY PERIPHERAL ARTERIAL DISEASE - A method of treating tissue within a body includes aiming an ultrasound transducer towards target tissue, and delivering ultrasound energy towards the target tissue to thereby reduce pain at the target tissue. A method of treating tissue within a body includes aiming an ultrasound transducer towards target tissue, and delivering ultrasound energy towards the target tissue to increase nitric oxide at the target tissue. An ultrasound system includes a first ultrasound transducer for emitting ultrasound energy from outside a patient, and drive circuitry coupled to the first ultrasound transducer, wherein the drive circuitry is configured to generate a drive signal at a frequency that is between 20 kHz and 100 kHz for the first ultrasound transducer. | 04-22-2010 |
Jeffrey R. Brooks, Ashburnham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080219458 | Self-Adjusting and Self-Modifying Addressable Speaker - A self-adjusting speaker integrated with an alarm system is provided. The self-adjusting speaker may be used to aurally monitor an area (such as monitoring the ambient noise in the vicinity of the speaker) and adjust the speaker accordingly. The circumstances under which to aurally monitor a premises (such as how to monitor, when to monitor, what type of monitoring, etc.) may be varied. For example, there are several ways how to perform the aural monitoring (such as how to sense the ambient noise), including using a separate microphone or the speaker itself. A self-monitoring speaker integrated with an alarm system is also provided. The self-monitoring speaker may monitor the aural output of the speaker using a microphone or similar type of transducer. The aural output monitored by the microphone may be analyzed, and, based on the analysis, the data and/or operation of the speaker may be modified. | 09-11-2008 |
| 20080266076 | Emergency Lighting System With Improved Monitoring - An emergency lighting unit includes a lamp, a backup battery, controller, and a network interface. The controller connects the backup battery to the lamp upon detection of an emergency condition and loss of main power. The network interface interfaces with and receives commands from a fire alarm control panel via a fire alarm network. Each emergency lighting unit may have a unique identifier with respect to the fire alarm network. | 10-30-2008 |
Jonathan Brooks, Wrentham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090156421 | ASSAYS AND METHODS FOR EVALUATING MULTIMERIC COMPLEXES - Assays, e.g., homogenous assays, and methods for identifying, quantifying and/or monitoring the formation and/or stability of a multimeric complex, e.g., a ternary complex are disclosed. The methods and assays of the invention can be used to identify and/or evaluate agents (e.g., proteins, peptides, antibody molecules, and small and large molecules) that interfere with and/or inhibit the formation of a multimeric complex (e.g., a ternary complex) or that disrupt a previously formed complex. | 06-18-2009 |
Kevin M. Brooks, Malden, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090244256 | Method and Apparatus for Enhancing and Adding Context to a Video Call Image - A method and apparatus for enhancing a video image sent from a first terminal of a video-telephony system to a second terminal of the video-telephony system during a video telephony call. An image style is selected at the first terminal and a description of the image style is transmitted from the first terminal to the second terminal. A sequence of video images transmitted from the first terminal to the second terminal is modified by a style generator at the second terminal in accordance with description of the image style before being displayed at the second terminal. The first terminal includes a user interface that controls a style selector to produce the style description that defines the properties or the style such as a cropping region, a border style, an image filter, a background and an animation. | 10-01-2009 |
Meredith Brooks, Attleboro, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110041823 | TOY DART MAGAZINE APPARATUS - A toy dart magazine apparatus that includes a housing divided into a drum portion and a clip portion, and a wheel structure rotatably mounted to the drum portion. The wheel has four portions, two spaced apart portions having peripheral recesses for receiving the darts and storing them until they are “fired” by a launcher to which the dart magazine apparatus is mounted. A third portion having a smooth circumference and a smaller diameter than the two recess bearing portions wherein the third portion separates the two spaced apart portions. The fourth portion of the wheel has a larger diameter than the two recess bearing portions and is positioned adjoining one of the two recess bearing portions for aligning the darts relative to the wheel. The wheel also includes an opening in the third portion leading to a chamber in a hollow support of the wheel. A spring-biased knob is mounted on a shaft that also mounts the wheel. Both the knob and the wheel have axially align protrusions that may engage each other to allow the wheel to be rotationally adjusted to correct any jam or misalignment of the darts stored on the wheel. A flexible arm and a pusher structure are also included with the magazine apparatus and are connected to a constant force spring, where the flexible arm and a portion of the constant force spring are lodged in the chamber of the hollow support during a dart loading process of the wheel, and the constant force spring uncoils when the wheel is rotated during the loading process. The constant force spring biases the wheel to feed the darts from both the drum and the clip to a firing position at the end of the clip located in the launcher, but the constant force spring is insufficient to discharge the darts when the magazine is not connected to the launcher. | 02-24-2011 |
Peter Brooks, Osterville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110304531 | METHOD AND SYSTEM FOR INTERFACING AND INTERACTION WITH LOCATION-AWARE DEVICES - A system and a method of using the system includes a motion detection subsystem for detecting a motions applied to a computing device about one or more axes. A storage subsystem stores motion command definitions. A motion processing subsystem is included for characterizing the motions, retrieving command definitions, comparing the characterized motions with the retrieved command definitions, and retrieving commands associated with matched command definitions. A command processing subsystem is included for defining new motions and storing new characterized motions as entries in the command definition, retrieving stored characterized motions and storing named characterized motions as entries in the command definitions, associating commands with stored characterized motions and storing the associated commands as entries in the command definitions, and processing retrieved commands for modification of and interaction with displayed information of the computing device and saving processing results. | 12-15-2011 |
Richard Brooks, Templeton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080236035 | Lawn Edging With Offset Channel - In general, the present invention discloses a landscape edging device for dividing distinct landscaping areas, comprising: a vertical barrier; a top portion disposed at the top of and integral to the vertical barrier; and an anchoring portion at the bottom and integral to the vertical barrier, wherein the anchoring portion in turn comprises: an offset channel formed from the vertical body and disposed on one side of the vertical body, wherein the offset channel comprises a first leg and a second leg; and an anchoring blade disposed on a second side of the vertical body and protruding from the intersection of the first leg and second leg. | 10-02-2008 |
| 20080257441 | Co-extruded plastic tubing - Two-layer tubing for housing an insert, comprising an extremely lubricious tubular inner layer and a tubular outer layer disposed radially outward of and surrounding the inner layer, wherein the co-efficient of friction of the inner layer is less than the co-efficient of friction of the outer layer. The outer layer consists essentially of a thermoplastic elastomer, preferably a polyolefin-based material, with a specific gravity averaging between about 0.91 and 0.97 g/cm | 10-23-2008 |
Wesley W. Brooks, Dedham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090093535 | Method and composition for treating heart failure - A method and composition for treating, preventing or ameliorating heart failure, cardiac hypertrophy, and/or myocardial dysfunction includes administering a therapeutically effective amount of a HDAC inhibitor, such as phenylbutyrate, in combination with an ACE inhibitor, such as captopril. | 04-09-2009 |