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Brooke

Brooke Ancrile, Durham, NC US

Patent application numberDescriptionPublished
20110003887TREATING ONCOGENIC RAS DRIVEN CANCERS - Oncogenic Ras-driven cancer is treated with agent by interrupting pathway comprising activation of Akt by oncogenic Ras, activated Akt causing phosphorylation of eNOS at S1177 site of eNOS to provide activated eNOS in cancer cells and activated eNOS causing activation of wildtype Ras by nitrosylation thereof at C118 to provide GTP-bound activated wildtype H and N Ras. L-NAME can be orally administered to interrupt this pathway. Wortmannin can be administered intravenously to interrupt this pathway. Novel siRNAs are disclosed useful to interrupt said pathway.01-06-2011

Brooke Kitzmiller, North Canton, OH US

Patent application numberDescriptionPublished
20110132788Films and Methods for Making Tampering Events Evident - Films and methods for making tampering events obvious are disclosed. In one embodiment, a tamper evident film includes a coating containing a first substance, and an observable change occurs when the first substance comes into contact with a second substance. In another embodiment, a tamper evident stretch wrap includes an inner portion, an outer portion, and a substance between the inner and outer portions that is adapted to escape from between the portions when the outer portion is breached. In another embodiment, a tamper evident stretch wrap includes a first layer of film having a first pattern and a second layer of film having a second pattern that overlap to form a predetermined third pattern. In yet another embodiment, a stretch wrap is exposed to ultraviolet light and checked for a change in a fluorescent signature to determine whether the stretch wrap has been breached.06-09-2011

Brooke Picotte, New York, NY US

Patent application numberDescriptionPublished
20120124718HEAD PROTECTOR FOR INFANTS, SMALL CHILDREN, SENIOR CITIZENS, ADULTS OR PHYSICALLY DISABLED INDIVIDUALS - The present invention is directed to a protective hat suitable for every day wear by infants, children, senior citizens or physically disabled individuals. Such hat protects at least the sides, top or rear of the wearer's head from injuries due to falls or bumps against bard objects while conducting routine, daily activities. Generally, the head protector of the present invention may comprise: (05-24-2012

Brooke Schumm, Iii, Ellicott City, MD US

Patent application numberDescriptionPublished
20090147335PERIODIC THREE DIMENSIONAL ILLUSION IN COLOR - The combination of a truly realistic three dimensional real image in color and a second device to produce a repetitive passage of a solid object through the real image creates the illusion of one solid body passing through another. A simple method of accomplishing this is to mount a clockworks with a pendulum over or under the image and allow a pendulum end to pass periodically through the real image. Other means such as a device running on a circular track could accomplish the same illusory effect. The pendulum end or the device can take various forms as can the real image. In principle the designs are not limited in size. Further, an amusement ride is contemplated by directing a track with a vehicle and a rider in the vehicle at the proper angle toward the real image creating an exciting visual moment passing through the apparently solid object.06-11-2009
20100112418MULTICAPABILITY PRINTED MICROACTUATORS (WITH SPIRAL OR FERROMAGNETIC ACTION) AND FUEL AND OXIDIZER CONTROL DEVICE GROUP - The invention proposes resealable, electrically responsive, thermally actuated valves in conjunction with a battery of cells, a case containing a battery, or a cell which valves have certain rotational characteristics that preferably operate spirally and away from an initial plane allowing entry of fluid, and then, on inactivation of a circuit, return to a resting sealed position. A further proposal is to provide the microactuation valve action with a micro ferromagnetic device either printed or otherwise deposited on a substrate to be included in the fuel cell or battery porting system. A further proposal is to increase the current supplying capability of small fuel cells and batteries by providing a metal, semiconductor or polymer barrier membrane containing metal oxides or other advantageous materials to allow increased fuel or oxygen diffusion into the fuel or oxygen depolarized cell or battery.05-06-2010
20100233193SYSTEMIC ADMINISTRATION OF NAC FOR VACCINATION PROPHYLAXIS - The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and /or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as 09-16-2010
20100233297SYSTEMIC ADMINISTRATION OF NAC AS AN ADJUNCT IN THE TREATMENT OF TERRORISM EXPOSURES SUCH AS RADIATION AND FOR PROPHYLAXIS - The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and/or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as 09-16-2010
20110042286INEXPENSIVE FOURTH WORLD PRIMITIVE WATER CLEANSER WITH KEY PARTS TRANSPORTABLE IN SUITCASE SIZE PACKAGING - This is a water cleansing system intended for very low technology primitive communities buildable for between $600 and $1,000 of parts with labor extra. A gravity feed system is contemplated with an initial filtering stage(s), a settling stage, a UV treatment stage, and an ozonator stage. Other filtering is useful and a stand-alone power system with solar power needing no infrastructure is contemplated to enhance purification. The objective is to improve water quality from the worst of conditions; and under some conditions to end up with clean water of a quality found in developed countries with mature water systems.02-24-2011
20110129523Liposomally Encapsulated Reduced Glutathione, including with Other Pharmacologic Preparation, Capable of Administration as an Oral, Topical, Intraoral or Transmucosal, Prepartion, for Reversal and Prevention of Oxidation of Cholesterol and of Low Density Lipoprotein - The invention proposes the sure of reduced glutathione in a liposome (liposomal reduced glutathione) for the oral administration of a therapeutically effective amount to ameliorate the progression of vascular disease, including atherosclerosis, diabetes, hypertension, narrowing of arteries leading to decreased blood flow, ischemic events, and the formation of blood clots, abnormal platelet aggregation, and thrombotic events, by reducing the amount and effect of oxidized cholesterol, oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with statin drugs to improve the effect of lowering not only cholesterol but also the oxidized cholesterol as well as oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with CoQ10 as a therapy for vascular disease and management of side effects of statin therapy.06-02-2011
20110281660COMBINATION FOR PASSING AN OBJECT THROUGH A THREE DIMENSIONAL TRUE COLOR IMAGE - The combination of a truly realistic three dimensional real image in color and a second device to produce a repetitive passage of a solid object through the real image creates the illusion of one solid body passing through another. A simple method of accomplishing this is to mount a clock with a pendulum over or under the image and allow a pendulum end to pass periodically through the real image. Other means such as a device running on a circular track could accomplish the same illusory effect. The pendulum end or the device can take various forms as can the real image. In principle the designs are not limited in size. The invention creates an exciting visual and illusory moment of a second object passing through an apparently solid object.11-17-2011
20120016175Direct visualization Robotic Intra-Operative Radiation Therapy Device with Radiation Ablation Capsule - This invention proposes a robotic applicator device to be deployed internally to a patient having a capsule (also referred to as a cassette) and aperture with a means of alternately occluding and exposing a radioactive source through the aperture. The capsule and aperture will be integrated with a surgical robot to create a robotic IORT (intra-operative radiation therapy) applicator device as more fully described below. The capsule, radiation source, and IORT applicator arm would be integrated to enable a physician, physicist or technician to interactively internally view and select tissue for exposure to ionizing radiation in sufficient quantities to deliver therapeutic radiation doses to tissue. Via the robotic manipulation device, the physician and physicist would remotely apply radiation to not only the tissue to be exposed, but also control the length of time of the exposure. Control means would be added to identify and calculate margin and depth of tissue to be treated and the proper radiation source or radioactive isotope (which can be any particle emitter, including neutron, x-ray, alpha, beta or gamma emitter) to obtain the desired therapeutic effects. The invention enables stereotactical surgery and close confines radiation therapy adjacent to radiosensitive tissue.01-19-2012
20120021073SYSTEMIC ADMINISTRATION OF NAC AS AN ADJUNCT IN THE TREATMENT OF BIOTERROR EXPOSURES SUCH AS SMALLPOX AND USE IN COMBINATION WITH DHEA FOR THE TREATMENT OF SMALLPOX - The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and/or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as 01-26-2012
20120087994SYSTEMIC ADMINISTRATION OF NAC AS AN ADJUNCT IN THE TREATMENT OF BIOTERROR EXPOSURES SUCH AS SMALLPOX AND USE IN COMBINATION WITH DHEA FOR THE TREATMENT OF SMALLPOX - The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and/or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as 04-12-2012

Patent applications by Brooke Schumm, Iii, Ellicott City, MD US

Brooke Schumm, Iii, Ellicott, MD US

Patent application numberDescriptionPublished
20100280374Direct Visualization Robotic Intra-Operative Radiation Therapy Applicator Device - This invention proposes a robotic applicator device to be deployed internally to a patient having a capsule (also referred to as a cassette) and aperture with a means of alternately occluding and exposing a radioactive source through the aperture. The capsule and aperture will be integrated with a surgical robot to create a robotic IORT (intra-operative radiation therapy) applicator device as more fully described below. The capsule, radiation source, and IORT applicator arm would be integrated to enable a physician, physicist or technician to interactively internally view and select tissue for exposure to ionizing radiation in sufficient quantities to deliver therapeutic radiation doses to tissue. Via the robotic manipulation device, the physician and physicist would remotely apply radiation to not only the tissue to be exposed, but also control the length of time of the exposure. Control means would be added to identify and calculate margin and depth of tissue to be treated and the proper radiation source or radioactive isotope (which can be any particle emitter, including neutron, x-ray, alpha, beta or gamma emitter) to obtain the desired therapeutic effects. The invention enables stereotactical surgery and close confines radiation therapy adjacent to radiosensitive tissue.11-04-2010

Brooke Schumm Ill, Ellicott City, MD US

Patent application numberDescriptionPublished
20110083870Combination of Impact Tool And Shaped Relatively Lower Modulus Material - An impacting tool, such as a jackhammer or electric hammer is proposed to be modified by a high modulus polymeric material, or metal of lower relative modulus than surrounding metal such as that of a piston. An interchangeable tool head is proposed to have inserted in a cavity in the impacted end such a high modulus polymeric material. Thus the term relatively lower modulus inclusion (“RLMI”) has been selected for the descriptive term. By using such relatively lower modulus material for an inclusion, which inclusion can be an insert, and modification of the piston or ram or impacting end of the tool, and additionally, if desired, the stop end of the piston or ram, the invention enables reduction of noise and vibration without substantially diminishing impact effectiveness and working time. Additionally, the working end of a cutting or impacting tool can be modified to a sharper angle because of diminished force through such relatively lower modulus inclusion. The edge angle, of for instance a chisel, may be modified to take advantage of mechanical changes resulting from the relatively lower modulus inclusion.04-14-2011

Brooke Schumm, Jr., Bay Village, OH US

Patent application numberDescriptionPublished
20090147335PERIODIC THREE DIMENSIONAL ILLUSION IN COLOR - The combination of a truly realistic three dimensional real image in color and a second device to produce a repetitive passage of a solid object through the real image creates the illusion of one solid body passing through another. A simple method of accomplishing this is to mount a clockworks with a pendulum over or under the image and allow a pendulum end to pass periodically through the real image. Other means such as a device running on a circular track could accomplish the same illusory effect. The pendulum end or the device can take various forms as can the real image. In principle the designs are not limited in size. Further, an amusement ride is contemplated by directing a track with a vehicle and a rider in the vehicle at the proper angle toward the real image creating an exciting visual moment passing through the apparently solid object.06-11-2009
20100112418MULTICAPABILITY PRINTED MICROACTUATORS (WITH SPIRAL OR FERROMAGNETIC ACTION) AND FUEL AND OXIDIZER CONTROL DEVICE GROUP - The invention proposes resealable, electrically responsive, thermally actuated valves in conjunction with a battery of cells, a case containing a battery, or a cell which valves have certain rotational characteristics that preferably operate spirally and away from an initial plane allowing entry of fluid, and then, on inactivation of a circuit, return to a resting sealed position. A further proposal is to provide the microactuation valve action with a micro ferromagnetic device either printed or otherwise deposited on a substrate to be included in the fuel cell or battery porting system. A further proposal is to increase the current supplying capability of small fuel cells and batteries by providing a metal, semiconductor or polymer barrier membrane containing metal oxides or other advantageous materials to allow increased fuel or oxygen diffusion into the fuel or oxygen depolarized cell or battery.05-06-2010
20100273073Fluid Regulating Microvalve Assembly For Fluid Consuming Cells - A fluid regulating microvalve assembly for use to control fluid flow to a fluid consuming electrode, such as an oxygen reduction electrode, in an electrochemical cell. The microvalve assembly includes a stationary valve body having an aperture and a microactuator movable from a first position where the microvalve body aperture is closed to fluid flow to at least a second position where fluid is able to pass through the microvalve body aperture. The fluid regulating microvalve assembly can utilize cell potential or a separate source to open and close the microvalve. The fluid regulating microvalve assembly can be located outside the cell housing or inside the cell housing, for example between one or more fluid inlet apertures and the fluid consuming electrode. The invention includes a method of making a multilayer microvalve assembly, particularly one for use in a fluid depolarized battery, using a printing process to deposit at least one of the layers.10-28-2010
20110281660COMBINATION FOR PASSING AN OBJECT THROUGH A THREE DIMENSIONAL TRUE COLOR IMAGE - The combination of a truly realistic three dimensional real image in color and a second device to produce a repetitive passage of a solid object through the real image creates the illusion of one solid body passing through another. A simple method of accomplishing this is to mount a clock with a pendulum over or under the image and allow a pendulum end to pass periodically through the real image. Other means such as a device running on a circular track could accomplish the same illusory effect. The pendulum end or the device can take various forms as can the real image. In principle the designs are not limited in size. The invention creates an exciting visual and illusory moment of a second object passing through an apparently solid object.11-17-2011

Patent applications by Brooke Schumm, Jr., Bay Village, OH US

Brooke Skora, San Diego, CA US

Patent application numberDescriptionPublished
20110152881CONTROL PORTION OF AND DEVICE FOR REMOTELY CONTROLLING AN ARTICULATING SURGICAL INSTRUMENT - A remotely controlled surgical device control portion comprises a user moveable bi-directional trigger, a finger loop disposed within the trigger, and a flange coupled to the finger loop. The trigger is configured for receiving a motion input in opposing first and second directions. The motion input is for controlling an articulation motion of an articulating surgical instrument. The finger loop is configured for receiving the motion input in the form of a user squeezing the trigger in the first direction with at least one finger or pushing the trigger in the second direction with said at least one finger. The flange is configured for receiving the motion input in the form of pushing the trigger in the second direction with a thumb.06-23-2011
20110178531Control portion of and device for remotely controlling an articulating surgical instrument - A control portion of a remotely controlled surgical device comprises a first set of controls, a second set of controls, and a function control mechanism. The first set of controls is configured for receiving motion from a human shoulder, arm, and hand and translating one or more of its received motion inputs into one or more macro motion control signals for controlling one or more macro motions associated with an articulating surgical instrument. The second set of controls is configured for receiving motion from the human shoulder, arm, and hand and translating one or more of its received motion inputs into one or more micro motion control signals for controlling one or more micro motions of the articulating surgical instrument. The function control mechanism is configured for receiving a function control input from a user of the control portion. The function control input is for controlling a function associated with the remotely controlled surgical device.07-21-2011
20110319911REMOTELY CONTROLLING AN ARTICULATING SURGICAL INSTRUMENT - A surgical device for remotely controlling an articulating surgical instrument comprises an articulating surgical instrument, a control portion, and a slave portion. The control portion is configured for receiving motion inputs in a plurality of degrees of freedom from a human shoulder, arm, and hand and translating the motion inputs into one or more control signals for controlling motion of the articulating surgical instrument. The control signals are generated within the control portion and wherein at least one of the control signals comprises displacement of hydraulic fluid. The slave portion is coupled between the control portion and the articulating surgical instrument. The control portion is configured for moving the articulating surgical instrument in response to the one or more control signals.12-29-2011
20120080040STERILE DRAPE HAVING MULTIPLE DRAPE INTERFACE MECHANISMS - A sterile drape configured for isolating a portion of a surgical device within a sterile environment, comprising: a plurality of drape interface mechanisms comprising: at least one drape/handle interface mechanism comprising a first ring defining a first opening through the sterile drape and configured for coupling with a control mechanism, the control mechanism comprising a surgical device for controlling a surgical instrument; and at least one drape/shaft interface mechanism comprising a second ring defining a second opening through the sterile drape, and configured for sealingly receiving a shaft there through as the shaft moves with a piston and is detachably coupled with the piston, wherein the piston is configured for responding to a first set of control signals sent by a first mechanical manipulation mechanism via a first connector by moving between a proximal end and a distal end of a first mechanical slave cylinder.04-05-2012
20120080041INTERFACE MECHANISM BETWEEN A DRAPE AND A HANDLE - A surgical device for use in positioning an instrument for use in a surgical procedure. The surgical device comprises: a mechanical positioning mechanism configured to couple with an instrument outside of a patient's body and to move the instrument relative to said patient's body; a control mechanism comprising a detachable control handle configured to be detachably coupled with the mechanical positioning mechanism and is sealingly coupled with a drape interface mechanism of a sterile drape, the sterile drape being configured for isolating a portion of the surgical device within a sterile environment, the drape interface mechanism comprising a ring defining an opening through the sterile drape; and a connector operatively coupled with the control mechanism and the mechanical positioning mechanism and configured for causing the mechanical positioning mechanism to move the instrument by transmitting force applied by a human to the control mechanism through the connector.04-05-2012
20120083768DETACHABLE HANDLE MECHANISM FOR USE IN INSTRUMENT POSITIONING - A detachable control handle of a surgical device for use in positioning an instrument for use in a surgical procedure. The detachable control handle comprises: a handle assembly configured for communicating with a mechanical positioning mechanism via a connector, wherein said mechanical positioning mechanism is configured to couple with said instrument outside of a patient's body and to move said instrument relative to said patient's body, said handle assembly comprising: a control handle; a detaching mechanism coupled with said control handle, said detaching mechanism configured for detachably coupling said control handle with said mechanical positioning mechanism, wherein said control handle and said mechanical positioning mechanism are sealingly coupled with a first and second portion of a drape interface mechanism of a sterile drape, respectively, wherein said sterile drape is configured for isolating a portion of said surgical device within a sterile environment.04-05-2012
20120083799INTERFACE MECHANISM BETWEEN A DETACHABLE SHAFT AND A STERILIZING DRAPE - An interface mechanism comprising: a ring defining an opening and configured for sealingly receiving a shaft there through, the ring comprising: an inner portion; and an outer portion, wherein the inner portion is sealingly coupled with a portion of a distal end of a mechanical slave cylinder of a surgical device, and the outer portion is coupled with the inner portion and is sealingly coupled with a draping material, the draping material configured for isolating a portion of the surgical device within a sterile environment.04-05-2012
20120083825DETACHABLE SHAFT - A surgical device comprising: a mechanical manipulation mechanism configured for transmitting a first set of control signals; and at least one mechanical slave cylinder coupled with the mechanical manipulation mechanism and positioned at a distal end of the surgical device, the at least one mechanical slave cylinder configured for receiving the first set of control signals, wherein the at least one mechanical slave cylinder comprises: a piston configured for responding to the first set of control signals by moving between a proximal end and a distal end of the mechanical slave cylinder; and a detachable shaft configured for detachably coupling with a distal end of the piston and for the moving with the piston.04-05-2012

Brooke Thompson, San Francisco, CA US

Patent application numberDescriptionPublished
20090244000USER INTERFACE FOR INTEGRATING DIVERSE METHODS OF COMMUNICATION - An integrated communication interface is provided for composing and sending messages. The interface is multi-configurable to seamlessly switch between different communication methods, e.g., electronic mail, instant messaging, SMS, chat, voice, and the like, without loss of message content. The interface allows a user to begin composing a message to be sent using one communication method, such as electronic mail, and subsequently change the communication method and send the message via a second communication method, such as instant messaging. When the communication method is changed, the user interface may also change to include elements specific to a particular communication method. The integrated communication interface may display information about participants in the communication, such as the participants' presence, i.e., whether they are online and available for communication, and may automatically choose the best method of communication based on the preferences and online presence of the participants.10-01-2009