Brochot, FR
Céline Brochot, Villers Sous Saint Leu FR
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20130060550 | METHOD OF TOXICOLOGICAL EVALUATION, METHOD OF TOXICOLOGICAL SCREENING AND ASSOCIATED SYSTEM - The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of the bioartificial tissue or organ in the form of biomarkers associated with the components of the data set that are adopted for the model. The present invention also relates to a method of toxicological screening and to a system for this purpose. | 03-07-2013 |
Céline Brochot, Villers Sous Saint Leu FR
Patent application number | Description | Published |
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20130060550 | METHOD OF TOXICOLOGICAL EVALUATION, METHOD OF TOXICOLOGICAL SCREENING AND ASSOCIATED SYSTEM - The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of the bioartificial tissue or organ in the form of biomarkers associated with the components of the data set that are adopted for the model. The present invention also relates to a method of toxicological screening and to a system for this purpose. | 03-07-2013 |
Jean Brochot, Feigeres FR
Patent application number | Description | Published |
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20090076477 | Automatic Liquid Injection System and Method - A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds. | 03-19-2009 |
20110245663 | Automatic Liquid Injection System and Method - A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds. | 10-06-2011 |
20120093732 | ULTRASOUND CONTRAST AGENTS AND METHODS OF MAKING AND USING THEM - The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents. | 04-19-2012 |
20120265065 | Automatic Liquid Injection System and Method - A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds. | 10-18-2012 |
20130101520 | ULTRASOUND CONTRAST AGENTS AND METHODS OF MAKING AND USING THEM - The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents. | 04-25-2013 |
20140163366 | Automatic Liquid Injection System and Method - A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds. | 06-12-2014 |
Patrice Brochot, Oullins FR
Patent application number | Description | Published |
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20110265591 | OFF-CENTRED PUSHER DEVICE FOR STEERING AN AUTOMOBILE - The invention relates to a pusher device ( | 11-03-2011 |
20110303034 | ECCENTRIC PUSH MEMBER DEVICE FOR MOTOR VEHICLE RACK-AND-PINION STEERING ASSEMBLY - The push member device ( | 12-15-2011 |
20120266707 | PUSH DEVICE WITH CLEARANCE COMPENSATION FOR RACK-AND-PINION STEERING OF A MOTOR VEHICLE - The invention relates to a push device ( | 10-25-2012 |