Patent application number | Description | Published |
20080243542 | Method and system for supporting clinical decision-making - A method and system are provided for facilitating decision making, such as in a clinical setting. In accordance with this technique, a set of encoded guidelines are executed to identify information that may be used to generate patient management options. The information is acquired, if available. Based on the encoded guidelines and the acquired information, a set of patient management options are generated and provided to one or more reviewers for review and selection of a patient management option. | 10-02-2008 |
20100106423 | METHOD AND APPARATUS FOR ASSESSING FEASIBILITY OF PROBES AND BIOMARKERS - The quantitative evaluation of biomarker-probe activity is disclosed. In certain embodiments, the biomarker-probe activity may be quantified and analyzed using biodistributions generated using a model. In some embodiments, such biodistributions may be used to generate simulated images from which quantitative thresholds may be derived. In some embodiments, the quantitative thresholds may be used to analyze the biodistributions. | 04-29-2010 |
20110091081 | METHOD AND SYSTEM FOR ANALYZING THE EXPRESSION OF BIOMARKERS IN CELLS IN SITU IN THEIR TISSUE OF ORIGIN - The present application discloses a technique for obtaining and storing data on expression of multiple biomarkers in individual cells or the compartments of individual cells in a tissue specimen and methods of utilizing that data to create groups, the members of which share some degree of similarity greater than the general population from which the data is drawn, by an analysis of digital images of a portion of the tissue specimen which has been iteratively stained to generate optical signals, typically fluorescent, reflective of the amount of each of the biomarkers examined. The analysis of the images involves a segmentation routine whereby each pixel of the examined images is assigned to an individual cell or a compartment of an individual cell, the intensity of the signal representative of each biomarker is measured for each pixel, a dataset is created in which each cell or compartments of each cell is associated with a signal intensity for each biomarker examined, and the dataset is interrogated with appropriate numerical tools to create groups. It also discloses the display of such groups on images of the tissue examined such that the individual cells belonging to a particular group are marked or indicated on one of the images examined. It further discloses examining the biomarker data for each group for possible association with a biological condition or process in cases in which tissue specimens drawn from different subjects or different portions of the tissue of a subject have been examined. It also discloses using this examination in the diagnoses, prognoses or assessment of the response to therapy of a condition or disease. | 04-21-2011 |
20110091091 | PROCESS AND SYSTEM FOR ANALYZING THE EXPRESSION OF BIOMARKERS IN CELLS - The invention relates generally to a process of analyzing and visualizing the expression of biomarkers in individual cells wherein the cells are examined to develop patterns of expression by using a grouping algorithm, and a system to perform and display the analysis | 04-21-2011 |
20130170728 | PROCESS AND SYSTEM FOR ANALYZING THE EXPRESSION OF BIOMARKERS IN A CELL - The invention relates generally to a process of analyzing and visualizing the expression of biomarkers in an individual cell wherein the cell is examined to develop patterns of expression by using a grouping algorithm, and a system to perform and display the analysis. | 07-04-2013 |
20130286038 | SYSTEMS AND METHODS FOR SELECTION AND DISPLAY OF MULTIPLEXED IMAGES OF BIOLOGICAL TISSUE - Exemplary embodiments enable selection and overlaid display of the expression of one or more biomarkers and/or one or more DNA sequences in a field-of-view of a biological tissue. The expressions of the biomarkers and/or DNA sequences are represented in one or more user-selected colors. The color settings are stored in associated with the biomarkers and/or DNA sequences such that a first user-selected color associated with a first biomarker in the saved color settings is automatically selected in response to receiving user input selecting the first biomarker. Similarly, a second user-selected color associated with a first DNA sequence in the saved color settings is automatically selected in response to receiving user input selecting the first DNA sequence. | 10-31-2013 |
20130286043 | SYSTEMS AND METHODS FOR ANALYZING BIOMARKER CO-LOCALIZATION IN A BIOLOGICAL TISSUE - Systems and methods are disclosed for selecting a field of view for a biological sample, selecting first and second biomarkers, each having a corresponding image in a multiplexed biomarker image of the selected field of view, automatically analyzing expression level criterion for each of the first and second biomarkers, rendering the corresponding images of the selected field-of-view in an overlaid manner on the graphical user interface and highlighting a first set of biological units in the biological tissue that meets both the biomarker expression level criterion for both the first and second biomarkers. | 10-31-2013 |
20130287283 | SYSTEMS AND METHODS FOR PERFORMING QUALITY REVIEW SCORING OF BIOMARKERS AND IMAGE ANALYSIS METHODS FOR BIOLOGICAL TISSUE - Exemplary embodiments include methods, systems, and devices for enabling users to provide quality scores for indicating the quality of image analysis methods performed on images of biological tissue. An exemplary user interface displays results of an image analysis method performed on an image of biological tissue in an overlaid manner on an image of biological tissue. The exemplary user interface enable a user to provide, directly on the user interface, one or more quality scores to indicate the user's assessment of the quality of the image analysis performed on the image. Exemplary embodiments store the quality scores provided by the user in association with the image analysis method and the image of biological tissue. | 10-31-2013 |
20130290006 | SYSTEMS AND METHODS FOR PERFORMING CORRELATION ANALYSIS ON CLINICAL OUTCOME AND CHARACTERISTICS OF BIOLOGICAL TISSUE - Embodiments disclosed herein include methods, systems, and devices for determining a positive or negative correlation between a clinical outcome and one or more features of biological tissue. An exemplary user interface enables a user to select a clinical outcome and one or more aspects of a displayed field-of-view of biological tissue. Exemplary embodiments may automatically perform correlation analysis between the selected clinical outcome and one or more features characteristic of the user-selected aspects of the field-of-view of biological tissue. For example, exemplary embodiments may automatically perform correlation analysis between the selected clinical outcome and one or more features characteristic of one or more biological units in the biological tissue. | 10-31-2013 |
20130290225 | SYSTEMS AND METHODS FOR SELECTING AND ANALYZING PARTICLES IN A BIOLOGICAL TISSUE - Systems and methods are disclosed for jointly presenting and analyzing morphological characteristics and biomarker expression levels of a biological sample. The systems and methods may utilize a morphological selection component to isolate a population of biological particles in a biological sample for exclusion from further processing. In addition, the systems and methods may simultaneously render morphological and statistical representations of the biological sample on a user interface. | 10-31-2013 |
20130317844 | METHOD AND SYSTEM FOR SUPPORTING CLINICAL DECISION-MAKING - A method and system are provided for facilitating decision making, such as in a clinical setting. In accordance with this technique, a set of encoded guidelines are executed to identify information that may be used to generate patient management options. The information is acquired, if available. Based on the encoded guidelines and the acquired information, a set of patient management options are generated and provided to one or more reviewers for review and selection of a patient management option. | 11-28-2013 |
20130332135 | METHOD AND APPARATUS FOR ASSESSING FEASIBILITY OF PROBES AND BIOMARKERS - The quantitative evaluation of biomarker-probe activity is disclosed. In certain embodiments, the biomarker-probe activity may be quantified and analyzed using biodistributions generated using a model. In some embodiments, such biodistributions may be used to generate simulated images from which quantitative thresholds may be derived. In some embodiments, the quantitative thresholds may be used to analyze the biodistributions. | 12-12-2013 |
20140372450 | METHODS OF VIEWING AND ANALYZING HIGH CONTENT BIOLOGICAL DATA - The invention relates generally to a method for interactive viewing and analysis of high content data in a biological pathway context. The high content data maybe related to the expression of biomarkers within a tissue, cellular, or cellular compartment of individual cell such that the data may reveal patterns of expression to identify a biological process, a clinical diagnosis or prognosis. | 12-18-2014 |
20150032671 | SYSTEMS AND METHODS FOR SELECTING AND ANALYZING PARTICLES IN A BIOLOGICAL TISSUE - Systems and methods are disclosed for jointly presenting and analyzing morphological characteristics and biomarker expression levels of a biological sample. The systems and methods may utilize a morphological selection component to isolate a population of biological particles in a biological sample for exclusion from further processing. In addition, the systems and methods may simultaneously render morphological and statistical representations of the biological sample on a user interface. | 01-29-2015 |